LOCUS       NM_001012027            1561 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus serpin family C member 1 (Serpinc1), mRNA.
ACCESSION   NM_001012027 XM_222802
VERSION     NM_001012027.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1561)
  AUTHORS   Yin J, Wang F, Kong Y, Wu R, Zhang G, Wang N, Wang L, Lu Z and
            Liang M.
  TITLE     Antithrombin III prevents progression of chronic kidney disease
            following experimental ischaemic-reperfusion injury
  JOURNAL   J Cell Mol Med 21 (12), 3506-3514 (2017)
   PUBMED   28767184
  REMARK    GeneRIF: Antithrombin III prevents progression of chronic kidney
            disease following experimental ischaemic-reperfusion injury.
REFERENCE   2  (bases 1 to 1561)
  AUTHORS   Wang F, Zhang G, Lu Z, Geurts AM, Usa K, Jacob HJ, Cowley AW, Wang
            N and Liang M.
  TITLE     Antithrombin III/SerpinC1 insufficiency exacerbates renal
            ischemia/reperfusion injury
  JOURNAL   Kidney Int 88 (4), 796-803 (2015)
   PUBMED   26108065
  REMARK    GeneRIF: SerpinC1 insufficiency in increasing the severity of renal
            ischemia/reperfusion injury.
REFERENCE   3  (bases 1 to 1561)
  AUTHORS   ElGendy AA and Abbas AM.
  TITLE     Effects of warfarin and L-carnitine on hemostatic function and
            oxidative stress in streptozotocin-induced diabetic rats
  JOURNAL   J Physiol Biochem 70 (2), 535-546 (2014)
   PUBMED   24671746
REFERENCE   4  (bases 1 to 1561)
  AUTHORS   Camara-Lemarroy CR, Guzman-de la Garza FJ, Alarcon-Galvan G,
            Cordero-Perez P, Munoz-Espinosa L, Torres-Gonzalez L and
            Fernandez-Garza NE.
  TITLE     Hepatic ischemia/reperfusion injury is diminished by atorvastatin
            in Wistar rats
  JOURNAL   Arch Med Res 45 (3), 210-216 (2014)
   PUBMED   24726586
REFERENCE   5  (bases 1 to 1561)
  AUTHORS   Ding Q, Wang M, Xu G, Ye X, Xi X, Yu T, Wang X and Wang H.
  TITLE     Molecular basis and thrombotic manifestations of antithrombin
            deficiency in 15 unrelated Chinese patients
  JOURNAL   Thromb Res 132 (3), 367-373 (2013)
   PUBMED   23932013
REFERENCE   6  (bases 1 to 1561)
  AUTHORS   Zee RY, Ying LH, Morris BJ and Griffiths LR.
  TITLE     Association and linkage analyses of restriction fragment length
            polymorphisms for the human renin and antithrombin III genes in
            essential hypertension
  JOURNAL   J Hypertens 9 (9), 825-830 (1991)
   PUBMED   1685742
REFERENCE   7  (bases 1 to 1561)
  AUTHORS   Ehrlich HJ, Gebbink RK, Keijer J, Linders M, Preissner KT and
            Pannekoek H.
  TITLE     Alteration of serpin specificity by a protein cofactor. Vitronectin
            endows plasminogen activator inhibitor 1 with thrombin inhibitory
            properties
  JOURNAL   J Biol Chem 265 (22), 13029-13035 (1990)
   PUBMED   1695900
REFERENCE   8  (bases 1 to 1561)
  AUTHORS   Emerson TE Jr, Fournel MA, Redens TB and Taylor FB Jr.
  TITLE     Efficacy of antithrombin III supplementation in animal models of
            fulminant Escherichia coli endotoxemia or bacteremia
  JOURNAL   Am J Med 87 (3B), 27S-33S (1989)
   PUBMED   2679067
REFERENCE   9  (bases 1 to 1561)
  AUTHORS   Sacks SH, Old JM, Reeders ST, Weatherall DJ, Douglas AS, Winter JH
            and Rizza CR.
  TITLE     Evidence linking familial thrombosis with a defective antithrombin
            III gene in two British kindreds
  JOURNAL   J Med Genet 25 (1), 20-24 (1988)
   PUBMED   3162535
REFERENCE   10 (bases 1 to 1561)
  AUTHORS   Takahara,H. and Sinohara,H.
  TITLE     Purification and characterization of rat plasma antithrombin III
  JOURNAL   Biochim Biophys Acta 612 (1), 185-194 (1980)
   PUBMED   7362830
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088467.1.
            
            On Feb 11, 2005 this sequence version replaced XM_222802.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088467.1, FQ211135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1561
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13q22"
     gene            1..1561
                     /gene="Serpinc1"
                     /note="serpin family C member 1"
                     /db_xref="GeneID:304917"
                     /db_xref="RGD:1307404"
     exon            1..93
                     /gene="Serpinc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1450
                     /gene="Serpinc1"
                     /note="antithrombin III; serine (or cysteine) proteinase
                     inhibitor, clade C (antithrombin), member 1; serine (or
                     cysteine) peptidase inhibitor, clade C (antithrombin),
                     member 1; serpin peptidase inhibitor, clade C
                     (antithrombin), member 1"
                     /codon_start=1
                     /product="antithrombin-III precursor"
                     /protein_id="NP_001012027.1"
                     /db_xref="GeneID:304917"
                     /db_xref="RGD:1307404"
                     /translation="MYSPGIGSAVAGERKLCLLSLLLIGALGCAVCHGNPVDDICIAK
                     PRDIPVNPMCIYRSPAKKATEEDVLEQKVPEATNRRVWELSKANSRFATNFYQHLADS
                     KNDNDNIFLSPLSISTAFAMTKLGACNNTLKQLMEVFKFDTISEKTSDQIHFFFAKLN
                     CRLYRKANKSSNLVSANRLFGDKSLTFNESYQDVSEIVYGAKLQPLDFKENPEQSRVT
                     INNWVANKTEGRIKDVIPQGAIDELTALVLVNTIYFKGLWKSKFSPENTRKEPFHKVD
                     GQSCLVPMMYQEGKFKYRRVGEGTQVLEMPFKGDDITMVLILPKPEKSLAKVEQELTP
                     ELLQEWLDELSEVMLVVHVPRFRIEDSFSLKEQLQDMGLVDLFSPEKSQLPGIIAEGR
                     DDLFVSDAFHKAFLEVNEEGSEAAASTSVVITGRSLNPSRVTFKANRPFLVLIREVAL
                     NTIIFMGRVSNPCVN"
     exon            94..463
                     /gene="Serpinc1"
                     /inference="alignment:Splign:2.1.0"
     exon            464..679
                     /gene="Serpinc1"
                     /inference="alignment:Splign:2.1.0"
     exon            680..817
                     /gene="Serpinc1"
                     /inference="alignment:Splign:2.1.0"
     exon            818..1208
                     /gene="Serpinc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1273
                     /gene="Serpinc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1527
                     /gene="Serpinc1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagggatt gctcagcact gtctccacgg cttctctgca gaagcgtcca ccatgtattc
       61 cccgggaata ggaagtgcgg ttgctggaga gaggaagctt tgtctcctct ctctgctact
      121 cattggtgcc ttgggctgtg ctgtctgtca tggaaaccct gtggacgaca tctgcatagc
      181 gaagccccga gacatccccg tgaaccccat gtgcatttac cgctcccctg cgaagaaggc
      241 cacggaggag gatgtcctag agcagaaggt tccggaagcc accaaccggc gggtctggga
      301 actgtccaag gccaattctc gatttgccac taacttctat cagcacctgg cagactccaa
      361 gaacgacaac gacaacattt tcctgtcacc cttgagcatc tccacggcgt ttgctatgac
      421 caagctgggt gcttgtaata acaccctcaa gcagctgatg gaggttttta aatttgatac
      481 catctccgag aagacatccg accagatcca cttcttcttt gccaaactga actgccgact
      541 ctatcgaaaa gccaacaagt cctctaactt ggtgtcagcc aaccgccttt ttggagacaa
      601 atcccttacc ttcaatgaga gctatcaaga cgttagtgag attgtctatg gagccaagct
      661 tcagcccctg gacttcaagg agaatccgga gcaatccaga gtgaccatca acaactgggt
      721 agctaataag actgaaggcc gcatcaaaga cgtcatcccc caaggagcca ttgatgagct
      781 cactgccctg gtgctggtta acaccattta cttcaagggc ctgtggaagt caaagttcag
      841 ccctgagaac acaaggaagg aaccattcca caaagttgat gggcagtcat gcctggtgcc
      901 catgatgtac caggaaggca aattcaaata caggcgtgtg ggagagggta cccaggtgct
      961 agagatgccc ttcaaggggg acgacatcac catggtgctc atcctgccca agcctgagaa
     1021 gagcctggct aaggtggagc aggaactcac cccggagctg ctgcaggagt ggctggatga
     1081 gctgtcggag gtcatgcttg tggtccacgt gccccgcttc cgcatcgagg acagcttcag
     1141 tctgaaggag cagctgcaag acatgggcct tgttgatctc ttcagccctg agaagtccca
     1201 actcccaggg atcattgctg aaggcaggga cgacctcttt gtctccgatg cattccacaa
     1261 agcgtttctt gaggtaaatg aggaaggcag tgaagcagca gcgagtactt ctgtcgtgat
     1321 tactggccgg tcactgaacc ccagtagggt gaccttcaag gccaacaggc ccttcctggt
     1381 tcttataagg gaagtcgcac tgaacactat tatattcatg gggagagtgt ctaatccttg
     1441 tgtgaactaa aatattctta atctttgcac cttttcctat ctcggtgttt gttaatggaa
     1501 gtaaaaataa atatgactgc cacctcaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1561 a
//
