LOCUS       NM_001007732            1833 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus serpin family B member 9 (Serpinb9), mRNA.
ACCESSION   NM_001007732 XM_341522
VERSION     NM_001007732.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1833)
  AUTHORS   Toossi Z, Wu M, Rojas R, Kalsdorf B, Aung H, Hirsch CS, Walrath J,
            Wolbink A, van Ham M and Silver RF.
  TITLE     Induction of serine protease inhibitor 9 by Mycobacterium
            tuberculosis inhibits apoptosis and promotes survival of infected
            macrophages
  JOURNAL   J Infect Dis 205 (1), 144-151 (2012)
   PUBMED   22090449
REFERENCE   2  (bases 1 to 1833)
  AUTHORS   El Haddad N, Moore R, Heathcote D, Mounayar M, Azzi J, Mfarrej B,
            Batal I, Ting C, Atkinson M, Sayegh MH, Ashton-Rickardt PG and Abdi
            R.
  TITLE     The novel role of SERPINB9 in cytotoxic protection of human
            mesenchymal stem cells
  JOURNAL   J Immunol 187 (5), 2252-2260 (2011)
   PUBMED   21795594
REFERENCE   3  (bases 1 to 1833)
  AUTHORS   Buschow SI, van Balkom BW, Aalberts M, Heck AJ, Wauben M and
            Stoorvogel W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
REFERENCE   4  (bases 1 to 1833)
  AUTHORS   Ghosh D, Lippert D, Krokhin O, Cortens JP and Wilkins JA.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 1833)
  AUTHORS   Zhang M, Liu N, Park SM, Wang Y, Byrne S, Murmann AE, Bahr S, Peter
            ME, Olson ST, Belaaouaj A and Ashton-Rickardt PG.
  TITLE     Serine protease inhibitor 6-deficient mice have increased
            neutrophil immunity to Pseudomonas aeruginosa
  JOURNAL   J Immunol 179 (7), 4390-4396 (2007)
   PUBMED   17878334
REFERENCE   6  (bases 1 to 1833)
  AUTHORS   Bots M, Kolfschoten IG, Bres SA, Rademaker MT, de Roo GM, Kruse M,
            Franken KL, Hahne M, Froelich CJ, Melief CJ, Offringa R and Medema
            JP.
  TITLE     SPI-CI and SPI-6 cooperate in the protection from effector
            cell-mediated cytotoxicity
  JOURNAL   Blood 105 (3), 1153-1161 (2005)
   PUBMED   15454490
REFERENCE   7  (bases 1 to 1833)
  AUTHORS   Bird CH, Blink EJ, Hirst CE, Buzza MS, Steele PM, Sun J, Jans DA
            and Bird PI.
  TITLE     Nucleocytoplasmic distribution of the ovalbumin serpin PI-9
            requires a nonconventional nuclear import pathway and the export
            factor Crm1
  JOURNAL   Mol Cell Biol 21 (16), 5396-5407 (2001)
   PUBMED   11463822
REFERENCE   8  (bases 1 to 1833)
  AUTHORS   Buzza MS, Hirst CE, Bird CH, Hosking P, McKendrick J and Bird PI.
  TITLE     The granzyme B inhibitor, PI-9, is present in endothelial and
            mesothelial cells, suggesting that it protects bystander cells
            during immune responses
  JOURNAL   Cell Immunol 210 (1), 21-29 (2001)
   PUBMED   11485349
REFERENCE   9  (bases 1 to 1833)
  AUTHORS   Young JL, Sukhova GK, Foster D, Kisiel W, Libby P and Schonbeck U.
  TITLE     The serpin proteinase inhibitor 9 is an endogenous inhibitor of
            interleukin 1beta-converting enzyme (caspase-1) activity in human
            vascular smooth muscle cells
  JOURNAL   J Exp Med 191 (9), 1535-1544 (2000)
   PUBMED   10790428
REFERENCE   10 (bases 1 to 1833)
  AUTHORS   Sun J, Bird CH, Sutton V, McDonald L, Coughlin PB, De Jong TA,
            Trapani JA and Bird PI.
  TITLE     A cytosolic granzyme B inhibitor related to the viral apoptotic
            regulator cytokine response modifier A is present in cytotoxic
            lymphocytes
  JOURNAL   J Biol Chem 271 (44), 27802-27809 (1996)
   PUBMED   8910377
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079063.1.
            
            On Nov 29, 2004 this sequence version replaced XM_341522.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079063.1, CF110792.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676806, SAMN16676807
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1833
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1833
                     /gene="Serpinb9"
                     /note="serpin family B member 9"
                     /db_xref="GeneID:361241"
                     /db_xref="RGD:1549730"
     exon            1..161
                     /gene="Serpinb9"
                     /inference="alignment:Splign:2.1.0"
     exon            162..339
                     /gene="Serpinb9"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..1296
                     /gene="Serpinb9"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 9; serpin peptidase inhibitor, clade B (ovalbumin),
                     member 9"
                     /codon_start=1
                     /product="serpin B9"
                     /protein_id="NP_001007733.1"
                     /db_xref="GeneID:361241"
                     /db_xref="RGD:1549730"
                     /translation="MNTLSEANGTFAIHLLKMLCQSNPSENVCYSPVSISSALAMVLL
                     GAKGQTQVQISQALGLNKEKDLHQGFQLLLSNLNKPERKYSLRVANRLFADKTCELLP
                     TYKESCLRFYNSEMEQLSFAEAAEESRKHINTWVSKQTEGKIPELLSGGSVDSETRLV
                     LVNALYFKGRWHQPFNKEYTVDMPFKINKNEKRLVQMMCCEDTYNLAHVKEVQAQVLM
                     MPYEGMELSFVVLLPDNDGDLSKVESNLTFEKLTAWTNPDFMKNTNVEVFLPKFKLQE
                     DYDMESVFQRLGIVDVFQEAKADLSAMSPERNLCVSKIVHKSLVEVNEEGTEAAAASA
                     VIEYCCAAFVPTFCADHPFLFFIKHNKTNSILFCGRFSSP"
     exon            340..477
                     /gene="Serpinb9"
                     /inference="alignment:Splign:2.1.0"
     exon            478..595
                     /gene="Serpinb9"
                     /inference="alignment:Splign:2.1.0"
     exon            596..738
                     /gene="Serpinb9"
                     /inference="alignment:Splign:2.1.0"
     exon            739..894
                     /gene="Serpinb9"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1810
                     /gene="Serpinb9"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgcaggca gcccgtttcc ccgcccttac cgagggtgct aaactagaag tccccgccct
       61 gtattgtatg aatacagggc cagcaaagcc tcgcaggcaa ctctgctagg ctactgggag
      121 catcaaggct gcaaatgctg gattgagaaa ccacaactgt gactctgcat catgaatact
      181 ctgtctgaag caaatggcac ctttgccatc catcttttga agatgctatg tcaaagcaac
      241 ccttcagaaa atgtatgtta ctctcctgtg agcatctcct ctgctctagc tatggtcctc
      301 ttgggggcaa agggacagac ccaagtccag atatctcagg cacttggttt gaacaaagag
      361 aaagacctcc atcagggctt ccagttgctt ctcagtaacc tgaacaagcc agagagaaaa
      421 tactccctta gagtggccaa caggctcttt gcagacaaaa cttgtgaact cctcccaacc
      481 tataaggagt cctgtcttcg attctataat tcagagatgg agcagctctc ctttgccgaa
      541 gctgcagagg agtcaaggaa acacataaac acgtgggtct ccaaacagac tgaaggcaaa
      601 attcctgagc tgttgtcagg tggttcagtt gattcagaga ccaggctggt tctcgtcaat
      661 gccttatatt tcaaaggaag gtggcatcaa ccatttaaca aagaatacac agtggatatg
      721 ccctttaaaa taaacaagaa tgagaaacga ctagtgcaga tgatgtgttg tgaggacaca
      781 tataaccttg cccatgtgaa ggaggtgcag gcgcaagtgc tcatgatgcc atatgaagga
      841 atggagctga gcttcgtggt cctgctccca gataatgacg gggacctcag caaggtggaa
      901 agcaatctca cttttgagaa gttaacagcc tggaccaacc cagactttat gaagaacact
      961 aatgttgagg ttttccttcc aaaatttaaa ctgcaagagg attatgacat ggagtctgtg
     1021 tttcagcgct tgggaatagt ggatgtcttc caagaggcca aggctgactt atcagcaatg
     1081 tctccagaga gaaacctgtg tgtgtccaag attgttcaca agagcttagt ggaggtcaat
     1141 gaggaaggca cagaggctgc agcagcctcc gctgtcatag aatactgctg tgctgctttt
     1201 gtcccaacat tctgtgctga ccaccccttc cttttcttca tcaagcacaa caaaaccaac
     1261 agcattctgt tctgtggcag gttctcatct ccataaagac acatttacta catggggaga
     1321 gtcctctctt cagtatctcc accactccaa agctctgcca ggatgggcaa gtagggggaa
     1381 accatgttcc aagatgagga tactttcttc ctgccagcct gatcttatga tgcctgcatt
     1441 cagctctccc tatcctgaat gcatttgtgc ccttttgcag gttatgtcta atgatgccat
     1501 atagcctttg ctatgccgct gatactcata acttatagcc aataacttac agcctggtag
     1561 aactgaatca atgtgtaaga atgctggaga gaaggacaga tactaggaaa agttgctgat
     1621 cttgcaaagg acacagggac atttcccacc acccacatgg ctgcttacaa cctctggaaa
     1681 ttccagtttc cacccatgtc ttgatgcctt tatttggcta ctactggccc cagcatcctg
     1741 tataagcatg taacatcact caaagttatg cagaaacaag taaattttaa aaaaataaat
     1801 aaaaatttaa aaaaaaaaaa aaaaaaaaaa aaa
//
