LOCUS       NM_001105948            3021 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus serpin family B member 8 (Serpinb8), mRNA.
ACCESSION   NM_001105948 XM_001056957 XM_222490
VERSION     NM_001105948.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3021)
  AUTHORS   Pigors,M., Sarig,O., Heinz,L., Plagnol,V., Fischer,J., Mohamad,J.,
            Malchin,N., Rajpopat,S., Kharfi,M., Lestringant,G.G., Sprecher,E.,
            Kelsell,D.P. and Blaydon,D.C.
  TITLE     Loss-of-Function Mutations in SERPINB8 Linked to Exfoliative
            Ichthyosis with Impaired Mechanical Stability of Intercellular
            Adhesions
  JOURNAL   Am J Hum Genet 99 (2), 430-436 (2016)
   PUBMED   27476651
REFERENCE   2  (bases 1 to 3021)
  AUTHORS   Sprecher,C.A., Morgenstern,K.A., Mathewes,S., Dahlen,J.R.,
            Schrader,S.K., Foster,D.C. and Kisiel,W.
  TITLE     Molecular cloning, expression, and partial characterization of two
            novel members of the ovalbumin family of serine proteinase
            inhibitors
  JOURNAL   J Biol Chem 270 (50), 29854-29861 (1995)
   PUBMED   8530382
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 11, 2023 this sequence version replaced NM_001105948.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643295.46076.1,
                                           SRR26643429.43910.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-277               JAXUCZ010000013.1  24141557-24141833
            278-459             JAXUCZ010000013.1  24147042-24147223
            460-597             JAXUCZ010000013.1  24148414-24148551
            598-715             JAXUCZ010000013.1  24158700-24158817
            716-858             JAXUCZ010000013.1  24160649-24160791
            859-1014            JAXUCZ010000013.1  24161785-24161940
            1015-3021           JAXUCZ010000013.1  24162888-24164894
FEATURES             Location/Qualifiers
     source          1..3021
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13p11"
     gene            1..3021
                     /gene="Serpinb8"
                     /note="serpin family B member 8"
                     /db_xref="GeneID:288937"
                     /db_xref="RGD:1309833"
     exon            1..277
                     /gene="Serpinb8"
                     /inference="alignment:Splign:2.1.0"
     exon            278..459
                     /gene="Serpinb8"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1419
                     /gene="Serpinb8"
                     /note="serine (or cysteine) peptidase inhibitor, clade B,
                     member 8; serine (or cysteine) peptdiase inhibitor, clade
                     B, member 8; serpin peptidase inhibitor, clade B
                     (ovalbumin), member 8"
                     /codon_start=1
                     /product="serpin B8"
                     /protein_id="NP_001099418.1"
                     /db_xref="GeneID:288937"
                     /db_xref="RGD:1309833"
                     /translation="MDDLCEANGSFAISLLKILGEEDKSRNLFFCPMSVSSALAMVYL
                     GAKGNTATQMSQVLGLSGDGDVHQGFQTLLAEVNKSGTQYLLKSACRLFGEESCDFLS
                     TFKESCQKFYQAGIEEMSFVKDTEGCRKRINDWVLEKTEGKISEVLSPGTVCPLTKLV
                     LVNAMYFKGKWKAQFDRKYTRGMPFKTNQEEKKTVQMMFKHAKFKMAHVDEVNAQVLA
                     LPYAEDELSMVVLLPDESSDLTVVEKALTYEKLRAWTNPETLTESKVQVFFPRLKLEE
                     SYDLETVLQSLGMTDAFEETKADFSGMTSKKNVPVSKVAHKCFVEVNEEGTEAAATTA
                     VIRNTRSCRIEPRFCADRPFLFFIWHQKTSSILFCGRFSSP"
     exon            460..597
                     /gene="Serpinb8"
                     /inference="alignment:Splign:2.1.0"
     exon            598..715
                     /gene="Serpinb8"
                     /inference="alignment:Splign:2.1.0"
     exon            716..858
                     /gene="Serpinb8"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1014
                     /gene="Serpinb8"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..3021
                     /gene="Serpinb8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgcgttatg ttctgagtca ttcaacaggc gccttgccca ggatcaaggc ggactttaag
       61 tgttcacaaa gcaagattag cagcagaagc agccacagca gcaggtatct tcaaagtgaa
      121 gctctaagga agctctaaga cctctcagac tctcggagcc tgggatctat attggctctt
      181 tagagtcagg acagaagcta agcaggacaa aggctgggat ctcaccagag ctgcaggaag
      241 agcccaggag ctagcaaaag actccagtga cagagagcct agaccctgca aatggatgac
      301 ctctgtgaag ccaatggctc ttttgccatc agcctattaa aaatattggg tgaagaagac
      361 aagtcacgga acctgttctt ctgccccatg agtgtctcct cagccctggc tatggtttac
      421 ctcggagcca aaggaaacac tgctacccag atgtcccagg tacttggttt gagtggagac
      481 ggagatgttc atcaaggttt ccagacactt ctcgccgaag ttaacaaaag tggcactcag
      541 tacttgttaa aaagtgcctg tcgactcttt ggagaggaat catgtgattt cctttcgacc
      601 ttcaaggaat cctgccagaa gttctaccag gctgggatag aagagatgtc ctttgttaaa
      661 gacactgaag ggtgcaggaa acgcatcaat gattgggtgt tggaaaaaac tgaaggtaaa
      721 atttccgaag ttctgagtcc tggaacagtt tgcccactga ctaagctggt tcttgtgaat
      781 gccatgtatt tcaaagggaa gtggaaggct cagtttgaca ggaagtacac gaggggcatg
      841 ccctttaaaa ctaatcagga ggagaagaag acagtccaga tgatgttcaa gcatgctaaa
      901 tttaagatgg cacatgtgga tgaggtgaac gcgcaggttc tggctctgcc ctatgctgag
      961 gacgagctga gcatggtcgt cctccttcct gatgagagct ctgatctcac tgtggtggag
     1021 aaagcactta catatgagaa gcttagagct tggacaaatc cagaaaccct gacagaaagt
     1081 aaagtgcaag tctttttccc cagactaaag ctggaggaaa gttatgacct ggaaactgtt
     1141 cttcagagtt tgggaatgac agatgccttt gaggaaacaa aggctgactt ctctgggatg
     1201 acaagtaaga agaatgtgcc tgtgtccaag gttgcccaca agtgctttgt ggaggttaat
     1261 gaggaaggca ccgaagcagc tgcgaccact gcagtgatca ggaatacccg gagctgcaga
     1321 atagagccaa ggttctgtgc tgaccgccca ttccttttct tcatctggca ccagaaaacc
     1381 agcagcatct tgttctgtgg caggttctct tctccataat gtccttatgg ggttgaggat
     1441 gtggttcagt tggcggagtg tttgcagaac aagcacaagg ccctaggctc agccctaagc
     1501 accctatgaa gctaggcatg attgtgccta cctgccatcc tagcatttgg gaggtgcagg
     1561 atgagtgagt cacacattca aggtcatcct aaatgacaca ggactctgtc tcaaacacca
     1621 ccaccaccac caccaccacc accaccacca ccaccgccaa caacaacaac aacaataaca
     1681 ataaaaaaca agaaagtaga tgtgtgattg attgacacat cattctctgc tgaattctgg
     1741 aattaaaatt ccatgttgtc agatttgcca aggtgatttc aatgtaaaaa taaaaagaat
     1801 atacttagta gttggtgact atccttcctg actgtcccaa tactgtgtat ggcagtttgg
     1861 agtggacgag aaggccatac ttggtttgga gtgtctgagg tgattctcag tatctccagc
     1921 cttactccca acccagattc taaagtgctg ctccaccctg ttaacatctc taaactgtcc
     1981 ccaccactga aagacttacc cgggaatgcc agtgaccatt cacaaagcca agggtaagag
     2041 ctacagaata actgctgtaa ctgcccatga ctcctacgta gctgagagag tgtctccttc
     2101 cgtcagtgtc actcaatgct ctcttatgac tcagggttca ggcaactctt tccacaagtt
     2161 ttcagtgaat gtttaagaac tcagtgagag ccttcaggat ggagctgaga catgacgctc
     2221 caaagtgttt cctcccccaa acccctgact gctttctaaa gctccaagtg ttttccttat
     2281 ttcccctgac tctaatgaaa atgtcacaca ggatgattct tacaaaccat ctctctaatt
     2341 aactacgtgc tcagacatga ttcaaatgta cccttaatgc cctaaatgca tatgcatgct
     2401 agcatcagta catagactca gtgggttgta cttatacatg tgtgtgtgtt tgtgcgtgtg
     2461 tgtgtgtgtg tatgtgcatg tgtaacaaag aagtcatgaa tatgagaggg agtgaggggg
     2521 gcacaggagg agtcaggtga gaagtgagga gtgggcaaaa atagactatt tatatatgaa
     2581 attctaaaat aaaattaaag attaaataaa aaagacaact atattttctg actgaataaa
     2641 atttttatta ttggcagaaa gtgggaaatt ataggaacac atacaaagaa atttaagctt
     2701 tctgcaagtc ccctcctcag aaatcactat tttgaatatg cattatatcc attatatgga
     2761 tgcaaatata aattcataat gttttagcac aggataatga tcattttttg tagcttattt
     2821 tcactgtaag tcttgctcaa gacaattatc attcagtgtc aacatcttgc tgtgcattga
     2881 attgtgggat gagggagcgt tttctgtaag caaacctatt tagacaattt ggaaaattaa
     2941 acatgtatta cagactactg tgttgaatat cttcaatggt tgattacact cttaatttct
     3001 caataaatat tgctaaaatg a
//
