LOCUS       NM_130404               1929 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus serpin family B member 7 (Serpinb7), mRNA.
ACCESSION   NM_130404 XM_008769420
VERSION     NM_130404.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1929)
  AUTHORS   Xia,Y., Zhang,Y., Shi,W., Liu,S., Chen,Y., Liang,X. and Ye,Z.
  TITLE     Overexpression of megsin induces mesangial cell proliferation and
            excretion of type IV collagen in vitro
  JOURNAL   Cell Immunol 271 (2), 413-417 (2011)
   PUBMED   21945418
  REMARK    GeneRIF: over-expression of megsin induced incorporation of
            [(3)H]thymidine in mesangial cells and PDGF-BB, TGF-beta1
            upregulation
REFERENCE   2  (bases 1 to 1929)
  AUTHORS   McDonough,C.W., Bostrom,M.A., Lu,L., Hicks,P.J., Langefeld,C.D.,
            Divers,J., Mychaleckyj,J.C., Freedman,B.I. and Bowden,D.W.
  TITLE     Genetic analysis of diabetic nephropathy on chromosome 18 in
            African Americans: linkage analysis and dense SNP mapping
  JOURNAL   Hum Genet 126 (6), 805-817 (2009)
   PUBMED   19690890
REFERENCE   3  (bases 1 to 1929)
  AUTHORS   Ohtomo,S., Nangaku,M., Izuhara,Y., Yamada,N., Dan,T., Mori,T.,
            Ito,S., van Ypersele de Strihou,C. and Miyata,T.
  TITLE     The role of megsin, a serine protease inhibitor, in diabetic
            mesangial matrix accumulation
  JOURNAL   Kidney Int 74 (6), 768-774 (2008)
   PUBMED   18580857
  REMARK    GeneRIF: high glucose per se induces megsin expression both in vivo
            in a model of type II diabetic nephropathy and in vitro in cultured
            mesangial cells, in which it also inhibits total MMP-2 and MMP-9
            activities and plasmin enzymatic activity.
REFERENCE   4  (bases 1 to 1929)
  AUTHORS   Lim,C.S., Kim,S.M., Oh,Y.K., Joo,K.W., Kim,Y.S., Han,J.S. and
            Kim,S.
  TITLE     Megsin 2093T-2180C haplotype at the 3' untranslated region is
            associated with poor renal survival in Korean IgA nephropathy
            patients
  JOURNAL   Clin Nephrol 70 (2), 101-109 (2008)
   PUBMED   18793525
REFERENCE   5  (bases 1 to 1929)
  AUTHORS   Takano,K., Kitao,Y., Inagi,R., Momoi,T., Matsuyama,T., Miyata,T.,
            Yoneda,Y., Iso,H., Stern,D.M., Hori,O. and Ogawa,S.
  TITLE     A rat model of human FENIB (familial encephalopathy with
            neuroserpin inclusion bodies)
  JOURNAL   Biochem Biophys Res Commun 346 (3), 1040-1047 (2006)
   PUBMED   16782060
REFERENCE   6  (bases 1 to 1929)
  AUTHORS   Wang,Z.H., Chen,N., Pan,X.X., Ren,H., Wang,W.M., Zhang,W.,
            Hao,C.L., Zhu,J., Lu,Y. and Han,B.
  TITLE     [Association of single nucleotide polymorphism of megsin gene with
            IgA nephropathy]
  JOURNAL   Zhonghua Yi Xue Za Zhi 86 (19), 1337-1341 (2006)
   PUBMED   16796905
REFERENCE   7  (bases 1 to 1929)
  AUTHORS   Xia,Y.F., Huang,S., Li,X., Yang,N., Huang,J., Xue,C., Zhang,M.,
            Leung,J.C., Lam,M.F. and Li,J.
  TITLE     A family-based association study of megsin A23167G polymorphism
            with susceptibility and progression of IgA nephropathy in a Chinese
            population
  JOURNAL   Clin Nephrol 65 (3), 153-159 (2006)
   PUBMED   16550745
REFERENCE   8  (bases 1 to 1929)
  AUTHORS   Inagi,R., Yamamoto,Y., Nangaku,M., Usuda,N., Okamato,H.,
            Kurokawa,K., van Ypersele de Strihou,C., Yamamoto,H. and Miyata,T.
  TITLE     A severe diabetic nephropathy model with early development of
            nodule-like lesions induced by megsin overexpression in RAGE/iNOS
            transgenic mice
  JOURNAL   Diabetes 55 (2), 356-366 (2006)
   PUBMED   16443768
REFERENCE   9  (bases 1 to 1929)
  AUTHORS   Nangaku,M., Miyata,T., Suzuki,D., Umezono,T., Hashimoto,T.,
            Wada,T., Yagi,M., Nagano,N., Inagi,R. and Kurokawa,K.
  TITLE     Cloning of rodent megsin revealed its up-regulation in
            mesangioproliferative nephritis
  JOURNAL   Kidney Int 60 (2), 641-652 (2001)
   PUBMED   11473647
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On or before Oct 12, 2022 this sequence version replaced
            XM_008769420.3, NM_130404.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ228843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16093042, SAMN16093043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                JAXUCZ010000013.1  23910306-23910350
            46-231              JAXUCZ010000013.1  23914539-23914724
            232-282             JAXUCZ010000013.1  23923349-23923399
            283-399             JAXUCZ010000013.1  23923919-23924035
            400-517             JAXUCZ010000013.1  23938606-23938723
            518-660             JAXUCZ010000013.1  23940520-23940662
            661-807             JAXUCZ010000013.1  23947774-23947920
            808-1929            JAXUCZ010000013.1  23955713-23956834
FEATURES             Location/Qualifiers
     source          1..1929
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13p11"
     gene            1..1929
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /note="serpin family B member 7"
                     /db_xref="GeneID:117092"
                     /db_xref="RGD:71063"
     exon            1..45
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /inference="alignment:Splign:2.1.0"
     exon            46..231
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..1206
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /note="serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 7; serine (or cysteine) proteinase
                     inhibitor, clade B, member 7; serine (or cysteine)
                     peptidase inhibitor, clade B, member 7; serpin peptidase
                     inhibitor, clade B (ovalbumin), member 7"
                     /codon_start=1
                     /product="serpin B7"
                     /protein_id="NP_569088.2"
                     /db_xref="GeneID:117092"
                     /db_xref="RGD:71063"
                     /translation="MASLAAANAEFGFDLFREMDSSQGNGNVFFSSLSIFTALSLIRL
                     GARGDCARQIDKALHFISPSRQGNSSNSQLGLQYQLKRVLADINSSHKDYELSIANGV
                     FAEKVFDFHKSYMECAENLYNAKVERVDFTNDIQETRFKINKWIENETHGKIKKVLGD
                     SSLSSSAVMVLVNAVYFKGKWKSAFTKSDTLSCHFRSPTCPGKAVNMMHQERRFNLST
                     IQEPPMQILELQYHGGISMYIMLPEDDLSEIESKLSFQNLMDWTNSRKMKSQYVNVFL
                     PQFKIEKDYEMRSHLKSVGLEDIFVESRADLSGIASGGRLYVSKLMHKSLIEVSEEGT
                     EATAATESNIVEKLLPESTVFRADRPFLFVIRKNGIILFTGKVSCP"
     exon            232..282
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /inference="alignment:Splign:2.1.0"
     exon            283..399
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /inference="alignment:Splign:2.1.0"
     exon            400..517
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /inference="alignment:Splign:2.1.0"
     exon            518..660
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /inference="alignment:Splign:2.1.0"
     exon            661..807
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1929
                     /gene="Serpinb7"
                     /gene_synonym="Megsin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagactcacc caagcagctg ctacttcctc tctgaagaga gtaaggagac acttggtttc
       61 aaaatggcct cccttgctgc agcaaatgca gaatttggct tcgacttatt cagagagatg
      121 gatagtagtc aaggaaacgg aaatgtattc ttctcttccc tgagcatctt cactgccctg
      181 agcctaatcc gtttgggtgc tcgaggtgac tgtgcacgtc agattgacaa ggccctgcac
      241 tttatctccc catcaagaca agggaattca tcgaacagtc agctaggact gcaatatcaa
      301 ttgaaaagag ttcttgctga cataaactca tctcataagg attatgaact cagcattgcc
      361 aatggagttt ttgcagagaa agtatttgat tttcataaga gctatatgga gtgtgctgaa
      421 aacttataca atgctaaagt ggaaagagtt gactttacaa atgatataca agaaaccaga
      481 tttaaaatta ataaatggat tgaaaatgaa acacatggca aaatcaagaa ggtgttgggg
      541 gacagcagcc tcagctcatc agctgtcatg gtgctagtga atgctgttta cttcaaaggc
      601 aagtggaaat cggccttcac caagagtgat accctcagtt gccatttcag gtctcccacg
      661 tgtcctggaa aagcagttaa tatgatgcat caagaacgga ggttcaattt gtctaccatt
      721 caggagccac caatgcagat tcttgagcta caatatcatg gtggcataag catgtacatc
      781 atgttgcccg aggatgacct atccgaaatt gaaagcaagc tgagtttcca gaatctaatg
      841 gactggacaa atagcaggaa gatgaaatct cagtatgtga atgtgtttct cccccagttc
      901 aagatagaga aagattatga aatgaggagc cacttgaaat ctgtaggctt ggaagacatc
      961 tttgttgagt ccagggctga tctgtctgga attgcctctg gaggtcgtct ctatgtatca
     1021 aagctaatgc acaagtccct catagaggtc tcagaagaag gcaccgaggc aactgctgcc
     1081 acagaaagta acatcgttga aaagctactt cctgaatcca cggtgttcag agctgaccgc
     1141 ccctttctgt ttgtcattag gaagaatggc atcatcttat ttactggcaa agtctcgtgt
     1201 ccttgaaatt ctatttggtt ttccatacac taacaggcat gaagaaacat cataagtgaa
     1261 tagaattgta attggaagta catgggtttg ctttgatttg tttcagttca ttggtggtca
     1321 gcaaattatt ttggtgactt aacctttttc actccctggt tggtagtctc aatccctgct
     1381 ctcatcattt ttactcccat ttacttccct tcatcttata ttattggctt tccctccatg
     1441 ttctactctt ccattctttc cgaaggccca tctggaaaca tggattctga ttctctcatg
     1501 aaagaatgca tgggctgcct gtggaaactt tcacatttga attccttagt tttcagagac
     1561 attcctgctt catgattcaa tgatctaaaa agtaagccca ttttttccca gaaatcaaaa
     1621 tgaaggctaa ctcattcttg acaaccaaga agatgctaga atttccttta gaacacttga
     1681 cttcccaatc actgtataat ccagggactc aaaatacaga attaagattg gtaagcaagc
     1741 aaagtgtttc attaatacct tcaaatttat agccttttgc ttacttggta agacttaata
     1801 tatacataat tttcaaatat taagtgcttt ttaaatgttg gcagttattt acaaaaaagt
     1861 atttcatatt cttatgagat tgtgtttctc atatttctca taataaagat gtataacacc
     1921 tgtacagtg
//
