LOCUS       NM_001395027            1347 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus serpin family B member 6A (Serpinb6a), transcript
            variant 3, mRNA.
ACCESSION   NM_001395027 XM_006253869
VERSION     NM_001395027.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1347)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   2  (bases 1 to 1347)
  AUTHORS   Sirmaci,A., Erbek,S., Price,J., Huang,M., Duman,D., Cengiz,F.B.,
            Bademci,G., Tokgoz-Yilmaz,S., Hismi,B., Ozdag,H., Ozturk,B.,
            Kulaksizoglu,S., Yildirim,E., Kokotas,H., Grigoriadou,M.,
            Petersen,M.B., Shahin,H., Kanaan,M., King,M.C., Chen,Z.Y.,
            Blanton,S.H., Liu,X.Z., Zuchner,S., Akar,N. and Tekin,M.
  TITLE     A truncating mutation in SERPINB6 is associated with
            autosomal-recessive nonsyndromic sensorineural hearing loss
  JOURNAL   Am J Hum Genet 86 (5), 797-804 (2010)
   PUBMED   20451170
REFERENCE   3  (bases 1 to 1347)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 1347)
  AUTHORS   Scott,F.L., Sun,J., Whisstock,J.C., Kato,K. and Bird,P.I.
  TITLE     SerpinB6 is an inhibitor of kallikrein-8 in keratinocytes
  JOURNAL   J Biochem 142 (4), 435-442 (2007)
   PUBMED   17761692
REFERENCE   5  (bases 1 to 1347)
  AUTHORS   Charron,Y., Madani,R., Nef,S., Combepine,C., Govin,J., Khochbin,S.
            and Vassalli,J.D.
  TITLE     Expression of serpinb6 serpins in germ and somatic cells of mouse
            gonads
  JOURNAL   Mol Reprod Dev 73 (1), 9-19 (2006)
   PUBMED   16175637
REFERENCE   6  (bases 1 to 1347)
  AUTHORS   Strik,M.C., Wolbink,A., Wouters,D., Bladergroen,B.A., Verlaan,A.R.,
            van Houdt,I.S., Hijlkema,S., Hack,C.E. and Kummer,J.A.
  TITLE     Intracellular serpin SERPINB6 (PI6) is abundantly expressed by
            human mast cells and forms complexes with beta-tryptase monomers
  JOURNAL   Blood 103 (7), 2710-2717 (2004)
   PUBMED   14670919
REFERENCE   7  (bases 1 to 1347)
  AUTHORS   Coughlin,P., Sun,J., Cerruti,L., Salem,H.H. and Bird,P.
  TITLE     Cloning and molecular characterization of a human intracellular
            serine proteinase inhibitor
  JOURNAL   Proc Natl Acad Sci U S A 90 (20), 9417-9421 (1993)
   PUBMED   8415716
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000017.1.
            
            On May 26, 2021 this sequence version replaced XM_006253869.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399489.3556139.1,
                                           SRR22582424.364439.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000017.1  31176255-31176345
            92-266              JAXUCZ010000017.1  31180741-31180915
            267-419             JAXUCZ010000017.1  31183297-31183449
            420-537             JAXUCZ010000017.1  31186468-31186585
            538-680             JAXUCZ010000017.1  31189773-31189915
            681-836             JAXUCZ010000017.1  31194071-31194226
            837-1347            JAXUCZ010000017.1  31194525-31195035
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1347
                     /gene="Serpinb6a"
                     /gene_synonym="Serpinb6"
                     /note="serpin family B member 6A"
                     /db_xref="GeneID:291085"
                     /db_xref="RGD:735108"
     exon            1..91
                     /gene="Serpinb6a"
                     /gene_synonym="Serpinb6"
                     /inference="alignment:Splign:2.1.0"
     exon            92..266
                     /gene="Serpinb6a"
                     /gene_synonym="Serpinb6"
                     /inference="alignment:Splign:2.1.0"
     CDS             102..1241
                     /gene="Serpinb6a"
                     /gene_synonym="Serpinb6"
                     /note="serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 6; serine (or cysteine) peptidase
                     inhibitor, clade B, member 6a; serpin peptidase inhibitor,
                     clade B (ovalbumin), member 6; serpin family B member 6"
                     /codon_start=1
                     /product="serpin B6"
                     /protein_id="NP_001381956.1"
                     /db_xref="GeneID:291085"
                     /db_xref="RGD:735108"
                     /translation="MDHLQEGNGIFALKLLKTLSEDSSNNIFLSPISISAALTMVFMG
                     AKGMTASQMVQTLSLDKCSGNGGGDVHQGFQSLLAEVNKTGTQYLLKTANRLFGEKTC
                     DILASFKDACRKFYEAEMEELDFKGDTEQSRQRINTWVAKKTEDKIKELLAPGIVDPD
                     TVLVLVNAIYFKGNWDKQFNKEHTREKPFKVSKTEEKPVQMMFMKSTFKMTYIGEIFT
                     KILLLPYAGNELNMIIMLPDEHIELKTVEKELTYEKFIEWTRLDMLDEEEVEVFLPRF
                     KLEENYDMKVVLGKLGMTDAFMEGRADFSGIASKQGLFLSKVIHKAFVEVNEEGTEAV
                     AATGSTITMRCLRFTPRFLADHPFLFFIQHVKTKGILFCGRFSSP"
     exon            267..419
                     /gene="Serpinb6a"
                     /gene_synonym="Serpinb6"
                     /inference="alignment:Splign:2.1.0"
     exon            420..537
                     /gene="Serpinb6a"
                     /gene_synonym="Serpinb6"
                     /inference="alignment:Splign:2.1.0"
     exon            538..680
                     /gene="Serpinb6a"
                     /gene_synonym="Serpinb6"
                     /inference="alignment:Splign:2.1.0"
     exon            681..836
                     /gene="Serpinb6a"
                     /gene_synonym="Serpinb6"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1347
                     /gene="Serpinb6a"
                     /gene_synonym="Serpinb6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cccgccccac aggtatttaa ggcctcgggc gcggctgggt ccctcccatc tcttctctgc
       61 ctgccactgg tccggaaatc cagagtctag ggttcaccat catggatcat ctacaggaag
      121 gaaatggcat ctttgcctta aagcttttga aaacactgag tgaagacagc tcaaacaata
      181 tatttttgtc acccattagc atctccgcag ccctcaccat ggtcttcatg ggggcaaaag
      241 gaatgactgc aagccagatg gttcagacac tgtctttgga taaatgcagc ggcaatggag
      301 gtggagacgt ccaccagggc ttccagtccc ttctcgccga agtgaacaag actggcacac
      361 agtacttgct caaaacagcc aacaggctct ttggggaaaa gacttgtgat attttagcat
      421 cttttaaaga tgcctgccgc aagttctacg aagcagaaat ggaagagctg gacttcaagg
      481 gtgacacaga gcagtctcga cagcgcatca acacctgggt agccaaaaag acagaagata
      541 aaatcaaaga gctgctggct ccaggtatag tggatcccga cacagtgcta gtccttgtga
      601 atgccatcta cttcaaagga aactgggaca agcagtttaa caaagagcac accagggaga
      661 agcctttcaa agtcagcaag actgaggaga aacctgtgca aatgatgttt atgaagtcta
      721 cttttaagat gacctatatt ggagagatat tcaccaagat tctgttgctt ccctatgctg
      781 gcaatgagct gaacatgatc atcatgcttc cagatgaaca cattgaactg aaaacggtgg
      841 aaaaggaatt aacttatgag aaatttatag agtggacgag gctggacatg ttggatgaag
      901 aagaggtgga agtatttctc ccaaggttta aactggagga gaattatgac atgaaggttg
      961 tcctcggcaa attgggcatg actgatgcct ttatggaggg cagggccgac ttttctggaa
     1021 tagcttccaa gcaaggcttg tttctgtcta aggtcatcca taaggccttt gtagaggtga
     1081 atgaggaggg tacagaggct gtagctgcta caggtagcac cataacgatg aggtgcttga
     1141 ggttcactcc ccgcttctta gctgaccatc ccttcctttt cttcattcag catgttaaga
     1201 ccaaggggat tctgttctgt ggccgcttct cctctccctg aggaaagtgt gtgcctgtca
     1261 gtcttttacc cgctttgcct ataacccaag tgaccttatg tgtaagtgca atgacagtta
     1321 tgaaataaag ggctttatgg cacccca
//
