LOCUS       NM_057108               2577 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus serpin family B member 5 (Serpinb5), mRNA.
ACCESSION   NM_057108 XM_346443
VERSION     NM_057108.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2577)
  AUTHORS   Sakabe,T., Wakahara,M., Shiota,G. and Umekita,Y.
  TITLE     Role of cytoplasmic localization of maspin in promoting cell
            invasion in breast cancer with aggressive phenotype
  JOURNAL   Sci Rep 11 (1), 11321 (2021)
   PUBMED   34059749
  REMARK    GeneRIF: Role of cytoplasmic localization of maspin in promoting
            cell invasion in breast cancer with aggressive phenotype.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2577)
  AUTHORS   Wang,N. and Chang,L.L.
  TITLE     The potential function of IKKalpha in gastric precancerous lesion
            via mediating Maspin
  JOURNAL   Tissue Cell 65, 101349 (2020)
   PUBMED   32746986
  REMARK    GeneRIF: The potential function of IKKalpha in gastric precancerous
            lesion via mediating Maspin.
REFERENCE   3  (bases 1 to 2577)
  AUTHORS   Chen,W.S., Yen,C.J., Chen,Y.J., Chen,J.Y., Wang,L.Y., Chiu,S.J.,
            Shih,W.L., Ho,C.Y., Wei,T.T., Pan,H.L., Chien,P.H., Hung,M.C.,
            Chen,C.C. and Huang,W.C.
  TITLE     miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma
            progression through suppression of maspin
  JOURNAL   Oncotarget 6 (28), 25962-25974 (2015)
   PUBMED   26296971
REFERENCE   4  (bases 1 to 2577)
  AUTHORS   Davaadorj,P., Tokuyama,R., Ide,S., Tadokoro,S., Kudoh,K. and
            Satomura,K.
  TITLE     Possible involvement of maspin in tooth development
  JOURNAL   Histochem Cell Biol 134 (6), 603-614 (2010)
   PUBMED   21069375
  REMARK    GeneRIF: During rat tooth development, maspin expression was
            observed for the first time in inner and outer enamel epithelial
            cells and dental papilla cells at early bell stage.
REFERENCE   5  (bases 1 to 2577)
  AUTHORS   Shao,L.J., Shi,H.Y., Ayala,G., Rowley,D. and Zhang,M.
  TITLE     Haploinsufficiency of the maspin tumor suppressor gene leads to
            hyperplastic lesions in prostate
  JOURNAL   Cancer Res 68 (13), 5143-5151 (2008)
   PUBMED   18593913
REFERENCE   6  (bases 1 to 2577)
  AUTHORS   Buchwalter,A., Van Dort,C., Schultz,S., Smith,R., Le,I.P.,
            Abbott,J.L., Oosterhouse,E., Johnson,A.E., Hansen-Smith,F. and
            Burnatowska-Hledin,M.
  TITLE     Expression of VACM-1/cul5 mutant in endothelial cells induces MAPK
            phosphorylation and maspin degradation and converts cells to the
            angiogenic phenotype
  JOURNAL   Microvasc Res 75 (2), 155-168 (2008)
   PUBMED   17950367
  REMARK    GeneRIF: Results show that VACM-1 protein regulates endothelial
            cell growth and may modulate angiogenesis by a mechanism that
            involves MAPK phosphorylation and maspin expression.
REFERENCE   7  (bases 1 to 2577)
  AUTHORS   Tokuyama,R., Satomura,K., Maeda,E., Kudoh,K., Yamasaki,Y. and
            Nagayama,M.
  TITLE     Maspin is involved in bone matrix maturation by enhancing the
            accumulation of latent TGF-beta
  JOURNAL   J Bone Miner Res 22 (10), 1581-1591 (2007)
   PUBMED   17563239
  REMARK    GeneRIF: maspin expressed in active osteoblasts plays an important
            physiological role during maturation of the bone matrix, and in
            particular, during the process of accumulation of latent TGF-beta
            in the extracellular matrix
REFERENCE   8  (bases 1 to 2577)
  AUTHORS   Bailey,C.M., Khalkhali-Ellis,Z., Kondo,S., Margaryan,N.V.,
            Seftor,R.E., Wheaton,W.W., Amir,S., Pins,M.R., Schutte,B.C. and
            Hendrix,M.J.
  TITLE     Mammary serine protease inhibitor (Maspin) binds directly to
            interferon regulatory factor 6: identification of a novel serpin
            partnership
  JOURNAL   J Biol Chem 280 (40), 34210-34217 (2005)
   PUBMED   16049006
REFERENCE   9  (bases 1 to 2577)
  AUTHORS   Szpirer,C., Van Vooren,P., Riviere,M., Scohy,S., Collau,G. and
            Szpirer,J.
  TITLE     Localization of 54 rat genes, and definition of new synteny groups
            conserved in the human and the rat
  JOURNAL   Mamm Genome 11 (9), 729-735 (2000)
   PUBMED   10967130
REFERENCE   10 (bases 1 to 2577)
  AUTHORS   Umekita,Y., Hiipakka,R.A. and Liao,S.
  TITLE     Rat and human maspins: structures, metastatic suppressor activity
            and mutation in prostate cancer cells
  JOURNAL   Cancer Lett 113 (1-2), 87-93 (1997)
   PUBMED   9065806
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Nov 26, 2020 this sequence version replaced NM_057108.2.
            
            Sequence Note: The sequence U58857.1 is from a chimeric clone. Only
            the serine (or cysteine) peptidase inhibitor, clade B, member 5
            sequence region was propagated into this RefSeq record.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582424.1122537.1,
                                           SRR23984936.861658.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760389,
                                           SAMEA5760434 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               JAXUCZ010000013.1  23500203-23500302
            101-275             JAXUCZ010000013.1  23508236-23508410
            276-413             JAXUCZ010000013.1  23510057-23510194
            414-531             JAXUCZ010000013.1  23512816-23512933
            532-674             JAXUCZ010000013.1  23513756-23513898
            675-842             JAXUCZ010000013.1  23517205-23517372
            843-2577            JAXUCZ010000013.1  23518667-23520401
FEATURES             Location/Qualifiers
     source          1..2577
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13p11"
     gene            1..2577
                     /gene="Serpinb5"
                     /gene_synonym="Maspin; PI-5; Pi5"
                     /note="serpin family B member 5"
                     /db_xref="GeneID:116589"
                     /db_xref="RGD:69342"
     exon            1..100
                     /gene="Serpinb5"
                     /gene_synonym="Maspin; PI-5; Pi5"
                     /inference="alignment:Splign:2.1.0"
     exon            101..275
                     /gene="Serpinb5"
                     /gene_synonym="Maspin; PI-5; Pi5"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1235
                     /gene="Serpinb5"
                     /gene_synonym="Maspin; PI-5; Pi5"
                     /note="protease inhibitor 5; peptidase inhibitor 5; serine
                     (or cysteine) proteinase inhibitor, clade B (ovalbumin),
                     member 5; serine (or cysteine) peptidase inhibitor, clade
                     B, member 5; serpin peptidase inhibitor, clade B
                     (ovalbumin), member 5"
                     /codon_start=1
                     /product="serpin B5"
                     /protein_id="NP_476449.2"
                     /db_xref="GeneID:116589"
                     /db_xref="RGD:69342"
                     /translation="MDALRLANSAFAVELFKQLCEKEPAGNILFSPICLSTSLSLAQV
                     GAKGDTANEIGQVLHFENVKDVPFGFQTITSDVNKLSSFYSLKLIKRLYIDKSLNLST
                     EFISSTKRPYANELETVDFKDKLEETKGQINSSIKELTDGHFEDILPENSISDQTKIL
                     VVNAAYFVGKWMKKFPESETKECPFRINKTDTKPVQMMNLEATFCLGNIDDINCKIIE
                     LPFQNKHLSMLIVLPKDVEDESTGLEKIEKQLNPETLLQWTNPSTMANAKVKLSLPKF
                     KVEKMIDPKASLESLGLKSLFNESTSDFSGMSETKGVSVSNVIHRVCLEITEDGGDSI
                     EVPGSRILQHKDEFKADHPFLFIVRHNKTRNIVFLGKFSSP"
     exon            276..413
                     /gene="Serpinb5"
                     /gene_synonym="Maspin; PI-5; Pi5"
                     /inference="alignment:Splign:2.1.0"
     exon            414..531
                     /gene="Serpinb5"
                     /gene_synonym="Maspin; PI-5; Pi5"
                     /inference="alignment:Splign:2.1.0"
     exon            532..674
                     /gene="Serpinb5"
                     /gene_synonym="Maspin; PI-5; Pi5"
                     /inference="alignment:Splign:2.1.0"
     exon            675..842
                     /gene="Serpinb5"
                     /gene_synonym="Maspin; PI-5; Pi5"
                     /inference="alignment:Splign:2.1.0"
     exon            843..2577
                     /gene="Serpinb5"
                     /gene_synonym="Maspin; PI-5; Pi5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttctcccta ggcccggaga acacagcttt cactgcctct gagttcttta ggcctttttc
       61 ccttcttgca gctcatttgc tgggatacct gcaactaaag gcccaggatg gatgccttga
      121 gactggcaaa ttcagctttt gctgttgaat tgttcaaaca actatgtgaa aaggagccag
      181 caggaaacat tctcttctct ccgatatgcc tctccacttc tctgtccctt gctcaagtag
      241 gcgccaaagg tgacacggca aatgaaattg gacaggtcct tcattttgag aatgttaaag
      301 atgtaccctt tgggtttcaa acaatcactt ctgatgttaa taagctcagt tccttttatt
      361 cgctgaaact aatcaagcga ctatacattg acaaatctct gaacctttct acagaattta
      421 tcagttctac aaaaagacca tatgccaacg aattggaaac tgttgacttc aaagataaac
      481 tggaagagac gaaaggtcaa attaacagct ccattaagga actcacagac ggccactttg
      541 aagatatttt gccagagaac agtataagtg accagaccaa aatccttgtg gttaatgctg
      601 cctactttgt tggaaagtgg atgaagaaat ttccagaatc agaaacaaaa gaatgtccat
      661 tcagaatcaa caagacagac accaaaccag tacaaatgat gaatcttgag gctaccttct
      721 gcttgggtaa cattgatgac atcaactgta agatcataga acttcctttc cagaataagc
      781 atctcagtat gctcattgtg ctccctaagg acgtggaaga tgaatccaca ggcctggaga
      841 agattgaaaa acaactcaac ccagaaacac tgttacagtg gaccaacccc agcaccatgg
      901 ccaatgccaa agtcaagctt tcccttccaa agtttaaggt agaaaagatg attgacccca
      961 aggctagtct ggaaagccta gggctgaaaa gtctcttcaa tgaaagtaca tcggatttct
     1021 ctggaatgtc agagaccaag ggagtgtccg tatcaaatgt gattcacaga gtatgcctag
     1081 aaataactga agatggtggt gattccatcg aggtgccagg gtcccggatc ttacagcaca
     1141 aggatgaatt caaagctgac catccatttc tttttatcgt tcgacacaac aaaactcgaa
     1201 acatcgtttt cttgggcaaa ttctcttctc cttagctggc agggcctggc caactctcag
     1261 gtaacttgtc tgtagttgca gggctctgta aactttgtat ccagaatcac tttctataca
     1321 ataaattgtg aatgttgctg aatcaggaag cactccatat ttgtcatatg tcaccttcat
     1381 actaacagac acttccccct aattcctcct tgttttcctt tgtcaaagga aacagaggat
     1441 acttgtgaaa gggaatccct ttagaaaaca tgtgctctgc atttgtcaaa gcatccagag
     1501 cgatgggcaa aaattcagtc ttcaagggag gaattgctgt agggatgacg tggggacatt
     1561 attctcaggg ctttgccttt actgagataa taaagaatgt tctagaaatc ttcactcctt
     1621 tcaaccctta aaaaacaata gtgtataagg cccacaaagt acccttttca agtgaatttg
     1681 tgtacatgtc acaatactgt aggtccagaa gacttcatgt taaaccttaa gaaacagttt
     1741 tttttcaaga tactaattgg agattttaga agaatgacat attgttaata ctatttatca
     1801 tggaatacca caaatagtat ctggaatatt accctatcaa ccaatatctt aatatttctt
     1861 ctataaatat acactatttt cacaaaatga gtatataaag atcgttcata agtgatcaat
     1921 ttttctgaaa aatgagtaca ttatcagctc ataaaaacac tttgaagaac attctagatc
     1981 ttggagtgtt ggataaagaa ttctgggcct attttagcag aagatcaaga ccccaaggga
     2041 aagctcagct tttaaaaaaa actggctttc attttcccta gctctcccac gtgatcattt
     2101 gggtaatgct gtatcggcca ggcttctaac cagatcacaa ggtccctgac gtctccagca
     2161 tcagcaactt aaaatctaca gggattctcg tgatgataag agttttgtgg ccattaaagg
     2221 gactttcctc tttgcctaat gtgtcggggg tggggaggta agggatccca aactctcaga
     2281 aaatacaagg aaaactattt aagtacccac aatgctttgg catatatttt tctcagttta
     2341 taaatttagc tatttcagat agcagtttgt agcctacata aataatttat aaaatggtaa
     2401 gtcagttatg ttgcaatcca atttttaaat tcaccaccaa aaggaagtat ttgctgcagt
     2461 ttttcttatg tgtctttcct tatccaattt cttaccattt atggcaaata agttgttcca
     2521 agggttcagt ggtgacttct tttctgtgct atttgacaat aaaatattat tgaatta
//
