LOCUS       NM_001031642            1289 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus serpin family B member 1A (Serpinb1a), mRNA.
ACCESSION   NM_001031642 XM_214459
VERSION     NM_001031642.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1289)
  AUTHORS   Wang,H., Hua,J., Chen,S. and Chen,Y.
  TITLE     SERPINB1 overexpression protects myocardial damage induced by acute
            myocardial infarction through AMPK/mTOR pathway
  JOURNAL   BMC Cardiovasc Disord 22 (1), 107 (2022)
   PUBMED   35291946
  REMARK    GeneRIF: SERPINB1 overexpression protects myocardial damage induced
            by acute myocardial infarction through AMPK/mTOR pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1289)
  AUTHORS   Choi,Y.J., Kim,S., Choi,Y., Nielsen,T.B., Yan,J., Lu,A., Ruan,J.,
            Lee,H.R., Wu,H., Spellberg,B. and Jung,J.U.
  TITLE     SERPINB1-mediated checkpoint of inflammatory caspase activation
  JOURNAL   Nat Immunol 20 (3), 276-287 (2019)
   PUBMED   30692621
  REMARK    Erratum:[Nat Immunol. 2019 May;20(5):664. doi:
            10.1038/s41590-019-0361-x.. PMID: 30846880]
REFERENCE   3  (bases 1 to 1289)
  AUTHORS   Barallobre-Barreiro,J., Gupta,S.K., Zoccarato,A.,
            Kitazume-Taneike,R., Fava,M., Yin,X., Werner,T., Hirt,M.N.,
            Zampetaki,A., Viviano,A., Chong,M., Bern,M., Kourliouros,A.,
            Domenech,N., Willeit,P., Shah,A.M., Jahangiri,M., Schaefer,L.,
            Fischer,J.W., Iozzo,R.V., Viner,R., Thum,T., Heineke,J.,
            Kichler,A., Otsu,K. and Mayr,M.
  TITLE     Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin
            Activity in Human Atrial Fibrillation
  JOURNAL   Circulation 134 (11), 817-832 (2016)
   PUBMED   27559042
REFERENCE   4  (bases 1 to 1289)
  AUTHORS   Barallobre-Barreiro,J., Oklu,R., Lynch,M., Fava,M., Baig,F.,
            Yin,X., Barwari,T., Potier,D.N., Albadawi,H., Jahangiri,M.,
            Porter,K.E., Watkins,M.T., Misra,S., Stoughton,J. and Mayr,M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   5  (bases 1 to 1289)
  AUTHORS   El Ouaamari,A., Dirice,E., Gedeon,N., Hu,J., Zhou,J.Y.,
            Shirakawa,J., Hou,L., Goodman,J., Karampelias,C., Qiang,G.,
            Boucher,J., Martinez,R., Gritsenko,M.A., De Jesus,D.F.,
            Kahraman,S., Bhatt,S., Smith,R.D., Beer,H.D., Jungtrakoon,P.,
            Gong,Y., Goldfine,A.B., Liew,C.W., Doria,A., Andersson,O.,
            Qian,W.J., Remold-O'Donnell,E. and Kulkarni,R.N.
  TITLE     SerpinB1 Promotes Pancreatic beta Cell Proliferation
  JOURNAL   Cell Metab 23 (1), 194-205 (2016)
   PUBMED   26701651
REFERENCE   6  (bases 1 to 1289)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 1289)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   8  (bases 1 to 1289)
  AUTHORS   Benarafa,C., Priebe,G.P. and Remold-O'Donnell,E.
  TITLE     The neutrophil serine protease inhibitor serpinb1 preserves lung
            defense functions in Pseudomonas aeruginosa infection
  JOURNAL   J Exp Med 204 (8), 1901-1909 (2007)
   PUBMED   17664292
REFERENCE   9  (bases 1 to 1289)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   10 (bases 1 to 1289)
  AUTHORS   Benarafa,C., Cooley,J., Zeng,W., Bird,P.I. and Remold-O'Donnell,E.
  TITLE     Characterization of four murine homologs of the human ov-serpin
            monocyte neutrophil elastase inhibitor MNEI (SERPINB1)
  JOURNAL   J Biol Chem 277 (44), 42028-42033 (2002)
   PUBMED   12189154
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC098686.1.
            
            On Aug 12, 2005 this sequence version replaced XM_214459.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098686.1, SRR8487226.146863.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132294, SAMD00132307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1289
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17p12"
     gene            1..1289
                     /gene="Serpinb1a"
                     /gene_synonym="Serpinb1"
                     /note="serpin family B member 1A"
                     /db_xref="GeneID:291091"
                     /db_xref="RGD:1306203"
     exon            1..14
                     /gene="Serpinb1a"
                     /gene_synonym="Serpinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            15..190
                     /gene="Serpinb1a"
                     /gene_synonym="Serpinb1"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1162
                     /gene="Serpinb1a"
                     /gene_synonym="Serpinb1"
                     /note="serpin B1a; serine protease inhibitor EIA; serine
                     (or cysteine) proteinase inhibitor, clade B, member 1a"
                     /codon_start=1
                     /product="leukocyte elastase inhibitor A"
                     /protein_id="NP_001026812.1"
                     /db_xref="GeneID:291091"
                     /db_xref="RGD:1306203"
                     /translation="MEQLSSANSLFALELFHTLSESSPTGNIFFSPFSISSALAMVFL
                     GTKGTTAAQLSKTFHFDSVEDVHSRFQSLNAEVSKRGASHTLKLANRLYGEKTYNFLP
                     EFLTSTQKMYGADLAPVDFQHASEDARKEINQWVKGQTEGKIPELLAVGVVDSMTKLV
                     LVNAIYFKGMWEEKFMKQDTTDAPFRLNKKNTKSVKMMYQKKKFFFGYISDLKCKVLE
                     MPYQGGELSMVILLPEDIEDESTGLKKIEEQITLEKLREWTKRENLENIDVHVKLPRF
                     KIEESYILNSNLGRLGLQDLFNSSKADLSGMSGSRDLFISKIVHKAFVEVNEEGTEAA
                     AATAGIATFCMLLPEEEFTADHPFIFFIRHNPTANVLFLGRVCSP"
     exon            191..328
                     /gene="Serpinb1a"
                     /gene_synonym="Serpinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            329..446
                     /gene="Serpinb1a"
                     /gene_synonym="Serpinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            447..589
                     /gene="Serpinb1a"
                     /gene_synonym="Serpinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            590..757
                     /gene="Serpinb1a"
                     /gene_synonym="Serpinb1"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1266
                     /gene="Serpinb1a"
                     /gene_synonym="Serpinb1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagctaagca agagccttca ccatggagca gctgagttca gccaacagcc tgttcgcctt
       61 ggagctgttc cacaccctga gtgaaagcag ccccacagga aacatcttct tctctccctt
      121 cagcatttct tctgccttgg ccatggtctt tctggggacc aaaggcacca ctgcagccca
      181 gctctctaag acttttcatt tcgactctgt tgaggacgtt cattcacgct ttcaaagcct
      241 gaatgctgaa gtgagcaagc gtggagcatc tcacactctg aaacttgcca acaggctgta
      301 tggagagaaa acctacaatt tccttcctga gttcttgact tcaactcaga agatgtatgg
      361 tgctgacttg gcccctgtgg attttcagca tgcctctgag gatgcaagga aggagataaa
      421 ccagtgggtc aaaggtcaaa ccgaaggtaa aatcccagaa ctgttggctg tgggtgtggt
      481 ggacagcatg accaaacttg tgctggtgaa cgccatctac ttcaagggga tgtgggagga
      541 gaaattcatg aaacaagaca caacagatgc tccattccgg ctgaataaga aaaacacaaa
      601 atctgtgaag atgatgtatc aaaagaaaaa atttttcttt ggctacattt cggatctgaa
      661 gtgcaaggtg ctggagatgc cataccaggg tggagaactg agcatggtca tcctgctgcc
      721 cgaagacatt gaggatgagt ccacgggtct taagaagatt gaggagcaaa taactttgga
      781 aaaactgcgt gaatggacca aacgtgagaa cttggaaaac attgatgtcc atgtcaaatt
      841 gccccggttc aagatagaag agagctacat cctcaactcg aacctgggcc gcttgggatt
      901 gcaggatctc tttaacagta gcaaggctga tctgtctggc atgtcaggat ccagagatct
      961 tttcatatca aaaattgtcc acaaggcctt tgtggaagtg aatgaggagg gaacagaggc
     1021 agccgctgcc acggcaggca tcgctacatt ctgcatgttg ctgcccgaag aagaattcac
     1081 agcggaccat ccattcattt tcttcattcg gcacaacccc acagctaatg tgctcttcct
     1141 tggcagggtt tgttccccat agaagaagac tttaccaata caaggcagaa cttagagttt
     1201 catcccctga gattttaaca gtgattatat tcctttgtac ttgacaataa aacctctaac
     1261 cagaaaaaaa aaaaaaaaaa aaaaaaaaa
//
