LOCUS       NM_001107168            1309 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serpin family B member 13 (Serpinb13), mRNA.
ACCESSION   NM_001107168 XM_001064253 XM_222497
VERSION     NM_001107168.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1309)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 1309)
  AUTHORS   Welss,T., Sun,J., Irving,J.A., Blum,R., Smith,A.I., Whisstock,J.C.,
            Pike,R.N., von Mikecz,A., Ruzicka,T., Bird,P.I. and Abts,H.F.
  TITLE     Hurpin is a selective inhibitor of lysosomal cathepsin L and
            protects keratinocytes from ultraviolet-induced apoptosis
  JOURNAL   Biochemistry 42 (24), 7381-7389 (2003)
   PUBMED   12809493
REFERENCE   3  (bases 1 to 1309)
  AUTHORS   Jayakumar,A., Kang,Y., Frederick,M.J., Pak,S.C., Henderson,Y.,
            Holton,P.R., Mitsudo,K., Silverman,G.A., EL-Naggar,A.K., Bromme,D.
            and Clayman,G.L.
  TITLE     Inhibition of the cysteine proteinases cathepsins K and L by the
            serpin headpin (SERPINB13): a kinetic analysis
  JOURNAL   Arch Biochem Biophys 409 (2), 367-374 (2003)
   PUBMED   12504904
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000013.1.
            
            On Apr 8, 2021 this sequence version replaced NM_001107168.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643294.47188.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                JAXUCZ010000013.1  23633220-23633269
            51-232              JAXUCZ010000013.1  23634356-23634537
            233-289             JAXUCZ010000013.1  23635035-23635091
            290-418             JAXUCZ010000013.1  23650044-23650172
            419-536             JAXUCZ010000013.1  23650523-23650640
            537-679             JAXUCZ010000013.1  23652121-23652263
            680-835             JAXUCZ010000013.1  23652443-23652598
            836-1309            JAXUCZ010000013.1  23664521-23664994
FEATURES             Location/Qualifiers
     source          1..1309
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13p11"
     gene            1..1309
                     /gene="Serpinb13"
                     /note="serpin family B member 13"
                     /db_xref="GeneID:304690"
                     /db_xref="RGD:1304661"
     exon            1..50
                     /gene="Serpinb13"
                     /inference="alignment:Splign:2.1.0"
     exon            51..232
                     /gene="Serpinb13"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..1237
                     /gene="Serpinb13"
                     /note="serine (or cysteine) peptidase inhibitor, clade B
                     (ovalbumin), member 13; serpin peptidase inhibitor, clade
                     B (ovalbumin), member 13"
                     /codon_start=1
                     /product="serpin B13"
                     /protein_id="NP_001100638.1"
                     /db_xref="GeneID:304690"
                     /db_xref="RGD:1304661"
                     /translation="MDSLSTATTHFLFDLFKELNKTSDGNVFFSPLGISTAIGMILLG
                     TQGATASELQKVLYSEQGTGSSRLKSEEKEIEKTEEIHHQFQKLLTEISKPTKDYDLI
                     ISNRLYGERTYLFLQKYIDYVEKYYHASLEPVDFVNAADESRKKINSWVESQTNEKVK
                     DLFPEGSLNSSTKLVLINTVYFKGLWDREFKKEHTKEEDFWLNKNISKPVQMMAQCSS
                     FSFTLLEDLQAKIVGIPYKNSDFSMFVLLPNDIDGLEKIIDKLSPEKLVEWTSPGQLK
                     QRKVDLRLPRLKVEETYDLQPTLEAVGIHSAFSEHADYSGMSAHSGLQTQNFLHRSFL
                     VVTEEGVEATAGTGVGFKVLSAASCELVHCNHPFLFFVRHRESDSILFFGRFSSP"
     exon            233..289
                     /gene="Serpinb13"
                     /inference="alignment:Splign:2.1.0"
     exon            290..418
                     /gene="Serpinb13"
                     /inference="alignment:Splign:2.1.0"
     exon            419..536
                     /gene="Serpinb13"
                     /inference="alignment:Splign:2.1.0"
     exon            537..679
                     /gene="Serpinb13"
                     /inference="alignment:Splign:2.1.0"
     exon            680..835
                     /gene="Serpinb13"
                     /inference="alignment:Splign:2.1.0"
     exon            836..1309
                     /gene="Serpinb13"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acatagcttc tgagtccttg tccagccact gctgtctctt caagagccag gttatttgga
       61 aaccatcatg gactcactaa gcacagcaac cacacatttc ctgtttgatc ttttcaaaga
      121 actgaataaa acaagtgacg gcaatgtctt cttttctcct ttgggcatct caacagccat
      181 tggcatgatc ctcttgggga cccaaggagc cactgcctct gagttacaga aggtacttta
      241 ttctgaacaa ggcacaggaa gctccagact aaagtctgaa gaaaaagaga ttgagaaaac
      301 agaagaaata catcatcaat tccaaaagct cttgactgaa ataagcaaac ctactaaaga
      361 ttatgaccta atcataagca accggctgta tggagaaaga acatacctct tccttcaaaa
      421 atacatagat tatgttgaaa aatattacca tgcatctctg gagcctgttg attttgtaaa
      481 tgctgcagat gaaagtcgaa agaagattaa ttcctgggtt gaaagccaaa caaatgaaaa
      541 agtcaaggac ctgtttcctg aaggctctct gaacagctcc accaaactgg tgctgataaa
      601 tacagtttat tttaaaggcc tgtgggacag agaatttaag aaagaacata ccaaggagga
      661 ggacttctgg ctgaacaaga acataagcaa acctgtgcag atgatggccc agtgcagctc
      721 cttcagcttc accctcttag aggacctgca ggccaaaatt gtggggattc catataaaaa
      781 cagtgatttc agcatgttcg tgcttctgcc caatgacata gatggcctag agaagataat
      841 cgataaacta tctcctgaga agttggtaga gtggaccagc cccggacaac tgaagcaaag
      901 gaaggtggac ttgcgccttc cccgcttgaa ggtggaggaa acctatgatc tgcaacccac
      961 gctggaagct gtgggcattc acagtgcctt cagtgagcat gcggactact cgggaatgtc
     1021 tgcgcactcc gggctgcaaa cccagaactt cctgcacaga tcgttcctgg tggtgactga
     1081 ggaaggcgtt gaggccactg caggcaccgg agtgggcttc aaggtcttgt cagctgcgag
     1141 ctgcgaactt gtacactgta accatccgtt tttgttcttc gtcaggcaca gagagtctga
     1201 cagcattctc ttttttggca gattttcttc tccctgagat agtgaggctg gaacattaga
     1261 acaccagtgc tcggggttga cagaccctga ggttcatgta tgcactgca
//
