LOCUS       NM_153733               1500 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus serpin family B member 10 (Serpinb10), mRNA.
ACCESSION   NM_153733
VERSION     NM_153733.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1500)
  AUTHORS   Stewart,L.V., Song,K., Hsing,A.Y. and Danielpour,D.
  TITLE     Regulation of trespin expression by modulators of cell growth,
            differentiation, and apoptosis in prostatic epithelial cells
  JOURNAL   Exp Cell Res 284 (2), 303-315 (2003)
   PUBMED   12651162
  REMARK    GeneRIF: Trespin decreases after differentiation of NRP-152 cells
            to a luminal variant, suggesting Trespin is specific for basal
            prostatic epithelial cells. Trespin is up-regulated by
            dexamethasone and IGF-I.
REFERENCE   2  (bases 1 to 1500)
  AUTHORS   Chipuk,J.E., Stewart,L.V., Ranieri,A., Song,K. and Danielpour,D.
  TITLE     Identification and characterization of a novel rat ov-serpin family
            member, trespin
  JOURNAL   J Biol Chem 277 (29), 26412-26421 (2002)
   PUBMED   11986314
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061735.1.
            
            On Feb 9, 2004 this sequence version replaced NM_153733.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061735.1, AY075037.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN06680412, SAMN06680413
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1500
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="13"
                     /map="13p11"
     gene            1..1500
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /note="serpin family B member 10"
                     /db_xref="GeneID:266775"
                     /db_xref="RGD:628853"
     exon            1..53
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /inference="alignment:Splign:2.1.0"
     exon            54..230
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1256
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /note="TGF-beta-repressible serine proteinase inhibitor;
                     transforming growth factor beta repressible serpin; serine
                     (or cysteine) proteinase inhibitor, clade B (ovalbumin),
                     member 10; serine (or cysteine) peptidase inhibitor, clade
                     B (ovalbumin), member 10; serpin peptidase inhibitor,
                     clade B (ovalbumin), member 10"
                     /codon_start=1
                     /product="serpin B10"
                     /protein_id="NP_714955.2"
                     /db_xref="GeneID:266775"
                     /db_xref="RGD:628853"
                     /translation="MASLAVSINQFAVEFSKKLAESAEGRNIFFSPWGISTSLAMVYL
                     GTKGTTAAQMSQVLHFGSIQDFKFGPDSEKKRKMECHSGKSEEIQSDFQTLTAKILKH
                     GNSYVLKIANRIYVEKTYLFHNKYLEDMKTYFGAEPQSVNFVEASGQIRKEINSWVGS
                     QTGGKIPNLLPDDAVDNKTTMVLVNALYFKGTWEHQFSVQNTTERPFRINKTTSKPVQ
                     MMSMKQSLQVFHIEELQTIGVQLHYQNREFSLLLLLPEEVEGLKQLERAITYEKLDKW
                     TSADMMDTYEVQLYLPKFKMEESYDLQSALRDMGMTDAFNQGKANFSNMTSERNLFLS
                     NVFHKTFLEINEEGTEAAAGTGSEVNFRIKAPSIELNADHPFLFLIRHNVTNTILFYG
                     RFYSP"
     exon            231..296
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /inference="alignment:Splign:2.1.0"
     exon            297..434
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /inference="alignment:Splign:2.1.0"
     exon            435..552
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /inference="alignment:Splign:2.1.0"
     exon            553..695
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /inference="alignment:Splign:2.1.0"
     exon            696..851
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /inference="alignment:Splign:2.1.0"
     exon            852..1410
                     /gene="Serpinb10"
                     /gene_synonym="Trespin"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcttttact agaggaacaa tttgtgaagt ttgctccagg agagggaaat aaggtttgcc
       61 caatggcctc actagcagta tccatcaacc agttcgctgt ggagttcagt aaaaagctcg
      121 ctgaatctgc tgagggtaga aacatcttct tttctccatg gggcatctca acttctttgg
      181 ctatggtgta tttgggtacc aaaggtacta ctgcagccca gatgtcccag gtacttcatt
      241 ttggcagcat ccaagacttc aaatttggtc ctgatagtga aaagaaaagg aaaatggaat
      301 gtcattcagg caaaagtgaa gaaatacagt ccgatttcca gaccctcact gcaaaaatcc
      361 tcaagcatgg aaattcttat gtccttaaaa tagctaatag gatatatgtg gagaaaacat
      421 acctatttca taataaatat ttggaggaca tgaaaacata ctttggtgca gaaccacagt
      481 ctgttaactt tgtcgaagct tctggacaga tcaggaagga gatcaactcc tgggttggaa
      541 gccagactgg gggtaaaatc ccaaatctcc tcccagatga cgcagtagac aacaagacta
      601 cgatggttct ggtgaatgcc ctttatttta aaggaacctg ggagcatcag ttctcagtgc
      661 aaaacaccac tgaaagacct ttcagaataa acaagacaac aagcaaacca gtgcaaatga
      721 tgtcaatgaa acagagtctt caagtcttcc acattgagga gctgcaaacc ataggcgttc
      781 aactccacta tcagaaccgt gagttcagcc tgcttctact gcttccagag gaagtggaag
      841 gcctgaaaca gctggagaga gccatcactt acgagaaact ggataagtgg accagtgcag
      901 acatgatgga cacatacgaa gtgcagctgt acctccccaa gttcaagatg gaggagagtt
      961 atgacctcca gtcagccctg agagatatgg ggatgaccga cgcttttaac cagggtaaag
     1021 ctaatttctc aaacatgact tcagagagaa acctattttt gtccaatgtt ttccataaga
     1081 cttttctgga aataaatgaa gaaggcacag aggctgcagc tggcacggga agtgaagtca
     1141 attttcgaat taaggcacct tccattgaat taaatgcaga tcatccattt ctatttctca
     1201 tcaggcacaa cgtaaccaat accattctat tttatggaag attctactcc ccctaaactc
     1261 tgcatctctc atttagtgaa aacttcatat agcacaaaac aaacaaccaa aaattcatat
     1321 taggagatgg aaaaatcaga catcacaaag tcagcccata gtctatacac attttatgct
     1381 tgcatattaa taaatgaatc ttcaagagtg aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1441 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
