LOCUS       NM_001009663            1489 bp    mRNA    linear   ROD 06-DEC-2024
DEFINITION  Rattus norvegicus serpin family A member 6 (Serpina6), mRNA.
ACCESSION   NM_001009663 XM_216777
VERSION     NM_001009663.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1489)
  AUTHORS   Toews,J.N.C., Philippe,T.J., Dordevic,M., Hill,L.A., Hammond,G.L.
            and Viau,V.
  TITLE     Corticosteroid-Binding Globulin (SERPINA6) Consolidates Sexual
            Dimorphism of Adult Rat Liver
  JOURNAL   Endocrinology 165 (1) (2023)
   PUBMED   38015819
  REMARK    GeneRIF: Corticosteroid-Binding Globulin (SERPINA6) Consolidates
            Sexual Dimorphism of Adult Rat Liver.
REFERENCE   2  (bases 1 to 1489)
  AUTHORS   Toews,J.N.C., Philippe,T.J., Hill,L.A., Dordevic,M.,
            Miguelez-Crespo,A., Homer,N.Z.M., Nixon,M., Hammond,G.L. and
            Viau,V.
  TITLE     Corticosteroid-binding Globulin (SERPINA6) Establishes Postpubertal
            Sex Differences in Rat Adrenal Development
  JOURNAL   Endocrinology 163 (11) (2022)
   PUBMED   36112420
  REMARK    GeneRIF: Corticosteroid-binding Globulin (SERPINA6) Establishes
            Postpubertal Sex Differences in Rat Adrenal Development.
REFERENCE   3  (bases 1 to 1489)
  AUTHORS   Simard,M., Underhill,C. and Hammond,G.L.
  TITLE     Functional implications of corticosteroid-binding globulin
            N-glycosylation
  JOURNAL   J Mol Endocrinol 60 (2), 71-84 (2018)
   PUBMED   29273683
  REMARK    GeneRIF: N-glycans at other sites also appear to protect CBG from
            neutrophil elastase or chymotrypsin.
REFERENCE   4  (bases 1 to 1489)
  AUTHORS   Hill,L.A., Bodnar,T.S., Weinberg,J. and Hammond,G.L.
  TITLE     Corticosteroid-binding globulin is a biomarker of inflammation
            onset and severity in female rats
  JOURNAL   J Endocrinol 230 (2), 215-225 (2016)
   PUBMED   27418032
  REMARK    GeneRIF: levels and integrity of plasma CBG are biomarkers of the
            onset and severity of inflammation
REFERENCE   5  (bases 1 to 1489)
  AUTHORS   Sivukhina,E., Schafer,H.H. and Jirikowski,G.F.
  TITLE     Differences in colocalization of corticosteroid-binding globulin
            and glucocorticoid receptor immunoreactivity in the rat brain
  JOURNAL   Ann Anat 195 (3), 219-224 (2013)
   PUBMED   23279724
  REMARK    GeneRIF: It is most likely that CBG in the brain may be involved in
            the response to changing systemic glucocorticoid levels.
REFERENCE   6  (bases 1 to 1489)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   7  (bases 1 to 1489)
  AUTHORS   Fernandez-Real,J.M., Pugeat,M., Grasa,M., Broch,M., Vendrell,J.,
            Brun,J. and Ricart,W.
  TITLE     Serum corticosteroid-binding globulin concentration and insulin
            resistance syndrome: a population study
  JOURNAL   J Clin Endocrinol Metab 87 (10), 4686-4690 (2002)
   PUBMED   12364459
REFERENCE   8  (bases 1 to 1489)
  AUTHORS   Orava,M., Zhao,X.F., Leiter,E. and Hammond,G.L.
  TITLE     Structure and chromosomal location of the gene encoding mouse
            corticosteroid-binding globulin: strain differences in coding
            sequence and steroid-binding activity
  JOURNAL   Gene 144 (2), 259-264 (1994)
   PUBMED   8039711
REFERENCE   9  (bases 1 to 1489)
  AUTHORS   Smith,C.L. and Hammond,G.L.
  TITLE     Rat corticosteroid binding globulin: primary structure and
            messenger ribonucleic acid levels in the liver under different
            physiological conditions
  JOURNAL   Mol Endocrinol 3 (2), 420-426 (1989)
   PUBMED   2710140
REFERENCE   10 (bases 1 to 1489)
  AUTHORS   Kato,E.A., Hsu,B.R. and Kuhn,R.W.
  TITLE     Comparative structural analyses of corticosteroid binding globulin
  JOURNAL   J Steroid Biochem 29 (2), 213-220 (1988)
   PUBMED   3347061
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088300.1.
            
            On Jan 13, 2005 this sequence version replaced XM_216777.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088300.1, FQ209977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1489
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1489
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /note="serpin family A member 6"
                     /db_xref="GeneID:299270"
                     /db_xref="RGD:1595901"
     exon            1..53
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
     exon            54..660
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1262
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /note="corticosteroid-binding globulin; transcortin;
                     serpin A6; serine (or cysteine) proteinase inhibitor,
                     clade A (alpha-1 antiproteinase, antitrypsin), member 6;
                     serine (or cysteine) peptidase inhibitor, clade A, member
                     6; serpin peptidase inhibitor, clade A, member 6; serpin
                     peptidase inhibitor, clade A (alpha-1 antiproteinase,
                     antitrypsin), member 6; Corticosteroid binding globulin"
                     /codon_start=1
                     /product="corticosteroid-binding globulin precursor"
                     /protein_id="NP_001009663.1"
                     /db_xref="GeneID:299270"
                     /db_xref="RGD:1595901"
                     /translation="MSLALYTCLLWLCTSGLWTAQASTNESSNSHRGLAPTNVDFAFN
                     LYQRLVALNPDKNTLISPVSISMALAMVSLGSAQTQSLQSLGFNLTETSEAEIHQSFQ
                     YLNYLLKQSDTGLEMNMGNAMFLLQKLKLKDSFLADVKQYYESEALAIDFEDWTKASQ
                     QINQHVKDKTQGKIEHVFSDLDSPASFILVNYIFLRGIWELPFSPENTREEDFYVNET
                     STVKVPMMVQSGSIGYFRDSVFPCQLIQMDYVGNGTAFFILPDQGQMDTVIAALSRDT
                     IDRWGKLMTPRQVNLYIPKFSISDTYDLKDMLEDLNIKDLLTNQSDFSGNTKDVPLTL
                     TMVHKAMLQLDEGNVLPNSTNGAPLHLRSEPLDIKFNKPFILLLFDKFTWSSLMMSQV
                     VNPA"
     exon            661..931
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1076
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1461
                     /gene="Serpina6"
                     /gene_synonym="Cbg"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cctgggcagc aaagcacaac cagaaggaac agccggagcc cacagcagca gacggcctgg
       61 tcaactgaac aatgtcactc gccctgtata cctgcctcct ctggctctgc accagtggcc
      121 tctggactgc ccaagccagc actaatgaga gttcaaattc tcaccgaggc ctggctccca
      181 ccaatgttga ctttgccttc aacttgtacc aacgcctagt ggccctaaat ccagacaaga
      241 acaccttaat ctccccagtg agcatctcca tggctctggc catggtatcc cttggctctg
      301 cccagactca gtctctccag agtctaggct tcaacctcac agagacctct gaagctgaga
      361 tccaccagag tttccagtac ctcaattacc ttctcaagca gtccgatact ggcttagaga
      421 tgaacatggg caatgccatg ttcctcctcc agaagctgaa gctgaaggac tcgttcttag
      481 cagacgtcaa acaatactat gagtcagagg ccttggccat cgatttcgag gactggacta
      541 aagccagcca acagatcaac cagcatgtca aggataagac acaggggaaa attgagcatg
      601 tgttctcaga cctggatagt ccagcctcct tcatcctggt caactacatc ttcctcagag
      661 gcatatggga acttcccttc agcccagaaa atactagaga ggaggacttc tatgtgaatg
      721 agacaagcac cgtgaaggtg cccatgatgg tccagtcagg cagcattggt tactttcgtg
      781 actcagtctt cccctgccag ctgatacaga tggactatgt gggaaatgga actgccttct
      841 tcattcttcc agaccagggc cagatggaca ctgtcatcgc tgcacttagt cgggacacaa
      901 ttgataggtg gggcaagctt atgaccccaa ggcaggtgaa cctatacatc ccgaaattct
      961 ccatatctga tacctatgac cttaaagaca tgctggaaga cctgaacatt aaggacttgc
     1021 tcaccaacca atcagatttc tcaggcaaca ccaaagatgt tcccttgaca ttaacgatgg
     1081 tccacaaggc catgctacaa ctggatgaag ggaatgtgtt gcctaattct accaacgggg
     1141 ctcccctaca cctgcgctct gaaccacttg acatcaagtt caacaagccc ttcatcctcc
     1201 tgctctttga caagttcaca tggagcagcc tgatgatgag ccaagtggtc aatccagcct
     1261 aagaacgtgt cctgagaagc cttggtgcca tctgactttg agggatggaa gcctttcccc
     1321 agtcttctca gggtctcccc aacccaatct acttttagat aactagcaat gagtagccct
     1381 tgttgccact ctcaagacaa agtcacttga gaagggagca ctgagaaaga ggtaacagtt
     1441 attaaaggat gtttttgcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
