LOCUS       NM_001244739            2130 bp    mRNA    linear   ROD 04-JAN-2024
DEFINITION  Rattus norvegicus serpin family A member 5 (Serpina5), transcript
            variant 1, mRNA.
ACCESSION   NM_001244739
VERSION     NM_001244739.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2130)
  AUTHORS   Zeng S, Liu Z, Yin J, Li S, Jiang M, Yang H and Long Y.
  TITLE     Improvement in Clinical Features of L-NAME-Induced
            Preeclampsia-like Rats through Reduced SERPINA5 Expression
  JOURNAL   Biomolecules 13 (12), 1792 (2023)
   PUBMED   38136662
  REMARK    GeneRIF: Improvement in Clinical Features of L-NAME-Induced
            Preeclampsia-like Rats through Reduced SERPINA5 Expression.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2130)
  AUTHORS   Zhu T, Tan Q, Xin X, Li F, Zhang K, Liu Z and Tian Y.
  TITLE     Proteomic analysis of human articular cartilage unravels the
            dyscoagulation in osteoarthritis and the potential value of
            serpinA5 as a biomarker for osteoarthritis
  JOURNAL   Proteomics Clin Appl 16 (3), e2100117 (2022)
   PUBMED   34964303
  REMARK    GeneRIF: Proteomic analysis of human articular cartilage unravels
            the dyscoagulation in osteoarthritis and the potential value of
            serpinA5 as a biomarker for osteoarthritis.
REFERENCE   3  (bases 1 to 2130)
  AUTHORS   Longstaff C and Kolev K.
  TITLE     Basic mechanisms and regulation of fibrinolysis
  JOURNAL   J Thromb Haemost 13 Suppl 1, S98-S105 (2015)
   PUBMED   26149056
  REMARK    Review article
REFERENCE   4  (bases 1 to 2130)
  AUTHORS   Bubenek S, Nastase A, Niculescu AM, Baila S, Herlea V, Lazar V,
            Paslaru L, Botezatu A, Tomescu D, Popescu I and Dima S.
  TITLE     Assessment of gene expression profiles in peripheral occlusive
            arterial disease
  JOURNAL   Can J Cardiol 28 (6), 712-720 (2012)
   PUBMED   22721676
REFERENCE   5  (bases 1 to 2130)
  AUTHORS   Li Y, Zhang Y, Qiu F and Qiu Z.
  TITLE     Proteomic identification of exosomal LRG1: a potential urinary
            biomarker for detecting NSCLC
  JOURNAL   Electrophoresis 32 (15), 1976-1983 (2011)
   PUBMED   21557262
REFERENCE   6  (bases 1 to 2130)
  AUTHORS   Zheng X, Geiger M, Ecke S, Bielek E, Donner P, Eberspacher U,
            Schleuning WD and Binder BR.
  TITLE     Inhibition of acrosin by protein C inhibitor and localization of
            protein C inhibitor to spermatozoa
  JOURNAL   Am J Physiol 267 (2 Pt 1), C466-C472 (1994)
   PUBMED   7521127
REFERENCE   7  (bases 1 to 2130)
  AUTHORS   Espana F, Gilabert J, Estelles A, Romeu A, Aznar J and Cabo A.
  TITLE     Functionally active protein C inhibitor/plasminogen activator
            inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at
            high concentrations in human seminal plasma and complexes with
            prostate-specific antigen
  JOURNAL   Thromb Res 64 (3), 309-320 (1991)
   PUBMED   1725227
REFERENCE   8  (bases 1 to 2130)
  AUTHORS   Meijers JC, Kanters DH, Vlooswijk RA, van Erp HE, Hessing M and
            Bouma BN.
  TITLE     Inactivation of human plasma kallikrein and factor XIa by protein C
            inhibitor
  JOURNAL   Biochemistry 27 (12), 4231-4237 (1988)
   PUBMED   2844223
REFERENCE   9  (bases 1 to 2130)
  AUTHORS   Stief TW, Radtke KP and Heimburger N.
  TITLE     Inhibition of urokinase by protein C-inhibitor (PCI). Evidence for
            identity of PCI and plasminogen activator inhibitor 3
  JOURNAL   Biol Chem Hoppe Seyler 368 (10), 1427-1433 (1987)
   PUBMED   3501295
REFERENCE   10 (bases 1 to 2130)
  AUTHORS   Suzuki,K., Nishioka,J., Kusumoto,H. and Hashimoto,S.
  TITLE     Mechanism of inhibition of activated protein C by protein C
            inhibitor
  JOURNAL   J Biochem 95 (1), 187-195 (1984)
   PUBMED   6323392
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CK603584.1 and BC081797.1.
            
            Transcript Variant: This variant (1) is the shorter transcript but
            encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081797.1, AB013128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                CK603584.1         1-32
            33-2130             BC081797.1         1-2098
FEATURES             Location/Qualifiers
     source          1..2130
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2130
                     /gene="Serpina5"
                     /gene_synonym="Pci"
                     /note="serpin family A member 5"
                     /db_xref="GeneID:65051"
                     /db_xref="RGD:619817"
     exon            1..103
                     /gene="Serpina5"
                     /gene_synonym="Pci"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1337
                     /gene="Serpina5"
                     /gene_synonym="Pci"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein C inhibitor; plasma serine protease inhibitor;
                     serine (or cysteine) peptidase inhibitor, clade A, member
                     5; serpin peptidase inhibitor, clade A, member 5; serpin
                     peptidase inhibitor, clade A (alpha-1 antiproteinase,
                     antitrypsin), member 5"
                     /codon_start=1
                     /product="plasma serine protease inhibitor isoform 1"
                     /protein_id="NP_001231668.1"
                     /db_xref="GeneID:65051"
                     /db_xref="RGD:619817"
                     /translation="MTFASYNSLCPLSSHKPGGLLPIKTLSHHNTEMAATMRFFPILC
                     LVLFFSHGVASRQRSHSKEKKKSKESSVGAVGTSRSRDFAFRLYRALASEAPGQNVFF
                     SPMSVSMSLGMLSLGSGLKTKAQILEGLGLSLQQGQEDMLHKGFQQLLQQFSQPSDGL
                     QLSLGSALFTDPAVHIRDHFLSAMKTLYMSDMFSTNFGNPESAKKQINDYVAKKTNGK
                     IVDLIKDLDSTHVMVVVNYIFFKAKWQTAFSSTNTHKMDYHVTPKKTIQVPMMNREDI
                     YSYILDQNISCTVVGIPYQGNTFALFILPSEGKMKRVEDGLDERTLRNWLKMFTKRQL
                     DLYLPKFSIEGTYKLEKILPKLGIQDIFTTHADLSGLTDHTNIKLSEMVHKSMVEVDE
                     SGTTAAASTGILFTLRSARPSSLKVEFTRPFLVVIMDGTNLYFIGKVIQP"
     exon            104..732
                     /gene="Serpina5"
                     /gene_synonym="Pci"
                     /inference="alignment:Splign:2.1.0"
     exon            733..1003
                     /gene="Serpina5"
                     /gene_synonym="Pci"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1151
                     /gene="Serpina5"
                     /gene_synonym="Pci"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..2105
                     /gene="Serpina5"
                     /gene_synonym="Pci"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgtgatccat gacatttgcc agctataatt cactctgtcc tctctcttct cataagccag
       61 gtggattgct acccatcaag acactcagcc accacaatac agaaatggca gccacaatga
      121 ggttcttccc cattctgtgc ctggtgctgt tcttcagtca cggggtggct tcccgccaac
      181 gctcccattc taaggagaag aagaagtcta aagagtcctc tgtgggtgct gtggggactt
      241 cccgaagcag agactttgcc ttcaggctct acagggcctt ggcttctgaa gcccctggtc
      301 agaatgtttt cttctccccc atgagcgtgt ctatgagctt gggtatgctc tccctggggt
      361 caggcttgaa gactaaggca cagatcctgg agggcctggg cctcagcctc cagcaaggcc
      421 aagaggatat gctccacaag ggcttccaac agctgctgca gcagttcagc cagcctagtg
      481 atggcctcca gctgagccta ggcagtgccc tttttacaga cccagcagta catatccggg
      541 accactttct gagtgccatg aagacattgt acatgtcaga catgttctct accaactttg
      601 ggaaccctga aagtgctaag aagcagatca atgactatgt agccaagaag accaacggca
      661 agattgtaga cttgatcaag gatcttgaca gcacccacgt catggtggtg gtaaattata
      721 tcttcttcaa agccaagtgg cagacggcct tcagtagcac caacacccac aagatggatt
      781 accatgtgac tcccaagaag accattcagg tgccaatgat gaaccgcgaa gatatatatt
      841 cctacatcct cgaccaaaac atttcctgca cggtggtggg gatcccttac caaggcaata
      901 catttgctct gtttattctt cccagcgagg gcaagatgaa gcgggtagag gatggcctgg
      961 atgagagaac gttgaggaac tggcttaaga tgttcacaaa gagacagtta gatctttacc
     1021 tccccaagtt ctccattgag ggtacctata aactggaaaa aatcctcccc aagctgggca
     1081 tccaggacat cttcaccacc catgctgact tgtctggcct tactgaccac accaatatta
     1141 agttgtctga gatggtacac aaatccatgg tggaggtaga cgagtcagga acaacagcag
     1201 ctgcctccac aggaattctc ttcacactca gatctgctcg accgagctct ctgaaggtag
     1261 aattcaccag accctttctg gtggtcatta tggatggtac aaacctctat ttcattggca
     1321 aagtgattca gccctgaggt gggactcctt ctgaaactca caggcctata cagaaggagc
     1381 caggcatatt ctacagacta tccacctctt ggtagctagt gattttcata gagtagattg
     1441 actaataagg tgttgtaagt gagaagatca atatcctggt ggaagcttcc ttgatcacag
     1501 ttgcaagatg tgctcttgct ctattttttc attattgaca ctgatgctaa agaggccact
     1561 tgattgctcc aaggtcctat caccatattt gtgacatagt tatgcccaga cctcagacct
     1621 ctcttgctca gtctagcgct acaaagctct gcaagaggct ggtcagcata gataaaggcc
     1681 accaggaagc acggttataa acctggtctc acacctatta gcaccatggt tgagaaagga
     1741 cattggactg agattctgaa atggtgctaa tagctatgta actcgaaaat gaaaatgttc
     1801 ctctctgcct gtgtttcttt gagtatccag tcaatgatca gaacaagtag cccattcagt
     1861 gatctgtgaa attgttacac aagggttggc tactctatgc tagccatggt tgatgtaaga
     1921 actcagttta atagcatact tgagcaatca gggtaaaagt gttccaccat gaacaaaggt
     1981 atcaaatcac aaacctggct gactgcagtt ggatgttaga ggtctgttgt aaatagtaga
     2041 acatagattg cagactgact tgttgatttc tactttggca atagcaataa agcactttgc
     2101 aaagaaaaaa aaaaaaaaaa aaaaaaaaaa
//
