LOCUS       NM_145097               1554 bp    mRNA    linear   ROD 24-SEP-2023
DEFINITION  Rattus norvegicus serpin family A member 4 (Serpina4), mRNA.
ACCESSION   NM_145097
VERSION     NM_145097.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1554)
  AUTHORS   Shen G, Li Y, Zeng Y, Hong F, Zhang J, Wang Y, Zhang C, Xiang W,
            Wang J, Fang Z, Qi W, Yang X, Gao G and Zhou T.
  TITLE     Kallistatin Deficiency Induces the Oxidative Stress-Related
            Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial
            Cells: A Novel Protagonist in Age-Related Macular Degeneration
  JOURNAL   Invest Ophthalmol Vis Sci 64 (12), 15 (2023)
   PUBMED   37682567
  REMARK    GeneRIF: Kallistatin Deficiency Induces the Oxidative
            Stress-Related Epithelial-Mesenchymal Transition of Retinal Pigment
            Epithelial Cells: A Novel Protagonist in Age-Related Macular
            Degeneration.
REFERENCE   2  (bases 1 to 1554)
  AUTHORS   Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X,
            Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins
            MT, Misra S, Stoughton J and Mayr M.
  TITLE     Extracellular matrix remodelling in response to venous
            hypertension: proteomics of human varicose veins
  JOURNAL   Cardiovasc Res 110 (3), 419-430 (2016)
   PUBMED   27068509
REFERENCE   3  (bases 1 to 1554)
  AUTHORS   Didangelos A, Yin X, Mandal K, Baumert M, Jahangiri M and Mayr M.
  TITLE     Proteomics characterization of extracellular space components in
            the human aorta
  JOURNAL   Mol Cell Proteomics 9 (9), 2048-2062 (2010)
   PUBMED   20551380
REFERENCE   4  (bases 1 to 1554)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1554)
  AUTHORS   Moreau ME, Garbacki N, Molinaro G, Brown NJ, Marceau F and Adam A.
  TITLE     The kallikrein-kinin system: current and future pharmacological
            targets
  JOURNAL   J Pharmacol Sci 99 (1), 6-38 (2005)
   PUBMED   16177542
  REMARK    Review article
REFERENCE   6  (bases 1 to 1554)
  AUTHORS   Ma JX, King LP, Yang Z, Crouch RK, Chao L and Chao J.
  TITLE     Kallistatin in human ocular tissues: reduced levels in vitreous
            fluids from patients with diabetic retinopathy
  JOURNAL   Curr Eye Res 15 (11), 1117-1123 (1996)
   PUBMED   8950506
REFERENCE   7  (bases 1 to 1554)
  AUTHORS   Chai KX, Chen LM, Chao J and Chao L.
  TITLE     Kallistatin: a novel human serine proteinase inhibitor. Molecular
            cloning, tissue distribution, and expression in Escherichia coli
  JOURNAL   J Biol Chem 268 (32), 24498-24505 (1993)
   PUBMED   8227002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC088111.1.
            
            On Jan 2, 2005 this sequence version replaced NM_145097.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC088111.1, FQ218835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1554
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1554
                     /gene="Serpina4"
                     /note="serpin family A member 4"
                     /db_xref="GeneID:246328"
                     /db_xref="RGD:708581"
     exon            1..36
                     /gene="Serpina4"
                     /inference="alignment:Splign:2.1.0"
     exon            37..692
                     /gene="Serpina4"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1324
                     /gene="Serpina4"
                     /note="kallistatin; serpin peptidase inhibitor, clade A
                     (alpha-1 antiproteinase, antitrypsin), member 4; sserpin
                     family A member 4; serine (or cysteine) proteinase
                     inhibitor, clade A (alpha-1 antiproteinase, antitrypsin),
                     member 4"
                     /codon_start=1
                     /product="kallistatin precursor"
                     /protein_id="NP_659565.2"
                     /db_xref="GeneID:246328"
                     /db_xref="RGD:708581"
                     /translation="MHYTRCLLLLLAGLLELSHSQPDQEEPDNTTNQTYRQFSQQNIS
                     SYQIASGNANFAFRLYHLIASQNSEKNIFFSPLSISVSLAILSTGAGGDTQAQILEGL
                     GFNLTKLSLPEIHEGFRSLQHTIARPFTEPQISVGSALILSQNLQILSEFVSAIETSY
                     NSKVLHANFRDKEAAVQLINNYVKQNTQGKIKNLVSDLSPDVKMVLVNYIFFQGLWKK
                     PFPSSRVSTSDFYVDENTVVKIPMMLQDKEDHWYLEDRRVPCTVLRMDYRGDAVAFFI
                     LPDQGKMNEVEQVLSPGMLLRWKRLLQNRFFYRKLILQLPKFSISNSYELDEILPDLG
                     FQDLFTPNANFSNISKKEKLYLSKVFHKTVLDVNEVGTKAAAATGSFATFFSAQPKKR
                     YLIFNRPFLVILYSTSSQDILFMGKVVNPTA"
     exon            693..966
                     /gene="Serpina4"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1126
                     /gene="Serpina4"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1528
                     /gene="Serpina4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatagtcacc agggtcacta caggaggaat tgttccatct gagagaccca gcatgcatta
       61 tactcgctgt ctgctgcttc tcctggctgg actcttggaa ctctctcaca gtcagccaga
      121 ccaagaagag cctgacaata caaccaacca aacctacaga cagttctcac agcagaacat
      181 ctccagctac cagattgcct ctggcaatgc caactttgcc ttccgcctct accacctgat
      241 agcgtcccaa aactctgaga agaacatttt cttctcccca ctcagcatct ctgtctcttt
      301 ggccatactg tccacagggg ctggtgggga cacccaggct cagatccttg aaggtctggg
      361 cttcaacctc acaaagctgt cactgcctga aattcatgag ggcttcaggt ccttgcagca
      421 cacaatagct cgcccgttca ctgagccaca gatctctgta ggcagtgcgc tgatcctgag
      481 ccagaacctg cagatcctct ctgagtttgt cagtgccatc gaaacctcct ataacagcaa
      541 agtcttacat gctaacttca gagataagga ggctgcggtc cagctcatca acaactatgt
      601 caagcagaat actcagggga agatcaaaaa tttggtcagt gacctgagcc cagatgtaaa
      661 gatggtgctg gtgaattaca tcttcttcca aggtctttgg aagaaaccct ttccttcttc
      721 cagagtctct accagtgact tctatgtaga tgagaacacg gttgtgaaga tacccatgat
      781 gctgcaagat aaggaggatc actggtatct tgaggacaga cgtgtaccct gcacagtact
      841 gcggatggac tacaggggtg atgcagtggc gttcttcatc cttcctgacc agggcaagat
      901 gaatgaggtg gagcaggtgc tgtccccagg catgctacta aggtggaaac gcttgctgca
      961 gaataggttc ttttacagaa agctcatatt gcagctcccc aaattctcca tttcaaattc
     1021 ctatgaattg gatgagattt tgcctgactt gggcttccag gatctgttca ccccaaatgc
     1081 caacttctca aatatcagca aaaaggagaa attgtactta tccaaagttt tccataagac
     1141 cgtcctggat gtgaatgaag ttggcacaaa ggcagcagca gccaccggct cctttgccac
     1201 ctttttctct gcccagccca agaaacgtta ccttatattc aaccggccct tcttggtgat
     1261 attgtattcc accagctccc aggatatcct cttcatgggg aaggtggtca accccacagc
     1321 atagcagacc taggattagg tggtctgtta ccagcaggag aacgtgactg ggtaggcctg
     1381 gatatgaata actctgcacc catggcttgg ggtgggaaag ggcccctgac tcccaagagt
     1441 ggtagaggga ggcgtggggc tagatggact ggaaagtggg agatacctcc ctggggacca
     1501 cgctgattaa accaaatggc atctctgaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
