LOCUS       NM_031531               2081 bp    mRNA    linear   ROD 11-SEP-2024
DEFINITION  Rattus norvegicus serpin family A member 3N (Serpina3n), mRNA.
ACCESSION   NM_031531
VERSION     NM_031531.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2081)
  AUTHORS   Vicuna,L., Strochlic,D.E., Latremoliere,A., Bali,K.K.,
            Simonetti,M., Husainie,D., Prokosch,S., Riva,P., Griffin,R.S.,
            Njoo,C., Gehrig,S., Mall,M.A., Arnold,B., Devor,M., Woolf,C.J.,
            Liberles,S.D., Costigan,M. and Kuner,R.
  TITLE     The serine protease inhibitor SerpinA3N attenuates neuropathic pain
            by inhibiting T cell-derived leukocyte elastase
  JOURNAL   Nat Med 21 (5), 518-523 (2015)
   PUBMED   25915831
  REMARK    GeneRIF: SerpinA3N attenuates neuropathic pain by inhibiting T
            cell-derived leukocyte elastase
REFERENCE   2  (bases 1 to 2081)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 2081)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   4  (bases 1 to 2081)
  AUTHORS   Wang,G.P., Zhang,X.S., Li,Y.H., Zheng,J.L., Tang,C.Z. and
            Zhang,W.X.
  TITLE     Cloning and prokaryotic expression of rat homolog of Serpina3n and
            its expression change during liver regeneration
  JOURNAL   Genet Mol Res 11 (3), 3175-3185 (2012)
   PUBMED   23007996
  REMARK    GeneRIF: The sequence of HM448398 was highly homologous to that of
            rat Serpina3n, suggesting that it may be a homolog of Serpina3n.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2081)
  AUTHORS   Yanaka,N., Ohata,T., Toya,K., Kanda,M., Hirata,A. and Kato,N.
  TITLE     Vitamin B6 suppresses serine protease inhibitor 3 expression in the
            colon of rats and in TNF-alpha-stimulated HT-29 cells
  JOURNAL   Mol Nutr Food Res 55 (4), 635-643 (2011)
   PUBMED   21462331
REFERENCE   6  (bases 1 to 2081)
  AUTHORS   Ohkubo,K., Ogata,S., Misumi,Y., Takami,N. and Ikehara,Y.
  TITLE     Molecular cloning and characterization of rat contrapsin-like
            protease inhibitor and related proteins
  JOURNAL   J Biochem 109 (2), 243-250 (1991)
   PUBMED   1864837
REFERENCE   7  (bases 1 to 2081)
  AUTHORS   Pages,G., Rouayrenc,J.F., Rossi,V., Le Cam,G., Mariller,M.,
            Szpirer,J., Szpirer,C., Levan,G. and Le Cam,A.
  TITLE     Primary structure and assignment to chromosome 6 of three related
            rat genes encoding liver serine protease inhibitors
  JOURNAL   Gene 94 (2), 273-282 (1990)
   PUBMED   2258058
REFERENCE   8  (bases 1 to 2081)
  AUTHORS   Pages,G., Rouayrenc,J.F., Le Cam,G., Mariller,M. and Le Cam,A.
  TITLE     Molecular characterization of three rat liver serine-protease
            inhibitors affected by inflammation and hypophysectomy. Protein and
            mRNA analysis and cDNA cloning
  JOURNAL   Eur J Biochem 190 (2), 385-391 (1990)
   PUBMED   1694763
REFERENCE   9  (bases 1 to 2081)
  AUTHORS   Baumann,H., Onorato,V., Gauldie,J. and Jahreis,G.P.
  TITLE     Distinct sets of acute phase plasma proteins are stimulated by
            separate human hepatocyte-stimulating factors and monokines in rat
            hepatoma cells
  JOURNAL   J Biol Chem 262 (20), 9756-9768 (1987)
   PUBMED   2439511
REFERENCE   10 (bases 1 to 2081)
  AUTHORS   Emmett,M., Miller,J.L. and Crowle,A.J.
  TITLE     Protein abnormalities in adult respiratory distress syndrome,
            tuberculosis, and cystic fibrosis sera
  JOURNAL   Proc Soc Exp Biol Med 184 (1), 74-82 (1987)
   PUBMED   2432615
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Mar 12, 2021 this sequence version replaced NM_031531.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ209856.1, BC078796.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                JAXUCZ010000006.1  129088392-129088482
            92-745              JAXUCZ010000006.1  129090311-129090964
            746-1019            JAXUCZ010000006.1  129092788-129093061
            1020-1170           JAXUCZ010000006.1  129093964-129094114
            1171-2081           JAXUCZ010000006.1  129095040-129095950
FEATURES             Location/Qualifiers
     source          1..2081
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..2081
                     /gene="Serpina3n"
                     /gene_synonym="CPi-26; Spi-2.2; SPI3; Spin2c; Spin3"
                     /note="serpin family A member 3N"
                     /db_xref="GeneID:24795"
                     /db_xref="RGD:3747"
     exon            1..91
                     /gene="Serpina3n"
                     /gene_synonym="CPi-26; Spi-2.2; SPI3; Spin2c; Spin3"
                     /inference="alignment:Splign:2.1.0"
     exon            92..745
                     /gene="Serpina3n"
                     /gene_synonym="CPi-26; Spi-2.2; SPI3; Spin2c; Spin3"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1365
                     /gene="Serpina3n"
                     /gene_synonym="CPi-26; Spi-2.2; SPI3; Spin2c; Spin3"
                     /note="serine protease inhibitor 2c; serine protease
                     inhibitor A3N; serpina3n-like protein; SPI-3; serpin A3N;
                     serine (or cysteine) peptidase inhibitor, clade A, member
                     3N; serine protease inhibitor 3; contrapsin-like protease
                     inhibitor 6"
                     /codon_start=1
                     /product="serine protease inhibitor A3N precursor"
                     /protein_id="NP_113719.3"
                     /db_xref="GeneID:24795"
                     /db_xref="RGD:3747"
                     /translation="MTRLVTLELLMAGIGSALLCFPDCILGEDTLFHEDQDKGTQLDS
                     LTLASINTDFAFSLYKKLALRNPDKNVVFSPLSISAALAVVSLGAKGNSMEEILEGLK
                     FNLTETPETEIHRGFGHLLQRLSQPRDEIQISTGNALFIEKRLQVLAEFQEKAKALYQ
                     AEAFTADFQQSREAKKLINDYVSKQTQGKIQGLITNLAKKTSMVLVNYIYFKGKWKVP
                     FDPRDTFQSEFYSGKRRPVKVPMMKLEDLTTPYVRDEELNCTVVELKYTGNASALFIL
                     PDQGKMQQVEASLQPETLRRWKDSLRPSMIDELYLPKFSISADYNLEDVLPELGIKEV
                     FSTQADLSGITGDKDLMVSQVVHKAVLDVAETGTEAAAATGVKFVPMSAKLDPLIIAF
                     DRPFLMIISDTETAIAPFLAKIFNPK"
     exon            746..1019
                     /gene="Serpina3n"
                     /gene_synonym="CPi-26; Spi-2.2; SPI3; Spin2c; Spin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1170
                     /gene="Serpina3n"
                     /gene_synonym="CPi-26; Spi-2.2; SPI3; Spin2c; Spin3"
                     /inference="alignment:Splign:2.1.0"
     exon            1171..2081
                     /gene="Serpina3n"
                     /gene_synonym="CPi-26; Spi-2.2; SPI3; Spin2c; Spin3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggataaca acacaccagg gaagtggcaa ccctgaacat caggagtcag caatcacaga
       61 ggctggcagc tggctggtat cggctctgca gcctgaagac tggagaagat gacccgcctt
      121 gtgactctgg agctcttgat ggctgggatc ggctctgctc tcctctgctt cccagattgc
      181 atactgggag aggacactct attccatgaa gaccaagaca aggggacaca actggacagt
      241 ctcacattgg cctccatcaa tactgacttt gccttcagcc tctacaagaa gctggctttg
      301 aggaatccag ataaaaatgt tgtcttctcc ccacttagca tctcagccgc cttggccgtc
      361 gtgtccctgg gagcaaaggg caacagcatg gaagagattc tagaaggtct caagttcaat
      421 ctcacagaga cccctgagac agaaatccac cggggctttg gacacctcct ccagaggctc
      481 agccagccaa gggacgagat acagatcagt acaggcaatg ccctgtttat tgaaaaacgc
      541 cttcaggtcc tggcagagtt ccaggagaag gcaaaggctc tgtaccaagc tgaggccttc
      601 acagctgatt tccagcagtc tcgtgaggcc aaaaagctca tcaatgacta tgtgagtaaa
      661 cagacccagg ggaagatcca gggactgatc acaaacctag ctaagaagac atccatggta
      721 ctggtgaatt acatctactt taaaggcaaa tggaaggtgc cttttgaccc tcgggacaca
      781 ttccagtctg agttctactc tggcaaaagg aggcctgtga aagtgcccat gatgaagctt
      841 gaggacctga ccacacccta cgtccgggat gaggagctga actgcactgt tgtggagctg
      901 aagtacacag gaaatgccag cgccctgttt atcctccctg accagggcaa gatgcagcag
      961 gtggaagcca gcttgcaacc agagaccctg aggagatgga aggactctct caggcccagc
     1021 atgatagatg agctctacct gcccaagttc tccatctctg ctgactacaa cctggaggac
     1081 gtccttccag agctgggcat caaagaagtc ttctccacac aggctgacct gtctgggatc
     1141 acaggggata aggacctgat ggtctctcag gtggtccaca aggctgttct ggatgtggct
     1201 gagacaggca cagaagcagc cgctgccaca ggggtcaaat ttgttccaat gtctgcaaaa
     1261 ctggaccctc tgattatagc tttcgaccgg cctttcctga tgattatctc tgacacagaa
     1321 actgcaatag ctcccttttt ggccaagata tttaacccca aatgagattc gaacttccca
     1381 agagttgatg cttctcctga ggcattgagc ctgtctgtgg gtctctgtgt gcattttggc
     1441 ttctatgctc tgattggcca tggcggcatg cctggatgag acagtaacta actgtgtaac
     1501 agcctcatgt acagacgcct gtgcagagtc gctgccatgc tcccaaactt cttggtacca
     1561 ctagctcata tttctgagcc taaaatttgt ctttcccctg cccttgctct ctctcccctg
     1621 tatctgcctc aacccagaag ccagggcccc atcaggttgt ctcagtccca acttaggctc
     1681 tagttatatc ttccttcagc gttgctgtct tgatgggact gtgcacgatt accggccaac
     1741 ccacatggac caagaagaac acttgctggt ccgtatcttt ctgcagtatg tgggatcact
     1801 tggtgcccag tgctgcctca ctatttcctt cctctgggca ctgctccttg cagcatggcc
     1861 tgaccttgtc cacatctggc acagagctgg agccctccct tctgcagatg catggcacct
     1921 gtgggtcaga ccagatcccc ctccccagca ctcctactta gagcaatgca gcctttcttt
     1981 tagttcccag ctgaccaacc tcacacaaaa gatgaccaac aacaaccaaa atgaagaggt
     2041 aggagcaaag gatcaataaa cacatcactg cattgaatgt a
//
