LOCUS       NM_001270982            1692 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus serpin family A member 3M (Serpina3m), mRNA.
ACCESSION   NM_001270982 XM_216782
VERSION     NM_001270982.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1692)
  AUTHORS   Vanni,S., Moda,F., Zattoni,M., Bistaffa,E., De Cecco,E., Rossi,M.,
            Giaccone,G., Tagliavini,F., Haik,S., Deslys,J.P., Zanusso,G.,
            Ironside,J.W., Ferrer,I., Kovacs,G.G. and Legname,G.
  TITLE     Differential overexpression of SERPINA3 in human prion diseases
  JOURNAL   Sci Rep 7 (1), 15637 (2017)
   PUBMED   29142239
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1692)
  AUTHORS   Thaysen-Andersen,M., Venkatakrishnan,V., Loke,I., Laurini,C.,
            Diestel,S., Parker,B.L. and Packer,N.H.
  TITLE     Human neutrophils secrete bioactive paucimannosidic proteins from
            azurophilic granules into pathogen-infected sputum
  JOURNAL   J Biol Chem 290 (14), 8789-8802 (2015)
   PUBMED   25645918
REFERENCE   3  (bases 1 to 1692)
  AUTHORS   Bastos-Amador,P., Royo,F., Gonzalez,E., Conde-Vancells,J.,
            Palomo-Diez,L., Borras,F.E. and Falcon-Perez,J.M.
  TITLE     Proteomic analysis of microvesicles from plasma of healthy donors
            reveals high individual variability
  JOURNAL   J Proteomics 75 (12), 3574-3584 (2012)
   PUBMED   22516433
REFERENCE   4  (bases 1 to 1692)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1692)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   6  (bases 1 to 1692)
  AUTHORS   Horvath,A.J., Forsyth,S.L. and Coughlin,P.B.
  TITLE     Expression patterns of murine antichymotrypsin-like genes reflect
            evolutionary divergence at the Serpina3 locus
  JOURNAL   J Mol Evol 59 (4), 488-497 (2004)
   PUBMED   15638460
REFERENCE   7  (bases 1 to 1692)
  AUTHORS   Ohkubo,K., Ogata,S., Misumi,Y., Takami,N., Sinohara,H. and
            Ikehara,Y.
  TITLE     Cloning, structure and expression of cDNA for mouse contrapsin and
            a related protein
  JOURNAL   Biochem J 276 (Pt 2) (Pt 2), 337-342 (1991)
   PUBMED   2049065
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Aug 17, 2012 this sequence version replaced XM_216782.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643286.20842.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760400,
                                           SAMEA5760476 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000006.1  128836755-128836839 c
            86-739              JAXUCZ010000006.1  128834210-128834863 c
            740-1013            JAXUCZ010000006.1  128832179-128832452 c
            1014-1164           JAXUCZ010000006.1  128831098-128831248 c
            1165-1692           JAXUCZ010000006.1  128829569-128830096 c
FEATURES             Location/Qualifiers
     source          1..1692
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1692
                     /gene="Serpina3m"
                     /gene_synonym="SPI-2.4"
                     /note="serpin family A member 3M"
                     /db_xref="GeneID:299276"
                     /db_xref="RGD:735068"
     exon            1..85
                     /gene="Serpina3m"
                     /gene_synonym="SPI-2.4"
                     /inference="alignment:Splign:2.1.0"
     exon            86..739
                     /gene="Serpina3m"
                     /gene_synonym="SPI-2.4"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1362
                     /gene="Serpina3m"
                     /gene_synonym="SPI-2.4"
                     /note="serine protease inhibitor 2.4; serine (or cysteine)
                     proteinase inhibitor, clade A, member 3M; serpin A3M;
                     serine protease inhibitor A3M"
                     /codon_start=1
                     /product="serine protease inhibitor A3M precursor"
                     /protein_id="NP_001257911.1"
                     /db_xref="GeneID:299276"
                     /db_xref="RGD:735068"
                     /translation="MAFIAALGLLMAGICPAVLGFPDGTLGNDTLLHKDQDKGTQLDS
                     LTLESINTDFAFSLYKMLALKNPDKNVVFSPLSISAALAIVSLGAKGNTLEEILEVLR
                     FNLTESYETDIHQGFGHLLQRLSQPGDQVKIITGNALFIDKNLQVLAEFQEKTRALYQ
                     VEAFTADFQQPRVTEKLINDYVRNQTQGKIQELVSGLKERTSMVLVNYLLFRGKWKVP
                     FDPDYTFESEFYVDEKRSVKVSMMKIEELTTPYFRDEELSCSVLELKYTGNSSALFIL
                     PDKGRMQQVEASLQPETLKKWKDSLRPRKIDELYLPRLSISTDYSLEEVLPELGIRDV
                     FSQQADLSRITGAKDLSVSQVVHKVVLDVNETGTEAAAATGANLVPRSGRPPMIVWFN
                     RPFLIAVSHTHGQTILFMAKVINPVGA"
     exon            740..1013
                     /gene="Serpina3m"
                     /gene_synonym="SPI-2.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1164
                     /gene="Serpina3m"
                     /gene_synonym="SPI-2.4"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1692
                     /gene="Serpina3m"
                     /gene_synonym="SPI-2.4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacaacacac caggcaaggg aaaaccttga acatcaggag tcggcaatca tagaggctgg
       61 cagctggctg gtgtcagctc ttcagccttc aggacagaga agatggcctt cattgcagct
      121 ttggggctcc tgatggctgg gatctgccct gctgtccttg gcttcccaga tggcacactg
      181 ggaaatgaca ctctactcca taaagatcaa gacaagggga cacaactgga cagtctcaca
      241 ttggagtcca tcaacactga ctttgccttc agcctttaca agatgctggc tttgaagaat
      301 ccagataaaa atgttgtctt ctccccactt agcatctcag ctgccttggc cattgtgtcc
      361 ctgggagcaa agggcaacac cctggaagag attctagaag ttctcaggtt caatctcaca
      421 gagagctatg agacagacat ccaccagggc tttgggcacc tcctccagag gctcagtcag
      481 ccaggggacc aggtaaagat catcacaggc aatgctctgt ttattgataa gaaccttcag
      541 gtcctggcag agttccagga gaagacaagg gctctgtacc aggttgaggc cttcacagct
      601 gacttccagc agcctcgtgt gaccgaaaag ctcatcaatg actatgtgag aaatcagacc
      661 caggggaaga tccaggaact ggtctcaggc ctgaaagaga ggacatccat ggtgctggtg
      721 aactacctcc tctttagagg caaatggaag gtgccctttg accctgatta cacatttgag
      781 tctgagttct acgtggatga gaagaggtct gtgaaggtgt ccatgatgaa aattgaggaa
      841 ctgactacac cttacttccg ggatgaggag ctgtcctgct ctgtgctgga actgaagtac
      901 acaggaaatt ccagtgccct gttcatcctc cctgataagg gcaggatgca gcaagtggaa
      961 gccagcttgc aaccagagac cctgaagaag tggaaggact ctctgaggcc caggaagata
     1021 gatgagctct acctgcccag gttatccatt tccactgact atagcctgga ggaggtcctt
     1081 ccagagctgg gcattaggga tgtcttctcc cagcaagctg atctgagtag gatcacaggg
     1141 gccaaggacc tgagtgtctc tcaggtggtc cacaaggttg tgctggatgt gaatgagaca
     1201 ggcacagaag cagctgctgc cacaggagcc aatttggtcc cacgtagtgg aaggccacct
     1261 atgattgtgt ggttcaacag gccattcctg atagctgtct ctcacacaca tggtcagact
     1321 atcctcttta tggccaaagt cattaacccc gtgggagcct aaagctcccc aatatctaat
     1381 agttctaccc aggtccatga gaccgagcct gcatgtggat ctctgtgtat aacccaacct
     1441 tcaaactctg attggctgtt gcaaagttgg cttagacagt gacatcgact atctctgtgg
     1501 ctcccagaca ttcaggagcg tttggactgt aatgtcaggt tctcaggccc cttgggagca
     1561 tctgcacatg tttctgaacc tggaatctgt cttttttctt cttcccttgt gactcctctt
     1621 tctgtgttca taccccaaac ctagccactg tcaagtacac ccagtcccaa taaaggcttt
     1681 gagcacatct gc
//
