LOCUS       NM_001389215            1679 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus serine (or cysteine) peptidase inhibitor, clade
            A, member 3L (Serpina3l), mRNA.
ACCESSION   NM_001389215
VERSION     NM_001389215.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1679)
  AUTHORS   Horvath,A.J., Forsyth,S.L. and Coughlin,P.B.
  TITLE     Expression patterns of murine antichymotrypsin-like genes reflect
            evolutionary divergence at the Serpina3 locus
  JOURNAL   J Mol Evol 59 (4), 488-497 (2004)
   PUBMED   15638460
REFERENCE   2  (bases 1 to 1679)
  AUTHORS   Ohkubo,K., Ogata,S., Misumi,Y., Takami,N. and Ikehara,Y.
  TITLE     Molecular cloning and characterization of rat contrapsin-like
            protease inhibitor and related proteins
  JOURNAL   J Biochem 109 (2), 243-250 (1991)
   PUBMED   1864837
REFERENCE   3  (bases 1 to 1679)
  AUTHORS   Pages,G., Rouayrenc,J.F., Rossi,V., Le Cam,G., Mariller,M.,
            Szpirer,J., Szpirer,C., Levan,G. and Le Cam,A.
  TITLE     Primary structure and assignment to chromosome 6 of three related
            rat genes encoding liver serine protease inhibitors
  JOURNAL   Gene 94 (2), 273-282 (1990)
   PUBMED   2258058
REFERENCE   4  (bases 1 to 1679)
  AUTHORS   Pages,G., Rouayrenc,J.F., Le Cam,G., Mariller,M. and Le Cam,A.
  TITLE     Molecular characterization of three rat liver serine-protease
            inhibitors affected by inflammation and hypophysectomy. Protein and
            mRNA analysis and cDNA cloning
  JOURNAL   Eur J Biochem 190 (2), 385-391 (1990)
   PUBMED   1694763
REFERENCE   5  (bases 1 to 1679)
  AUTHORS   Yoon,J.B., Towle,H.C. and Seelig,S.
  TITLE     Growth hormone induces two mRNA species of the serine protease
            inhibitor gene family in rat liver
  JOURNAL   J Biol Chem 262 (9), 4284-4289 (1987)
   PUBMED   3494016
REFERENCE   6  (bases 1 to 1679)
  AUTHORS   Hill,R.E. and Hastie,N.D.
  TITLE     Accelerated evolution in the reactive centre regions of serine
            protease inhibitors
  JOURNAL   Nature 326 (6108), 96-99 (1987)
   PUBMED   3493437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 11, 2021 this sequence version replaced NM_001389215.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D00752.1, FQ210703.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                JAXUCZ010000006.1  129063206-129063290
            86-733              JAXUCZ010000006.1  129065290-129065937
            734-1007            JAXUCZ010000006.1  129067740-129068013
            1008-1158           JAXUCZ010000006.1  129068925-129069075
            1159-1679           JAXUCZ010000006.1  129070053-129070573
FEATURES             Location/Qualifiers
     source          1..1679
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1679
                     /gene="Serpina3l"
                     /gene_synonym="Ab1-021; CPi-23; SPI1; Spin1; Spin2a"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 3L"
                     /db_xref="GeneID:299282"
                     /db_xref="RGD:3745"
     exon            1..85
                     /gene="Serpina3l"
                     /gene_synonym="Ab1-021; CPi-23; SPI1; Spin1; Spin2a"
                     /inference="alignment:Splign:2.1.0"
     exon            86..733
                     /gene="Serpina3l"
                     /gene_synonym="Ab1-021; CPi-23; SPI1; Spin1; Spin2a"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1344
                     /gene="Serpina3l"
                     /gene_synonym="Ab1-021; CPi-23; SPI1; Spin1; Spin2a"
                     /note="serine protease inhibitor 2a; serine protease
                     inhibitor 2.1; serine protease inhibitor A3L;
                     contrapsin-like protease inhibitor 3; liver regeneration
                     protein lrryan; serine protease inhibitor 1;
                     contrapsin-like protease inhibitor-related protein; SPI-1;
                     SPI-2.1; serpin A3L"
                     /codon_start=1
                     /product="serine protease inhibitor A3L precursor"
                     /protein_id="NP_001376144.2"
                     /db_xref="GeneID:299282"
                     /db_xref="RGD:3745"
                     /translation="MAFIAALGLLMAGICPAVLCDGTLGRDTLSHEDHGKGRQLHSLT
                     LASSNTDFALSLYKKLALRNPDKNVVFSPLSISAALTILSLGAKDSTMEEILEGLKFN
                     LTEITEEEIHQGFGHLLQRLSQPEDQVEINTGSALFIDKEQPILSEFQEKTRALYQAE
                     AFIADFKQPNEAKKLINDYVSNQTQGKIAELFSDLEERTSMVLVNYLLFKGKWKVPFN
                     PNDTFESEFYLDEKRSVKVPMMKIKEVTTPYVRDEELSCSVLELKYTGNASALFILPD
                     QGKMQQVESSLQPETLKKWKDSLIPRIINDLRMPKFSISTDYSLKEVLPELGIKKVFS
                     QQADLSRITGTKDLYVSQVVHKAVLDVDETGTEATAATGVATVIRRQPRTLNFNRPFM
                     VVITDMDSQSILFVAKITNPK"
     exon            734..1007
                     /gene="Serpina3l"
                     /gene_synonym="Ab1-021; CPi-23; SPI1; Spin1; Spin2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1008..1158
                     /gene="Serpina3l"
                     /gene_synonym="Ab1-021; CPi-23; SPI1; Spin1; Spin2a"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1679
                     /gene="Serpina3l"
                     /gene_synonym="Ab1-021; CPi-23; SPI1; Spin1; Spin2a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aacaacacac cagggaagtg acaaccctga acatcaggtg tcagcaaaca cagaggctgg
       61 cagctggctg gtatcagctc tgcagccagg aggacagaga agatggcctt cattgcagct
      121 ttggggctct tgatggcagg gatctgccct gctgtcctct gtgatggcac actgggaagg
      181 gacactctat cccatgaaga ccacggcaag gggagacaac tgcacagtct cacattggct
      241 tccagcaaca ctgacttcgc attgagcctc tacaagaagc tggctttgag gaatccagat
      301 aaaaatgttg tcttctcccc tcttagcatc tcagctgcct tgaccatttt gtctctggga
      361 gcaaaagaca gcaccatgga agagattcta gaaggtctca agttcaatct cacagagatc
      421 actgaggaag aaatccacca gggctttggg cacctcctac agaggctcag ccagccagag
      481 gaccaggtag agatcaatac aggtagtgcc ctgtttattg acaaagagca gccgatactg
      541 tcagaattcc aggagaagac aagggctctg taccaggctg aggccttcat agctgacttc
      601 aagcagccca atgaggccaa aaagctcatc aatgactatg tgagcaatca gacccagggg
      661 aagatcgcag aactgttctc agacctggag gagaggacat ccatggtgct ggtgaactat
      721 ctcctattta aaggcaaatg gaaggtcccc tttaacccta atgacacatt tgagtctgag
      781 ttctacttgg atgagaagag gtctgtgaag gtgcccatga tgaaaattaa ggaagtaacc
      841 acaccctatg tccgggatga ggaactctcc tgctctgtgt tggagctgaa gtacacagga
      901 aatgccagcg ccctgtttat cctccctgac caaggcaaga tgcagcaggt ggaatccagc
      961 ttgcaaccag agaccctgaa gaagtggaag gactctttga tccctaggat tataaatgat
     1021 ctccgcatgc ccaagttctc catctccaca gactacagtc taaaagaggt ccttccagag
     1081 ctgggcatta agaaagtctt ctcccagcaa gctgatctga gtaggatcac agggaccaag
     1141 gatctgtatg tctctcaagt ggtccacaag gctgtgctgg atgtggatga gacaggcaca
     1201 gaagcaactg ctgctacagg ggtcgctaca gtcatacgta gacaacctcg aactctgaat
     1261 ttcaaccggc cattcatggt ggttatcact gacatggata gtcagtctat cctctttgtt
     1321 gccaaaatca ctaaccccaa gtaagcccaa agctccccaa gatctgacag ttctgcccag
     1381 gaccctggga ctgagcctgc atgtggatct ctgtatatgt cctgacattc atgctctgat
     1441 tggctgtttc aaagttgtct tagacagtga catcgactat ctctatggcc cccatgtgca
     1501 caggagcctt tagactgtca gtgtcaggct cttaggcccc ttgggagcat ctacccatgt
     1561 ttctgaacct ggaatctatc tttattcttc cctagtgact cctctttctg tgttcatacc
     1621 ccaaacctag ttattggcaa gtacatccag tcccaataaa tgctttgagc acatctgct
//
