LOCUS       NM_012657               1700 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus serine (or cysteine) proteinase inhibitor, clade
            A, member 3C (Serpina3c), mRNA.
ACCESSION   NM_012657
VERSION     NM_012657.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1700)
  AUTHORS   Sanchez-Navarro,A., Murillo-de-Ozores,A.R., Perez-Villalva,R.,
            Linares,N., Carbajal-Contreras,H., Flores,M.E., Gamba,G.,
            Castaneda-Bueno,M. and Bobadilla,N.A.
  TITLE     Transient response of serpinA3 during cellular stress
  JOURNAL   FASEB J 36 (3), e22190 (2022)
   PUBMED   35147994
  REMARK    GeneRIF: Transient response of serpinA3 during cellular stress.
REFERENCE   2  (bases 1 to 1700)
  AUTHORS   Dai,Z., Lu,L., Yang,Z., Mao,Y., Lu,J., Li,C., Qi,W., Chen,Y.,
            Yao,Y., Li,L., Chen,S., Zhang,Y., Cai,W., Yang,X. and Gao,G.
  TITLE     Kallikrein-binding protein inhibits LPS-induced TNF-alpha by
            upregulating SOCS3 expression
  JOURNAL   J Cell Biochem 114 (5), 1020-1028 (2013)
   PUBMED   23129128
  REMARK    GeneRIF: KBP suppressed lipopolysaccharide-induced TNF-alpha
            production via upregulating SOCS3 expression.
REFERENCE   3  (bases 1 to 1700)
  AUTHORS   Hoffmann,D.C., Textoris,C., Oehme,F., Klaassen,T., Goppelt,A.,
            Romer,A., Fugmann,B., Davidson,J.M., Werner,S., Krieg,T. and
            Eming,S.A.
  TITLE     Pivotal role for alpha1-antichymotrypsin in skin repair
  JOURNAL   J Biol Chem 286 (33), 28889-28901 (2011)
   PUBMED   21693707
  REMARK    GeneRIF: Pivotal role for alpha1-antichymotrypsin in skin repair
REFERENCE   4  (bases 1 to 1700)
  AUTHORS   Zhang,B., Zhou,K.K. and Ma,J.X.
  TITLE     Inhibition of connective tissue growth factor overexpression in
            diabetic retinopathy by SERPINA3K via blocking the WNT/beta-catenin
            pathway
  JOURNAL   Diabetes 59 (7), 1809-1816 (2010)
   PUBMED   20299474
  REMARK    GeneRIF: SERPINA3K is an antifibrogenic factor, and its
            antifibrogenic activity is through blocking the Wnt pathway.
            Decreased SERPINA3K levels may contribute to the fibrosis in
            diabetic retinopathy.
REFERENCE   5  (bases 1 to 1700)
  AUTHORS   Zhang,B., Abreu,J.G., Zhou,K., Chen,Y., Hu,Y., Zhou,T., He,X. and
            Ma,J.X.
  TITLE     Blocking the Wnt pathway, a unifying mechanism for an angiogenic
            inhibitor in the serine proteinase inhibitor family
  JOURNAL   Proc Natl Acad Sci U S A 107 (15), 6900-6905 (2010)
   PUBMED   20351274
  REMARK    GeneRIF: SERPINA3K is a high-affinity, endogenous antagonist of
            LRP6
REFERENCE   6  (bases 1 to 1700)
  AUTHORS   Chai,K.X., Ma,J.X., Murray,S.R., Chao,J. and Chao,L.
  TITLE     Molecular cloning and analysis of the rat kallikrein-binding
            protein gene
  JOURNAL   J Biol Chem 266 (24), 16029-16036 (1991)
   PUBMED   1874745
REFERENCE   7  (bases 1 to 1700)
  AUTHORS   Ohkubo,K., Ogata,S., Misumi,Y., Takami,N. and Ikehara,Y.
  TITLE     Molecular cloning and characterization of rat contrapsin-like
            protease inhibitor and related proteins
  JOURNAL   J Biochem 109 (2), 243-250 (1991)
   PUBMED   1864837
REFERENCE   8  (bases 1 to 1700)
  AUTHORS   Pages,G., Rouayrenc,J.F., Rossi,V., Le Cam,G., Mariller,M.,
            Szpirer,J., Szpirer,C., Levan,G. and Le Cam,A.
  TITLE     Primary structure and assignment to chromosome 6 of three related
            rat genes encoding liver serine protease inhibitors
  JOURNAL   Gene 94 (2), 273-282 (1990)
   PUBMED   2258058
REFERENCE   9  (bases 1 to 1700)
  AUTHORS   Chao,J., Chai,K.X., Chen,L.M., Xiong,W., Chao,S.,
            Woodley-Miller,C., Wang,L.X., Lu,H.S. and Chao,L.
  TITLE     Tissue kallikrein-binding protein is a serpin. I. Purification,
            characterization, and distribution in normotensive and
            spontaneously hypertensive rats
  JOURNAL   J Biol Chem 265 (27), 16394-16401 (1990)
   PUBMED   2398056
REFERENCE   10 (bases 1 to 1700)
  AUTHORS   Pages,G., Rouayrenc,J.F., Le Cam,G., Mariller,M. and Le Cam,A.
  TITLE     Molecular characterization of three rat liver serine-protease
            inhibitors affected by inflammation and hypophysectomy. Protein and
            mRNA analysis and cDNA cloning
  JOURNAL   Eur J Biochem 190 (2), 385-391 (1990)
   PUBMED   1694763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC062236.1, CO560755.1 and JAXUCZ010000006.1.
            
            On Sep 27, 2011 this sequence version replaced NM_012657.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC062236.1, FQ210286.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760476 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-675               BC062236.1         5-679
            676-1204            CO560755.1         171-699
            1205-1658           JAXUCZ010000006.1  129007590-129008043 c
            1659-1700           BC062236.1         1663-1704
FEATURES             Location/Qualifiers
     source          1..1700
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1700
                     /gene="Serpina3c"
                     /gene_synonym="CPi-21; GHR-P63; Kbp; Klkbp; Serpina3k;
                     SPI-2; SPI-2.3; SPI2; Spin2; Spin2b"
                     /note="serine (or cysteine) proteinase inhibitor, clade A,
                     member 3C"
                     /db_xref="GeneID:24794"
                     /db_xref="RGD:2972"
     exon            1..77
                     /gene="Serpina3c"
                     /gene_synonym="CPi-21; GHR-P63; Kbp; Klkbp; Serpina3k;
                     SPI-2; SPI-2.3; SPI2; Spin2; Spin2b"
                     /inference="alignment:Splign:2.1.0"
     exon            78..725
                     /gene="Serpina3c"
                     /gene_synonym="CPi-21; GHR-P63; Kbp; Klkbp; Serpina3k;
                     SPI-2; SPI-2.3; SPI2; Spin2; Spin2b"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1345
                     /gene="Serpina3c"
                     /gene_synonym="CPi-21; GHR-P63; Kbp; Klkbp; Serpina3k;
                     SPI-2; SPI-2.3; SPI2; Spin2; Spin2b"
                     /note="serine protease inhibitor 2b; serine protease
                     inhibitor A3K; thyroid hormone-regulated protein;
                     kallistatin; serine (or cysteine) peptidase inhibitor,
                     clade A, member 3K; serpin A3K; kallikrein-binding
                     protein; contrapsin-like protease inhibitor 1; growth
                     hormone-regulated proteinase inhibitor"
                     /codon_start=1
                     /product="serine protease inhibitor A3K precursor"
                     /protein_id="NP_036789.2"
                     /db_xref="GeneID:24794"
                     /db_xref="RGD:2972"
                     /translation="MAFIAALGLLMAGICPAVLCDGILGRDTLPHEDQGKGRQLHSLT
                     LASINTDFTLSLYKKLALRNPDKNVVFSPLSISAALAILSLGAKDSTMEEILEGLKFN
                     LTEITEEEIHQGFGHLLQRLSQPEDQAEINTGSALFIDKEQPILSEFQEKTRALYQAE
                     AFVADFKQCNEAKKFINDYVSNQTQGKIAELFSDLDERTSMVLVNYLLFKGKWKVPFN
                     PNDTFESEFYLDEKRSVKVPMMKIKDLTTPYVRDEELSCSVLELKYTGNASALFILPD
                     QGKMQQVESSLQPETLKKWKDSLRPRIISELRMPKFSISTDYNLEEVLPELGIRKIFS
                     QQADLSRITGTKNLHVSQVVHKAVLDVDETGTEGAAATAVTAALKSLPQTVPLLNFNR
                     PFMLVITDNNGQSVFFMGKVTNPM"
     exon            726..999
                     /gene="Serpina3c"
                     /gene_synonym="CPi-21; GHR-P63; Kbp; Klkbp; Serpina3k;
                     SPI-2; SPI-2.3; SPI2; Spin2; Spin2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1150
                     /gene="Serpina3c"
                     /gene_synonym="CPi-21; GHR-P63; Kbp; Klkbp; Serpina3k;
                     SPI-2; SPI-2.3; SPI2; Spin2; Spin2b"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1670
                     /gene="Serpina3c"
                     /gene_synonym="CPi-21; GHR-P63; Kbp; Klkbp; Serpina3k;
                     SPI-2; SPI-2.3; SPI2; Spin2; Spin2b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaaacacacc agggcaccct gaacatcagg agtcggcaaa cacagaggct agtagctggc
       61 tggtatcacc tctgcagcca ggaggacaga gaagatggcc ttcattgcag ctttggggct
      121 cttgatggca gggatctgcc ctgctgtcct ctgtgatggc atactgggaa gggacactct
      181 accccatgaa gaccaaggca aggggagaca actgcacagt ctcacattgg cttccatcaa
      241 cactgacttc acattgagcc tctacaagaa gctggctttg aggaatccag ataaaaatgt
      301 tgtcttctcc cctcttagca tctcagctgc cttggccatt ttgtctctgg gagcaaaaga
      361 cagcaccatg gaagagattc tagaaggtct caagttcaat ctcacagaga tcactgagga
      421 agaaatccac cagggctttg ggcacctcct acagaggctc agccagccag aggaccaggc
      481 agagatcaat acaggtagtg ccctgtttat tgacaaagag cagccgatac tgtcagaatt
      541 ccaggagaag acaagggctc tgtaccaggc tgaggccttc gtagctgact tcaagcagtg
      601 caatgaggcc aaaaagttca tcaatgacta tgtgagcaat cagacccagg ggaagatcgc
      661 agaactgttc tcagacctgg atgagaggac atccatggtg ctggtgaact atctcctctt
      721 taaaggcaaa tggaaggtac catttaaccc caatgacaca tttgagtctg agttctactt
      781 ggatgagaag aggtctgtga aggtgcccat gatgaaaatt aaggatctca ccacacccta
      841 tgtccgggat gaggagctgt cctgctctgt gctggaactg aagtacacag gaaatgccag
      901 cgccctgttt atcctccctg accagggcaa gatgcagcag gtggaatcca gcttgcaacc
      961 agagaccctg aagaagtgga aggactctct gaggcccagg attataagtg agcttcgcat
     1021 gcccaagttc tccatctcca cagactacaa cctggaggag gtccttccag agctgggcat
     1081 taggaaaatc ttctcccagc aagctgatct gagtaggatc acagggacca agaacctgca
     1141 tgtctctcag gtggtccaca aagctgtgct ggatgtggat gagacaggca cagaaggagc
     1201 cgctgccaca gcagtcacag cagccctaaa aagtttaccg caaactgtac ctcttctgaa
     1261 tttcaaccgg ccattcatgc tggttatcac tgacaataat ggtcagtctg tcttctttat
     1321 gggcaaagtc actaacccca tgtgagtctg aagctcccca aaatctgaca attctgccca
     1381 ggatcctgga acagagcctg gatgctgatc tctgtatatg ccctgacata catgctctga
     1441 ttggctattg caaagttggc ttagacagtg acatcaacta tctctatggc tcccatgtgc
     1501 actggagcct ttggattgtc agtgtcaggc acttaggacc cttgggagca tctacacatg
     1561 tttctgaact tggaatcttt ctttattctt cttccctggt gactcctctt tctgtgttca
     1621 taccccaaac caagccattg ataagtccca gtaaaggctc tgagaacatc aaaaaaaaaa
     1681 aaaaaaaaaa aaaaaaaaaa
//
