LOCUS       NM_138825               1487 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus serpin family A member 12 (Serpina12), mRNA.
ACCESSION   NM_138825
VERSION     NM_138825.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1487)
  AUTHORS   He,H., Lu,M., Shi,H., Yue,G. and Luo,H.
  TITLE     Vaspin regulated cartilage cholesterol metabolism through
            miR155/LXRalpha and participated in the occurrence of
            osteoarthritis in rats
  JOURNAL   Life Sci 269, 119096 (2021)
   PUBMED   33482192
  REMARK    GeneRIF: Vaspin regulated cartilage cholesterol metabolism through
            miR155/LXRalpha and participated in the occurrence of
            osteoarthritis in rats.
REFERENCE   2  (bases 1 to 1487)
  AUTHORS   Li,X., Ke,X., Li,Z. and Li,B.
  TITLE     Vaspin prevents myocardial injury in rats model of diabetic
            cardiomyopathy by enhancing autophagy and inhibiting inflammation
  JOURNAL   Biochem Biophys Res Commun 514 (1), 1-8 (2019)
   PUBMED   31014675
  REMARK    GeneRIF: These results demonstrate that Vaspin alleviates
            STZ-induced myocardial injury and renders a cardioprotective effect
            by suppressing NLRP3 inflammasome activation and promoting
            autophagy.
REFERENCE   3  (bases 1 to 1487)
  AUTHORS   Salek-Maghsoudi,A., Hassani,S., Momtaz,S., Shadboorestan,A.,
            Ganjali,M.R., Ghahremani,M.H., Hosseini,R., Norouzi,P. and
            Abdollahi,M.
  TITLE     Biochemical and molecular evidence on the role of vaspin in early
            detection of the insulin resistance in a rat model of high-fat diet
            and use of diazinon
  JOURNAL   Toxicology 411, 1-14 (2019)
   PUBMED   30359674
  REMARK    GeneRIF: in contrast to oxidative stress and inflammatory
            biomarkers, vaspin level would be a more reliable diagnostic factor
            when it comes to the insulin resistance
REFERENCE   4  (bases 1 to 1487)
  AUTHORS   Bao,J.P., Xu,L.H., Ran,J.S., Xiong,Y. and Wu,L.D.
  TITLE     Vaspin prevents leptin-induced inflammation and catabolism by
            inhibiting the activation of nuclear factor-kappaB in rat
            chondrocytes
  JOURNAL   Mol Med Rep 16 (3), 2925-2930 (2017)
   PUBMED   28677772
  REMARK    GeneRIF: These results demonstrated that vaspin prevented
            leptininduced inflammation and catabolism by inhibiting the
            activation of NFkappa B in rat chondrocytes.
REFERENCE   5  (bases 1 to 1487)
  AUTHORS   Zhuang,X., Ni,Y., Jiang,D., Pu,Y., Liu,X., Chen,S., Sun,F., Sun,A.
            and Pan,Z.
  TITLE     Vaspin as a Risk Factor of Insulin Resistance in Obstructive Sleep
            Apnea-Hypopnea Syndrome in an Animal Model
  JOURNAL   Clin Lab 61 (8), 883-889 (2015)
   PUBMED   26427130
  REMARK    GeneRIF: In the chronic intermittent hypoxia rat model, the
            expression of vaspin in visceral adipose tissues and plasma were
            increased, which were correlated with insulin resistance.
REFERENCE   6  (bases 1 to 1487)
  AUTHORS   Phalitakul,S., Okada,M., Hara,Y. and Yamawaki,H.
  TITLE     A novel adipocytokine, vaspin inhibits platelet-derived growth
            factor-BB-induced migration of vascular smooth muscle cells
  JOURNAL   Biochem Biophys Res Commun 423 (4), 844-849 (2012)
   PUBMED   22713468
  REMARK    GeneRIF: The present study for the first time revealed that vaspin
            inhibits PDGF-BB-induced SMCs migration through inhibiting
            p38/HSP27 signals via preventing the ROS generation.
REFERENCE   7  (bases 1 to 1487)
  AUTHORS   Phalitakul,S., Okada,M., Hara,Y. and Yamawaki,H.
  TITLE     Vaspin prevents TNF-alpha-induced intracellular adhesion molecule-1
            via inhibiting reactive oxygen species-dependent NF-kappaB and
            PKCtheta; activation in cultured rat vascular smooth muscle cells
  JOURNAL   Pharmacol Res 64 (5), 493-500 (2011)
   PUBMED   21683791
  REMARK    GeneRIF: Vaspin inhibits TNF-alpha-induced expression of ICAM-1 via
            preventing the reactive oxygen species generation and subsequent
            activation of NF-kappaB and PKCtheta;.
REFERENCE   8  (bases 1 to 1487)
  AUTHORS   Caminos,J.E., Bravo,S.B., Garces,M.F., Gonzalez,C.R., Cepeda,L.A.,
            Gonzalez,A.C., Nogueiras,R., Gallego,R., Garcia-Caballero,T.,
            Cordido,F., Lopez,M. and Dieguez,C.
  TITLE     Vaspin and amylin are expressed in human and rat placenta and
            regulated by nutritional status
  JOURNAL   Histol Histopathol 24 (8), 979-990 (2009)
   PUBMED   19554505
  REMARK    GeneRIF: Vaspin is expressed in the rat placenta and regulated by
            nutritional status.
REFERENCE   9  (bases 1 to 1487)
  AUTHORS   Wada,J.
  TITLE     [Vaspin and insulin resistance]
  JOURNAL   Rinsho Byori 56 (8), 705-711 (2008)
   PUBMED   18800627
  REMARK    GeneRIF: may be the compensatory molecule in the pathogenesis of
            metabolic syndrome. (review)
            Review article
REFERENCE   10 (bases 1 to 1487)
  AUTHORS   Hida,K., Wada,J., Eguchi,J., Zhang,H., Baba,M., Seida,A.,
            Hashimoto,I., Okada,T., Yasuhara,A., Nakatsuka,A., Shikata,K.,
            Hourai,S., Futami,J., Watanabe,E., Matsuki,Y., Hiramatsu,R.,
            Akagi,S., Makino,H. and Kanwar,Y.S.
  TITLE     Visceral adipose tissue-derived serine protease inhibitor: a unique
            insulin-sensitizing adipocytokine in obesity
  JOURNAL   Proc Natl Acad Sci U S A 102 (30), 10610-10615 (2005)
   PUBMED   16030142
  REMARK    GeneRIF: Visceral adipose tissue-derived serpin (vaspin) exerts an
            insulin-sensitizing effect targeted toward white adipose tissues in
            states of obesity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Oct 17, 2007 this sequence version replaced NM_138825.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF245398.1, SRR26643290.23933.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN09345329, SAMN16093043
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-195               JAXUCZ010000006.1  128731855-128732049 c
            196-846             JAXUCZ010000006.1  128725446-128726096 c
            847-1117            JAXUCZ010000006.1  128723337-128723607 c
            1118-1265           JAXUCZ010000006.1  128718942-128719089 c
            1266-1487           JAXUCZ010000006.1  128717334-128717555 c
FEATURES             Location/Qualifiers
     source          1..1487
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1487
                     /gene="Serpina12"
                     /gene_synonym="Ol-64; Ol64"
                     /note="serpin family A member 12"
                     /db_xref="GeneID:191570"
                     /db_xref="RGD:708485"
     exon            1..195
                     /gene="Serpina12"
                     /gene_synonym="Ol-64; Ol64"
                     /inference="alignment:Splign:2.1.0"
     exon            196..846
                     /gene="Serpina12"
                     /gene_synonym="Ol-64; Ol64"
                     /inference="alignment:Splign:2.1.0"
     CDS             213..1457
                     /gene="Serpina12"
                     /gene_synonym="Ol-64; Ol64"
                     /note="serine (or cysteine) peptidase inhibitor, clade A,
                     member 12; serpin A12; vaspin; visceral adipose
                     tissue-derived serpin; serine (or cysteine) peptidase
                     inhibitor, clade A (alpha-1 antiproteinase, antitrypsin),
                     member 12; serpin peptidase inhibitor, clade A, member 12;
                     visceral adipose-specific serpin; visceral adipose
                     tissue-derived serine protease inhibitor; serpin peptidase
                     inhibitor, clade A (alpha-1 antiproteinase, antitrypsin),
                     member 12"
                     /codon_start=1
                     /product="serpin A12 precursor"
                     /protein_id="NP_620180.2"
                     /db_xref="GeneID:191570"
                     /db_xref="RGD:708485"
                     /translation="MNLVLGLGLFLAGLLTVKGLLQDRDAPDTYESPVRVQEWRGKKD
                     ARELTRHNMEFGFKLLQRLASNSRQGNIFLSPLSISTAFSMLSLGAQNSTLEEIREGF
                     NFKEMSDRDMHMGFHYLLQKLNRETQDVKMSIGNALFMDQRLRPQQRFLKLAKNLYDA
                     DMILTNFQDLENTQKNINKYISRKTHNRIENMVKNIDPGTVMLLTNYIYFQGRWQYEF
                     DPKQTKEEDFFIEEGKTVKVPMMFQRGMYDMAYDSQLSCTILEMPYRRNITATFVLPD
                     SGKLRLLEQGLQADIFAKWKSLLSKRVVDVWVPRLHISATYNMKKVLSRLGISKIFEE
                     HGDLTRISSHRSLKVGEAVHKAELRMNEKGTEGAAGSGAQTLPMETPRRMKLNAPFLM
                     MIYENLMPSMIFLARIYNPSEK"
     exon            847..1117
                     /gene="Serpina12"
                     /gene_synonym="Ol-64; Ol64"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1265
                     /gene="Serpina12"
                     /gene_synonym="Ol-64; Ol64"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1487
                     /gene="Serpina12"
                     /gene_synonym="Ol-64; Ol64"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggttccaga ggtgggagct aaggaggatc catcagggga agtggtgtgg ccactgctcc
       61 tggaagccca ttgactgaga ctcagccagc tgcttcaatt ggccacactc tgcctcttca
      121 ggaggccctg gaggtataaa taataaagta aaccaggcag gtccgtttgg cctgtggatg
      181 gcgcctggat ccactgataa ttcccaagga caatgaacct cgtgctgggc ctgggtctgt
      241 ttctggcagg cctcctcact gtgaaaggtc tcctgcagga cagagatgct ccagatacat
      301 atgagtctcc agtcagggtc caagagtgga ggggcaagaa ggatgcccgg gagcttactc
      361 ggcacaacat ggaatttggc ttcaagctac tgcagaggct ggccagcaac agccgtcagg
      421 ggaacatctt cttatctcca ctgagcatct caactgcctt ctccatgctg tctctggggg
      481 cccaaaactc cacactggag gaaatcaggg agggtttcaa tttcaaggag atgtcagaca
      541 gggacatgca catgggtttc cactaccttc tccaaaagct caaccgggag acacaggacg
      601 taaagatgag cataggcaat gctttattta tggaccagag gctgaggccc caacagaggt
      661 tcctgaaact ggctaagaac ttgtatgatg cggacatgat actcactaat ttccaggact
      721 tagaaaacac tcagaagaat atcaacaagt acatcagtcg gaaaacccac aacagaatcg
      781 aaaacatggt caaaaacata gacccaggga cggtgatgct cctcacaaac tatatttact
      841 ttcaaggcag gtggcagtat gaattcgacc caaaacaaac caaagaggag gacttcttca
      901 tagaggaagg caagaccgtg aaggtgccca tgatgttcca aaggggcatg tacgacatgg
      961 cctatgacag tcagctctcc tgcaccatct tggaaatgcc ctaccgaaga aacatcacgg
     1021 ccacctttgt ccttcctgac agtggcaaac tgaggctcct ggagcagggc ttgcaagcag
     1081 acatctttgc caaatggaaa agccttctct ctaaaagagt ggtagatgtg tgggtgccca
     1141 ggctccacat ctcggctact tacaacatga agaaggttct gtcccgcctg ggcatcagca
     1201 aaatctttga agagcatggt gacctcaccc gcatctcgtc tcatcgaagc ctgaaggtgg
     1261 gagaggctgt gcacaaggct gagctgagga tgaatgagaa gggcacagaa ggagctgcag
     1321 gctcgggagc ccagacactg cccatggaga ccccacgaag gatgaagcta aacgcaccct
     1381 tcctgatgat gatttatgag aacctcatgc cttccatgat cttcttggca aggatttata
     1441 accctagtga gaaataaagg agaattccct gttggcttca gacccca
//
