LOCUS       NM_001166352            1468 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Rattus norvegicus serpin family A member 11 (Serpina11), transcript
            variant 2, mRNA.
ACCESSION   NM_001166352
VERSION     NM_001166352.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1468)
  AUTHORS   Hida,K., Wada,J., Eguchi,J., Zhang,H., Baba,M., Seida,A.,
            Hashimoto,I., Okada,T., Yasuhara,A., Nakatsuka,A., Shikata,K.,
            Hourai,S., Futami,J., Watanabe,E., Matsuki,Y., Hiramatsu,R.,
            Akagi,S., Makino,H. and Kanwar,Y.S.
  TITLE     Visceral adipose tissue-derived serine protease inhibitor: a unique
            insulin-sensitizing adipocytokine in obesity
  JOURNAL   Proc Natl Acad Sci U S A 102 (30), 10610-10615 (2005)
   PUBMED   16030142
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EX492846.1 and BC111708.1.
            
            [WARNING] On May 2, 2024 this sequence was replaced by
            NM_001166352.2.
            
            Transcript Variant: This variant (2) contains a different 5'
            segment and lacks an alternate segment in its 3' CDS, compared to
            variant 1. The resulting protein (isoform 2) has a shorter
            C-terminue when compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111708.1, FQ211426.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760400, SAMEA5760476
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                EX492846.1         1-88
            89-1468             BC111708.1         1-1380
FEATURES             Location/Qualifiers
     source          1..1468
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1468
                     /gene="Serpina11"
                     /note="serpin family A member 11"
                     /db_xref="GeneID:362774"
                     /db_xref="RGD:1359239"
     exon            1..103
                     /gene="Serpina11"
                     /inference="alignment:Splign:2.1.0"
     exon            104..749
                     /gene="Serpina11"
                     /inference="alignment:Splign:2.1.0"
     CDS             107..1375
                     /gene="Serpina11"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; Ab1-046; serpin A11; serine (or cysteine)
                     peptidase inhibitor, clade A (alpha-1 antiproteinase,
                     antitrypsin), member 11; serpin peptidase inhibitor, clade
                     A (alpha-1 antiproteinase, antitrypsin), member 11; serpin
                     peptidase inhibitor, clade A, member 11; liver
                     regeneration-related protein LRRG023"
                     /codon_start=1
                     /product="serpin A11 isoform 2 precursor"
                     /protein_id="NP_001159824.1"
                     /db_xref="GeneID:362774"
                     /db_xref="RGD:1359239"
                     /translation="MGPVWLWLLIAELLLPVHYQPSSAHGDKSLGAPQPASHQSLEPA
                     PAYHKVTPTITNFALRLYKQLAEEIPGNILFSPVSLSSTVALLSLGAHADTQAQILQS
                     LGFNLTETPAADIHRGFQSLLHTLDLPSPKLELKLGHSLFLDRQLKPQQRFLDSAKEL
                     YGALAFSANFTEAAATGQQINDLVRKQTYGQVVGCLPEFDRDTLMVLLNYIFFKAKWK
                     HPFDRYQTRKQESFFVDQRLQLRIPMMRQKEMHRFLYDQEASCTVLQIEYSGTALLLL
                     VLPDPGKMQQVEAALQPETLRRWGQRFLPSLLDLHLPRFSVSATYNLEEILPLVGLSS
                     LFDVEADLSGIMGQLNKTVSRVSHKAVVDMNEKGTEAAAASGLLSQPPSLNMTSAPHA
                     HFNRPFLLLLWEVTTQSLLFLGKVVNPAAG"
     exon            750..1023
                     /gene="Serpina11"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1171
                     /gene="Serpina11"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1463
                     /gene="Serpina11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgacaagta tcgaccaggc tgctgtggtg ttcaaacact atgatcctgt gagcaggagg
       61 ccgtacgaga ctgtggagct gggcccacct gggtggcttc tctacaatgg ggccagtgtg
      121 gctgtggctg ctgatagctg agctcctgct tcctgtccat tatcagccat cttctgccca
      181 tggagataag agtctagggg cacctcaacc agccagccac cagtccctgg agccagcacc
      241 cgcctatcac aaagtcacac ccaccattac taattttgct ttgcgcctat acaagcaact
      301 agcagaggaa ataccaggga acatcctctt ctcccccgtg agcctctcca gcaccgtggc
      361 tctgctctct ctcggggcac atgctgacac ccaggctcaa attctgcaaa gcttgggctt
      421 caacctcaca gagaccccag cagctgacat ccatcggggc ttccagagcc tcctgcacac
      481 gcttgacttg cccagcccca aactggaact gaaactgggg cactctctgt tccttgacag
      541 gcagctaaag cctcagcaac gctttctgga cagtgccaag gagctgtatg gagccctggc
      601 tttttccgcc aatttcacag aagcagctgc cacagggcag cagatcaatg acctagtgag
      661 gaagcagacc tatgggcagg tggtgggctg tctcccagag ttcgatcgtg acacccttat
      721 ggttctcttg aactatatct tcttcaaagc caagtggaag catccctttg atcgctacca
      781 gacccggaag caggagagct tcttcgtgga ccagaggctg cagctccgca ttcccatgat
      841 gcggcagaag gaaatgcata ggttcctgta cgaccaggag gcatcgtgca ctgtgctgca
      901 aatcgagtac agcggcaccg ccttgctgct gctggtcctc cctgaccctg ggaagatgca
      961 gcaggtagag gctgccctcc agccagagac actgagaagg tggggccagc ggttcctgcc
     1021 cagtctgttg gatttgcacc tgccacggtt ttcagtttct gcaacctaca acctggaaga
     1081 gatcctgccc ctcgttggcc tcagcagcct ctttgacgtg gaagccgacc tatcaggaat
     1141 tatggggcag ctcaacaaaa ctgtctccag ggtatcgcac aaggccgtcg tggacatgaa
     1201 cgagaaggga actgaggccg cagctgcctc tggcctgctc tcccagcccc catccctgaa
     1261 catgacgtca gccccacacg cccactttaa caggcccttc ctgcttctgc tctgggaggt
     1321 gaccacccag agcctgctct tcctagggaa agtagtcaac ccagctgctg ggtaattgtg
     1381 gtggtggggg ccacaggaag gccagcccaa cctgcacggc aggacccctg tgctgcggtt
     1441 ctaataaatc tgaatttggc tgtaaaaa
//
