LOCUS       NM_022519               1603 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus serpin family A member 1 (Serpina1), mRNA.
ACCESSION   NM_022519
VERSION     NM_022519.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Pan,S., Aizezi,Y., Wang,H., Lu,Y. and Xue,B.
  TITLE     Role and mechanism of alpa1-antitrypsin in polycystic ovary
            syndrome
  JOURNAL   Saudi Med J 43 (12), 1309-1316 (2022)
   PUBMED   36517050
  REMARK    GeneRIF: Role and mechanism of alpa1-antitrypsin in polycystic
            ovary syndrome.
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Zhong,H., Zhou,Z., Guo,L., Liu,F.S., Wang,X., Li,J., Lv,G.H. and
            Zou,M.X.
  TITLE     SERPINA1 is a hub gene associated with intervertebral disc
            degeneration grade and affects the nucleus pulposus cell phenotype
            through the ADIRF-AS1/miR-214-3p axis
  JOURNAL   Transl Res 245, 99-116 (2022)
   PUBMED   35196590
  REMARK    GeneRIF: SERPINA1 is a hub gene associated with intervertebral disc
            degeneration grade and affects the nucleus pulposus cell phenotype
            through the ADIRF-AS1/miR-214-3p axis.
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Shen,S., Sanchez,M.E., Blomenkamp,K., Corcoran,E.M., Marco,E.,
            Yudkoff,C.J., Jiang,H., Teckman,J.H., Bumcrot,D. and Albright,C.F.
  TITLE     Amelioration of Alpha-1 Antitrypsin Deficiency Diseases with Genome
            Editing in Transgenic Mice
  JOURNAL   Hum Gene Ther 29 (8), 861-873 (2018)
   PUBMED   29641323
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Hernandez-Perez,J.M., Ramos-Diaz,R. and Perez,J.A.
  TITLE     Identification of a new defective SERPINA1 allele (PI*Zla palma)
            encoding an alpha-1-antitrypsin with altered glycosylation pattern
  JOURNAL   Respir Med 131, 114-117 (2017)
   PUBMED   28947017
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Maicas,N., van der Vlag,J., Bublitz,J., Florquin,S., Bakker-van
            Bebber,M., Dinarello,C.A., Verweij,V., Masereeuw,R., Joosten,L.A.
            and Hilbrands,L.B.
  TITLE     Human Alpha-1-Antitrypsin (hAAT) therapy reduces renal dysfunction
            and acute tubular necrosis in a murine model of bilateral kidney
            ischemia-reperfusion injury
  JOURNAL   PLoS One 12 (2), e0168981 (2017)
   PUBMED   28235038
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Chao,J., Chen,L.M., Chai,K.X. and Chao,L.
  TITLE     Expression of kallikrein-binding protein and alpha 1-antitrypsin
            genes in response to sex hormones, growth, inflammation and
            hypertension
  JOURNAL   Agents Actions Suppl 38 (Pt 1), 174-181 (1992)
   PUBMED   1466268
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Maruyama,K., Ye,C.L., Woo,M., Venkatacharya,H., Lines,L.D.,
            Silver,M.M. and Rabinovitch,M.
  TITLE     Chronic hypoxic pulmonary hypertension in rats and increased
            elastolytic activity
  JOURNAL   Am J Physiol 261 (6 Pt 2), H1716-H1726 (1991)
   PUBMED   1836309
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Espana,F., Gilabert,J., Aznar,J., Estelles,A., Kobayashi,T. and
            Griffin,J.H.
  TITLE     Complexes of activated protein C with alpha 1-antitrypsin in normal
            pregnancy and in severe preeclampsia
  JOURNAL   Am J Obstet Gynecol 164 (5 Pt 1), 1310-1316 (1991)
   PUBMED   1852102
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Misumi,Y., Sohda,M., Ohkubo,K., Takami,N., Oda,K. and Ikehara,Y.
  TITLE     Molecular cloning and sequencing of the cDNA of rat alpha
            1-protease inhibitor and its expression in COS-1 cells
  JOURNAL   J Biochem 108 (2), 230-234 (1990)
   PUBMED   2229024
REFERENCE   10 (bases 1 to 1603)
  AUTHORS   Chao,S., Chai,K.X., Chao,L. and Chao,J.
  TITLE     Molecular cloning and primary structure of rat alpha 1-antitrypsin
  JOURNAL   Biochemistry 29 (2), 323-329 (1990)
   PUBMED   2302382
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078824.1.
            
            On Aug 8, 2004 this sequence version replaced NM_022519.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078824.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5756307,
                                           SAMEA5760383 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q32"
     gene            1..1603
                     /gene="Serpina1"
                     /gene_synonym="AAT; Pi; Spi1"
                     /note="serpin family A member 1"
                     /db_xref="GeneID:24648"
                     /db_xref="RGD:3326"
     exon            1..89
                     /gene="Serpina1"
                     /gene_synonym="AAT; Pi; Spi1"
                     /inference="alignment:Splign:2.1.0"
     exon            90..249
                     /gene="Serpina1"
                     /gene_synonym="AAT; Pi; Spi1"
                     /inference="alignment:Splign:2.1.0"
     exon            250..881
                     /gene="Serpina1"
                     /gene_synonym="AAT; Pi; Spi1"
                     /inference="alignment:Splign:2.1.0"
     CDS             254..1489
                     /gene="Serpina1"
                     /gene_synonym="AAT; Pi; Spi1"
                     /note="alpha-1-protease inhibitor; serine protease
                     inhibitor alpha 1; alpha-1-antiproteinase;
                     alpha-1-proteinase inhibitor; serpin A1; serpin peptidase
                     inhibitor, clade A (alpha-1 antiproteinase, antitrypsin),
                     member 1; serine (or cysteine) proteinase inhibitor, clade
                     A (alpha-1 antiproteinase, antitrypsin), member 1;
                     alpha-1-antitrypsin (protease inhibitor); serine (or
                     cysteine) proteinase inhibitor, clade A, member 1"
                     /codon_start=1
                     /product="alpha-1-antiproteinase precursor"
                     /protein_id="NP_071964.2"
                     /db_xref="GeneID:24648"
                     /db_xref="RGD:3326"
                     /translation="MAPSISRGLLLLAGLCCLAPSFLAEDAQETDTSQQDQSPTYRKI
                     SSNLADFAFSLYRELVHQSNTSNIFFSPMSITTAFAMLSLGSKGDTRKQILEGLEFNL
                     TQIPEADIHKAFHHLLQTLNRPDSELQLNTGNGLFVNKNLKLVEKFLEEVKNNYHSEA
                     FSVNFADSEEAKKVINDYVEKGTQGKIVDLMKQLDEDTVFALVNYIFFKGKWKRPFNP
                     EHTRDADFHVDKSTTVKVPMMNRLGMFDMHYCSTLSSWVLMMDYLGNATAIFLLPDDG
                     KMQHLEQTLTKDLISRFLLNRQTRSAILYFPKLSISGTYNLKTLLSSLGITRVFNNDA
                     DLSGITEDAPLKLSQAVHKAVLTLDERGTEAAGATVVEAVPMSLPPQVKFDHPFIFMI
                     VESETQSPLFVGKVIDPTR"
     exon            882..1152
                     /gene="Serpina1"
                     /gene_synonym="AAT; Pi; Spi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1300
                     /gene="Serpina1"
                     /gene_synonym="AAT; Pi; Spi1"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1579
                     /gene="Serpina1"
                     /gene_synonym="AAT; Pi; Spi1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tggctccaga caaaatatag acgcaccacc agcctggcta ggaagtaatg cttcccatga
       61 gcccccaaag aacgggaaac cagacactgc aggcaaacat ctccttcttg gggagtctgg
      121 aagccagata tccataccac caatgctgtg atgtcagcca tgtctcccgg caacctgttg
      181 cagggtggtg ctcacccatg gcacaagagg aaacagatgg caaacattcc tggaaactga
      241 attgccaagg aaaatggcac cctccatctc acgggggctc ctgcttctgg caggcctgtg
      301 ttgcctggcc cccagcttcc tggctgagga tgcccaggaa accgatacct cccagcagga
      361 ccagagtcca acctaccgta agatttcttc aaacctggca gactttgcct tcagcctata
      421 ccgggagctg gtccatcaat ccaatacatc caacatcttc ttctccccta tgagcatcac
      481 cacagccttc gccatgctct ccctggggag caagggtgac actcgcaaac agattctaga
      541 gggcctggag ttcaacctca cacagatacc tgaggctgac atccacaagg ccttccatca
      601 cctcctccaa actctcaaca ggccagacag tgagctgcag ctgaacacag gcaatggcct
      661 ctttgtcaac aagaatctga agctggtgga gaagtttctg gaagaggtca agaacaatta
      721 ccactcagaa gccttctctg tcaactttgc cgactcagaa gaggctaaga aagtaattaa
      781 tgattatgta gagaagggaa cccaaggaaa gatagttgat ttgatgaaac agctggacga
      841 agacacggtt tttgccctgg tgaattacat tttctttaaa ggcaagtgga agaggccatt
      901 caatcctgag cacactaggg atgctgactt ccacgtagac aagtccacca cggtgaaggt
      961 gcccatgatg aaccgcctgg gcatgtttga catgcactat tgcagcacac tgtccagctg
     1021 ggtgctgatg atggattacc tgggcaacgc cactgccatc ttcctcctgc ccgatgatgg
     1081 caagatgcag catctggagc aaactctcac caaggatctc atttcccggt tcctgctaaa
     1141 caggcaaaca aggtcagcca ttctctactt ccccaaactg tccatctctg gaacctataa
     1201 cttgaagaca ctcctgagct cactgggcat cacccgggtc ttcaacaatg atgctgatct
     1261 ctctggaatc acagaggatg cccccctgaa gcttagccag gctgtgcata aggctgtgct
     1321 gaccttagat gagaggggaa cagaggctgc aggagccact gtggtggagg ccgtccccat
     1381 gtctctgccc cctcaagtga agttcgacca ccctttcatt ttcatgatag ttgaatcaga
     1441 aactcagagc cccctctttg tgggaaaagt gatagatccc acacgttaat cactgtcctc
     1501 agaagtcaca tcccttctgg atcgggtccc cttcctaata atattaaact caggctggcc
     1561 tggcctgatg cttctgcaaa aaaaaaaaaa aaaaaaaaaa aaa
//
