LOCUS       NM_030835               2442 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus stress-associated endoplasmic reticulum protein 1
            (Serp1), mRNA.
ACCESSION   NM_030835
VERSION     NM_030835.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2442)
  AUTHORS   Cai,J., Sun,Z., Zhang,L. and Xu,H.
  TITLE     SERP1 reduces inchoate acute hepatic injury through regulation of
            endoplasmic reticulum stress via the GSK3beta/beta-catenin/TCF/LEF
            signaling pathway
  JOURNAL   Mol Med Rep 25 (6) (2022)
   PUBMED   35419615
  REMARK    GeneRIF: SERP1 reduces inchoate acute hepatic injury through
            regulation of endoplasmic reticulum stress via the
            GSK3beta/betacatenin/TCF/LEF signaling pathway.
REFERENCE   2  (bases 1 to 2442)
  AUTHORS   Fong,K.W., Leung,J.W., Li,Y., Wang,W., Feng,L., Ma,W., Liu,D.,
            Songyang,Z. and Chen,J.
  TITLE     MTR120/KIAA1383, a novel microtubule-associated protein, promotes
            microtubule stability and ensures cytokinesis
  JOURNAL   J Cell Sci 126 (Pt 3), 825-837 (2013)
   PUBMED   23264731
REFERENCE   3  (bases 1 to 2442)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
REFERENCE   4  (bases 1 to 2442)
  AUTHORS   Matsuki,T., Nakae,S., Sudo,K., Horai,R. and Iwakura,Y.
  TITLE     Abnormal T cell activation caused by the imbalance of the
            IL-1/IL-1R antagonist system is responsible for the development of
            experimental autoimmune encephalomyelitis
  JOURNAL   Int Immunol 18 (2), 399-407 (2006)
   PUBMED   16415102
REFERENCE   5  (bases 1 to 2442)
  AUTHORS   Yamaguchi,A., Hori,O., Stern,D.M., Hartmann,E., Ogawa,S. and
            Tohyama,M.
  TITLE     Stress-associated endoplasmic reticulum protein 1
            (SERP1)/Ribosome-associated membrane protein 4 (RAMP4) stabilizes
            membrane proteins during stress and facilitates subsequent
            glycosylation
  JOURNAL   J Cell Biol 147 (6), 1195-1204 (1999)
   PUBMED   10601334
REFERENCE   6  (bases 1 to 2442)
  AUTHORS   Schroder,K., Martoglio,B., Hofmann,M., Holscher,C., Hartmann,E.,
            Prehn,S., Rapoport,T.A. and Dobberstein,B.
  TITLE     Control of glycosylation of MHC class II-associated invariant chain
            by translocon-associated RAMP4
  JOURNAL   EMBO J 18 (17), 4804-4815 (1999)
   PUBMED   10469658
  REMARK    Erratum:[EMBO J 2002 Dec 16;21(24):6954]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061854.1.
            
            On Feb 9, 2004 this sequence version replaced NM_030835.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061854.1, AB018546.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132297, SAMEA5756307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2442
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..2442
                     /gene="Serp1"
                     /gene_synonym="RAMP4"
                     /note="stress-associated endoplasmic reticulum protein 1"
                     /db_xref="GeneID:80881"
                     /db_xref="RGD:620790"
     exon            1..451
                     /gene="Serp1"
                     /gene_synonym="RAMP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             368..568
                     /gene="Serp1"
                     /gene_synonym="RAMP4"
                     /note="ribosome-attached membrane protein 4; ribosome
                     associated membrane protein 4"
                     /codon_start=1
                     /product="stress-associated endoplasmic reticulum protein
                     1"
                     /protein_id="NP_110462.1"
                     /db_xref="GeneID:80881"
                     /db_xref="RGD:620790"
                     /translation="MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLA
                     LFIFVVCGSAIFQIIQSIRMGM"
     exon            452..527
                     /gene="Serp1"
                     /gene_synonym="RAMP4"
                     /inference="alignment:Splign:2.1.0"
     exon            528..2427
                     /gene="Serp1"
                     /gene_synonym="RAMP4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaagggcctg gctgcagcgg cggccggccc tcgccctcct tctctggagc gggcggagtc
       61 catacttccg cggggcgggg tctgcccagt gctgacgttg gcagccgaac ccgaactagt
      121 tcgaggttgc cggctgcact gtcgggtggt tggactcttt cctcccggtc ctgcggccct
      181 ctttctccgg cgcgccgccc ctcggttgct cagaccgctg tgatcggagg ttgccggtgc
      241 tccagcgctt ggcgtcccgg cccagtggcc gtaggcggcg taggcaccgc gagccgagcc
      301 tcccggtggc cggggaacgg caagcgagcg agtccgagag gttcttgggg caggtggcgc
      361 cgcgaagatg gtcgccaagc agaggatccg tatggccaac gagaagcaca gcaagaacat
      421 aactcagcgc ggcaacgtcg ctaagacctc gagaaatgcc cccgaagaaa aggcgtcggt
      481 aggaccctgg ttattggccc tcttcatttt tgtcgtttgt ggatctgcaa ttttccagat
      541 tattcaaagt atcaggatgg gcatgtgaag tgactgacct tgagatgttt ccattctcct
      601 gtgaatttta acttgaactc attcctgatg ttcgatgccc tggttaaaaa caattcagta
      661 aatcaccctg cctcagaatg actttttcat atcaaccttc atgtgtcatt ccaaggtttc
      721 ttcaagagtc attccaggtt tgctagtcca tgccacagtg ccttgcaaaa gcaccacatg
      781 aataaagcaa taaaatttga ttattaagtt ccagtagtag accatactta ttcagtacag
      841 aatgagtttt atgtggttat taaaacttat gactaattag attaaatctg tgtagacagg
      901 gtatagattt tgttaaccct aatgtgtaaa tgcaattagc taatttaaat tttggaaact
      961 taaggtttta tatagctagg cactttacta ctcttggatt gaaaaagcac actccattat
     1021 agggacatgt aactatccta taatcaggtg cttataaatg gacaactaca cggcctagtt
     1081 ttaccacaat cattgtcacc taaatttttt taaaaactcc tagggcatat gtaagtggag
     1141 atgctcactg ctgcatctgt ttctaatgat aatgtttctg ttacacagcc ttgagttttg
     1201 catgagtaag tatagtcacc taggatccca tttgagactg ggttgagcat tttgtaactt
     1261 aatcaaagtg actgcagttt cactaaaagc tatcatggtg agatgaaatt agggatggtt
     1321 tgctgatgtc atacagatca gaattaactt atcaaggggt ttactgtgta gaaaaaaagt
     1381 taaggggaaa agtctacaag aagtaaatgc cttgtcaaaa tatgtggaat cctgtgtgcc
     1441 atatgatatc ttagcatgtg aattgcactt ttaataccaa aaaggcacat caactaaaaa
     1501 gttatgattg aaatgccctt agggttctag gtatgtcaac ctaaactagc atttggagtt
     1561 aaatgaattt actgataagg atcagtctag tcttcctctg tatgacttag taggttgtga
     1621 ttggtcagat ttccttttta ctaacggtaa gggtgagagt gatgaggcag gtttgaggtt
     1681 ttctggtact attgaaaact gcaagtcctg actatgcact tagccagaac ttggtgtaga
     1741 caccaagcaa tatctgtgta tgaattggaa gaaacctgct tatgtttgct ttgttatttg
     1801 cctcaggaga tctcttttga aataagctgt tttcaaagga acagaaggga aacttgctac
     1861 ctgttctgag agcagtgtaa acctcacagg actttggatc tcctcagatg tagaggagaa
     1921 tgaaggaaag gaatagttag ggatgcacag gaatttatct gtctctgatc aggaaagaaa
     1981 gctggctatg ggtctgcagg ggcatgactg atggttgtct gcctcttttc accctgtaag
     2041 tgaatccctg aactggattc actgaagcaa gtcttggtta actaattcta ttttactata
     2101 actttaaaag tgaaaaatat tctctaaatt tatagcaggt gccttatttc ctttgaatca
     2161 aatcattcca taccagaatt tcccttggtt tactattaga taattggctt taagatactt
     2221 ttgttttgaa acatacagtg ttttaattga tttgttaaat tgctgtagcc atcaatcatt
     2281 tcacatttgt aaaatacatt ccctttgtat catgtaattt gcctattcag tgcattttat
     2341 attcaggttg ggttatgcat atttgggtca atgaaagttg tgtctgtttg atttatgctt
     2401 taaaaataaa gttccctgga tatttgaaaa aaaaaaaaaa aa
//
