LOCUS       NM_133395               5410 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine incorporator 5 (Serinc5), mRNA.
ACCESSION   NM_133395 XM_346610
VERSION     NM_133395.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5410)
  AUTHORS   Rosa,A., Chande,A., Ziglio,S., De Sanctis,V., Bertorelli,R.,
            Goh,S.L., McCauley,S.M., Nowosielska,A., Antonarakis,S.E.,
            Luban,J., Santoni,F.A. and Pizzato,M.
  TITLE     HIV-1 Nef promotes infection by excluding SERINC5 from virion
            incorporation
  JOURNAL   Nature 526 (7572), 212-217 (2015)
   PUBMED   26416734
REFERENCE   2  (bases 1 to 5410)
  AUTHORS   Usami,Y., Wu,Y. and Gottlinger,H.G.
  TITLE     SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted
            by Nef
  JOURNAL   Nature 526 (7572), 218-223 (2015)
   PUBMED   26416733
REFERENCE   3  (bases 1 to 5410)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   4  (bases 1 to 5410)
  AUTHORS   Fukazawa,N., Ayukawa,K., Nishikawa,K., Ohashi,H., Ichihara,N.,
            Hikawa,Y., Abe,T., Kudo,Y., Kiyama,H., Wada,K. and Aoki,S.
  TITLE     Identification and functional characterization of mouse TPO1 as a
            myelin membrane protein
  JOURNAL   Brain Res 1070 (1), 1-14 (2006)
   PUBMED   16405874
REFERENCE   5  (bases 1 to 5410)
  AUTHORS   Inuzuka,M., Hayakawa,M. and Ingi,T.
  TITLE     Serinc, an activity-regulated protein family, incorporates serine
            into membrane lipid synthesis
  JOURNAL   J Biol Chem 280 (42), 35776-35783 (2005)
   PUBMED   16120614
  REMARK    GeneRIF: Serinc proteins incorporate serine into membrane lipid
            synthesis
REFERENCE   6  (bases 1 to 5410)
  AUTHORS   Krueger,W.H., Gonye,G.E., Madison,D.L., Murray,K.E., Kumar,M.,
            Spoerel,N. and Pfeiffer,S.E.
  TITLE     TPO1, a member of a novel protein family, is developmentally
            regulated in cultured oligodendrocytes
  JOURNAL   J Neurochem 69 (4), 1343-1355 (1997)
   PUBMED   9326262
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Feb 6, 2015 this sequence version replaced NM_133395.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L20319.1, SRR26360194.1513994.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               JAXUCZ010000002.1  25581971-25582152
            183-350             JAXUCZ010000002.1  25631876-25632043
            351-529             JAXUCZ010000002.1  25651093-25651271
            530-612             JAXUCZ010000002.1  25651676-25651758
            613-706             JAXUCZ010000002.1  25653596-25653689
            707-918             JAXUCZ010000002.1  25659398-25659609
            919-1014            JAXUCZ010000002.1  25661807-25661902
            1015-1141           JAXUCZ010000002.1  25664347-25664473
            1142-1208           JAXUCZ010000002.1  25674816-25674882
            1209-1248           JAXUCZ010000002.1  25678773-25678812
            1249-1393           JAXUCZ010000002.1  25679391-25679535
            1394-5410           JAXUCZ010000002.1  25681387-25685403
FEATURES             Location/Qualifiers
     source          1..5410
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q12"
     gene            1..5410
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /note="serine incorporator 5"
                     /db_xref="GeneID:170907"
                     /db_xref="RGD:621571"
     exon            1..182
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1541
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /note="developmentally regulated protein TPO1"
                     /codon_start=1
                     /product="serine incorporator 5"
                     /protein_id="NP_596886.2"
                     /db_xref="GeneID:170907"
                     /db_xref="RGD:621571"
                     /translation="MSARCCAGQLACCCGSAGCALCCGCCPKFRQSRSTRFMYLFYFT
                     LVIIPCCVMMSPSVMKQMTEHIPFFEDFCKGIKAGDTCENLVGYSAVYRVCFGMACFF
                     FVFCVLTFKVNNSKSCRASIHNGFWFFKLLLLGAMCSGAFFIPDQETFLNVWRYVGAV
                     GSFFFICIQLLLIVEFAHKWNKNWTAGTVRNKLWYASLSLATLIMYSIAVGGLALMAV
                     FYTQWDDCMDNKILLGVHGGLCVLISLAAISPCVQNRQPHSGLLQPGLISCYVTYLTF
                     SALTSKPEKVVKDEHGKNVTICVPDFGQDFRRDESMVTWLGTLLLVVCISYSCLTSTT
                     RSSSDALQRRYGAPELEVARCCFCFGPDGEDTEEQQNVKEGPRVIYDEKKGTVYSYSY
                     FHFVLLLASLYVMMTLTSWFHYENATIETFFVGSWSIFWVKMASCWMCVLLYLWTLVA
                     PLCCPSRQFSV"
     exon            183..350
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            351..529
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            530..612
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            613..706
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..918
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1014
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1141
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1208
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1248
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1393
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..5410
                     /gene="Serinc5"
                     /gene_synonym="Tpo1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ttgttttcag gccacggtac acagctctca gctgcgctac tggactccgg gctgggaagc
       61 tagaccagct tcttctgacg cgcgctgcgg acccagccga gaggacgcga gtggcgggcc
      121 cagcgggcag ggtccggagg tcgtcggccg cggcgatgtc tgcccggtgc tgtgctggcc
      181 agttggcctg ctgctgcgga tctgctggtt gtgccctctg ctgtggctgc tgccctaagt
      241 tccggcaatc tcggagcacc cgcttcatgt atttattcta cttcaccctg gtcatcatcc
      301 cctgctgcgt gatgatgtca ccctctgtga tgaagcagat gacggagcac attccctttt
      361 ttgaagactt ctgtaaaggc atcaaagcgg gcgacacctg tgagaacctg gtgggctatt
      421 ccgcggtgta cagagtctgc tttggaatgg cttgtttctt ctttgtgttt tgtgtgctga
      481 ccttcaaagt caacaacagc aaaagttgtc gggcctccat tcacaacggc ttttggttct
      541 ttaaattgct gctgttaggg gccatgtgtt caggagcatt cttcattcca gatcaggaga
      601 cctttctgaa tgtctggcgc tatgtgggag ctgtggggag cttcttcttc atttgtatcc
      661 agctcctcct gattgtggag tttgcacata aatggaacaa gaactggact gcaggcaccg
      721 tccgtaataa gctgtggtac gcctccctgt cgctggcgac actcatcatg tattccattg
      781 ccgttggcgg cttggccttg atggcagtgt tctacacaca gtgggatgac tgcatggaca
      841 acaagattct cctgggagtg cacggtggcc tatgcgtgct aatctctctg gcagccatct
      901 caccctgcgt ccagaatcga cagccacact ctgggctgct gcagccaggg ctcataagct
      961 gctatgtcac ctacctcacc ttctcagcac tgaccagcaa gcccgaaaaa gtagtcaaag
     1021 atgaacacgg gaagaatgtc accatatgtg tgcctgactt cgggcaagac tttcgtcgag
     1081 atgaaagcat ggtgacctgg ctgggcaccc ttctcttagt tgtgtgcatc tcatattcat
     1141 gtttgacatc gacgacgagg tcgagctcgg atgccctgca gcggcgatac ggagctcctg
     1201 agctggaggt ggcccggtgc tgtttctgct tcggtccaga tggggaagac acggaagagc
     1261 agcagaatgt caaggaggga cccagggtca tttacgatga gaagaaaggc accgtctaca
     1321 gctactccta tttccacttt gtcttgctcc tggcttccct ctacgtgatg atgactttga
     1381 ccagctggtt ccactatgaa aacgccacca ttgagacctt cttcgttggg agctggtcca
     1441 tcttctgggt caagatggcc tcctgttgga tgtgtgtgct gctgtacctg tggaccctgg
     1501 tggctcccct ttgctgtcct tccaggcagt tctctgtctg aggatgtcca ggtgccccac
     1561 agctcagcag gcctgtgccc actctggagg gctgcccctg gaacgtgtgc accaggggtt
     1621 aagcagcagc tggtgccctg tgcaaagctg acatccccag gctagcttaa ttaagcctga
     1681 caaagcgcca tctccagatg agcttctcac tgtcaagtcc aaaaggaaac aaactaccag
     1741 tttgctctac aggaattgaa ccccgtagcc aagctggtag gtgcggttat atcgtctctg
     1801 tatgccttac ccacaagcta gctagagttt tgctgctgcc attcctgggt gtgcagagct
     1861 gggggcacag cagccaccac agggagagca cggcctttct ggcctgccac tctcatcctt
     1921 ggcataaaga gcaacaacaa aacactgagt cctcagcctg aggtgggcct gttctctgtc
     1981 actcactctt gcccctggag cccccacagc tcctgtttat acagagtaca gaggaagtcc
     2041 ccccccccac tttgagcccc cctttgagtc caccctcaac tacttctgca tgtccctgcc
     2101 ccagcatttt ctattgaggt catgatgctg ggagtcacgg ccttcccgtc ccctctgcgc
     2161 ctgacagaag tccttcattc ttgtctaggg tagtgtctat aataatgtga aaagcacagt
     2221 ttgctcacac ctctgtggga cactccacca tgcttcccct acccgatgca ggtcactgca
     2281 gtaatcctgg tgacggtgtc catgcctgta aaacagggtg cttgctgtta tcttgcccag
     2341 gcagtggagg attacagttc ttacttgttt gtctcattaa caggaatgct ttaaggatct
     2401 taacaaaaac gttgcttctt tactgcagcc tgccacaccc tctcagagtg ttaaggtcag
     2461 cctccctggt tctcccccac catgaggact tcctcactta cagtgtgtcc ccaatgctaa
     2521 catcatagat ttttggaagt agagaagggc tggggtgagg atccaggcag cttctaacag
     2581 agctggccag acagattggc tgggcaagct gtggaagtgc ggaattagac tgagatgcaa
     2641 aagcaggtga ttggggttat ctcacaagac tacgattata tccacagaaa ttcccagata
     2701 tggttttgga aagtaatgct cacgtgtgtg cattttagtg ctggtgttct tggcaaggga
     2761 ggaaatttcc ccagtgccta tctgaacaag tcaggcagaa ccgggaccac ctaagcccag
     2821 ttcccgcatg ccgaaatgtc agattcttca cttctgctca ctcctgtgcc cctgctaaaa
     2881 ggacccaggg gaaagaaata gcaaattctt tggagaactt gcctggttta cagtattcga
     2941 gatcctgtct taaaaggtat acaaataagg acatttattt gtctgtaaac ttcatcataa
     3001 ttcctggtat aggaggaaga ggtcagggcc tctcagcagt tcacagacac aggagaatca
     3061 cagaaagcat agctataccc taactctaac aagtctagtt aatccaatag gagtgggacc
     3121 ctcaaaaact gggaatgaat ggttcagaaa gtggcctgtg ccagccggct ccgtgcagca
     3181 gcccctgctg tgcctgcggg aggttctgtg accgaggcag aggggaactc aggtagtggt
     3241 gggagcagta ttgtttttca aaggtcagtc ttctctgctg agactggcag cctcatgcca
     3301 ggtcacagcc aggctgacaa ggccacacat tcctgggctg gcctcttttg gccccttttc
     3361 ctctcagtaa agcagctcag gcaaacccag tcagaaccag tgacagagcc ctagtggctt
     3421 ctctctgaac caaccaagcc ccactcactc tccggctgcc tgagtcttgg ttgagtgcat
     3481 ggcccgtcct tcagaagtta ggtctcaccg aaggaagagc tggccatgcc cttctttact
     3541 ctcagctgat ggtattggat tgatggtcag aatgaagatg gctgtgcttg aggatgaatg
     3601 gtttccaagt aagctatacc taagaattga acctttaatc tcagccgaag cccggggagc
     3661 tctgagattt ctaggccagc tagaccctat ttcaaaacaa aaggttaaca tttgtgatca
     3721 gctgtgagaa actactcagg tagaagcctg tttgtgagct taagaacact gttgtttgtg
     3781 agacttgaga aaactggaaa gtgtgccatt gctctggggt aacaacagca aagctcactt
     3841 gcttgttcca ccggtgactt ttaacgatac agacctttgc tttgagcagt accggggcag
     3901 gactgaaagt gcatgcttta aagctctgct acttagccat gcagtcctgg aggcagagtt
     3961 ttggaaatca tgtgttctct ccctctcgtt tttgtgagta aaacattagt tatgccaggg
     4021 aaagattctc ctggggtctc gttcccactg acctagttcc cacaccattg ctgagtcctg
     4081 ctttgtggtg ctggatagct gatctgggct tcttgggaag tcagcacatg acttattctc
     4141 cagaggtttg gggagtttta tatagtgagt gaatggtgat gtggaaagag ttgtaggggc
     4201 atagagtatt gagactttgg ggttccgaat cccataagga gtggccaatg agagacatag
     4261 tgccatgttt ccatggagac ttcactcaag tgttaattgc tcccttccca aattgtcacc
     4321 ctctgccttt atccgatgat gtactcatgt aaactttgcg gaatggcccg tccttggtgc
     4381 ttcatattac cctggaaaga gagctccaga gcctgcattt aaacttctgg gcttctcttc
     4441 ttccattgcc tttctaagca gtggctcttt tttatgtgct gaaacaaacc aatgcacatc
     4501 ccacatactg ccaagaagtg aaagggcttc aggaagacga gctccagaga ggaccctggg
     4561 cctcctccat cagacatgag cttgcaatct ggtcatagac tctcaaggtt tcttctgtga
     4621 ctcactcact agtaagcatt ttcatttcct gcagagatga gctctctggc attggggtga
     4681 cttcagtaga taggtgagct gacaagaggg cttgagctcg ttctcatttt ctgtttccta
     4741 ttggtgaagc actcacagag acaagttatt tcgaaaggcc ggaacacttg gcttttacca
     4801 aagaggtaat ttaattttgt tttagttgcg caagggcaga gccagaatgc attcatccag
     4861 ttgacttcca gaagcttaac cacattcatg tgagggaaat gatagaagtc tttaaggtaa
     4921 tcctttggga tcctgggaaa ttctctcagg taaagaaaga ttacagcaga tgagtaatat
     4981 atgtcttgag agctatttat aaaaactgta agaggatcat tttgtttcca tttattaaag
     5041 atttaaactt ttttactttg taaagaaaaa ctacattttt atagtcataa ctgttaattt
     5101 tttaagaaag atttttttgg aaacaattag ctgtagccaa attttgtggt tacagttttg
     5161 ctatagtgga gtttgaatgc aatttctgtg gtaagtctac tgtttgttta taaaggtctc
     5221 cgacctggtt agattttgct accttttaaa atagttattt tttccccatt agccacaagg
     5281 ccaattatgg atttgtattt gtttttccaa tgctaatttt tctatgaagc acctgaaatt
     5341 aactggcctt ttcctatgta gaaaactcaa acttgttaac tgtgtattta ataaaatgta
     5401 aacttgaaaa
//
