LOCUS       NM_001008312            2169 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus serine incorporator 3 (Serinc3), mRNA.
ACCESSION   NM_001008312 XM_215930
VERSION     NM_001008312.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2169)
  AUTHORS   Rosa,A., Chande,A., Ziglio,S., De Sanctis,V., Bertorelli,R.,
            Goh,S.L., McCauley,S.M., Nowosielska,A., Antonarakis,S.E.,
            Luban,J., Santoni,F.A. and Pizzato,M.
  TITLE     HIV-1 Nef promotes infection by excluding SERINC5 from virion
            incorporation
  JOURNAL   Nature 526 (7572), 212-217 (2015)
   PUBMED   26416734
REFERENCE   2  (bases 1 to 2169)
  AUTHORS   Usami,Y., Wu,Y. and Gottlinger,H.G.
  TITLE     SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted
            by Nef
  JOURNAL   Nature 526 (7572), 218-223 (2015)
   PUBMED   26416733
REFERENCE   3  (bases 1 to 2169)
  AUTHORS   Bossolasco,M., Veillette,F., Bertrand,R. and Mes-Masson,A.M.
  TITLE     Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro
            and stimulates in vivo tumorigenesis
  JOURNAL   Oncogene 25 (33), 4549-4558 (2006)
   PUBMED   16547497
  REMARK    GeneRIF: TDE1 inhibits apoptosis and stimulates tumorigenesis
REFERENCE   4  (bases 1 to 2169)
  AUTHORS   Inuzuka,M., Hayakawa,M. and Ingi,T.
  TITLE     Serinc, an activity-regulated protein family, incorporates serine
            into membrane lipid synthesis
  JOURNAL   J Biol Chem 280 (42), 35776-35783 (2005)
   PUBMED   16120614
  REMARK    GeneRIF: Serinc proteins incorporate serine into membrane lipid
            synthesis
REFERENCE   5  (bases 1 to 2169)
  AUTHORS   Aoki,S., Su,Q., Li,H., Nishikawa,K., Ayukawa,K., Hara,Y.,
            Namikawa,K., Kiryu-Seo,S., Kiyama,H. and Wada,K.
  TITLE     Identification of an axotomy-induced glycosylated protein, AIGP1,
            possibly involved in cell death triggered by endoplasmic
            reticulum-Golgi stress
  JOURNAL   J Neurosci 22 (24), 10751-10760 (2002)
   PUBMED   12486168
REFERENCE   6  (bases 1 to 2169)
  AUTHORS   Grossman,T.R., Luque,J.M. and Nelson,N.
  TITLE     Identification of a ubiquitous family of membrane proteins and
            their expression in mouse brain
  JOURNAL   J Exp Biol 203 (Pt 3), 447-457 (2000)
   PUBMED   10637174
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085853.1.
            
            On Dec 16, 2004 this sequence version replaced XM_215930.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085853.1, EU220431.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2169
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..2169
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /note="serine incorporator 3"
                     /db_xref="GeneID:296350"
                     /db_xref="RGD:1308390"
     exon            1..132
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1512
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /note="tumor differentially expressed 1"
                     /codon_start=1
                     /product="serine incorporator 3"
                     /protein_id="NP_001008313.1"
                     /db_xref="GeneID:296350"
                     /db_xref="RGD:1308390"
                     /translation="MGAVLGVFSLASWVPCLCSGASCLLCSCCPMSKNSTVTRLIYAS
                     ILILGTIVSCIMMTEGIQTQLKKIPGFCEGEFQIKIVDTKAEKDCDVLVGFKAVYRIN
                     FAVAIFFFAFFLLMLKVKTSKDPRAAVHNGFWFFKIAAIIGIMVGSFYIPGGHFTKVW
                     FSAGMLGATFFIFIQLVLLVDLAHSWNELWVNRMEEGNPRLWYAALLSFTSLFYILSI
                     VFAALLYIFYTKPDGCTENKVFISLNLIFCVAVSIVSILPKVQEHQPRSGLLQSSIIT
                     LYTLYLTWSAMTNEPDRSCNPSLMSIITQLTSPTVSPANSTTPAPAYVPPSQNGHFIN
                     LDDLGGLTIFVICLIYSSIRTSSNSQVNKLTLSGSDSVILGDTTNGASDEEDGRPRRA
                     VDNEKDGVQYNYSFFHLMLCCASLYIMMTITSWYSPDAKFQKVSSERLAVWVKMGSSW
                     VCLLLYLWTLVAPLVLTGRDFS"
     exon            133..294
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
     exon            295..488
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..568
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..706
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
     exon            707..876
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
     exon            877..967
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1148
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1373
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..2146
                     /gene="Serinc3"
                     /gene_synonym="Tde1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aattcgtccc gtttctgagg cgacgcctca gccggcagtt agccatcgcg cagggacccg
       61 ctcggagcgg tgggtctcgg ccccagcgac accatggggg ccgtccttgg cgtcttctcc
      121 ctcgctagct gggttccatg cctatgtagt ggtgcatcat gtctgctgtg cagttgctgc
      181 cccatgagta agaattccac tgtaactcgg ctcatctacg cttctattct catccttggc
      241 actattgtgt cttgcatcat gatgacagaa ggcatacaaa ctcagctgaa gaagattcct
      301 ggattctgtg aaggagaatt tcaaatcaag atagttgata caaaggcaga gaaagactgt
      361 gacgtgctgg tcggttttaa agctgtgtat cggatcaact ttgctgtggc catctttttc
      421 tttgccttct ttttgctcat gttaaaagtg aaaacgagta aagatcccag agcagcagta
      481 cacaatgggt tttggttctt caaaatcgcg gccattattg gtatcatggt tggatctttc
      541 tacatacctg ggggccattt cactaaagtt tggtttagtg ctggaatgtt aggagccact
      601 ttcttcattt tcatccagct ggtgctcttg gtagacctgg ctcactcttg gaatgaatta
      661 tgggtaaatc gaatggagga aggaaaccca aggctctggt atgctgcctt gctgtcgttt
      721 acaagcctct tctatatcct gtctatcgtc tttgccgcac tgctctacat cttctacact
      781 aagcctgacg gctgcacaga gaacaaggtc ttcatcagcc tgaacctcat cttctgtgtt
      841 gcagtttcta ttgtgtccat cctccccaaa gttcaggaac atcagcctcg ctctggcctc
      901 ctacagtcct ccatcatcac tctgtacacc ctttacctca cgtggtcggc catgaccaat
      961 gaacctgatc ggtcctgcaa cccctccctc atgagcatca tcacacaact cacctccccc
     1021 actgtgtctc cagcaaattc gaccactcct gctcctgcct atgtcccccc atcccagaat
     1081 ggacacttca taaatttgga tgatttgggg ggactgacta tctttgttat ctgccttata
     1141 tattctagca tccgtacttc gagcaacagc caagtgaaca agctgaccct ctctgggagc
     1201 gacagtgtta tccttggtga caccaccaat ggagccagcg atgaagaaga tggacggcca
     1261 cggcgggctg tagacaacga gaaggacggg gtgcagtata actactcctt cttccacctg
     1321 atgctctgct gtgcctccct gtacatcatg atgaccataa ccagctggta cagccctgat
     1381 gccaaattcc agaaggtgtc cagcgagcgg ctagctgtgt gggtcaaaat gggctccagc
     1441 tgggtgtgcc tcctccttta cctctggact cttgtggctc ccctggtcct cacaggtcgg
     1501 gacttcagct gagctcagtg tatggaggat actactaaag ctgacagagt tcctctcctg
     1561 gaaatgcata tccattttac atttcatcaa ctagactact aagtgaacac tttgcagatt
     1621 tggctgtctt caggtttata tcaaaaggca agattgaata atgcttgctg caaagtctga
     1681 acttcatata aatgcatata tatattacgt ttatttgtaa ggctatagca caaagggaac
     1741 atttttgtgt tttaacatga acagctgtgc tgtgaagaga attctttata aagacctgta
     1801 gattcctaca actttggttt aagttgtaag tcagaagatt gttggatatt taaggctatc
     1861 tttaatatat ttctattaca gtctccttaa aaaccaaaaa ggaatgcatt aatccacatt
     1921 tccctccttc agaggtcctg gttcttggca aggaattact atgtgtgtag gtccttcccc
     1981 agaaatgcag ctgctcatga ggctgaaaga agaaggctat tttgttcctt tgcttacttt
     2041 ttatactaca ctgatgctgc ttgatagaag tctgtggctt tgtcagaaat gtcatcccag
     2101 taaatgcttt gtagatctga ttaaaaagaa cacttgactt gggaaaaaaa aaaaaaaaaa
     2161 aaaaaaaaa
//
