LOCUS       NM_001031656            1811 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus serine incorporator 2 (Serinc2), mRNA.
ACCESSION   NM_001031656 XM_232776
VERSION     NM_001031656.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1811)
  AUTHORS   Hu S, Huang M, Mao S, Yang M, Ju H, Liu Z, Cheng M and Wu G.
  TITLE     Serinc2 deficiency exacerbates sepsis-induced cardiomyopathy by
            enhancing necroptosis and apoptosis
  JOURNAL   Biochem Pharmacol 218, 115903 (2023)
   PUBMED   37918695
  REMARK    GeneRIF: Serinc2 deficiency exacerbates sepsis-induced
            cardiomyopathy by enhancing necroptosis and apoptosis.
REFERENCE   2  (bases 1 to 1811)
  AUTHORS   Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta
            R, Wang NS and Knepper MA.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   3  (bases 1 to 1811)
  AUTHORS   Inuzuka M, Hayakawa M and Ingi T.
  TITLE     Serinc, an activity-regulated protein family, incorporates serine
            into membrane lipid synthesis
  JOURNAL   J Biol Chem 280 (42), 35776-35783 (2005)
   PUBMED   16120614
  REMARK    GeneRIF: Serinc proteins incorporate serine into membrane lipid
            synthesis
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JACYVU010000162.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_001031656.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001031656.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099093.1, DQ103709.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-84                JACYVU010000162.1  57163844-57163927   c
            85-246              JACYVU010000162.1  57153747-57153908   c
            247-437             JACYVU010000162.1  57152956-57153146   c
            438-517             JACYVU010000162.1  57152297-57152376   c
            518-655             JACYVU010000162.1  57151758-57151895   c
            656-825             JACYVU010000162.1  57149421-57149590   c
            826-916             JACYVU010000162.1  57146840-57146930   c
            917-1052            JACYVU010000162.1  57146295-57146430   c
            1053-1262           JACYVU010000162.1  57143388-57143597   c
            1263-1811           JACYVU010000162.1  57141607-57142155   c
FEATURES             Location/Qualifiers
     source          1..1811
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1811
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /note="serine incorporator 2"
                     /db_xref="GeneID:313057"
                     /db_xref="RGD:1311396"
     exon            1..84
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..1398
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /codon_start=1
                     /product="serine incorporator 2 precursor"
                     /protein_id="NP_001026826.1"
                     /db_xref="GeneID:313057"
                     /db_xref="RGD:1311396"
                     /translation="MGACLGACSLLSCASCLCGSAPCILCSCCPSTRNSTVSRLLFTG
                     FLFLGVLVSIIMLSPGVESQLYKLPWVCEDRAQQPVVLQGPLDCGSLLGFRAVYRMCF
                     ATAAFFFLFMMLMICVRSSRDPRAAIQNGFWFFKFLILVGITVGAFYIPDGSFPKIWF
                     YFGVVGSFLFILIQLILFIDFAHSWNQRWLCKAEECDSPVWYAGLFFFTFLFYLLSIA
                     AVALMFVYYTESGACHEGKVFIGLNLTFCVCVSIIAVLPKVQSAQPNSGLLQASVVTL
                     YTMFVTWSALSNVPDQKCNPHLPTKNGTGQVNLEDYSTVWWDAPSIVGLVIFILCTFF
                     ISLRSSDHRQVNSLMQTEECPAEMVQQQQVAVGDGRTYDNEQDGVTYSYSFFHFCLVL
                     ASLHVMMTLTNWYSPGETRKMISTWTSVWVKICASWAGLFLYLWTLVAPLLLPNRDFS
                     "
     exon            85..246
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            247..437
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            438..517
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            518..655
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            656..825
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            826..916
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1052
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1262
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
     exon            1263..1811
                     /gene="Serinc2"
                     /gene_synonym="Tde2l"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgggatccg aggctggtgc cccgcgcccc gcgccccgca ccgccatggg ggcctgtctg
       61 ggggcctgct ccctgctcag ctgcgcatcc tgcctctgtg gctctgcacc ctgcatccta
      121 tgcagctgct gcccctcaac ccgcaactcc acggtgagcc gcctcctctt caccggcttc
      181 ctcttcttgg gggtgctggt gtctatcatc atgctgagcc ccggagtgga gagtcagctt
      241 tacaagctgc cctgggtgtg tgaggacagg gcccagcaac ccgtggtcct gcaggggccc
      301 ctggactgtg gctccctgct gggtttccgc gctgtctacc gtatgtgctt tgccacagca
      361 gcctttttct tcctcttcat gatgttaatg atctgcgtcc gcagtagccg ggacccgcga
      421 gcagccatcc agaatgggtt ttggtttttt aaattcctga tccttgtggg aatcaccgtg
      481 ggtgccttct acatccctga tggctccttt cccaagatct ggttctactt tggcgtcgtg
      541 ggctccttcc tcttcatcct catccagctg atcctgttca ttgactttgc tcactcctgg
      601 aatcagcggt ggctgtgtaa ggccgaggag tgtgattctc ctgtctggta cgcaggcctt
      661 ttcttcttca ccttcctctt ttacctgttg tccattgccg ccgtggcact gatgttcgtc
      721 tactacacgg agtctggtgc ctgccacgag ggcaaggtct tcatcggcct caacctcacc
      781 ttctgtgtct gcgtctccat cattgctgtc ctgcccaaag tccagagtgc ccagcctaac
      841 tcaggtctgc tacaagcctc tgtcgtaacc ttgtatacaa tgtttgtcac ctggtctgcc
      901 ctatccaacg tccctgacca aaaatgcaac cctcacctgc ccactaagaa cgggacgggc
      961 caggtgaacc tggaggacta cagcacagtg tggtgggacg ccccgagcat tgtgggcctc
     1021 gtcatcttca tcctgtgcac cttcttcatt agcctgagat cctctgacca ccgtcaggtg
     1081 aacagcttga tgcagacaga ggagtgtcca gcagaaatgg tgcagcagca gcaggtggcc
     1141 gtcggtgacg gccgaaccta tgacaatgag caggacggtg tcacctacag ctattccttc
     1201 ttccacttct gcctggtgct ggcctccctg catgtcatga tgacacttac caactggtac
     1261 agccctgggg agacccggaa gatgattagc acgtggacct cggtgtgggt gaagatctgt
     1321 gccagctggg cagggctgtt cctctacctg tggaccctgg tggcgcctct gctcctgccc
     1381 aacagagact tcagctgaga atgccctgca gcctgcctac ctggtgcctt ggggctcaac
     1441 aagggccagc ccaccgctgg ccacacttac ccactctcct ccaggacctg cccgagtcag
     1501 gattctccat tctcagtgcc tccggggtct gtgggacatt gtattctgat cgaagcccca
     1561 ccttcctttg accatggtca tgcgtactca cccctgggac agaagtaacc cccccccccc
     1621 cccccccccc gttcttaggg tcccgagaag agggcctgaa aggagagagt ggtccagagc
     1681 tgctcagctg atgggggtac ccaccttata cactaaggcc tgtgctcggg gcctccagag
     1741 cccaccccct tcctagacca tgtgccttac tgagtctcta agacttcacc caataaacat
     1801 gcctgtatcc a
//
