LOCUS       NM_001400924            1452 bp    mRNA    linear   ROD 31-MAR-2024
DEFINITION  Rattus norvegicus secretion regulating guanine nucleotide exchange
            factor (Sergef), mRNA.
ACCESSION   NM_001400924 XM_344891
VERSION     NM_001400924.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1452)
  AUTHORS   Xue,Y., Guo,Y., Luo,S., Zhou,W., Xiang,J., Zhu,Y., Xiang,Z. and
            Shen,J.
  TITLE     Aberrantly Methylated-Differentially Expressed Genes Identify Novel
            Atherosclerosis Risk Subtypes
  JOURNAL   Front Genet 11, 569572 (2020)
   PUBMED   33381146
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1452)
  AUTHORS   Sjolinder,M., Uhlmann,J. and Ponstingl,H.
  TITLE     DelGEF, a homologue of the Ran guanine nucleotide exchange factor
            RanGEF, binds to the exocyst component Sec5 and modulates secretion
  JOURNAL   FEBS Lett 532 (1-2), 211-215 (2002)
   PUBMED   12459492
REFERENCE   3  (bases 1 to 1452)
  AUTHORS   Uhlmann,J., Wiemann,S. and Ponstingl,H.
  TITLE     DelGEF, an RCC1-related protein encoded by a gene on chromosome
            11p14 critical for two forms of hereditary deafness
  JOURNAL   FEBS Lett 460 (1), 153-160 (1999)
   PUBMED   10571079
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 28, 2022 this sequence version replaced XM_344891.9.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22399481.102934.1,
                                           SRR26360190.1334072.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                JAXUCZ010000001.1  106288695-106288789 c
            96-231              JAXUCZ010000001.1  106284389-106284524 c
            232-387             JAXUCZ010000001.1  106282722-106282877 c
            388-482             JAXUCZ010000001.1  106280284-106280378 c
            483-543             JAXUCZ010000001.1  106274180-106274240 c
            544-657             JAXUCZ010000001.1  106269347-106269460 c
            658-720             JAXUCZ010000001.1  106266959-106267021 c
            721-879             JAXUCZ010000001.1  106262712-106262870 c
            880-1046            JAXUCZ010000001.1  106238067-106238233 c
            1047-1083           JAXUCZ010000001.1  106152608-106152644 c
            1084-1452           JAXUCZ010000001.1  106085955-106086323 c
FEATURES             Location/Qualifiers
     source          1..1452
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..1452
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /note="secretion regulating guanine nucleotide exchange
                     factor"
                     /db_xref="GeneID:365243"
                     /db_xref="RGD:1563497"
     exon            1..95
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     CDS             36..1388
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /codon_start=1
                     /product="secretion-regulating guanine nucleotide exchange
                     factor"
                     /protein_id="NP_001387853.1"
                     /db_xref="GeneID:365243"
                     /db_xref="RGD:1563497"
                     /translation="MARESCASEAVSAAAVLFAWGANSYGQLGLGHKEDVLLPQQLSD
                     FCKSGCIKSVTGGGGHSVVVTDGGGLFVCGLNKDGQLGLGHTEEVLRFTICKPLLGCP
                     IRQVACGWDFTIMLTEKGQVLSCGSNAFGQLGVPHGPRKCVVPQAIECLREKVVCVAA
                     GLRHALATTDTGSTFQWGTGLASSGRRLCPGQNLPLFLTAKEPSRVTGLESSTVVCAV
                     AGSDHSASLTDTGELYVWGRNKHGQLASLATFLPLPQRVEAHYFQDEKVTAVWSGWTH
                     LVAKTETGKVFTWGRADYGQLGRTLGSPEAQKHGEQDSSLAFQRLQNSVPSPLHCLTG
                     AAEVSCGSEHNLAVIRDKCCSWGWNEHGMCGDGTESNVWTPTPVQALPSPSRLLLVGC
                     GAGHSLALCQLPAHPAPCQDLTVTCPLPDATETTESQGAVDRERQEGETIGDFNPKPF
                     "
     exon            96..231
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     exon            232..387
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     exon            388..482
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     exon            483..543
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     exon            544..657
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     exon            658..720
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     exon            721..879
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1046
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1083
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1452
                     /gene="Sergef"
                     /gene_synonym="RGD1563497"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcagccctc ccggaagcgc cggtggtgcg tgtgcatggc gcgggagtcc tgcgcctcgg
       61 aggctgtctc cgccgctgcc gtgctcttcg cctggggtgc aaacagctac gggcaacttg
      121 gcctgggcca taaggaagat gtgcttcttc cccagcaact gagtgacttc tgtaaatcgg
      181 ggtgtatcaa gagtgtcaca ggaggaggag ggcattctgt agttgtcaca gatggaggag
      241 gtctttttgt ttgtggcctg aataaagatg ggcagttggg gcttggccac acagaggaag
      301 ttctgcgctt taccatctgc aagcctctcc tgggttgtcc catccggcag gtggcctgtg
      361 gctgggattt cactatcatg ctcacggaaa aaggtcaagt tctgtcatgt ggatccaatg
      421 cctttggcca gttaggtgtg ccgcacggcc ctcgcaaatg tgtggttccg caggccattg
      481 agtgcctgag agagaaggtt gtttgtgtcg ctgctggact gaggcatgca ttagccacta
      541 cagacactgg cagtacgttc cagtggggga ctggcttggc atcttctggt cgacgcttgt
      601 gtcctgggca gaatctccca ttgttcttga cagcaaagga acccagtaga gtgacaggcc
      661 tagagagttc tacagtggta tgtgctgttg cgggatctga ccactcagcc tcattaacag
      721 atacaggaga gctgtatgtc tggggccgta acaagcatgg gcagctggcc tccctcgcca
      781 ccttccttcc tctgccccag agagtagaag cacattactt ccaggatgaa aaggtcactg
      841 ctgtctggag tggttggacg catctggttg ctaagacaga aactggcaag gtgtttacct
      901 ggggtcgagc agactacggt cagcttggga ggacgttggg gtctcctgaa gctcagaaac
      961 acggagagca agattcatcg ctcgccttcc agaggctgca gaacagtgtg ccttcacccc
     1021 tgcactgcct gacaggagca gcagaggttt cttgtggctc agagcacaat ttggcggtaa
     1081 ttagggacaa gtgctgctcc tggggctgga atgaacatgg catgtgtggg gacggcaccg
     1141 agtccaatgt ctggactcca actccagtgc aggccctgcc gtcaccatca agactcctcc
     1201 tcgtgggctg tggggcgggc cactccttgg ccttatgtca gctgccggca caccctgcac
     1261 catgccagga tctcacggtt acctgcccac tcccagatgc cacagagacc actgaatctc
     1321 agggtgccgt ggacagagag agacaggaag gagagaccat tggtgacttc aacccaaagc
     1381 cattctgacc tgacgagaag ttgggggtgg ggaggcatga aagagaccat tcaataaagt
     1441 ggcttattcc aa
//
