LOCUS       NM_001400935            3199 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus serine active site containing 1 (Serac1), mRNA.
ACCESSION   NM_001400935 XM_574308
VERSION     NM_001400935.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3199)
  AUTHORS   Wortmann,S.B., Vaz,F.M., Gardeitchik,T., Vissers,L.E.,
            Renkema,G.H., Schuurs-Hoeijmakers,J.H., Kulik,W., Lammens,M.,
            Christin,C., Kluijtmans,L.A., Rodenburg,R.J., Nijtmans,L.G.,
            Grunewald,A., Klein,C., Gerhold,J.M., Kozicz,T., van Hasselt,P.M.,
            Harakalova,M., Kloosterman,W., Baric,I., Pronicka,E., Ucar,S.K.,
            Naess,K., Singhal,K.K., Krumina,Z., Gilissen,C., van Bokhoven,H.,
            Veltman,J.A., Smeitink,J.A., Lefeber,D.J., Spelbrink,J.N.,
            Wevers,R.A., Morava,E. and de Brouwer,A.P.
  TITLE     Mutations in the phospholipid remodeling gene SERAC1 impair
            mitochondrial function and intracellular cholesterol trafficking
            and cause dystonia and deafness
  JOURNAL   Nat Genet 44 (7), 797-802 (2012)
   PUBMED   22683713
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3199)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 28, 2022 this sequence version replaced XM_574308.8.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2168461.1,
                                           SRR26643292.605.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-121               JAXUCZ010000001.1  49061733-49061853   c
            122-216             JAXUCZ010000001.1  49056904-49056998   c
            217-253             JAXUCZ010000001.1  49052701-49052737   c
            254-390             JAXUCZ010000001.1  49051697-49051833   c
            391-480             JAXUCZ010000001.1  49050239-49050328   c
            481-612             JAXUCZ010000001.1  49048952-49049083   c
            613-734             JAXUCZ010000001.1  49048541-49048662   c
            735-863             JAXUCZ010000001.1  49046832-49046960   c
            864-977             JAXUCZ010000001.1  49043652-49043765   c
            978-1140            JAXUCZ010000001.1  49042192-49042354   c
            1141-1291           JAXUCZ010000001.1  49039924-49040074   c
            1292-1433           JAXUCZ010000001.1  49035126-49035267   c
            1434-1528           JAXUCZ010000001.1  49034265-49034359   c
            1529-1626           JAXUCZ010000001.1  49033056-49033153   c
            1627-1809           JAXUCZ010000001.1  49031977-49032159   c
            1810-1953           JAXUCZ010000001.1  49028890-49029033   c
            1954-3199           JAXUCZ010000001.1  49025845-49027090   c
FEATURES             Location/Qualifiers
     source          1..3199
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     gene            1..3199
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /note="serine active site containing 1"
                     /db_xref="GeneID:499015"
                     /db_xref="RGD:1565064"
     exon            1..121
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            122..216
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2090
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /codon_start=1
                     /product="protein SERAC1"
                     /protein_id="NP_001387864.1"
                     /db_xref="GeneID:499015"
                     /db_xref="RGD:1565064"
                     /translation="MSLAASYCVICCRRIGTFVPRSKSHTSWRNIRNIVRFTGSLIVG
                     GSLFITYQVLALKKSLTLDTQVVEREKMKSYIYVHKALVDSLDNHGIVWQARKELHRA
                     VRKVLAAAAKVLRSPFAGPFSTVDIEDHDCAVWLLLRKSRQDDLAARLEAVREMSEAH
                     HWHDYQYRIIAQACDPRTLIGLARSKESDLRFFLPPPPLPSLKEDSSTEEEFGHLLAS
                     LPQTELDECLQYFTSLALSESSQSLAAQKGGLWCFGGNGLPYAESFGETPSATVEMLS
                     LEAIVKHSEIPSHCDYIEAGGGLQLLQRLYQLHKDCPKIQRSVLRIIGNMALNEHLHP
                     AIVHSGWVSLLAEALKSCHIMEASHAARTLANLDRETVSEKYQDGVYVLHPQCRTSQP
                     IKADVLFIHGLMGAAFKTWRQHDSQRALTENALVDEDSYTTCWPKTWLAKDCPALRII
                     SVEYDTSLSDWRARCPMERKSIAFRSNELLSKLRAAGVGERPVIWVSHSMGGLLVKKM
                     LLEASQKPELSALINNTRGIIFYSVPHHGSRLAEYSVNIRYLLFPSLEVKELSKDSPA
                     LKMLQDEFLELVKDKDLQVLNFVETQPTFIGSMIKLQVVPVESADLGIGDLIPVDVNH
                     LNICKPKTKDAFLYQRTLQFICETLARDLEN"
     exon            217..253
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            254..390
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            391..480
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            481..612
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            613..734
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            735..863
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            864..977
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1140
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1291
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1433
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1528
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1626
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1809
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1953
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..3199
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtcacgtgc ccactgacgc ttgactgggg cgcaggtaac ttgtagcagc gaaggttggg
       61 cgctgtagcc cgtggagtcc accgcgagcg gccggggctg ccagagtcct tgcgccagca
      121 ggatgtccct tgctgcaagc tactgtgtta tctgctgcag aaggatagga acctttgttc
      181 cccgatcaaa aagtcacaca tcctggagaa atatccgaaa tattgtaaga tttaccggat
      241 ccctcattgt agggggttct ttatttatta cataccaagt actggccctg aaaaagtctt
      301 taacattgga tactcaggtg gttgaaagag aaaaaatgaa gtcttacatc tatgtgcaca
      361 aagctctcgt ggacagttta gacaaccatg ggattgtttg gcaggcaaga aaagaacttc
      421 acagagcagt aaggaaagtg ttggcggcgg cagccaaggt actgcggagc ccatttgctg
      481 gtcccttcag cacagttgac atagaagatc atgactgtgc agtgtggctg ctcctgagga
      541 agagccggca ggacgatcta gcagcacggc tggaggctgt gcgggaaatg tcagaggctc
      601 accactggca tgactaccag tacaggataa tcgcccaagc ctgtgacccg aggaccctta
      661 ttggtttggc acgaagcaaa gaaagtgatc ttcgcttttt tctcccaccc cctcctttgc
      721 cgtctttaaa agaagactcc tccaccgaag aggaattcgg gcatttgctg gcttctttac
      781 ctcagacaga gcttgatgag tgtctccagt attttacatc attggctctt agtgaaagca
      841 gccagagcct ggccgcacag aagggcggac tatggtgctt tggaggaaac gggcttcctt
      901 acgcagaaag ctttggggaa accccctcag ccacagtgga gatgctctct ctagaagcca
      961 tagtaaagca ctcagagata ccttcacact gtgactacat tgaagcagga gggggcttgc
     1021 aactcctgca gagactctac cagcttcaca aggactgccc caaaatacag agaagcgtcc
     1081 tgaggatcat tggaaacatg gctttgaatg agcatcttca ccctgccatc gtccactcag
     1141 gctgggtctc tctcttggca gaagccttga aatcctgcca cattatggag gcttcccacg
     1201 ctgccagaac cctggctaac ctggaccgag aaactgtgag tgagaaatac caggacggag
     1261 tgtatgtgct ccacccccag tgtcggacaa gtcagcccat taaagccgat gtccttttta
     1321 ttcatggcct tatgggagca gcgtttaaaa cctggcgcca gcatgacagc cagcgggctc
     1381 tgaccgaaaa tgctttggtg gatgaagaca gctacactac atgctggccc aagacatggc
     1441 tggctaagga ctgccccgct cttcgcatca tatctgtgga gtacgacacg agcctcagtg
     1501 actggagggc aaggtgccct atggagagaa agtccattgc attcagaagc aacgaacttc
     1561 tcagcaagct gagagccgct ggcgttgggg agagaccagt gatatgggtc tcacacagca
     1621 tgggaggtct tcttgtcaag aagatgctgt tggaagcctc tcagaagcca gaactgagtg
     1681 ctcttataaa caataccaga gggataattt tctacagtgt ccctcaccac ggatcgcggt
     1741 tggctgaata ctccgttaat attcgatatc ttctcttccc ctctctggaa gtcaaagaac
     1801 tcagcaagga ctctcctgca ctgaagatgc tacaggatga atttctggag cttgtgaaag
     1861 acaaagactt gcaggtgctg aactttgtag aaacacaacc aacatttatc ggcagcatga
     1921 ttaaactgca agtagtgccc gtggagtcag cagatttagg cattggggat ctaattcctg
     1981 tggacgtcaa ccacttgaac atttgcaagc cgaagacaaa ggatgcgttt ttgtaccaac
     2041 gtactctaca gttcatctgt gaaactttag ccagagacct tgaaaactga cagctacatt
     2101 cttccatgtt tttgtgtgaa tacagtgcag gaaacgtggt gttctccatc tcttgttaag
     2161 ctctacgcag ttctgtgcac tcagtgcaca tgtggtgcac acagcagagt gcagctcctc
     2221 acacaagcgc tgggaaatgc ccgagtagac ctggaggtca cagagggagg gttaaattga
     2281 gtttctatgg tttaaaagaa actcctttgc catagggtag ggagcagagc tgctgtggct
     2341 gctgtggcct gaccacctga gcctgtccca gcttacccaa gagtcctgac aggcaaccta
     2401 gcacaccctg agaatgaagt ctggggggaa caagctagaa cttacagaag ctgtgtttga
     2461 cctgggtacc gtgtgctgtg atgtttaact atcaatatgt cagttacaca tttgacactt
     2521 cagaggctcc cgcatgcctg ctcgcacgtg cagaccagtc ttgtacgctt ctgttttttt
     2581 tttttttcat attgctgaga atagttgttt taaatattct ttctagggta ttttaattcg
     2641 ctattcaata atatgctcca gataaggtaa ggatcaggtt atgaacaaac ctatctgaag
     2701 caatcaggga cactaaccac ttatatcaag actctcagat tctctgactc cataaagtac
     2761 atcttccctc atgctccctt ctgagggact tctgcatggg aggataggaa ctcatgctga
     2821 tgacctgttt ttgtgtttga gtaatagcat tattaacatg aaattctgtg tgtgtgtgtg
     2881 tgtccctgtc cctgcatgca tgtgtgctat ggatcaaacc tgaaaccttg tgcatgctag
     2941 ccaagtactg tgttagtaca ctatgttctc agctccaaat ttataccttc gaagaatata
     3001 acttactgat tttggtatat tcagagttgc cagctatgat cactgtccaa tttcagacta
     3061 ttgtatcatc cccaaagacg ctctctcagc agcaggcagt tcccctcctc tgacccaaac
     3121 cccaggaaac accatttcca tcttgtgcat ttgcctaatg gacattcata aagttggtag
     3181 gttcaccttg tcgctctta
//
