LOCUS       NP_001387864             655 aa            linear   ROD 09-APR-2024
DEFINITION  protein SERAC1 [Rattus norvegicus].
ACCESSION   NP_001387864 XP_574308
VERSION     NP_001387864.1
DBSOURCE    REFSEQ: accession NM_001400935.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 655)
  AUTHORS   Wortmann,S.B., Vaz,F.M., Gardeitchik,T., Vissers,L.E.,
            Renkema,G.H., Schuurs-Hoeijmakers,J.H., Kulik,W., Lammens,M.,
            Christin,C., Kluijtmans,L.A., Rodenburg,R.J., Nijtmans,L.G.,
            Grunewald,A., Klein,C., Gerhold,J.M., Kozicz,T., van Hasselt,P.M.,
            Harakalova,M., Kloosterman,W., Baric,I., Pronicka,E., Ucar,S.K.,
            Naess,K., Singhal,K.K., Krumina,Z., Gilissen,C., van Bokhoven,H.,
            Veltman,J.A., Smeitink,J.A., Lefeber,D.J., Spelbrink,J.N.,
            Wevers,R.A., Morava,E. and de Brouwer,A.P.
  TITLE     Mutations in the phospholipid remodeling gene SERAC1 impair
            mitochondrial function and intracellular cholesterol trafficking
            and cause dystonia and deafness
  JOURNAL   Nat Genet 44 (7), 797-802 (2012)
   PUBMED   22683713
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 655)
  AUTHORS   Manabe,R., Tsutsui,K., Yamada,T., Kimura,M., Nakano,I., Shimono,C.,
            Sanzen,N., Furutani,Y., Fukuda,T., Oguri,Y., Shimamoto,K.,
            Kiyozumi,D., Sato,Y., Sado,Y., Senoo,H., Yamashina,S., Fukuda,S.,
            Kawai,J., Sugiura,N., Kimata,K., Hayashizaki,Y. and Sekiguchi,K.
  TITLE     Transcriptome-based systematic identification of extracellular
            matrix proteins
  JOURNAL   Proc Natl Acad Sci U S A 105 (35), 12849-12854 (2008)
   PUBMED   18757743
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Jan 28, 2022 this sequence version replaced XP_574308.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2168461.1,
                                           SRR26643292.605.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..655
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q11"
     Protein         1..655
                     /product="protein SERAC1"
                     /calculated_mol_wt=73581
     Region          397..536
                     /region_name="EstA"
                     /note="Triacylglycerol esterase/lipase EstA, alpha/beta
                     hydrolase fold [Lipid transport and metabolism]; COG1075"
                     /db_xref="CDD:440693"
     CDS             1..655
                     /gene="Serac1"
                     /gene_synonym="RGD1565064"
                     /coded_by="NM_001400935.1:123..2090"
                     /db_xref="GeneID:499015"
                     /db_xref="RGD:1565064"
ORIGIN      
        1 mslaasycvi ccrrigtfvp rskshtswrn irnivrftgs livggslfit yqvlalkksl
       61 tldtqvvere kmksyiyvhk alvdsldnhg ivwqarkelh ravrkvlaaa akvlrspfag
      121 pfstvdiedh dcavwlllrk srqddlaarl eavremseah hwhdyqyrii aqacdprtli
      181 glarskesdl rfflpppplp slkedsstee efghllaslp qteldeclqy ftslalsess
      241 qslaaqkggl wcfggnglpy aesfgetpsa tvemlsleai vkhseipshc dyieaggglq
      301 llqrlyqlhk dcpkiqrsvl riignmalne hlhpaivhsg wvsllaealk schimeasha
      361 artlanldre tvsekyqdgv yvlhpqcrts qpikadvlfi hglmgaafkt wrqhdsqral
      421 tenalvdeds yttcwpktwl akdcpalrii sveydtslsd wrarcpmerk siafrsnell
      481 sklraagvge rpviwvshsm ggllvkkmll easqkpelsa linntrgiif ysvphhgsrl
      541 aeysvniryl lfpslevkel skdspalkml qdeflelvkd kdlqvlnfve tqptfigsmi
      601 klqvvpvesa dlgigdlipv dvnhlnickp ktkdaflyqr tlqficetla rdlen
//
