LOCUS       NM_031837               3754 bp    mRNA    linear   ROD 26-APR-2024
DEFINITION  Rattus norvegicus septin 9 (Septin9), transcript variant 1, mRNA.
ACCESSION   NM_031837
VERSION     NM_031837.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3754)
  AUTHORS   Kan,H.W., Ho,Y.C., Chang,Y.S. and Hsieh,Y.L.
  TITLE     SEPT9 Upregulation in Satellite Glial Cells Associated with
            Diabetic Polyneuropathy in a Type 2 Diabetes-like Rat Model
  JOURNAL   Int J Mol Sci 23 (16), 9372 (2022)
   PUBMED   36012625
  REMARK    GeneRIF: SEPT9 Upregulation in Satellite Glial Cells Associated
            with Diabetic Polyneuropathy in a Type 2 Diabetes-like Rat Model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3754)
  AUTHORS   Bach,S., Paulis,I., Sluiter,N.R., Tibbesma,M., Martin,I., van de
            Wiel,M.A., Tuynman,J.B., Bahce,I., Kazemier,G. and
            Steenbergen,R.D.M.
  TITLE     Detection of colorectal cancer in urine using DNA methylation
            analysis
  JOURNAL   Sci Rep 11 (1), 2363 (2021)
   PUBMED   33504902
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3754)
  AUTHORS   Bai,X., Karasmanis,E.P. and Spiliotis,E.T.
  TITLE     Septin 9 interacts with kinesin KIF17 and interferes with the
            mechanism of NMDA receptor cargo binding and transport
  JOURNAL   Mol Biol Cell 27 (6), 897-906 (2016)
   PUBMED   26823018
  REMARK    GeneRIF: The first evidence of an interaction between septins and a
            nonmitotic kinesin is provided and it is suggested that SEPT9
            modulates the interactions of KIF17 with membrane cargo.
REFERENCE   4  (bases 1 to 3754)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3754)
  AUTHORS   Ghossoub,R., Hu,Q., Failler,M., Rouyez,M.C., Spitzbarth,B.,
            Mostowy,S., Wolfrum,U., Saunier,S., Cossart,P., Jamesnelson,W. and
            Benmerah,A.
  TITLE     Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the
            primary cilium and control ciliary length
  JOURNAL   J Cell Sci 126 (Pt 12), 2583-2594 (2013)
   PUBMED   23572511
REFERENCE   6  (bases 1 to 3754)
  AUTHORS   Nagata,K., Asano,T., Nozawa,Y. and Inagaki,M.
  TITLE     Biochemical and cell biological analyses of a mammalian septin
            complex, Sept7/9b/11
  JOURNAL   J Biol Chem 279 (53), 55895-55904 (2004)
   PUBMED   15485874
  REMARK    GeneRIF: Sept7/9b/11 form a complex that has effects on filament
            elongation, bundling, or disruption
REFERENCE   7  (bases 1 to 3754)
  AUTHORS   Farkas,R.H., Qian,J., Goldberg,J.L., Quigley,H.A. and Zack,D.J.
  TITLE     Gene expression profiling of purified rat retinal ganglion cells
  JOURNAL   Invest Ophthalmol Vis Sci 45 (8), 2503-2513 (2004)
   PUBMED   15277470
REFERENCE   8  (bases 1 to 3754)
  AUTHORS   Surka,M.C., Tsang,C.W. and Trimble,W.S.
  TITLE     The mammalian septin MSF localizes with microtubules and is
            required for completion of cytokinesis
  JOURNAL   Mol Biol Cell 13 (10), 3532-3545 (2002)
   PUBMED   12388755
  REMARK    GeneRIF: These results reveal that MSF is required for the
            completion of cytokinesis and suggest a role that is distinct from
            that of Nedd5.
REFERENCE   9  (bases 1 to 3754)
  AUTHORS   Jackisch,B.O., Hausser,H., Schaefer,L., Kappler,J., Muller,H.W. and
            Kresse,H.
  TITLE     Alternative exon usage of rat septins
  JOURNAL   Biochem Biophys Res Commun 275 (1), 180-188 (2000)
   PUBMED   10944462
REFERENCE   10 (bases 1 to 3754)
  AUTHORS   Fung,E.T. and Scheller,R.H.
  TITLE     Identification of a novel alternatively spliced septin
  JOURNAL   FEBS Lett 451 (2), 203-208 (1999)
   PUBMED   10371165
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF173899.1, CK364935.1, AF180525.1, DY311267.1, CO403626.1,
            BI284394.1 and AW534888.1.
            
            On Jan 15, 2008 this sequence version replaced NM_031837.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF173899.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132294, SAMD00132299
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               AF173899.1         1-311
            312-850             CK364935.1         136-674
            851-1901            AF180525.1         130-1180
            1902-2559           DY311267.1         57-714
            2560-3177           CO403626.1         80-697
            3178-3730           BI284394.1         14-566              c
            3731-3754           AW534888.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..3754
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.2"
     gene            1..3754
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /note="septin 9"
                     /db_xref="GeneID:83788"
                     /db_xref="RGD:708523"
     exon            1..313
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     CDS             259..1989
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /note="isoform 1 is encoded by transcript variant 1;
                     E-septin; SLP; eighth septin; septin-like protein; septin
                     9-like 1; septin-9-like; MLL septin-like fusion"
                     /codon_start=1
                     /product="septin-9 isoform 1"
                     /protein_id="NP_114025.2"
                     /db_xref="GeneID:83788"
                     /db_xref="RGD:708523"
                     /translation="MSDPAVNAQLDGIISDFEALKRSFEVEEIEPPNSTPPRRVQTPL
                     LRATVASSSQKFQDLGVKNSEPAARLVDTLSQRSPKPSLRRVDLAGAKAPEPMSRRTE
                     LSIDISSKQVESTASTPGPSRFGLKRAEVLGHKTPEPVPRRTEITIVKPQESGLRRVE
                     TPASKAPEGSAMPVTDAAPKRVEIQVPKPAEAPNCPLPPQTLENSEAPMSQLQSRLEP
                     RPPVTEVPYRNQEDSEVAPSCVGDMADNPRDAMLKQAPVSRNEKAPVDFGYVGIDSIL
                     EQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPISEERIPKTIEIK
                     SITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKK
                     RIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVYFKQ
                     RITSDLLSNGIDVYPQKEFDEDAEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRK
                     TKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSNIHFEAYRVKRLNEGNSAMANG
                     IEKEPETQEM"
     exon            314..952
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1144
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1273
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1355
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1493
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1611
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1612..1707
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1708..1804
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1856
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..3738
                     /gene="Septin9"
                     /gene_synonym="Eseptin; Msf; Sept9; Septin9l1; Slpa"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccaggccc agttttgaca ggcgggcgca acagccagtg ccgagtcgcg gaggccggct
       61 ggggtgcggg aacctgatcc agccgggagg cgggggcggg gcgggggccc gggtgcttgg
      121 ggaggggccg gcgcccgcct tcctccccca ttcattcagc cgaccgtggg ggccgagggg
      181 ctcgtgcggc cagctcggca ccgggagcgg gagcgcgcag ggcccggtct ccgcgggact
      241 ccctgcgcac cagccaccat gtccgacccc gcggtcaacg cacagctgga cgggatcatt
      301 tcagactttg aagccttaaa gagatcgttt gaagtcgagg agattgagcc gccgaactcc
      361 acaccacccc ggagggtcca gacccctctg ctccgagcca cggtggccag ctccagccag
      421 aaattccagg acctgggggt gaagaactca gagcctgctg ctcgccttgt agacaccctg
      481 agccagcgct cccccaagcc ttccctgcgg agggtggacc tggcaggggc caaggcgcct
      541 gagcccatgt ctcgccgcac cgagctctcc attgatatct cctccaagca ggtggagagc
      601 acagcctcaa cccccgggcc ctcacggttc gggcttaaga gggccgaagt cctgggccat
      661 aagacaccag agcctgtccc ccggaggacg gaaatcacca ttgtcaagcc tcaagagtca
      721 gggctccgca gggtagagac ccctgcctcc aaggctcccg agggctctgc catgcctgtc
      781 accgatgcag cccccaagag ggtagagatc caggtgccca agccagcgga ggcacccaac
      841 tgcccgctcc caccccagac cctggagaac tccgaggccc cgatgtctca gctgcagagc
      901 aggctggagc ccaggccccc tgtgactgag gtcccatatc ggaaccagga agactccgag
      961 gtggctccca gctgtgttgg cgacatggct gacaacccta gagatgccat gctcaagcaa
     1021 gcgcccgtgt cgaggaatga gaaggccccc gtggactttg gctatgtggg gatcgactcc
     1081 atcctggagc agatgcgcag gaaggctatg aaacagggct tcgagttcaa catcatggtg
     1141 gttgggcaga gtggcctcgg gaagtccacc ttaatcaaca ccctcttcaa gtccaaaatc
     1201 agccggaagt cggtgcaacc catctcggag gagcgtatcc ccaagacgat tgaaatcaag
     1261 tccatcactc acgatattga agagaagggg gtccgaatga agttgacagt gattgacact
     1321 ccaggcttcg gggaccacat caacaatgag aactgctggc agcctatcat gaagtttatc
     1381 aatgaccagt atgagaagta cctccaggag gaagtcaata tcaaccggaa gaaacgcatc
     1441 cctgacaccc gcgtccactg ctgcctctac ttcatcccag ccaccggcca ctcactcagg
     1501 cccctggaca ttgagttcat gaagcgccta agcaaggtgg tgaacatagt ccccgtcatt
     1561 gccaaggctg acacgctgac cctggaggag agggtctact tcaaacagcg gatcacctca
     1621 gacctgctgt ccaacggtat tgacgtgtac ccccagaagg agtttgatga ggacgcagag
     1681 gaccgactgg tgaacgagaa gtttcgggag atgatcccat ttgccgtggt gggcagcgac
     1741 catgagtatc aagtcaatgg caagaggatt ctgggaagga agaccaagtg gggcaccatt
     1801 gaagttgaga ataccactca ctgtgaattt gcctacctgc gggatctcct tatcaggacg
     1861 cacatgcaga acatcaaaga catcaccagc aacatccact tcgaagccta ccgtgtgaaa
     1921 cgcctcaacg agggcaacag tgccatggcc aacgggatcg agaaggagcc ggaaacccag
     1981 gagatgtaga tgcgtcccgc ccctggaccc cacccccaga tcttttcatc atccctggcc
     2041 cacccaccta ccctgtctta ttttatataa ttatctccat ttgtcacctg cctccatctc
     2101 tttccacact ttgccaggta acaagagagg gtttacctcc caagtgtgtt cttattggct
     2161 gcagcatcag ggtgggcggg gctacagcct gggcttgccc ctgtgctcta cttcctcccc
     2221 aagttgtgaa ggctcgacct ggctcagccc ctgaggagtt agaagagcta tgtgtccgtg
     2281 cccgctctga gttcttagct gaatcctgtg ggggccaggt cctaggacgt gcagagaagc
     2341 ccattaagcc acaagacccc atggccagcc tcaagcaggt tagaggctgt accagaggag
     2401 gatggggctg gccaggtagt cctggttccc cacgtacccc tccaggaggc attgctcaca
     2461 gcaccctcag ctgcctgccc ctcaagggaa ctagagacgt cacagccaaa gttgccaatc
     2521 acttagacaa agtgacaacc atgtccctcg aacttgtccc agagcagaaa gtgccttgac
     2581 ccataagaac tagtcgcctc ttcccaaatg tccctttggg tgaaaagcag ggacgtgctg
     2641 gagaggggga aatgtctttt ctccctcacc cttcgattct ctctcccctg tgctgtagat
     2701 agcgctacta cactgggctt taattaaaag agacggagca tgaaaaaggc atcccagccc
     2761 cgctcccaat attaggaagg tcaaagcaag aagatttgtg gaagccatga gggaggaaac
     2821 ctcctgaggg aggaaagctg tggaaggaaa gcacaagggt gcatgggagc tctcctgccc
     2881 aggtgcctcg tttctgtctg gtcctcagtt tggcccaaga tgctctggtt acattggcgc
     2941 tccgttgccc caccctacac accccaccct caagccttga tccagtgact gtactgggtg
     3001 ggagccagaa acctgaccat tttgttatct acacgagcct agacccctgt gccccagaac
     3061 ccatcaagaa tacctgcaaa gagggagaga tgagggggtc agagagggat agtcgggctc
     3121 actcatcttc tctcagaggg aaccattagg gaccagccat gcacagctga ccaaagccat
     3181 gtccttcctg cctgcctacc atgcttgatt gcctctgggg aggagtttgg tgaggttagt
     3241 taggtcggac ccgcttgggg aaggtgcctc tacagacccc gggctagctc tctgcagcct
     3301 agaagtgtag tgggaggggt aggtgtgcag acagatgtga ggagagcatt gttccctgcg
     3361 ttgggcgcct actcacccac ccaagcgtgg aaggcccctc cctcgtcacg ctctacggcc
     3421 gaacagttcg cttgctagct tgccaagttc ttttgccaaa atcaggactt tgaaggaaat
     3481 ctccagcacg ctggacccag ggcaccccgg tcttctctga tcccagtgtc cctggggatt
     3541 tatcagtgac cggtgtcatc aggatgactt tgtgcctctg taaccaggta ttgaaactgt
     3601 tcgtctcacc aggccattcc acgtggccct ttgctggggg cttcctggtg gggggtggaa
     3661 aagtctcttt ttttgtataa ataacaaagt gttgaaatgt atttcctgaa ataaatgttt
     3721 caaatacaaa ctggctcaaa aaaaaaaaaa aaaa
//
