LOCUS       NM_001414347            2673 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus septin 8 (Septin8), transcript variant 1, mRNA.
ACCESSION   NM_001414347 XM_039085932
VERSION     NM_001414347.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2673)
  AUTHORS   Kurkinen,K.M., Marttinen,M., Turner,L., Natunen,T., Makinen,P.,
            Haapalinna,F., Sarajarvi,T., Gabbouj,S., Kurki,M., Paananen,J.,
            Koivisto,A.M., Rauramaa,T., Leinonen,V., Tanila,H., Soininen,H.,
            Lucas,F.R., Haapasalo,A. and Hiltunen,M.
  TITLE     SEPT8 modulates beta-amyloidogenic processing of APP by affecting
            the sorting and accumulation of BACE1
  JOURNAL   J Cell Sci 129 (11), 2224-2238 (2016)
   PUBMED   27084579
REFERENCE   2  (bases 1 to 2673)
  AUTHORS   Ito,H., Atsuzawa,K., Morishita,R., Usuda,N., Sudo,K., Iwamoto,I.,
            Mizutani,K., Katoh-Semba,R., Nozawa,Y., Asano,T. and Nagata,K.
  TITLE     Sept8 controls the binding of vesicle-associated membrane protein 2
            to synaptophysin
  JOURNAL   J Neurochem 108 (4), 867-880 (2009)
   PUBMED   19196426
  REMARK    GeneRIF: These results suggest that Sept8 may participate in the
            process of the SNARE complex formation and subsequent
            neurotransmitter release.
            Erratum:[J Neurochem. 2009 Mar;108(6):1621]
REFERENCE   3  (bases 1 to 2673)
  AUTHORS   Tsang,C.W., Fedchyshyn,M., Harrison,J., Xie,H., Xue,J.,
            Robinson,P.J., Wang,L.Y. and Trimble,W.S.
  TITLE     Superfluous role of mammalian septins 3 and 5 in neuronal
            development and synaptic transmission
  JOURNAL   Mol Cell Biol 28 (23), 7012-7029 (2008)
   PUBMED   18809578
REFERENCE   4  (bases 1 to 2673)
  AUTHORS   Yamaguchi,Y., Miyagi,Y. and Baba,H.
  TITLE     Two-dimensional electrophoresis with cationic detergents: a
            powerful tool for the proteomic analysis of myelin proteins. Part
            2: analytical aspects
  JOURNAL   J Neurosci Res 86 (4), 766-775 (2008)
   PUBMED   17960831
REFERENCE   5  (bases 1 to 2673)
  AUTHORS   Hara,A., Taguchi,A., Niwa,M., Aoki,H., Yamada,Y., Ito,H.,
            Nagata,K., Kunisada,T. and Mori,H.
  TITLE     Localization of septin 8 in murine retina, and spatiotemporal
            expression of septin 8 in a murine model of photoreceptor cell
            degeneration
  JOURNAL   Neurosci Lett 423 (3), 205-210 (2007)
   PUBMED   17709200
  REMARK    GeneRIF: Septin 8 is present in specific location within retina.
            Disappearance of septin 8 in nuclei of photoreceptor cells is
            concomitant with nuclear DNA fragmentation.
REFERENCE   6  (bases 1 to 2673)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 18, 2022 this sequence version replaced XM_039085932.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1569082.1,
                                           SRR26643298.60435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               JAXUCZ010000010.1  38185457-38185588
            133-253             JAXUCZ010000010.1  38197392-38197512
            254-449             JAXUCZ010000010.1  38199094-38199289
            450-636             JAXUCZ010000010.1  38199612-38199798
            637-798             JAXUCZ010000010.1  38200629-38200790
            799-895             JAXUCZ010000010.1  38201293-38201389
            896-1064            JAXUCZ010000010.1  38201811-38201979
            1065-1197           JAXUCZ010000010.1  38202137-38202269
            1198-1388           JAXUCZ010000010.1  38202390-38202580
            1389-2673           JAXUCZ010000010.1  38213218-38214502
FEATURES             Location/Qualifiers
     source          1..2673
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     gene            1..2673
                     /gene="Septin8"
                     /note="septin 8"
                     /db_xref="GeneID:303135"
                     /db_xref="RGD:1308449"
     exon            1..132
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..1554
                     /gene="Septin8"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="septin-8 isoform 1"
                     /protein_id="NP_001401276.1"
                     /db_xref="GeneID:303135"
                     /db_xref="RGD:1308449"
                     /translation="MAATDLERISNAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQGFS
                     FNILCVGETGIGKSTLMNTLFNTTFETEEASHHEECVRLRPQTYDLQESNVHLKLTIV
                     DAVGFGDQINKDDSYRPIVDYIDTQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPT
                     GHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFP
                     TDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKL
                     REMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQETYEAKRKEFL
                     SELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRIHQEEKRKVEEKRRELE
                     EETNAFNCRKAAMEALQSQALHATSQQPLRKDKDKKNRSDIGAQQSGMSLSSSKVMMT
                     KANVEPLNCSSWWPAIQCCSCLVRDATWREGFL"
     exon            133..253
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
     exon            254..449
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
     exon            450..636
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
     exon            637..798
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
     exon            799..895
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1064
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1197
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1388
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..2673
                     /gene="Septin8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attcagccgc agccgccccg gcggagcgcg tcccgcagcc ggctcgtccc tcccgcggcc
       61 ccggcgctcc ccgcaacccg cccgcccggt gcgcagctcg ccatggcggc caccgacctg
      121 gaacgcatct cgaacgcaga gcctgagccc cggagcctgt ccctgggtgg ccatgtgggc
      181 ttcgacagcc tccctgacca gctggtcagc aagtcagtca ctcagggctt cagcttcaac
      241 attctctgtg tgggggaaac tgggattggc aagtccacac taatgaacac gctcttcaac
      301 acgacctttg agactgaaga agccagtcac catgaagagt gtgtacgcct gcggcctcag
      361 acctatgacc tccaagagag taacgttcat ctcaaactga ccatcgtgga tgctgtgggc
      421 tttggggatc agatcaataa ggatgacagt tacaggccca tagttgatta catcgacacg
      481 cagtttgaaa actatctaca ggaggagttg aagattcgcc gttccctctt tgactaccat
      541 gacacgagga tccacgtttg cctctacttt atcacaccca ccgggcactc cctgaagtcc
      601 ctggatctgg tgaccatgaa gaaactagat agcaaggtga acataatccc catcattgcc
      661 aaggctgaca ccatctccaa gagcgagctc cacaagttca agatcaagat catgggtgag
      721 ctggtcagca atggagtcca gatctaccag tttcccaccg acgatgaggc tgtcgccgag
      781 attaatgcgg tcatgaatgc acacttgcct tttgccgtgg tgggcagcac agaggaggtg
      841 aaggtgggga acaagctggt tcgagcacga cagtacccct ggggcgtggt gcaggtggag
      901 aacgagaacc actgtgactt cgtgaagttg cgggagatgt tgatccgggt gaacatggag
      961 gacctgcgtg agcagaccca cagtcggcac tacgagctct accggcgctg caagttggag
     1021 gagatgggct tccaggacag tgatggtgac agccagccct tcagcctcca agagacgtac
     1081 gaggcaaaga ggaaggagtt cctgagcgag ctacagagga aggaggaaga gatgaggcag
     1141 atgtttgtca acaaagtgaa ggagacagag cttgaattga aggagaagga acgggagctc
     1201 catgagaagt ttgagcacct gaagcggatc caccaggagg agaagcgcaa ggtagaggag
     1261 aagcgcaggg agctggaaga ggagaccaac gccttcaact gccggaaggc agccatggag
     1321 gccctgcagt cacaggcctt acatgccact tcacagcagc ctctgaggaa agacaaggac
     1381 aagaagaaca gatcagatat aggagcacag cagtcgggca tgagcctctc cagctctaag
     1441 gtgatgatga ccaaagcaaa tgtggaaccc ttgaactgca gcagctggtg gcctgccatc
     1501 cagtgctgta gctgcctggt cagggacgcg acgtggaggg aaggattcct ctgaggcaac
     1561 agttcctcca cacgggggcc ggctccggac catcagggcg tggaactgga gaccatgttt
     1621 ttttaatgtt aggacagagg cccctcccct agttttcaca tatcaacgac caaaagtgca
     1681 aacggtttcc gatttccatc agggagcatc tggtgtggcc caaccctttt cattcccaga
     1741 cagtctgatt tgtgacatgg tactctgagg ctaaagtgta tagatggcca tgtttggatt
     1801 ctgagacatg cgaatctact gttaaaggga gcagaggagt tacgtgtaac cgcttgacct
     1861 gagaagaaac caggaacttt gtcaacagca ccagttttcc ataatgaaac tgcccttagt
     1921 gatttaacct tcatgctttg taacagacca aaacgccatg acatttcctc atttgcataa
     1981 ttttgcctta ctaacaagca catcctgaaa gacggcccct attcccccaa ctaaaaccaa
     2041 ccgatacctg atatttttta agtgccagat cagtgcggtc taacgcctca ataaggattg
     2101 tgtgtaggtg aataaagaca gctgagtgaa tgtgtgtaaa gtatagcaaa ggcagacaga
     2161 tatttatata cgatattcat agaatggaaa gttaaatatt tttgcagtgt gtatctaaga
     2221 gagaaactga ccataatagt gccgttcaaa tgtctttgtc aagtgaactc tgtgtccttt
     2281 agacgtgaga atttggtgga agggtgtggg gtataaagat aacatttttt ttccactctt
     2341 ctgtatgttg tgagcctttg tggatcacct cgccgtggtg catgtgcaag gacgtgttgc
     2401 acgcctgtgc cttgcctgtt ctgtgttgta aacagctgtt ccaaaggcac agacgagtct
     2461 cagggagact ctataaactc atgctcatta taatcaagaa atccagcgac gttcccacgt
     2521 ggaggttcta atgaagtctg tccagattag ccaaccccat cctcagcagc tcattcgggg
     2581 tacagctaga gccacacgct ttatgaggtc ttttacacgt ggaattgact gtaaaaaaat
     2641 aaataaataa agaggccaaa gccttccacc atg
//
