LOCUS       NP_001401276             483 aa            linear   ROD 03-APR-2024
DEFINITION  septin-8 isoform 1 [Rattus norvegicus].
ACCESSION   NP_001401276 XP_038941860
VERSION     NP_001401276.1
DBSOURCE    REFSEQ: accession NM_001414347.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 483)
  AUTHORS   Kurkinen,K.M., Marttinen,M., Turner,L., Natunen,T., Makinen,P.,
            Haapalinna,F., Sarajarvi,T., Gabbouj,S., Kurki,M., Paananen,J.,
            Koivisto,A.M., Rauramaa,T., Leinonen,V., Tanila,H., Soininen,H.,
            Lucas,F.R., Haapasalo,A. and Hiltunen,M.
  TITLE     SEPT8 modulates beta-amyloidogenic processing of APP by affecting
            the sorting and accumulation of BACE1
  JOURNAL   J Cell Sci 129 (11), 2224-2238 (2016)
   PUBMED   27084579
REFERENCE   2  (residues 1 to 483)
  AUTHORS   Ito,H., Atsuzawa,K., Morishita,R., Usuda,N., Sudo,K., Iwamoto,I.,
            Mizutani,K., Katoh-Semba,R., Nozawa,Y., Asano,T. and Nagata,K.
  TITLE     Sept8 controls the binding of vesicle-associated membrane protein 2
            to synaptophysin
  JOURNAL   J Neurochem 108 (4), 867-880 (2009)
   PUBMED   19196426
  REMARK    GeneRIF: These results suggest that Sept8 may participate in the
            process of the SNARE complex formation and subsequent
            neurotransmitter release.
            Erratum:[J Neurochem. 2009 Mar;108(6):1621]
REFERENCE   3  (residues 1 to 483)
  AUTHORS   Tsang,C.W., Fedchyshyn,M., Harrison,J., Xie,H., Xue,J.,
            Robinson,P.J., Wang,L.Y. and Trimble,W.S.
  TITLE     Superfluous role of mammalian septins 3 and 5 in neuronal
            development and synaptic transmission
  JOURNAL   Mol Cell Biol 28 (23), 7012-7029 (2008)
   PUBMED   18809578
REFERENCE   4  (residues 1 to 483)
  AUTHORS   Yamaguchi,Y., Miyagi,Y. and Baba,H.
  TITLE     Two-dimensional electrophoresis with cationic detergents: a
            powerful tool for the proteomic analysis of myelin proteins. Part
            2: analytical aspects
  JOURNAL   J Neurosci Res 86 (4), 766-775 (2008)
   PUBMED   17960831
REFERENCE   5  (residues 1 to 483)
  AUTHORS   Hara,A., Taguchi,A., Niwa,M., Aoki,H., Yamada,Y., Ito,H.,
            Nagata,K., Kunisada,T. and Mori,H.
  TITLE     Localization of septin 8 in murine retina, and spatiotemporal
            expression of septin 8 in a murine model of photoreceptor cell
            degeneration
  JOURNAL   Neurosci Lett 423 (3), 205-210 (2007)
   PUBMED   17709200
  REMARK    GeneRIF: Septin 8 is present in specific location within retina.
            Disappearance of septin 8 in nuclei of photoreceptor cells is
            concomitant with nuclear DNA fragmentation.
REFERENCE   6  (residues 1 to 483)
  AUTHORS   Werner,H.B., Kuhlmann,K., Shen,S., Uecker,M., Schardt,A.,
            Dimova,K., Orfaniotou,F., Dhaunchak,A., Brinkmann,B.G., Mobius,W.,
            Guarente,L., Casaccia-Bonnefil,P., Jahn,O. and Nave,K.A.
  TITLE     Proteolipid protein is required for transport of sirtuin 2 into CNS
            myelin
  JOURNAL   J Neurosci 27 (29), 7717-7730 (2007)
   PUBMED   17634366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Nov 18, 2022 this sequence version replaced XP_038941860.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR22582416.1569082.1,
                                           SRR26643298.60435.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..483
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q22"
     Protein         1..483
                     /product="septin-8 isoform 1"
                     /calculated_mol_wt=55675
     Region          41..309
                     /region_name="CDC_Septin"
                     /note="CDC/Septin GTPase family; cd01850"
                     /db_xref="CDD:206649"
     Site            51..58
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206649"
     Site            order(53..59,103,106,186..187,189,241..242)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206649"
     Site            78..86
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206649"
     Site            80
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206649"
     Site            103..106
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206649"
     Site            order(105..143,145..152)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206649"
     Site            186..189
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206649"
     Site            241..243
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206649"
     CDS             1..483
                     /gene="Septin8"
                     /coded_by="NM_001414347.1:103..1554"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:303135"
                     /db_xref="RGD:1308449"
ORIGIN      
        1 maatdleris naepeprsls lgghvgfdsl pdqlvsksvt qgfsfnilcv getgigkstl
       61 mntlfnttfe teeashheec vrlrpqtydl qesnvhlklt ivdavgfgdq inkddsyrpi
      121 vdyidtqfen ylqeelkirr slfdyhdtri hvclyfitpt ghslksldlv tmkkldskvn
      181 iipiiakadt iskselhkfk ikimgelvsn gvqiyqfptd deavaeinav mnahlpfavv
      241 gsteevkvgn klvrarqypw gvvqvenenh cdfvklreml irvnmedlre qthsrhyely
      301 rrckleemgf qdsdgdsqpf slqetyeakr keflselqrk eeemrqmfvn kvketelelk
      361 ekerelhekf ehlkrihqee krkveekrre leeetnafnc rkaamealqs qalhatsqqp
      421 lrkdkdkknr sdigaqqsgm slssskvmmt kanveplncs swwpaiqccs clvrdatwre
      481 gfl
//
