LOCUS       NM_001113740            2462 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Rattus norvegicus septin 7 (Septin7), transcript variant 2, mRNA.
ACCESSION   NM_001113740
VERSION     NM_001113740.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2462)
  AUTHORS   Yadav,S., Oses-Prieto,J.A., Peters,C.J., Zhou,J., Pleasure,S.J.,
            Burlingame,A.L., Jan,L.Y. and Jan,Y.N.
  TITLE     TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine
            Maturation through Septin7 Phosphorylation
  JOURNAL   Neuron 93 (2), 379-393 (2017)
   PUBMED   28065648
REFERENCE   2  (bases 1 to 2462)
  AUTHORS   Kuo,Y.C., Shen,Y.R., Chen,H.I., Lin,Y.H., Wang,Y.Y., Chen,Y.R.,
            Wang,C.Y. and Kuo,P.L.
  TITLE     SEPT12 orchestrates the formation of mammalian sperm annulus by
            organizing core octameric complexes with other SEPT proteins
  JOURNAL   J Cell Sci 128 (5), 923-934 (2015)
   PUBMED   25588830
REFERENCE   3  (bases 1 to 2462)
  AUTHORS   Ewers,H., Tada,T., Petersen,J.D., Racz,B., Sheng,M. and Choquet,D.
  TITLE     A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks
  JOURNAL   PLoS One 9 (12), e113916 (2014)
   PUBMED   25494357
  REMARK    GeneRIF: show that diffusion of receptors and bulk membrane, but
            not cytoplasmic proteins, is slower in spines bearing Sept7 at
            their neck. Finally, when Sept7 expression was suppressed by RNA
            interference, membrane molecules explored larger membrane areas.
            Our findings indicate that Sept7 regulates membrane protein access
            to spines
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2462)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2462)
  AUTHORS   Menon,M.B., Sawada,A., Chaturvedi,A., Mishra,P.,
            Schuster-Gossler,K., Galla,M., Schambach,A., Gossler,A.,
            Forster,R., Heuser,M., Kotlyarov,A., Kinoshita,M. and Gaestel,M.
  TITLE     Genetic deletion of SEPT7 reveals a cell type-specific role of
            septins in microtubule destabilization for the completion of
            cytokinesis
  JOURNAL   PLoS Genet 10 (8), e1004558 (2014)
   PUBMED   25122120
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2462)
  AUTHORS   Nagata,K., Asano,T., Nozawa,Y. and Inagaki,M.
  TITLE     Biochemical and cell biological analyses of a mammalian septin
            complex, Sept7/9b/11
  JOURNAL   J Biol Chem 279 (53), 55895-55904 (2004)
   PUBMED   15485874
  REMARK    GeneRIF: Sept7/9b/11 form a complex that has effects on filament
            elongation, bundling, or disruption.
REFERENCE   7  (bases 1 to 2462)
  AUTHORS   Peng,X.R., Jia,Z., Zhang,Y., Ware,J. and Trimble,W.S.
  TITLE     The septin CDCrel-1 is dispensable for normal development and
            neurotransmitter release
  JOURNAL   Mol Cell Biol 22 (1), 378-387 (2002)
   PUBMED   11739749
REFERENCE   8  (bases 1 to 2462)
  AUTHORS   Kinoshita,A., Noda,M. and Kinoshita,M.
  TITLE     Differential localization of septins in the mouse brain
  JOURNAL   J Comp Neurol 428 (2), 223-239 (2000)
   PUBMED   11064363
REFERENCE   9  (bases 1 to 2462)
  AUTHORS   Walikonis,R.S., Jensen,O.N., Mann,M., Provance,D.W. Jr.,
            Mercer,J.A. and Kennedy,M.B.
  TITLE     Identification of proteins in the postsynaptic density fraction by
            mass spectrometry
  JOURNAL   J Neurosci 20 (11), 4069-4080 (2000)
   PUBMED   10818142
REFERENCE   10 (bases 1 to 2462)
  AUTHORS   Nakatsuru,S., Sudo,K. and Nakamura,Y.
  TITLE     Molecular cloning of a novel human cDNA homologous to CDC10 in
            Saccharomyces cerevisiae
  JOURNAL   Biochem Biophys Res Commun 202 (1), 82-87 (1994)
   PUBMED   8037772
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA512303.1, EV764168.1 and BC128738.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128738.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                CA512303.1         1-59
            60-102              EV764168.1         32-74
            103-1688            BC128738.1         1-1586
            1689-2462           BC128738.1         1588-2361
FEATURES             Location/Qualifiers
     source          1..2462
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q13"
     gene            1..2462
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="septin 7"
                     /db_xref="GeneID:64551"
                     /db_xref="RGD:620469"
     exon            1..186
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     CDS             126..1439
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /note="isoform b is encoded by transcript variant 2; CDC10
                     protein homolog; CDC10 (cell division cycle 10,
                     S.cerevisiae, homolog)"
                     /codon_start=1
                     /product="septin-7 isoform b"
                     /protein_id="NP_001107212.1"
                     /db_xref="GeneID:64551"
                     /db_xref="RGD:620469"
                     /translation="MSVSARSAAAEERSVNCSTMVAQPKNLEGYVGFANLPNQVYRKS
                     VKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKE
                     GGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQC
                     CLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEH
                     KIKIYEFPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVEN
                     GEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKS
                     PLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEA
                     QHKELEEKRRQFEEEKANWEAQQRILEQQNSSRTLEKNKKKGKIF"
     exon            187..191
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            192..294
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            295..401
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            402..502
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            503..637
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            638..755
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            756..848
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            849..945
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            946..997
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1123
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1124..1259
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1399
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..2462
                     /gene="Septin7"
                     /gene_synonym="Cdc10; Sept7"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccgcctgctg ccgtgtgcgt aagtggggca gtgacgctgg gcggctacgc tgcggaatcg
       61 gcgtaggagg ttttggagaa tccgccggct gcgacgcgcc ggggctggtc gcggaggggg
      121 aggggatgtc ggtcagtgcg agatccgctg ctgctgagga gaggagcgtc aactgcagca
      181 ccatggtagc tcaaccgaag aaccttgagg gctatgtggg atttgccaac ctcccaaatc
      241 aagtgtacag aaaatcggtg aaaagaggat ttgaattcac tcttatggta gtaggtgaat
      301 ctggactggg aaagtcgaca ttaatcaact cattattcct cacagatttg tattctccag
      361 agtatccagg accttctcat agaatcaaaa agactgttca ggtggagcaa tccaaagttt
      421 taatcaaaga aggtggcgtt cagttgctgc tgacgatagt tgatactccg ggatttggag
      481 atgcagtgga taatagtaat tgctggcagc ctgttatcga ctacattgat agtaaatttg
      541 aagattactt aaatgcagaa tctcgagtga acagacgaca gatgcctgat aacagggtgc
      601 agtgttgttt atacttcatt gctccttcag gacatggact taaaccattg gatattgagt
      661 ttatgaaacg tttgcatgaa aaagtgaata tcattccttt aattgccaaa gcagacacac
      721 ttacaccaga ggaatgccaa cagtttaaaa agcagataat gaaagaaatc caagaacata
      781 aaattaaaat atatgaattt ccagaaacgg atgatgaaga agagaataag ctggttaaga
      841 agataaagga ccgtttacct cttgctgtgg tgggtagtaa tactatcatt gaagttaatg
      901 gcaaaagagt cagaggaagg cagtatcctt ggggtgtggc tgaagttgaa aatggtgagc
      961 attgtgattt tacaattcta agaaatatgt tgatacgaac acacatgcag gacttgaaag
     1021 atgttaccaa taacgtacac tatgagaact acagaagcag aaaactagca gcagtgacct
     1081 acaatggagt agataacaac aagaacaaag ggcaacttac caagagccct ctggcgcaga
     1141 tggaggagga gagaagggag cacgtggcca agatgaagaa gatggagatg gagatggagc
     1201 aggtgtttga gatgaaggtc aaggaaaaag ttcaaaagct gaaggactct gaagccgagc
     1261 tccagcggcg ccatgagcaa atgaaaaaga atttagaagc acagcacaaa gaattagagg
     1321 aaaaacgtcg tcagtttgaa gaagaaaaag caaactggga agctcaacaa cgtattttag
     1381 agcaacagaa ttcttcaaga accttggaaa agaacaagaa gaaaggcaag atcttttaaa
     1441 ctctattgac caccagttat gtattagttg ccaatacgcc agcttggaca tcagtgtttg
     1501 ttggatccgt ttgaccaatt tgcaccaatt ttatccataa tgatggattt aacagcatga
     1561 caaaaattat ttttttgttg ttgttctcga aggagattaa gatgccttga attgtctagg
     1621 atattgtgta cttagaaatt aacagctcta agtacctttc tacatttttt cttttttttt
     1681 ttttttttaa attaaaaaga tgtcttcagt ttaatgcaag aaaacatttt actgttgtac
     1741 aatcatgttc tggtggtttg attgtttaca gaatattcta aaataaaagg actctggaag
     1801 gttttcattg aggataaatt gccataatat gatgcaaact atgctactct atgataatta
     1861 taatacagag gttccattcg atgcagccta tacaataatg tatttagtct aacacagtgg
     1921 accctatttt ttgacacttc cattgtttaa aagtacacat ggaaaaaacc tatatgctta
     1981 cagtgcacct agagcttttt ataacagcct tttttgttgt ttgttttgga ttctttaaat
     2041 atatatatat atatattatt ctcgtttagt acccctttag ccagaatctc attactgctt
     2101 catttttgta ataacattta atttagatat tttccatgta ttggccctgc taaaatagaa
     2161 gatagcatct ttcatatggt agaaaccaac gaggaaactt tactttaact ccctttttac
     2221 attttatggt aagtagcagg aggaaaaatg catttgtaga tcatttctag gcaaattgtg
     2281 aagtttacga ccagcctgtt tctacctata ctcagtcttg ttttactaga aatgggaatc
     2341 atggcctctt gaagagaaaa aaagtcacca ttctgcattt agctgtatct atatattgca
     2401 tacctgtatt ttttgtttgt attgtaaaaa aaattcacat aataaacaat gttgtgacgt
     2461 aa
//
