LOCUS       NM_001173429            2088 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus septin 6 (Septin6), mRNA.
ACCESSION   NM_001173429 XM_001077761 XM_002727663
VERSION     NM_001173429.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2088)
  AUTHORS   Fan Y, Du Z, Steib CJ, Ding Q, Lu P, Tian D and Liu M.
  TITLE     Effect of SEPT6 on the biological behavior of hepatic stellate
            cells and liver fibrosis in rats and its mechanism
  JOURNAL   Lab Invest 99 (1), 17-36 (2019)
   PUBMED   30315255
  REMARK    GeneRIF: regulates various biological behaviors in hepatic stellate
            cells through TGF-beta1/Smad, mitogen-activated protein kinases and
            phosphatidylinositol-3-kinase/protein kinase B signaling pathways,
            thus promoting liver fibrosis
REFERENCE   2  (bases 1 to 2088)
  AUTHORS   Kuo YC, Shen YR, Chen HI, Lin YH, Wang YY, Chen YR, Wang CY and Kuo
            PL.
  TITLE     SEPT12 orchestrates the formation of mammalian sperm annulus by
            organizing core octameric complexes with other SEPT proteins
  JOURNAL   J Cell Sci 128 (5), 923-934 (2015)
   PUBMED   25588830
REFERENCE   3  (bases 1 to 2088)
  AUTHORS   Gilden JK, Peck S, Chen YC and Krummel MF.
  TITLE     The septin cytoskeleton facilitates membrane retraction during
            motility and blebbing
  JOURNAL   J Cell Biol 196 (1), 103-114 (2012)
   PUBMED   22232702
REFERENCE   4  (bases 1 to 2088)
  AUTHORS   Cho SJ, Lee H, Dutta S, Song J, Walikonis R and Moon IS.
  TITLE     Septin 6 regulates the cytoarchitecture of neurons through
            localization at dendritic branch points and bases of protrusions
  JOURNAL   Mol Cells 32 (1), 89-98 (2011)
   PUBMED   21544625
  REMARK    GeneRIF: Septin 6 regulates the cytoarchitecture of neurons through
            localization at dendritic branch points and bases of protrusions.
REFERENCE   5  (bases 1 to 2088)
  AUTHORS   Tsang CW, Fedchyshyn M, Harrison J, Xie H, Xue J, Robinson PJ, Wang
            LY and Trimble WS.
  TITLE     Superfluous role of mammalian septins 3 and 5 in neuronal
            development and synaptic transmission
  JOURNAL   Mol Cell Biol 28 (23), 7012-7029 (2008)
   PUBMED   18809578
REFERENCE   6  (bases 1 to 2088)
  AUTHORS   Kinoshita A, Noda M and Kinoshita M.
  TITLE     Differential localization of septins in the mouse brain
  JOURNAL   J Comp Neurol 428 (2), 223-239 (2000)
   PUBMED   11064363
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169051.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_001077761.2, XM_002727663.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169051.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2088
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..2088
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /note="septin 6"
                     /db_xref="GeneID:691335"
                     /db_xref="RGD:1585082"
     exon            1..82
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..1336
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /codon_start=1
                     /product="septin-6"
                     /protein_id="NP_001166900.1"
                     /db_xref="GeneID:691335"
                     /db_xref="RGD:1585082"
                     /translation="MAAADIARQVGEDCRTVPLAGHVGFDSLPDQLVNKSVSQGFCFN
                     ILCVGETGLGKSTLMDTLFNTKFEGEPTTHTQPGVQLRSSTYDLQESNVGLKLTIVST
                     VGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRVLHSYHDSRIHACLYFIAPTGH
                     SLKSLDLVTMKKLDSKVNIIPIIAKSDAISKSELAKFKIKITSELVSNGVQIYQFPTD
                     DESVAEINGTMNAHLPFAVVGSTEEVKIGNKMMRARQYPWGTVQVENEAHCDFVKLRE
                     MLIRINMEDLREQTHARHYELYRRCKLEEMGFKDTDPDSKPFSLQETYEAKRNEFLGE
                     LQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKFDRLKKLHQEEKKKLEDKKKCLDEE
                     MNAFKQRKAAAELLQSQGSQAGGSQTLKRDKEKKN"
     exon            83..197
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            198..393
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            394..580
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            581..742
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            743..839
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1008
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1141
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1332
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1333..1377
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..2064
                     /gene="Septin6"
                     /gene_synonym="Sept6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagctccc gttgtggagg cacccgtagc agccctggcg gaccaaggag cgatggcagc
       61 ggccgatata gctcgccagg tgggcgaaga ctgtcgaact gtccccctgg ctggacatgt
      121 ggggtttgac agcttgcctg accagctggt gaataagtca gtcagccagg gcttctgctt
      181 caacatcctg tgcgtggggg agacaggttt gggcaagtcc accctcatgg ataccctgtt
      241 caacaccaag tttgaagggg agccaacgac tcacacacag ccaggtgttc agctccggtc
      301 cagtacctac gacctccagg agagcaatgt ggggttgaag ctcacaattg tgagcactgt
      361 aggctttggg gaccagatca acaaggagga cagctacaag cccatcgtgg aattcattga
      421 tgctcagttc gaggcctacc tacaggagga gctgaagatc cggagagtac tgcactccta
      481 ccatgactcc cgaatccacg cctgcttgta tttcattgcc ccgacagggc attcgcttaa
      541 gtctctggac ctagtaacca tgaagaagct ggatagtaag gtgaacatca ttcccatcat
      601 tgccaagtca gatgccattt ctaagagtga gctggcaaag ttcaagatca aaatcaccag
      661 tgagcttgtg agcaatggag tccagatcta tcagttcccc acagatgatg agtcggtggc
      721 cgagatcaat ggaaccatga atgcccacct gccgtttgct gttgttggca gcacagaaga
      781 agtgaagata gggaacaaga tgatgcgagc tcggcagtat ccttggggga ccgtgcaggt
      841 tgaaaatgag gcccactgcg actttgtgaa gctgcgggag atgctgattc gaatcaacat
      901 ggaggatctg cgggagcaga cccatgcccg gcactacgaa ttgtaccgcc gctgtaagct
      961 ggaggagatg ggcttcaagg acaccgaccc tgacagcaaa ccattcagtt tacaggagac
     1021 atatgaggcg aaaagaaacg agttcctggg ggagctccag aagaaagaag aggagatgag
     1081 acagatgttt gtccagagag tcaaagagaa ggaagcagag ctcaaggagg ctgaaaaaga
     1141 gctgcatgag aagtttgacc gtctgaagaa actgcaccag gaggagaaga agaagctgga
     1201 agataagaag aagtgtctgg atgaggaaat gaatgctttc aagcagagaa aggcggcagc
     1261 cgagctgctc cagtctcagg gctctcaggc tggaggctcg cagactctga aaagagacaa
     1321 agagaagaag aattaaccct gctgtttgct gcatgctgca tgacacccag ggtcctgttt
     1381 gggcttcctg tagacgcgct ctttcctgtg caacagagct gggcctccct ctctttattt
     1441 cccccttaac atgcttaggg ggcatacacc ccatgccttc cccttttctt cctgcgaatg
     1501 tttatagaag cctgagagtc aaatgacgat gtctggcccc tgaccaagaa gccaacaatc
     1561 acgtggcttg gagatacatt ccatacctca gtccctctcc tagtaccctc agccatatgc
     1621 acccccactt ccccaatcta tcttcgccag actgtcatgt gtttacgggt tgctgtttgc
     1681 cacattttat gtactccatt tgaattccac tgatacttgt ttccttgaag tatttccagc
     1741 cactgactgg ataagactcc tgcatccttg tcactgggat tgttctccca ctcctaatgc
     1801 caggagcata gcccctcatc acaggttcta aaagaattgc tggagatgcc tatttcttct
     1861 actatcttag cccagccctt tctcgattcc atttcctcgg aatcactttg cacaagctat
     1921 gttaaaagtc agccacacat ttatttacac caagcccttc ctatacaaaa tacaactgct
     1981 ggggcagaca gtctatactc cccctctgta attctgggta cctcacagat acagaaggga
     2041 caataaacca gaatgtcatt accaaaaaaa aaaaaaaaaa aaaaaaaa
//
