LOCUS       NM_053931               3663 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Rattus norvegicus septin 5 (Septin5), mRNA.
ACCESSION   NM_053931
VERSION     NM_053931.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3663)
  AUTHORS   Rahimmi,A., Peluso,I., Rajabi,A. and Hassanzadeh,K.
  TITLE     miR-185 and SEPT5 Genes May Contribute to Parkinson's Disease
            Pathophysiology
  JOURNAL   Oxid Med Cell Longev 2019, 5019815 (2019)
   PUBMED   31814881
  REMARK    GeneRIF: The expression levels of miR-185, SEPT5, LRRK2, and PARK2
            genes were measured at a mRNA level in dopaminergic areas of rats'
            brains and SHSY-5Y cells using the SYBR Green Real-Time PCR Method.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3663)
  AUTHORS   Wilhelm,B.G., Mandad,S., Truckenbrodt,S., Krohnert,K., Schafer,C.,
            Rammner,B., Koo,S.J., Classen,G.A., Krauss,M., Haucke,V., Urlaub,H.
            and Rizzoli,S.O.
  TITLE     Composition of isolated synaptic boutons reveals the amounts of
            vesicle trafficking proteins
  JOURNAL   Science 344 (6187), 1023-1028 (2014)
   PUBMED   24876496
REFERENCE   3  (bases 1 to 3663)
  AUTHORS   Corominas,R., Yang,X., Lin,G.N., Kang,S., Shen,Y., Ghamsari,L.,
            Broly,M., Rodriguez,M., Tam,S., Wanamaker,S.A., Fan,C., Yi,S.,
            Tasan,M., Lemmens,I., Kuang,X., Zhao,N., Malhotra,D.,
            Michaelson,J.J., Vacic,V., Calderwood,M.A., Roth,F.P.,
            Tavernier,J., Horvath,S., Salehi-Ashtiani,K., Korkin,D., Sebat,J.,
            Hill,D.E., Hao,T., Vidal,M. and Iakoucheva,L.M.
  TITLE     Protein interaction network of alternatively spliced isoforms from
            brain links genetic risk factors for autism
  JOURNAL   Nat Commun 5, 3650 (2014)
   PUBMED   24722188
  REMARK    Erratum:[Nat Commun. 2023 Feb 2;14(1):569. doi:
            10.1038/s41467-023-36264-y.. PMID: 36732511]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3663)
  AUTHORS   Harper,K.M., Hiramoto,T., Tanigaki,K., Kang,G., Suzuki,G.,
            Trimble,W. and Hiroi,N.
  TITLE     Alterations of social interaction through genetic and environmental
            manipulation of the 22q11.2 gene Sept5 in the mouse brain
  JOURNAL   Hum Mol Genet 21 (15), 3489-3499 (2012)
   PUBMED   22589251
REFERENCE   5  (bases 1 to 3663)
  AUTHORS   Tsang,C.W., Estey,M.P., DiCiccio,J.E., Xie,H., Patterson,D. and
            Trimble,W.S.
  TITLE     Characterization of presynaptic septin complexes in mammalian
            hippocampal neurons
  JOURNAL   Biol Chem 392 (8-9), 739-749 (2011)
   PUBMED   21767234
  REMARK    GeneRIF: Knockdown of SEPT5 or SEPT7 in developing hippocampal
            neurons impaired axon growth.
REFERENCE   6  (bases 1 to 3663)
  AUTHORS   Macara,I.G., Baldarelli,R., Field,C.M., Glotzer,M., Hayashi,Y.,
            Hsu,S.C., Kennedy,M.B., Kinoshita,M., Longtine,M., Low,C.,
            Maltais,L.J., McKenzie,L., Mitchison,T.J., Nishikawa,T., Noda,M.,
            Petty,E.M., Peifer,M., Pringle,J.R., Robinson,P.J., Roth,D.,
            Russell,S.E., Stuhlmann,H., Tanaka,M., Tanaka,T., Trimble,W.S.,
            Ware,J., Zeleznik-Le,N.J. and Zieger,B.
  TITLE     Mammalian septins nomenclature
  JOURNAL   Mol Biol Cell 13 (12), 4111-4113 (2002)
   PUBMED   12475938
REFERENCE   7  (bases 1 to 3663)
  AUTHORS   Peng,X.R., Jia,Z., Zhang,Y., Ware,J. and Trimble,W.S.
  TITLE     The septin CDCrel-1 is dispensable for normal development and
            neurotransmitter release
  JOURNAL   Mol Cell Biol 22 (1), 378-387 (2002)
   PUBMED   11739749
REFERENCE   8  (bases 1 to 3663)
  AUTHORS   Kinoshita,A., Noda,M. and Kinoshita,M.
  TITLE     Differential localization of septins in the mouse brain
  JOURNAL   J Comp Neurol 428 (2), 223-239 (2000)
   PUBMED   11064363
REFERENCE   9  (bases 1 to 3663)
  AUTHORS   Toda,S., Kajii,Y., Sato,M. and Nishikawa,T.
  TITLE     Reciprocal expression of infant- and adult-preferring transcripts
            of CDCrel-1 septin gene in the rat neocortex
  JOURNAL   Biochem Biophys Res Commun 273 (2), 723-728 (2000)
   PUBMED   10873671
REFERENCE   10 (bases 1 to 3663)
  AUTHORS   Beites,C.L., Xie,H., Bowser,R. and Trimble,W.S.
  TITLE     The septin CDCrel-1 binds syntaxin and inhibits exocytosis
  JOURNAL   Nat Neurosci 2 (5), 434-439 (1999)
   PUBMED   10321247
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Jun 10, 2015 this sequence version replaced NM_053931.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB027143.1, SRR26643298.67652.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               JAXUCZ010000011.1  95877946-95878298
            354-450             JAXUCZ010000011.1  95878938-95879034
            451-537             JAXUCZ010000011.1  95879131-95879217
            538-661             JAXUCZ010000011.1  95879419-95879542
            662-796             JAXUCZ010000011.1  95879633-95879767
            797-914             JAXUCZ010000011.1  95879862-95879979
            915-1016            JAXUCZ010000011.1  95880064-95880165
            1017-1113           JAXUCZ010000011.1  95880705-95880801
            1114-1249           JAXUCZ010000011.1  95880886-95881021
            1250-1352           JAXUCZ010000011.1  95881208-95881310
            1353-3663           JAXUCZ010000011.1  95881428-95883738
FEATURES             Location/Qualifiers
     source          1..3663
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..3663
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /note="septin 5"
                     /db_xref="GeneID:116728"
                     /db_xref="RGD:621763"
     exon            1..353
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1409
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /EC_number="3.1.5.1"
                     /note="peanut-like protein 1; cell division
                     control-related protein 1; peanut-like 1; Platelet
                     glycoprotein Ib beta chain; GP-Ib beta"
                     /codon_start=1
                     /product="septin-5"
                     /protein_id="NP_446383.4"
                     /db_xref="GeneID:116728"
                     /db_xref="RGD:621763"
                     /translation="MDSLAAPQDRLVEQLLSPRTQAQRRLKDIDKQYVGFATLPNQVH
                     RKSVKKGFDFTLMVAGESGLGKSTLVHSLFLTDLYKDRKLLSAEERINQTVEILKHTV
                     DIEEKGVKLKLTIVDTPGFGDAVNNFECWKPITDYVDQQFEQYFRDESGLNRKNIQDN
                     RVHCCLYFISPFGHGLRPVDVGFMKALHEKVNIVPLIAKADCLVPSEIRKLKDRIREE
                     IDKFGIHVYQFPECDSDEDEDFKQQDRELKESAPFAVIGSNTVVEAKGQRVRGRLYPW
                     GIVEVENQAHCDFVKLRNMLIRTHMHDLKDVTCDVHYENYRAHCIQQMTSKLTQDSRM
                     ESPIPILPLPTPDSETEKLIRMKDEELRRMQEMLQKMKQQMQDQ"
     exon            354..450
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            451..537
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            538..661
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            662..796
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            797..914
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1016
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1113
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1249
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1352
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..3663
                     /gene="Septin5"
                     /gene_synonym="CDCrel-1; CDCrel-1A; GPIb-beta; GPIbB;
                     Pnutl1; Sept5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 actggagcgc ctgctgagcc tcgacgcggc cacggctcgc ggctcccggg caaaggcaag
       61 ggaatggctc gcaagacttc tgaggtcagc ggcctaccgg gtgggcgacg ctccccctcc
      121 gggcttcagt tctcgcgtct tcaaaacctg aggcagaaga gggcttaaga gcaaatttac
      181 ccagcgcgag tcgctcgaga tcgctggcct cgactggcct gaccctggtg tagggtcgga
      241 acgaggccgt cagggtctgc ggggtcgccg cgatggactc actggcagca ccccaggacc
      301 gcctggtgga gcagctgctg tcgccgcgca cccaggccca gaggcggctc aaggacatcg
      361 acaagcagta cgttggcttc gctacactgc ccaaccaggt gcaccgcaag tcagtcaaga
      421 agggtttcga cttcacactc atggtagccg gtgagtccgg cctggggaag tctacccttg
      481 tccacagtct cttcctgact gacctgtaca aggaccggaa actgctgagt gctgaggaac
      541 gcatcaacca gacagtagag atcctgaaac acactgttga catcgaggag aagggagtca
      601 agctgaagct caccatcgtg gacacgcccg gctttgggga tgcagtgaac aacttcgagt
      661 gctggaagcc catcactgac tatgtagacc agcagtttga acagtatttc cgtgatgaaa
      721 gcggcctcaa ccgcaagaac atccaggaca accgggtgca ctgctgcctc tacttcatct
      781 cccccttcgg acatggattg aggccagtgg acgtaggctt catgaaggcg ctgcacgaga
      841 aggtgaacat cgttccactc atcgccaaag ccgactgcct ggttcccagt gagatccgga
      901 agctgaagga caggatacga gaggagatcg acaagtttgg gatccacgtg taccagtttc
      961 cagaatgtga ctcagatgaa gatgaagact tcaagcagca ggaccgggaa ctgaaggaaa
     1021 gtgctccctt cgccgttatc ggcagcaaca ctgtggtgga ggccaagggg cagcgggtcc
     1081 gggggcgact gtacccctgg gggatcgtcg aagtggagaa tcaggcgcac tgcgatttcg
     1141 tgaagctacg caacatgctg atccgcacgc acatgcacga cctcaaagac gtgacgtgcg
     1201 atgtgcacta tgagaactac cgtgctcact gcatccagca gatgaccagc aaactcacgc
     1261 aggacagccg catggagagc cccatcccta tcctcccact gcccacacca gattcggaga
     1321 ccgagaagct catcaggatg aaggatgaag agctgaggcg catgcaggag atgttgcaga
     1381 agatgaagca gcaaatgcag gaccagtgac agccgccccg gtccacatcg ccaaggatag
     1441 acagccagtt tccaggctgg cccctcctac ccctggatcc tagactgtcc tggattccac
     1501 cctgggttta tctggatctc agaaggcctg gacctaaccc taatccaaag tggctttgac
     1561 cagactattc agacctagag ccacagagcc acagccccca gatgacccta atttattctc
     1621 agcatccacc cttcccggtc atttatttgt atctgaacca cagtccctcc tcaactcatg
     1681 ccccatccca ccccacacct ccccgcctgt cttaagggaa caagttgtgc ataacctcca
     1741 agatctccct tccaagaaga tcgctgcccg cagcgggcca ataaaccagg gtagaggagg
     1801 gacgtggatg cagaatcttg ggcctgttac ccaagctagt gccgctgatg gagttgggag
     1861 gccctgctct gctggttaca gtgggctatg aaacatatgc taatgtccta ctgagcgtgg
     1921 aagtaggccg gttcctccct tactccaaat catgctctgt tcaggaccag agctggcggg
     1981 ctttggaggc tgaggccctt aggaagaccc cagacctgaa ggcttctggg aggaaggcgg
     2041 ggccgcgatg cgctagaccg ctcgcgcccc ttctgggtct acctaaagga ctccaggggc
     2101 ggcaggaacg gggtgtcccc tacgtcccct atgactactt tcatccaccc ataggtcaag
     2161 gtcttttctt cccagcagct ctgttccgca ggggttccag cccttggcct cctccatctc
     2221 tccacccgca tgattcttcc ccacacaccc catgctccgt tttgttcagt tgtgaatgcc
     2281 gcgtcctgtc ctggtgacag gagaacaaag ttagtgaacg tcgcaccgag tgtccgagtg
     2341 ttccatgagc ccatgggagc gggcgggggc ggaagcccgg gctgcctgcg ggcccaggag
     2401 atagtaccct atctgcctct gcaacgccct tgcgcgccgg ctcggagtta tttctggcca
     2461 ggcggcagaa ctgtggtctg ttgctgtgga gtcaggcagg ctctcgggcc aacgccactc
     2521 cagaacgaag taggcctcca tcctctcgcc atgggctccc gtgagttctg gggtcgggtc
     2581 tgcactttat gggaagagcc acatcagaag gtgtcctagt atgggcagca aaagagcttg
     2641 gctcagaggt ggagggaaac tacagtcagc gctcagggtg gccggggtgg agggacctgc
     2701 ggactcgtgg gacgctggcc ctaggagctg gcgggagcag cgccggcgtt cccaaagatg
     2761 ctcccggctc atcccagcgc ttctcttcca gggccgcgcg gggcgctgag cctgctgctt
     2821 ctgctgctag cgccgcccag ccgcccagcc tctggctgtc ccgcgccatg ccgctgctct
     2881 gagacgcgcg tggactgcgg gcgccgcggg ctgacctggg cctcgctgcc ggctgccttc
     2941 cctcccgaca ctacagaatt ggtgctgacc gacaacaacc tgacggcgct gccgcccggg
     3001 cttctggata cgctgccggc gctgcgcaga gtgcacctgg gcgctaaccc atggcgctgc
     3061 gactgtcgct tattgccgct gcgcgcctgg ctggccggcc gccctgagcg cgagttctac
     3121 cgcgacctgc gctgtgtcgc gcctctggcg ctgcgtggcc gcttgctgcc ctacgtggcg
     3181 gaggatgagc tgcgggccgc atgcgcgccc ggcctacttt gctggggagc tctggtggcg
     3241 cagctagcgc tgctggtcct cgggctgcta cacgcgctgc tgctggcact cctactgagt
     3301 cgcctgcgga ggctacgcgc gcaggcgcgc gctcgctcca cccgcgagtt ctcactcaca
     3361 gccccgctgg tggccgagtc ggccggaggt ggtgcatctt aagaaaggac aggcgcagag
     3421 caacgacgac ctgcaaattt tacaggtccc tgctggagga ccctccgcct tcacctggat
     3481 cggccttggc ctctatcctt gcccaacttc ccagacccaa gctctgcaag cctgaatcca
     3541 catggggtca aactgctgcc agtactacca gaatgaggca accttgagtc ttcagagcct
     3601 agagtgctgg agcagtccag tctcctgcca gactccgcac tgaataaacc tttctcctcc
     3661 tca
//
