LOCUS       NM_019375               2454 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus septin 3 (Septin3), mRNA.
ACCESSION   NM_019375
VERSION     NM_019375.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2454)
  AUTHORS   Tsang,C.W., Fedchyshyn,M., Harrison,J., Xie,H., Xue,J.,
            Robinson,P.J., Wang,L.Y. and Trimble,W.S.
  TITLE     Superfluous role of mammalian septins 3 and 5 in neuronal
            development and synaptic transmission
  JOURNAL   Mol Cell Biol 28 (23), 7012-7029 (2008)
   PUBMED   18809578
REFERENCE   2  (bases 1 to 2454)
  AUTHORS   Maimaitiyiming,M., Kumanogoh,H., Nakamura,S., Nagata,K., Suzaki,T.
            and Maekawa,S.
  TITLE     Biochemical characterization of membrane-associated septin from rat
            brain
  JOURNAL   J Neurochem 106 (3), 1175-1183 (2008)
   PUBMED   18466330
  REMARK    GeneRIF: Septin 3 localizes in the membrane microdomains of the
            synaptic plasma membrane in adult brain and may have important
            roles in the membrane dynamics of neurons.
REFERENCE   3  (bases 1 to 2454)
  AUTHORS   Xue,J., Tsang,C.W., Gai,W.P., Malladi,C.S., Trimble,W.S.,
            Rostas,J.A. and Robinson,P.J.
  TITLE     Septin 3 (G-septin) is a developmentally regulated phosphoprotein
            enriched in presynaptic nerve terminals
  JOURNAL   J Neurochem 91 (3), 579-590 (2004)
   PUBMED   15485489
  REMARK    GeneRIF: Sept3 is a neurone-specific developmentally regulated
            protein highly enriched in nerve terminals which supports a
            secretory role in synaptic vesicle recycling.
REFERENCE   4  (bases 1 to 2454)
  AUTHORS   Xue,J., Milburn,P.J., Hanna,B.T., Graham,M.E., Rostas,J.A. and
            Robinson,P.J.
  TITLE     Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein
            kinase-I in nerve terminals
  JOURNAL   Biochem J 381 (Pt 3), 753-760 (2004)
   PUBMED   15107017
REFERENCE   5  (bases 1 to 2454)
  AUTHORS   Xue,J., Wang,X., Malladi,C.S., Kinoshita,M., Milburn,P.J.,
            Lengyel,I., Rostas,J.A. and Robinson,P.J.
  TITLE     Phosphorylation of a new brain-specific septin, G-septin, by
            cGMP-dependent protein kinase
  JOURNAL   J Biol Chem 275 (14), 10047-10056 (2000)
   PUBMED   10744683
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000007.1.
            
            On Nov 20, 2020 this sequence version replaced NM_019375.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1438976.1, AF111179.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               JAXUCZ010000007.1  115669807-115669962
            157-348             JAXUCZ010000007.1  115674406-115674597
            349-477             JAXUCZ010000007.1  115677649-115677777
            478-559             JAXUCZ010000007.1  115678251-115678332
            560-697             JAXUCZ010000007.1  115679060-115679197
            698-815             JAXUCZ010000007.1  115680751-115680868
            816-911             JAXUCZ010000007.1  115681456-115681551
            912-1011            JAXUCZ010000007.1  115684548-115684647
            1012-1063           JAXUCZ010000007.1  115686952-115687003
            1064-1157           JAXUCZ010000007.1  115687299-115687392
            1158-2454           JAXUCZ010000007.1  115689875-115691171
FEATURES             Location/Qualifiers
     source          1..2454
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q34"
     gene            1..2454
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /note="septin 3"
                     /db_xref="GeneID:56003"
                     /db_xref="RGD:621745"
     exon            1..156
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     CDS             147..1223
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /note="alternatively spliced; P40; G-septin alpha"
                     /codon_start=1
                     /product="neuronal-specific septin-3"
                     /protein_id="NP_062248.2"
                     /db_xref="GeneID:56003"
                     /db_xref="RGD:621745"
                     /translation="MSKGLPEARTDTAMSELVPEPRPKPAVPMKPVSINSNLLGYIGI
                     DTIIEQMRKKTMKTGFDFNIMVVGQSGLGKSTLVNTLFKSQVSRKASSWNREEKIPKT
                     VEIKAIGHVIEEGGVKMKLTVIDTPGFGDQINNENCWEPIEKYINEQYEKFLKEEVNI
                     ARKKRIPDTRVHCCLYFISPTGHSLRPLDLEFMKHLSKVVNVIPVIAKADTMTLEEKS
                     EFKQRVRKELEVNGIEFYPQKEFDEDLEDKTENDKIRQESMPFAVVGSDKEYQVNGKR
                     VLGRKTPWGIIEVENLNHCEFALLRDFVIRTHLQDLKEVTHNIHYETYRAKRLNDNGG
                     LPPGEGLLGTVLPPVPATPCPTAE"
     exon            157..348
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     exon            349..477
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     exon            478..559
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     exon            560..697
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     exon            698..815
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..911
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1011
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1063
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1157
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..2454
                     /gene="Septin3"
                     /gene_synonym="Sep3; Sept3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggtcggg cgggtaggcg gtacggcgcc gaggggcgag gcccggctgc aggggccgct
       61 tggcccaggg agagcccgcg cccggctcag cctcgcagcc ccgcgccctg agcatctccc
      121 ggaggacccg agacaaagga ggattcatgt ccaaagggct cccagaggct aggacggaca
      181 cagccatgtc agagctggtg cccgagccca ggcctaagcc ggcggtgccc atgaagccgg
      241 tcagcatcaa ctccaaccta ctaggctaca ttggcattga caccattatc gaacagatgc
      301 gcaagaagac catgaagact ggttttgact tcaacatcat ggtcgttggc cagagtggac
      361 tgggcaagtc gacgctggtc aacacactat tcaagtctca agtgagccgg aaggcctcca
      421 gctggaaccg ggaggagaag atcccgaaga cagtggagat caaagcgatt gggcatgtga
      481 tagaggaagg tggtgtcaaa atgaagctga cggtcatcga cacgccaggc tttggagacc
      541 agatcaacaa tgaaaactgc tgggagccca ttgagaagta catcaatgaa cagtatgaaa
      601 agttcctgaa agaggaggtt aatattgcca ggaagaagcg catccctgac acccgggtcc
      661 actgctgcct ctacttcatc tccccaacgg gacactcctt acgaccactt gatcttgagt
      721 tcatgaaaca cctcagcaaa gtggtgaacg tcattcctgt cattgccaag gctgacacca
      781 tgaccctgga ggagaagtct gaattcaagc agagggttcg caaagagctt gaagtaaacg
      841 gcattgagtt ctaccctcag aaggagtttg atgaggattt ggaggacaag acagagaatg
      901 acaaaatccg gcaggagagc atgcccttcg cggtggtggg gagtgacaag gagtaccaag
      961 tgaatggcaa gagggtcctc gggagaaaaa caccctgggg gatcatcgaa gtcgaaaacc
     1021 tcaaccactg tgagtttgcc ctgcttcgag acttcgtcat caggactcac ctccaggacc
     1081 tcaaagaagt aacacacaac atccactatg aaacttacag ggccaagagg ctcaatgaca
     1141 atggaggcct ccctccggga gaaggcctcc tgggcactgt ccttccacct gtgccagcca
     1201 ccccctgccc cactgctgaa tgaaggccat ttcaagtgct gcttctccct ccccagctgt
     1261 tattgctgca gggccacgcc ccctttagtg cccaccagca cagcccctct cagccctcgg
     1321 ccagtgggag gggctagctg cgtctctagg acagttgctt cctccgttta gccaaactac
     1381 tcctctcctc ccccacggaa tggagttccc gccagcacca ccctgctcta ccatctatgt
     1441 tcagcagccc cagcccttgt gtaggcagga ggaactcacg gagagcttct cctgcccttg
     1501 caagcgcaca ccagcgactg gtaactgtct ccaagggaac cggcattgct ccctagccat
     1561 tcatctgcat gagtgctttc ttggctaccg taaccggtca agaaagcagc tttcctgctt
     1621 gtcagagtca ctgaggtcag ccgtgtgagc ccctgtgtgg gacaagggtg tctccttcat
     1681 tgcttcaaag tatttataag ggtgattgat tatacatgtt ggggagccag atgactagcg
     1741 tcactttaaa aaaaaaatca ccgctggtgg ctggcccagt gagtatgtgt gtagacaacc
     1801 tgtttacccc aaaatatggc catcccggaa gtggttttgc tgaaaagagg ttgctggagt
     1861 tgacttccct atccccaaac tttaaaataa agggaattaa acacacacag actactccaa
     1921 acccacaagc tatacactct aggaagaaaa aaatagcacc cttttgtaca tttagcaata
     1981 agaggcaatc tcttcccacc taccctgact attcctgctc ccatccccca ccctgttaat
     2041 gtgagcgatg cattagcctg accacaggtg gtcgctatag gctaatggaa aatacccaac
     2101 ggagggcaaa gcccccctca gatgcatgaa tgtttgcgga cggctgccac tgccccatac
     2161 actgtgtctt tataggaccc tccctcagcc accccacctg ccatctccac ctggacacaa
     2221 cttgctcaaa ggctggtgac ttgtgggcca ttcatctaca agtcctgatg gaacaaggcc
     2281 taagcctagg ggatgcaaga acgacccatt tttaaaacgt tattagtccc agccaatgtt
     2341 ttggtgatat tccagtttag tttcccagtt gaaaacaagc caacagacac tcagactggt
     2401 cgtgtaaatg ttgctagcct ctgttgtaca actaaacatt actgtttgaa caat
//
