LOCUS       NM_057148               3225 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus septin 2 (Septin2), mRNA.
ACCESSION   NM_057148
VERSION     NM_057148.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3225)
  AUTHORS   Kuo,Y.C., Shen,Y.R., Chen,H.I., Lin,Y.H., Wang,Y.Y., Chen,Y.R.,
            Wang,C.Y. and Kuo,P.L.
  TITLE     SEPT12 orchestrates the formation of mammalian sperm annulus by
            organizing core octameric complexes with other SEPT proteins
  JOURNAL   J Cell Sci 128 (5), 923-934 (2015)
   PUBMED   25588830
REFERENCE   2  (bases 1 to 3225)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3225)
  AUTHORS   Lu,Y., Cai,G., Cui,S., Geng,W., Chen,D., Wen,J., Zhang,Y.,
            Zhang,F., Xie,Y., Fu,B. and Chen,X.
  TITLE     FHL2-driven molecular network mediated Septin2 knockdown inducing
            apoptosis in mesangial cell
  JOURNAL   Proteomics 14 (21-22), 2485-2497 (2014)
   PUBMED   25103794
  REMARK    GeneRIF: This study illustrated the FHL2-driven molecular network
            controlling SEPT2-mediated apoptosis in mesangial cell and their
            potential roles in mesangial proliferative nephritis.
REFERENCE   4  (bases 1 to 3225)
  AUTHORS   Cui,C., Chatterjee,B., Lozito,T.P., Zhang,Z., Francis,R.J.,
            Yagi,H., Swanhart,L.M., Sanker,S., Francis,D., Yu,Q., San
            Agustin,J.T., Puligilla,C., Chatterjee,T., Tansey,T., Liu,X.,
            Kelley,M.W., Spiliotis,E.T., Kwiatkowski,A.V., Tuan,R.,
            Pazour,G.J., Hukriede,N.A. and Lo,C.W.
  TITLE     Wdpcp, a PCP protein required for ciliogenesis, regulates
            directional cell migration and cell polarity by direct modulation
            of the actin cytoskeleton
  JOURNAL   PLoS Biol 11 (11), e1001720 (2013)
   PUBMED   24302887
REFERENCE   5  (bases 1 to 3225)
  AUTHORS   Ghossoub,R., Hu,Q., Failler,M., Rouyez,M.C., Spitzbarth,B.,
            Mostowy,S., Wolfrum,U., Saunier,S., Cossart,P., Jamesnelson,W. and
            Benmerah,A.
  TITLE     Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the
            primary cilium and control ciliary length
  JOURNAL   J Cell Sci 126 (Pt 12), 2583-2594 (2013)
   PUBMED   23572511
REFERENCE   6  (bases 1 to 3225)
  AUTHORS   Kinoshita,N., Kimura,K., Matsumoto,N., Watanabe,M., Fukaya,M. and
            Ide,C.
  TITLE     Mammalian septin Sept2 modulates the activity of GLAST, a glutamate
            transporter in astrocytes
  JOURNAL   Genes Cells 9 (1), 1-14 (2004)
   PUBMED   14723703
REFERENCE   7  (bases 1 to 3225)
  AUTHORS   Vega,I.E. and Hsu,S.C.
  TITLE     The septin protein Nedd5 associates with both the exocyst complex
            and microtubules and disruption of its GTPase activity promotes
            aberrant neurite sprouting in PC12 cells
  JOURNAL   Neuroreport 14 (1), 31-37 (2003)
   PUBMED   12544826
  REMARK    GeneRIF: Nedd5 may be required for polarized neurite outgrowth,
            perhaps, by facilitating the exocyst complex function during
            neuronal differentiation.
REFERENCE   8  (bases 1 to 3225)
  AUTHORS   Peng,X.R., Jia,Z., Zhang,Y., Ware,J. and Trimble,W.S.
  TITLE     The septin CDCrel-1 is dispensable for normal development and
            neurotransmitter release
  JOURNAL   Mol Cell Biol 22 (1), 378-387 (2002)
   PUBMED   11739749
REFERENCE   9  (bases 1 to 3225)
  AUTHORS   Hoja,M.R., Wahlestedt,C. and Hoog,C.
  TITLE     A visual intracellular classification strategy for uncharacterized
            human proteins
  JOURNAL   Exp Cell Res 259 (1), 239-246 (2000)
   PUBMED   10942595
REFERENCE   10 (bases 1 to 3225)
  AUTHORS   Beites,C.L., Xie,H., Bowser,R. and Trimble,W.S.
  TITLE     The septin CDCrel-1 binds syntaxin and inhibits exocytosis
  JOURNAL   Nat Neurosci 2 (5), 434-439 (1999)
   PUBMED   10321247
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081745.1.
            
            On Sep 16, 2004 this sequence version replaced NM_057148.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081745.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3225
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q36"
     gene            1..3225
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /note="septin 2"
                     /db_xref="GeneID:117515"
                     /db_xref="RGD:620056"
     exon            1..43
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            44..74
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..1151
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /note="vascular endothelial cell specific protein 11"
                     /codon_start=1
                     /product="septin-2"
                     /protein_id="NP_476489.1"
                     /db_xref="GeneID:117515"
                     /db_xref="RGD:620056"
                     /translation="MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVG
                     ESGLGKSTLINSLFLTDLYPERIIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDT
                     PGYGDAINSRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGL
                     KPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHSIKIYHLPDAES
                     DEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKL
                     RTMLITHMQDLQEVTQDLHYENFRSERLKRGGRKVENEDMNKDQILLEKEAELRRMQE
                     MIARMQAQMQMQMQGGDTDSSTLGHHV"
     exon            75..195
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            196..282
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            283..406
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            407..541
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            542..659
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            660..761
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            762..907
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            908..991
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1049
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1169
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
     exon            1170..3194
                     /gene="Septin2"
                     /gene_synonym="Nedd5; Sept2; Vesp11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtccgtgctg tcgcctgacg ggcattctct ggcgtgttag cggatagacc gaaaaatcaa
       61 gaaagatgtc taagcaacaa ccaacccagt ttataaatcc agaaactcct ggctatgttg
      121 gatttgcaaa tctccccaat caagttcacc gaaaatcagt gaagaagggg ttcgagttca
      181 ctctgatggt ggtcggtgaa tctggtctag gaaaatcaac tctcataaac agcttattct
      241 tgaccgatct ctacccagaa agaattattc ctggagctgc agaaaaaatc gaaagaactg
      301 tccagataga ggcttcgaca gttgaaatcg aagagcgggg tgtcaagctg cggcttacag
      361 tagtggacac gcctggctat ggggatgcca tcaactccag ggattgtttc aagacaatta
      421 tctcctacat tgatgagcag tttgaacgct acctacacga tgagagtgga ctgaacaggc
      481 ggcacatcat tgataacagg gtacattgtt gcttctactt catttcacct tttggacatg
      541 gactgaagcc cttagatgtt gcatttatga aagcgataca caataaggtg aatattgtgc
      601 ctgtcattgc gaaagctgac actctcactc tgaaggagcg ggagcggcta aagaaaagga
      661 ttttggatga aattgaagag cacagcatta aaatctatca tttacctgat gcagaatcag
      721 atgaagatga agactttaag gaacagacta gactcctcaa agccagtatc ccattctctg
      781 tggttggctc caaccagttg attgaagcca agggcaagaa ggttagaggc cgtctctacc
      841 cgtggggcgt tgtcgaggtg gagaacccag aacataatga ctttctgaag ctgagaacaa
      901 tgctcatcac ccacatgcag gacctacagg aagtgaccca agaccttcac tatgaaaact
      961 tccgttctga gaggctgaag agaggcggca ggaaagtaga gaatgaggac atgaataaag
     1021 accagatttt gcttgaaaag gaggctgagc tccgccgaat gcaagagatg attgcgagga
     1081 tgcaggcgca gatgcagatg cagatgcagg gcggcgacac tgacagcagc actcttgggc
     1141 accacgtgtg aggtccagct tcaatgttgg aaacactttg gataaaaaga aagtcttcct
     1201 gataagtgct acagcatcaa gtttcttagc cccgtggaag ggtacccatc tacattgaag
     1261 tgcctgtgtc tgaggatttc agttgttttg ttgtgttttg gttttttaac atttgatttt
     1321 tggttttttt tttccttctt tctccctcca acccccaact ccctttggta tgaagtacct
     1381 ttaacattta tatttcattg ctatgttaca ttttaaattt tgtgaggaaa actgatactt
     1441 tattcctcct gaaccactaa tgttagaatt tatttctaag aatctgtcaa catgtatact
     1501 ctgaatagtg aatttcttcg atatagctgg cctgactaat cactgacaag tactcttggt
     1561 ttctatccag ccatttttgt ttgctcagaa tgtccctgtg tggtgaacat gtgtaccttt
     1621 gacagaagtg gctgtgcata cttggtggca agatgtttgc ttattagaat gaagtcacac
     1681 tgttaacttt atatttgtac aaaacaccta aaaccaattt tgctgctgta gttcatccgg
     1741 ttaattcatc tgcaccatta tctgttaacc agtagaccag aagagcgtta tctaatgaga
     1801 tacatgttta tacttaaata gcttttaaaa agcaggattt cagggttgaa ttttaagagc
     1861 tctggattct agtgccagat cattttcaaa cctctgtaga gaaaactcac tacaaggact
     1921 ttttatactg tgggtggtga ttatgctgtg ctgtggagag aaccaaagca gctatgagct
     1981 ccagcttcag ttgtaacaag actctcttta taaggaagag tcagtaaact ttttactcaa
     2041 ctaaaaaggc aatacttttt ttaaagaaac caaaattttt atattttata ctgcacttta
     2101 atgtactttc tataactagg tgcaaaagat cagccatggc agtggaaatc atagtcttcg
     2161 gctggcgtgg gtccaaaccc aggcttgtga ttgggtgtgc tcttgcacaa acccagcctt
     2221 gtgattgggt gtgctcttgc acaaaaagcc acttgaagcc caaatgcctg ccaggttttc
     2281 ctctaactct tccccttttc agtgattctc ctattgaaag ggaaataaca gtgctgggtt
     2341 ggtttttgtt ttgttttgtt ttgtttttta atgtgcagac tgtctcatct gttttccagc
     2401 actgtcattt tcttcagttt gtgtagtata aatgtcttca tgacatgatt gaaaggggca
     2461 gatctgtgcc ccaagcaggt gagcagagtc aggcctggtt tacactccgg cacttccctt
     2521 ctaccatgtc ttctcatgtc agtcagtggt ctgagaaagg aagaggcagg tgaaggaggc
     2581 agggtgtgga gaagcagagc cggtgctagc tgtgtgtttc catttgctgc aggaggaagt
     2641 gcttgattga tgatgaggca gggatttaca tttaattcag gccaaaaatc aataggacga
     2701 ataaagtgaa gcttaagaat ggttatcaat tacaaaggat atgcatttgc tcactttgcc
     2761 tcttcacgtc gcatcactgt gagcagtcag ggaagttcac tgtgtgaagt ccctacgagg
     2821 aaaagtgtca gtgactttaa agtggacccg tgcggtcctt tgtttggctt attttgatat
     2881 tagttttgtt ggagaaagat ttaaaaacaa aaaccaacaa aaaggaagga attcccaagc
     2941 attcagtgtg agtcccattt gtgagttaag ggtgccactt aggaccagct gacatctaag
     3001 gatggcagtg tacatgtgag gtcttgcagc cacaattcta atccccttca gttttactgc
     3061 ttttgctaac aaatacttgc tctttcacta agaagtaact tgtagaaatg tattttgaaa
     3121 acatttcaca cttcaacttt gtatccattt aaaataacct tttttcaata aagcactatt
     3181 gtttagatat taaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
