LOCUS       NM_001100865            1320 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Rattus norvegicus septin 12 (Septin12), mRNA.
ACCESSION   NM_001100865 XM_001079122 XM_343859
VERSION     NM_001100865.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Kuo,Y.C., Shen,Y.R., Chen,H.I., Lin,Y.H., Wang,Y.Y., Chen,Y.R.,
            Wang,C.Y. and Kuo,P.L.
  TITLE     SEPT12 orchestrates the formation of mammalian sperm annulus by
            organizing core octameric complexes with other SEPT proteins
  JOURNAL   J Cell Sci 128 (5), 923-934 (2015)
   PUBMED   25588830
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Kuo,Y.C., Lin,Y.H., Chen,H.I., Wang,Y.Y., Chiou,Y.W., Lin,H.H.,
            Pan,H.A., Wu,C.M., Su,S.M., Hsu,C.C. and Kuo,P.L.
  TITLE     SEPT12 mutations cause male infertility with defective sperm
            annulus
  JOURNAL   Hum Mutat 33 (4), 710-719 (2012)
   PUBMED   22275165
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   Ding,X., Yu,W., Liu,M., Shen,S., Chen,F., Cao,L., Wan,B. and Yu,L.
  TITLE     GTP binding is required for SEPT12 to form filaments and to
            interact with SEPT11
  JOURNAL   Mol Cells 25 (3), 385-389 (2008)
   PUBMED   18443421
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Ding,X., Yu,W., Liu,M., Shen,S., Chen,F., Wan,B. and Yu,L.
  TITLE     SEPT12 interacts with SEPT6 and this interaction alters the
            filament structure of SEPT6 in Hela cells
  JOURNAL   J Biochem Mol Biol 40 (6), 973-978 (2007)
   PUBMED   18047794
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Steels,J.D., Estey,M.P., Froese,C.D., Reynaud,D., Pace-Asciak,C.
            and Trimble,W.S.
  TITLE     Sept12 is a component of the mammalian sperm tail annulus
  JOURNAL   Cell Motil Cytoskeleton 64 (10), 794-807 (2007)
   PUBMED   17685441
  REMARK    GeneRIF: Study describes Sept12, a novel septin, identified in a
            yeast two hybrid screen using Sept5 as the bait; Sept12 protein
            levels rise upon sexual maturity and the Sept12 protein colocalizes
            with the annulus in isolated mature spermatozoa.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC097401.1.
            
            On or before May 13, 2010 this sequence version replaced
            XM_001079122.1, XM_343859.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC097401.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q12"
     gene            1..1320
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /note="septin 12"
                     /db_xref="GeneID:363542"
                     /db_xref="RGD:1565511"
     exon            1..49
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            50..237
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..1148
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /codon_start=1
                     /product="septin-12"
                     /protein_id="NP_001094335.1"
                     /db_xref="GeneID:363542"
                     /db_xref="RGD:1565511"
                     /translation="MDERRTPSPCSSRPSSPRTPPCEMFGPVGIEAVLDQLRIKAMKT
                     GFEFNIMVVGQSGLGKSTMVNTLFKSKVWQSPAPNLDVPMPQTLELHSVTHVIEEKGL
                     KLKLTVTDTPGFGDQINNDKCWDPILSYINQQYEQYLQEELLITRQRHIPDTRVHCCV
                     YFVPPTGHCLRPLDIEFLRRLCRTVNVVPVIARADSLTIEERDAFRSRIQQNLKNHCI
                     DVYPQQCFDEDINDRLLNSKIREQIPFAVVGADREHIVNGRCVLGRKTKWGIIEVENM
                     AHCEFLLLRDLLIRSHLQDLKDITHNVHYENYRVLRLNESHVLPRGPGWVNLAPASPG
                     QLMAPGPEKVRKRSKDPRDDEC"
     exon            238..363
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            364..445
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            446..583
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            584..701
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            702..797
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            798..894
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            895..946
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1296
                     /gene="Septin12"
                     /gene_synonym="Sept12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcagccttg ccagctactc ccagctcccc caagggaatc atccaccagc aacaggcacc
       61 attgtaccct tggccccatg gatgagaggc gaacaccctc tccctgctct tcgaggccct
      121 ccagtcccag gaccccaccc tgtgagatgt ttggtcctgt gggcattgag gctgtgctag
      181 accagctgag gatcaaggct atgaagactg ggtttgagtt caatatcatg gtggtcgggc
      241 agagtgggct aggcaagtcc accatggtga acacattgtt caagtccaaa gtatggcagt
      301 cacctgcacc caacctggat gtacccatgc cacaaacatt ggagctgcac tctgtgaccc
      361 acgtcatcga ggagaaggga ctgaagctga agctgacagt gacagataca cctggctttg
      421 gagaccagat caacaatgac aagtgctggg accctatcct gagttacatc aaccaacagt
      481 acgagcagta tctacaggag gagcttctca tcacccgcca gcgccacatc cccgacaccc
      541 gtgtgcactg ctgcgtgtac tttgtgccac ctactggcca ctgcctacgg cccctggaca
      601 ttgagttcct gcgacggctg tgccggaccg tgaatgtggt gcctgtgatc gcccgggctg
      661 acagcctgac cattgaagaa cgagatgcct tcaggagcag gattcagcaa aacctgaaaa
      721 atcactgcat cgatgtgtac ccgcagcagt gtttcgacga ggacatcaat gacagactcc
      781 tcaatagtaa gatccgggag cagatccctt ttgctgtggt cggggctgac cgagagcaca
      841 tagtgaacgg gagatgtgtc ctgggccgga agaccaaatg gggcatcatc gaagtggaga
      901 acatggcgca ctgtgagttt cttctcctga gagacctgct catccgctcc catctccagg
      961 acctgaagga catcacccac aatgtacact acgagaacta ccgggtcctc agactcaatg
     1021 agagccacgt gctgccccgg gggccaggct gggtgaacct ggccccagcc tcccctggac
     1081 agctgatggc tccaggacca gaaaaggtcc gaaagcgatc taaggatccc agggatgatg
     1141 agtgctgagg ggcatgaccc caagcctgct aggctcctcc cttcctcagc agccagctcc
     1201 caacacacac cctagagcat ctatgtgaac ctggagttgc tttgtacaaa aaagctgtgc
     1261 tttgacaact aaagggtttg taaacgagtc ctctgaaaaa aaaaaaaaaa aaaaaaaaaa
//
