LOCUS       NP_001100678             432 aa            linear   ROD 27-MAR-2024
DEFINITION  septin-11 [Rattus norvegicus].
ACCESSION   NP_001100678 XP_001063271 XP_223227
VERSION     NP_001100678.1
DBSOURCE    REFSEQ: accession NM_001107208.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 432)
  AUTHORS   Li,X., Serwanski,D.R., Miralles,C.P., Nagata,K.I. and De Blas,A.L.
  TITLE     Septin 11 is present in GABAergic synapses and plays a functional
            role in the cytoarchitecture of neurons and GABAergic synaptic
            connectivity
  JOURNAL   J Biol Chem 284 (25), 17253-17265 (2009)
   PUBMED   19380581
  REMARK    GeneRIF: Electron microscopy immunocytochemistry of the cerebellum
            revealed the accumulation of septin 11 at the neck of dendritic
            spines, at the bifurcation of dendritic branches, and at some
            GABAergic synapses.
REFERENCE   2  (residues 1 to 432)
  AUTHORS   Tsang,C.W., Fedchyshyn,M., Harrison,J., Xie,H., Xue,J.,
            Robinson,P.J., Wang,L.Y. and Trimble,W.S.
  TITLE     Superfluous role of mammalian septins 3 and 5 in neuronal
            development and synaptic transmission
  JOURNAL   Mol Cell Biol 28 (23), 7012-7029 (2008)
   PUBMED   18809578
REFERENCE   3  (residues 1 to 432)
  AUTHORS   Sudo,K., Ito,H., Iwamoto,I., Morishita,R., Asano,T. and Nagata,K.
  TITLE     SEPT9 sequence alternations causing hereditary neuralgic amyotrophy
            are associated with altered interactions with SEPT4/SEPT11 and
            resistance to Rho/Rhotekin-signaling
  JOURNAL   Hum Mutat 28 (10), 1005-1013 (2007)
   PUBMED   17546647
  REMARK    GeneRIF: SEPT9 sequence alternations causing hereditary neuralgic
            amyotrophy are associated with altered interactions with
            SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
REFERENCE   4  (residues 1 to 432)
  AUTHORS   Nagata,K., Asano,T., Nozawa,Y. and Inagaki,M.
  TITLE     Biochemical and cell biological analyses of a mammalian septin
            complex, Sept7/9b/11
  JOURNAL   J Biol Chem 279 (53), 55895-55904 (2004)
   PUBMED   15485874
  REMARK    GeneRIF: Sept7/9b/11 form a complex that has effects on filament
            elongation, bundling, or disruption.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000014.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XP_223227.4, XP_001063271.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.32766.1,
                                           SRR26643298.53646.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760386,
                                           SAMEA5760393 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..432
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="14"
                     /map="14p22"
     Protein         1..432
                     /product="septin-11"
                     /calculated_mol_wt=49651
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylalanine. /evidence=ECO:0000269|Ref.4;
                     propagated from UniProtKB/Swiss-Prot (B3GNI6.1)"
     Site            9
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9NVA2; propagated from
                     UniProtKB/Swiss-Prot (B3GNI6.1)"
     Region          38..306
                     /region_name="CDC_Septin"
                     /note="CDC/Septin GTPase family; cd01850"
                     /db_xref="CDD:206649"
     Region          48..55
                     /region_name="G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (B3GNI6.1)"
     Site            48..55
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206649"
     Site            order(50..56,100,103,183..184,186,238..239)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206649"
     Site            75..83
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206649"
     Site            77
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206649"
     Region          100..103
                     /region_name="G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (B3GNI6.1)"
     Site            100..103
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206649"
     Site            order(102..139,141..149)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206649"
     Region          183..186
                     /region_name="G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (B3GNI6.1)"
     Site            183..186
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206649"
     Site            238..240
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206649"
     CDS             1..432
                     /gene="Septin11"
                     /gene_synonym="Sept11"
                     /coded_by="NM_001107208.3:134..1432"
                     /db_xref="GeneID:305227"
                     /db_xref="RGD:1307405"
ORIGIN      
        1 mavavgrpsn eelrnlslsg hvgfdslpdq lvnkstsqgf cfnilcvget gigkstlmdt
       61 lfntkfesdp athnepgvrl karsyelqes nvrlkltivd tvgfgdqink ddsykpivey
      121 idaqfeaylq eelkikrslf nyhdtrihac lyfiaptghs lksldlvtmk kldskvniip
      181 iiakadtiak nelhkfkski mselvsngvq iyqfptdeet vaeinatmsv hlpfavvgst
      241 eevkignkma karqypwgvv qvenenhcdf vklremlirv nmedlreqth trhyelyrrc
      301 kleemgfkdt dpdskpfslq etyeakrnef lgelqkkeee mrqmfvmrvk ekeaelkeae
      361 kelhekfdll krthqeekkk vedkkkelee evsnfqkkka aaqllqsqaq qsgaqqtkkd
      421 kdkknspwlc te
//
