LOCUS       NP_001012478             366 aa            linear   ROD 03-APR-2024
DEFINITION  septin-1 [Rattus norvegicus].
ACCESSION   NP_001012478 XP_215071
VERSION     NP_001012478.1
DBSOURCE    REFSEQ: accession NM_001012460.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 366)
  AUTHORS   Zhu,J., Qi,S.T., Wang,Y.P., Wang,Z.B., Ouyang,Y.C., Hou,Y.,
            Schatten,H. and Sun,Q.Y.
  TITLE     Septin1 is required for spindle assembly and chromosome congression
            in mouse oocytes
  JOURNAL   Dev Dyn 240 (10), 2281-2289 (2011)
   PUBMED   21932310
REFERENCE   2  (residues 1 to 366)
  AUTHORS   Chen,T.C., Lee,S.A., Hong,T.M., Shih,J.Y., Lai,J.M., Chiou,H.Y.,
            Yang,S.C., Chan,C.H., Kao,C.Y., Yang,P.C. and Huang,C.Y.
  TITLE     From midbody protein-protein interaction network construction to
            novel regulators in cytokinesis
  JOURNAL   J Proteome Res 8 (11), 4943-4953 (2009)
   PUBMED   19799413
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC089897.1.
            
            On Apr 20, 2005 this sequence version replaced XP_215071.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089897.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132274,
                                           SAMD00132279 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..366
                     /organism="Rattus norvegicus"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     Protein         1..366
                     /product="septin-1"
                     /EC_number="3.1.5.1"
                     /calculated_mol_wt=41927
     Region          23..295
                     /region_name="Septin"
                     /note="pfam00735"
                     /db_xref="CDD:395596"
     Region          32..39
                     /region_name="G1 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EB96.1)"
     Site            32..39
                     /site_type="other"
                     /note="G1 box"
                     /db_xref="CDD:206649"
     Site            order(34..40,89,92,170..171,173,229..230)
                     /site_type="other"
                     /note="GTP/Mg2+ binding site [chemical binding]"
                     /db_xref="CDD:206649"
     Site            64..72
                     /site_type="other"
                     /note="Switch I region"
                     /db_xref="CDD:206649"
     Site            66
                     /site_type="other"
                     /note="G2 box"
                     /db_xref="CDD:206649"
     Region          89..92
                     /region_name="G3 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EB96.1)"
     Site            89..92
                     /site_type="other"
                     /note="G3 box"
                     /db_xref="CDD:206649"
     Site            order(91..126,127..136)
                     /site_type="other"
                     /note="Switch II region"
                     /db_xref="CDD:206649"
     Region          170..173
                     /region_name="G4 motif.
                     /evidence=ECO:0000255|PROSITE-ProRule:PRU01056"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EB96.1)"
     Site            170..173
                     /site_type="other"
                     /note="G4 box"
                     /db_xref="CDD:206649"
     Site            206
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:22673903; propagated from
                     UniProtKB/Swiss-Prot (Q5EB96.1)"
     Site            229..231
                     /site_type="other"
                     /note="G5 box"
                     /db_xref="CDD:206649"
     Site            247
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AURKB.
                     /evidence=ECO:0000250|UniProtKB:Q8WYJ6; propagated from
                     UniProtKB/Swiss-Prot (Q5EB96.1)"
     Site            250
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:P42209; propagated from
                     UniProtKB/Swiss-Prot (Q5EB96.1)"
     Site            306
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AURKB.
                     /evidence=ECO:0000250|UniProtKB:Q8WYJ6; propagated from
                     UniProtKB/Swiss-Prot (Q5EB96.1)"
     Site            314
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by AURKB.
                     /evidence=ECO:0000250|UniProtKB:Q8WYJ6; propagated from
                     UniProtKB/Swiss-Prot (Q5EB96.1)"
     Region          347..366
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q5EB96.1)"
     CDS             1..366
                     /gene="Septin1"
                     /gene_synonym="Sept1"
                     /coded_by="NM_001012460.1:44..1144"
                     /db_xref="GeneID:293507"
                     /db_xref="RGD:1307216"
ORIGIN      
        1 mdkeyvgfaa lpnqlhrksv kkgfdftlmv agesglgkst linslfltnl yedrqvpdas
       61 arttqtltie rrgveieegg ikvkltlvdt pgfgdsvdcs dcwlpvvrfi eeqfeqylrd
      121 esglnrkniq dsrvhcclyf ispfgrglrp ldvaflravh ekvniipvig kadallpret
      181 qvlkqkirdq lkeeeiniyq fpecdsdede efkkqneemk enipfavvgs sevvregtrp
      241 vrgrryswgt vevenphhcd flnlrrmlvq thlqdlkevt hdllyegyra rclqslarpg
      301 ardrasrskl srqsateipl pmlpladtek lirekdeelr rmqemlekmq aqmqqsqaqg
      361 eqsdvl
//
