LOCUS       NP_001098100             392 aa            linear   ROD 30-MAR-2024
DEFINITION  selenide, water dikinase 1 [Rattus norvegicus].
ACCESSION   NP_001098100 XP_001066465 XP_214509
VERSION     NP_001098100.1
DBSOURCE    REFSEQ: accession NM_001104630.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 392)
  AUTHORS   Hu,T., Shi,Z., Sun,Y., Hu,F., Rong,Y., Wang,J., Wang,L., Xu,W.,
            Zhang,F. and Zhang,W.Z.
  TITLE     SEPHS1 attenuates intervertebral disc degeneration by delaying
            nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway
  JOURNAL   Am J Physiol Cell Physiol 326 (2), C386-C399 (2024)
   PUBMED   38105759
  REMARK    GeneRIF: SEPHS1 attenuates intervertebral disc degeneration by
            delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz
            pathway.
REFERENCE   2  (residues 1 to 392)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   3  (residues 1 to 392)
  AUTHORS   Kim,J.Y., Lee,K.H., Shim,M.S., Shin,H., Xu,X.M., Carlson,B.A.,
            Hatfield,D.L. and Lee,B.J.
  TITLE     Human selenophosphate synthetase 1 has five splice variants with
            unique interactions, subcellular localizations and expression
            patterns
  JOURNAL   Biochem Biophys Res Commun 397 (1), 53-58 (2010)
   PUBMED   20471958
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY724491.1, DV714794.1, DY318079.1, DY313865.1, JAXUCZ010000017.1,
            CB704759.1 and BG375377.1.
            
            On or before Sep 16, 2007 this sequence version replaced
            XP_214509.2, XP_001066465.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY724491.1, SRR26643298.69876.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN12840107 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Rattus norvegicus"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q12.3"
     Protein         1..392
                     /product="selenide, water dikinase 1"
                     /EC_number="2.7.9.3"
                     /calculated_mol_wt=42762
     Region          19..333
                     /region_name="selD"
                     /note="selenium donor protein; TIGR00476"
                     /db_xref="CDD:273100"
     Site            order(81..84,86,88,110,121,124,127,163,170..171,175,277)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:100031"
     Site            order(106,110,161..163)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:100031"
     CDS             1..392
                     /gene="Sephs1"
                     /coded_by="NM_001104630.1:365..1543"
                     /db_xref="GeneID:291314"
                     /db_xref="RGD:1311182"
ORIGIN      
        1 mstresfnpe tyeldksfrl trftelkgtg ckvpqdvlqk lleslqenhf qedeqflgav
       61 mprlgigmdt cviplrhggl slvqttdyiy pivddpymmg riacanvlsd lyamgvtecd
      121 nmlmllgvsn kmtdrerdkv mpliiqgfkd aaeeagtsvt ggqtvlnpwi vlggvattvc
      181 qpnefimpdn avpgdvlvlt kplgtqvava vhqwldipek wnkiklvvtq edvelayqea
      241 mvnmarlnrt aaglmhtfna haatditgfg ilghaqnlak qqrnevsfvi hnlpvlakma
      301 avskacgnmf glmhgtcpet sgglliclpr eqaarfcaei kspkygeghq awiigivekg
      361 nrtariidkp riievapqva tqnvnptpga ts
//
