LOCUS       NM_001106842            4514 bp    mRNA    linear   ROD 22-MAR-2023
DEFINITION  Rattus norvegicus SUMO specific peptidase 6 (Senp6), mRNA.
ACCESSION   NM_001106842 XM_001061212 XM_217209
VERSION     NM_001106842.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4514)
  AUTHORS   Li Q, Liu D, Pan F, Ho CSH and Ho RCM.
  TITLE     Ethanol Exposure Induces Microglia Activation and Neuroinflammation
            through TLR4 Activation and SENP6 Modulation in the Adolescent Rat
            Hippocampus
  JOURNAL   Neural Plast 2019, 1648736 (2019)
   PUBMED   31781182
  REMARK    GeneRIF: Our data suggest that ethanol exposure during adolescence
            induces the microglia-mediated neuroinflammation via TLR4
            activation, and SENP6 plays an essential role in dampening
            NF-kappaB activation and neuroinflammation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4514)
  AUTHORS   Mukhopadhyay D, Arnaoutov A and Dasso M.
  TITLE     The SUMO protease SENP6 is essential for inner kinetochore assembly
  JOURNAL   J Cell Biol 188 (5), 681-692 (2010)
   PUBMED   20212317
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473954.2.
            
            On Oct 1, 2011 this sequence version replaced NM_001106842.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMD00132261,
                              SAMD00132262 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4514
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4514
                     /gene="Senp6"
                     /note="SUMO specific peptidase 6"
                     /db_xref="GeneID:300860"
                     /db_xref="RGD:1304565"
     exon            1..271
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..3630
                     /gene="Senp6"
                     /EC_number="3.4.22.68"
                     /note="SUMO/sentrin specific protease 6; SUMO/sentrin
                     specific peptidase 6; Sumo1/sentrin/SMT3 specific
                     peptidase 6; SUMO1/sentrin specific peptidase 6"
                     /codon_start=1
                     /product="sentrin-specific protease 6"
                     /protein_id="NP_001100312.2"
                     /db_xref="GeneID:300860"
                     /db_xref="RGD:1304565"
                     /translation="MAAGKSGGSAGGVFLKALARSESKRDGGFKNNWSFDHEEESEGD
                     ADKDGANLLSVEDEDSETSKGKKLNRRSEIVATSSGDFILKTYVRRNKTDGFKTLKGN
                     AIGLNMLSNNKKLSENTQATALCSGTVVHGRRFHHAHVQMPGIKTAAQSNQDRKERKE
                     YPPHVHKAENNPVMLSHGQGGDHVMKKTEDSESYVEPEVKRKVQQKRHCSTYQLSPLS
                     PASKKCLTHFEVSEQRECCPKCGKEKENQTRCQSCGIVFHNDLQRNCRQAVTLNESTG
                     PLLRTSIHQNSGGQKSQNTGLTAKKFYGNSVDKIPIDILLTCDGSRHNYIQTNGKVIL
                     PGGKIPKITNPKERKTSVSDLNDPIILSSDDDDDDDRTKRRESTSPQPADSACSSPAP
                     STGKVEAALNANTCRAEQEPRSSPAESELNTVVIPRKARMKDQLGNSISTPLKRRKVN
                     THGALIPVTSLSCQDFGSVILNCRSIRVGTLFRLLVEPVIFSLELIKIRLDGPDSVEI
                     ILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSLQLQMSKEDKVWNDCKGINRITSL
                     EEQYIILIFQTGLDHQADVVFESIITDIGIRNNVCNFFAKIPFEEANSRLVACTRSYE
                     ESIKGNCVQKENKVKTVSFESKIQLRSKQELQFFDDEEEAGESHTIFIGPVEKLIVYP
                     PPPAKGGISVTNEDLHCLSEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSFFYK
                     RLNQRERRNSETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVVCFP
                     GLEKPKYEPNPHYHENAVMQKPSRAEDSYVSSASEVDACSQNSAAKPVIKKMLHRKHC
                     LAVTDSSAAQEDSEPCYRRNAYSVKCSMKKKNHAVHENEEPSNGESACQEISDRTESE
                     HGLQDECLNSAHHPDALSKIRLNYGDQSAEGGKLLEDELIDFSEDQDDPDDSSDDGLL
                     ADENYNSEIGQWHLKPTVCKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKGSKR
                     SFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPILNFELPMNLVNWFPPPRMK
                     TKREEIRNIILKLQEEQSKEKRLLRDTSSAETSLGEGAEQYASSVSE"
     exon            272..365
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            366..423
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            424..569
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            570..674
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            675..695
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            696..766
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            767..909
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1297
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1527
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1692
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1693..1726
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1915
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2142
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2252
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2253..2369
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2489
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2490..2582
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2583..3007
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3008..3111
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..3200
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3201..3269
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3270..3420
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
     exon            3421..4514
                     /gene="Senp6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagaagaaac ccaggccgtg ggcctcaccg cctcccgtca gcccgcgaca ggcccgcttt
       61 tgtgtggggg cccggccggc ggggagcgcc cctcgcggac ggtcgagccc gaggcccgcc
      121 accctgcggc tgctaccctc ccgacgtgcg gcccccattc cccgcgagca ccgcggcggt
      181 gccggccatg gagtaagaag gaggcggcgt gggaggagga agatggcggc gggcaagagc
      241 ggtggcagcg ctgggggtgt tttcctgaaa gctttggcta gatcagaatc taagagggat
      301 ggaggcttta aaaataattg gagctttgat catgaagaag aaagtgaagg agatgcagat
      361 aaagatgggg caaatctact cagtgtagaa gatgaggatt ctgaaacctc aaaaggaaaa
      421 aagttaaatc ggagatctga aatcgttgct actagttctg gtgatttcat cttgaagact
      481 tatgtaaggc gaaacaagac tgacggcttt aaaactttga aaggcaacgc aattggactt
      541 aacatgttaa gcaacaataa gaaactgagt gaaaacacac aagctacggc gttatgttct
      601 ggaactgtag ttcatggtag acgcttccat catgcccacg tacagatgcc aggcatcaaa
      661 acggcagctc agagcaatca ggaccgaaaa gaaaggaaag aatacccacc tcatgtccac
      721 aaagccgaaa acaaccctgt aatgttaagt catggccaag gcggagacca tgtaatgaag
      781 aaaactgaag attcagaatc gtatgtagag cctgaagtta agaggaaagt acagcagaaa
      841 cggcactgta gcacttacca gctttctcct ctgtcccctg cctcaaagaa gtgtctgacc
      901 catttcgagg tttctgaaca gcgtgaatgt tgcccaaaat gcggaaaaga aaaagaaaat
      961 caaaccagat gccaaagttg tggtattgtt tttcataatg atttgcaaag aaattgccga
     1021 caagcagtaa cgttgaatga atctactgga ccattgctaa gaacatcaat tcatcagaac
     1081 tctggaggac agaaatcaca aaacacagga ttaacagcta agaagtttta tgggaacagt
     1141 gtggataaga ttccaattga tattttgctc acctgtgatg gtagcagaca taattacata
     1201 cagacaaatg ggaaagtcat tttacctgga ggaaaaatac ctaaaatcac aaacccgaaa
     1261 gaacgaaaaa caagcgtgtc agatttaaac gatccaatca ttttgtccag tgatgacgat
     1321 gacgacgacg acaggactaa gagaagagag agcacgtccc cgcagcctgc cgactcagca
     1381 tgctcctctc cagcaccgtc tactgggaaa gttgaagccg cactgaatgc aaatacgtgc
     1441 agagcagagc aggaacctag aagcagtccc gcagagtctg agttaaatac cgttgtcata
     1501 ccaagaaaag caagaatgaa ggaccagctt ggtaattcca tcagcacacc tctaaaacgt
     1561 cgtaaagtaa acactcatgg agctttaatt cccgttacat ctttaagctg ccaagacttt
     1621 ggcagtgtca ttttaaactg ccgaagtata cgagttggaa cactcttccg actgttggta
     1681 gagcctgtaa ttttttcttt agagttaatc aagatacgtc tagatggacc agattctgta
     1741 gagattattt taaatacctc tgatctaact aaatgtgaat ggtgtaatgt ccgcaaatta
     1801 ccagtagtgt ttctccaggc aataccagca gtttatcaga agctgagctt gcagctgcag
     1861 atgagcaaag aagataaagt ttggaatgat tgtaaaggaa taaacaggat aacgagttta
     1921 gaagaacagt acattatttt aatttttcaa actggccttg atcatcaggc agatgtggtc
     1981 tttgaaagta tcattactga cattggtata agaaataatg tttgcaactt ttttgcaaaa
     2041 attccttttg aagaagccaa cagcagactt gttgcctgta caagaagcta tgaagagagc
     2101 atcaaaggaa actgtgtgca aaaagagaac aaagtgaaaa ctgtgtcctt tgaatctaaa
     2161 atacaactta gaagcaaaca agaattgcag ttttttgatg atgaagaaga agctggagag
     2221 agccatacaa tcttcattgg ccctgtagaa aaattgatag tatatccacc acctccagcc
     2281 aagggaggca tttctgttac taatgaggac ctgcactgtc tgagtgaagg agagttttta
     2341 aatgatgtta ttatcgactt ttatttgaaa tacttggtgc ttgaaaaact gaagaaagaa
     2401 gatgctgacc gaattcatat attcagttct tttttctata aacgccttaa tcagagagag
     2461 aggagaaatt ctgagacaac taatctgtcg atacaacaaa aacggcatgg gagagtgaaa
     2521 acatggaccc ggcatgtaga tatttttgag aaggatttta tttttgtacc ccttaatgaa
     2581 gctgcacatt ggtttttggc tgttgtttgt ttccctggtt tggaaaaacc aaaatatgaa
     2641 cctaatcctc attaccatga aaatgcagtc atgcaaaaac cttcacgtgc agaggacagt
     2701 tatgtttctt ctgccagtga ggtggatgct tgttcacaga actctgctgc caagcctgtg
     2761 attaagaaga tgctacacag aaagcattgc ttagctgtaa ccgattcgag tgctgcacag
     2821 gaagacagtg agccttgtta ccggagaaac gcatacagtg tgaagtgtag catgaaaaaa
     2881 aaaaatcatg ctgtccatga aaatgaagaa ccaagcaacg gagagtctgc atgccaggaa
     2941 atttctgata gaactgaaag tgagcatggc ctccaggatg aatgcttaaa ttctgcacat
     3001 catccagatg ccttaagcaa aatcagacta aactatggtg atcagtcagc agaaggtgga
     3061 aaactgcttg aagatgagct cattgacttc tcagaggatc aggatgaccc ggatgatagc
     3121 agcgatgacg ggctccttgc tgatgaaaac tacaattcag aaataggaca gtggcattta
     3181 aagcctactg tctgcaaaca accttgtatt ctacttatgg actcactcag aggcccttct
     3241 cggtcaaatg ttgtcaaaat tctaagagag tatttagaag tggaatggga ggttaaaaaa
     3301 ggaagcaaaa gaagtttttc caaagatgtt atgaaagggt ccaacccaaa ggttccacag
     3361 cagaacaact tcagtgactg cggtgtgtat gtactgcagt atgtagagag cttttttgag
     3421 aatccaatac taaattttga gctccctatg aatttggtga actggtttcc tccccccaga
     3481 atgaaaacaa aaagagaaga gatccgaaac ataattttga agctgcagga agagcagagt
     3541 aaagagaaga ggctgctgag ggacacctcc tcagcggaga catccttagg ggaaggggcg
     3601 gagcagtacg ccagcagtgt ctcagagtga caggagctgg gcctcgaagg gtcgccttct
     3661 gaaggacaca gcattcactt tcgggtgtcg acagtaaaga gccagagagc tcactactca
     3721 gagacttggg gtgataaagc ctgtacagat gtcataagtg atttccaaag gagtgtgtat
     3781 taagtaaaag tctgtaaata tgttaatgag gccaactttt ccaacattta taattatttt
     3841 tttcactttt aggaagcctt tgttatgtat tttctgttaa tagtactaaa actgcaactt
     3901 ctaaacacaa ataaataaaa tatttatagg aggaaatgat taatttgata ttctttagtg
     3961 aacttgcata attcctcagt gtgattttat ttcatgggaa tagaagtatc tatgattttt
     4021 tttttaacct ttgttctaaa gtagtaaaaa atgtgaaaat ataattgtta aagacatttt
     4081 aaactaaaag tgcatcttta tatgcttgca tagcaagaaa aattaatatc ttttcaattc
     4141 atgcttcatc tgttctgaga acccccaaag tatagtaact ataattttac acaaatactt
     4201 aaacgtcatt aggagcagtc aaagacagcg ggccttgact tctagtgaag cgtccctgcc
     4261 ccagcacccc tgcaactcag gcgaaagcca tcctgcaggt gcagctcgag tctcagagcc
     4321 caggattacc tttgcagttt atcttccagt ttgtgcgatg ggactagtta ggaacatttt
     4381 taatctgtgt gaacataggg tttcaagtag gaatttattt tctgtatctt ttgctatttt
     4441 tcattatttt gtcctcattg ttttgataaa gtaccagact ttttgcttgg gtttttctga
     4501 gtaaattatt ttaa
//
