LOCUS       NM_001402158            5981 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus SUMO specific peptidase 5 (Senp5), transcript
            variant 1, mRNA.
ACCESSION   NM_001402158 XM_006248475
VERSION     NM_001402158.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5981)
  AUTHORS   Ding,Y., Chen,F., Yang,W., Fu,X. and Xie,Y.
  TITLE     SENP5 deteriorates traumatic brain injury via SUMO2-dependent
            suppression of E2F1 SUMOylation
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (8), 1193-1203 (2023)
   PUBMED   37403456
  REMARK    GeneRIF: SENP5 deteriorates traumatic brain injury via
            SUMO2-dependent suppression of E2F1 SUMOylation.
REFERENCE   2  (bases 1 to 5981)
  AUTHORS   Mikolajczyk,J., Drag,M., Bekes,M., Cao,J.T., Ronai,Z. and
            Salvesen,G.S.
  TITLE     Small ubiquitin-related modifier (SUMO)-specific proteases:
            profiling the specificities and activities of human SENPs
  JOURNAL   J Biol Chem 282 (36), 26217-26224 (2007)
   PUBMED   17591783
REFERENCE   3  (bases 1 to 5981)
  AUTHORS   Gong,L. and Yeh,E.T.
  TITLE     Characterization of a family of nucleolar SUMO-specific proteases
            with preference for SUMO-2 or SUMO-3
  JOURNAL   J Biol Chem 281 (23), 15869-15877 (2006)
   PUBMED   16608850
REFERENCE   4  (bases 1 to 5981)
  AUTHORS   Florea,L., Di Francesco,V., Miller,J., Turner,R., Yao,A.,
            Harris,M., Walenz,B., Mobarry,C., Merkulov,G.V., Charlab,R.,
            Dew,I., Deng,Z., Istrail,S., Li,P. and Sutton,G.
  TITLE     Gene and alternative splicing annotation with AIR
  JOURNAL   Genome Res 15 (1), 54-66 (2005)
   PUBMED   15632090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000011.1.
            
            On Mar 8, 2022 this sequence version replaced XM_006248475.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643297.38453.1,
                                           SRR26643292.46047.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN11044071, SAMN12840112
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-180               JAXUCZ010000011.1  82289707-82289886
            181-1709            JAXUCZ010000011.1  82298208-82299736
            1710-1815           JAXUCZ010000011.1  82303078-82303183
            1816-1954           JAXUCZ010000011.1  82303318-82303456
            1955-2002           JAXUCZ010000011.1  82303641-82303688
            2003-2080           JAXUCZ010000011.1  82307753-82307830
            2081-2218           JAXUCZ010000011.1  82316155-82316292
            2219-2302           JAXUCZ010000011.1  82318749-82318832
            2303-2353           JAXUCZ010000011.1  82320216-82320266
            2354-5981           JAXUCZ010000011.1  82320911-82324538
FEATURES             Location/Qualifiers
     source          1..5981
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q22"
     gene            1..5981
                     /gene="Senp5"
                     /note="SUMO specific peptidase 5"
                     /db_xref="GeneID:103689978"
                     /db_xref="RGD:1304604"
     exon            1..180
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
     exon            181..1709
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..2464
                     /gene="Senp5"
                     /EC_number="3.4.22.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sentrin-specific protease 5; SUMO/sentrin specific
                     protease 5; SUMO1/sentrin specific peptidase 5;
                     Sumo1/sentrin/SMT3 specific peptidase 5"
                     /codon_start=1
                     /product="sentrin-specific protease 5 isoform 1"
                     /protein_id="NP_001389087.1"
                     /db_xref="GeneID:103689978"
                     /db_xref="RGD:1304604"
                     /translation="MKKQKKILWKKGIHLAFSEKWNAGFGGFKKLYFPQNLCFLKAKL
                     GRPVVWHRQSKHFQCNKRGLHIQKTWTQDVPLCSKTKSGVATQNVSSLYAKVKRKDTK
                     HFISSSRSLLKLQADKLLSSAKNLGREYCREKSLLKAVTGLSANTVLGKANGHKPSTD
                     PQASDFPMKFNGESQSPSDSGKTVVLNKHRKRVCYGCYQGLEHHRNRRPLIPKKFQPN
                     QHRRVKVSLMMYEKLSMIRFRYRIFRSQHFRTKSRVCKLRKAQRSWVQKVTGDHQENF
                     RDNNTEGGDCSPVPSLEPKDPCRCQPYFPDMDSSAVVKGKNCHVPDGHTKESPALDKE
                     HGLDAAFPDQQNGSTTYTWDQPSSSPKWECTEQIHEIPLMGHPSSDNFTPGTERALMT
                     LGQESGTSAVSDDGVKLSVSGADESVSSVDGPVSEEPAQNENFQMEEDGSLRQNILSS
                     KLLDHPYCKSPLDAPLVCSELKVENQVAGGKSGQTASPVDDEQLSTCLSGFLDEVMKK
                     YGSLVPLSEKDVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNKHMLDM
                     DDLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKRWTKKV
                     DLFKKSLLLIPIHLEVHWSLITVTLSSRIISFYDSQGIHFKFCVENIRKYLLTEAREK
                     NRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRVRKRIY
                     KELCECRLLD"
     exon            1710..1815
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1954
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1955..2002
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2080
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2081..2218
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2302
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2303..2353
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2354..5981
                     /gene="Senp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccggtgtcg cgctgctgct gggaggaagc tgggccgcct cgccggccga aagcaggccg
       61 gagccctggt cgctggcctg gcttctccgg gcgtgggcgt gggcgagggc gaggcagcgg
      121 tcccagacgc tgcagcgttc gtccaggcag aagattaggt gccgggagca aagaaagtag
      181 ttacatccaa ttctcattat gcatcagaaa aatgaaaaaa cagaagaaaa ttctatggaa
      241 gaaaggaatt cacttagcct tttctgagaa atggaatgcg ggatttggag gctttaagaa
      301 actctatttt ccccaaaact tgtgctttct gaaagctaag ctgggaaggc cagttgtttg
      361 gcatcggcag tcgaagcatt tccagtgtaa taagaggggt cttcacatcc agaaaacatg
      421 gacccaggat gtaccacttt gttcaaagac caagtctgga gtggccactc aaaatgttag
      481 ttctttgtat gccaaagtga aaagaaagga cactaagcac ttcatttcct cctccaggag
      541 tctcctgaaa ctccaagcag ataaattact ttcttcagca aagaacttgg gccgtgaata
      601 ctgcagagag aaaagccttc tgaaggcagt tactggcttg tcggcaaata ctgttttagg
      661 taaggccaat ggtcacaaac ctagcacgga cccacaagct tcagactttc ccatgaagtt
      721 caatggggag agccaaagtc caagtgacag tggcaagact gtggttttga acaaacatag
      781 aaaacgagtt tgttatggct gctaccaagg gctagagcac cacaggaaca ggagacccct
      841 gattccaaaa aagttccaac ctaaccaaca tcgaagagtc aaagtgtctc ttatgatgta
      901 tgagaaacta tccatgatta gatttcggta taggattttc agatcccagc acttcagaac
      961 gaaaagcaga gtttgcaagc taagaaaagc ccagcgaagc tgggtgcaga aggtcactgg
     1021 ggaccatcaa gagaacttta gggataacaa cactgagggt ggcgattgca gcccagtccc
     1081 ttccctagaa cctaaagacc cttgtcggtg tcagccatac tttccagaca tggacagtag
     1141 tgctgtggtg aagggaaaaa actgtcacgt gcctgatggc cacactaaag aaagtcctgc
     1201 cttggacaaa gagcatggtt tagatgcagc attccctgac cagcagaatg gcagcaccac
     1261 atacacttgg gaccagccat cctcttctcc taagtgggag tgtacagagc aaattcatga
     1321 aatccctttg atgggacatc cttctagtga caacttcact ccgggaactg aaagagctct
     1381 tatgactctg gggcaggaaa gcgggacaag tgctgtcagc gatgacggag tgaagctgtc
     1441 agtgtctgga gcagacgaat ctgtgagtag tgtagatggg cctgtgtctg aggagcccgc
     1501 tcagaacgag aacttccaga tggaggagga tgggtctctc aggcagaaca ttcttagttc
     1561 gaaactgctg gaccaccctt actgtaagag tccactggat gctcccttgg tgtgcagtga
     1621 gctcaaagta gaaaaccaag tggcaggtgg caagagtggc cagacagcgt ctcccgtgga
     1681 tgatgagcag ctctcgacct gcctttctgg gttcctagac gaggttatga aaaagtatgg
     1741 aagtctggtc ccactcagtg agaaagatgt ccttgggaga ttaaaagatg tctttaatga
     1801 agacttttct aatagaaaac catttatcaa tagggaaata acaaactacc gggccagaca
     1861 tcaaaagtgt aacttccgaa tcttctacaa caagcacatg ctggatatgg acgacctggc
     1921 aactttggat ggtcagaatt ggttgaatga ccaggttatt aatatgtatg gcgagctgat
     1981 aatggatgca gtccccgaca aggtccactt cttcaacagc tttttccata gacagctggt
     2041 aaccaaaggc tataatggag ttaagagatg gactaagaag gtggatttgt ttaaaaagag
     2101 tcttctgttg attcccatcc acctggaggt ccactggtct ctcattactg tgacactctc
     2161 cagtcggatt atttcatttt atgattccca aggcattcat tttaaatttt gtgtagagaa
     2221 tataagaaag tatttgctga ctgaagccag agaaaaaaat agacctgaat ttcttcaggg
     2281 ttggcagact gctgttacaa agtgtattcc acaacagaaa aatgacagtg actgtggagt
     2341 ctttgtgctc cagtactgca agtgcctcgc cctagagcag cctttccagt tttctcaaga
     2401 agacatgcct cgagtgcgga agaggatcta taaggagctg tgtgagtgcc ggctcctgga
     2461 ctgacactca ctcagcaggg actccagaag gcgccatgtt ggagcagatg gtttgttact
     2521 tgaatctcca aacacttact gaatctttac agatacttca gattggtggt attgggccac
     2581 ttattgttac ctcagattta tttttgccct tcatttctcc tgctatcatg tacttttttt
     2641 ttaatgttca atttagtttc atttttaact ttatggattc catacatccc tcccatattt
     2701 aatatttatt atccaaacgc atgcatatag acagagcatg cagtaaagag tattaaaaaa
     2761 aaaagcctag tagatttggt gcagcttttg aaacatagtt agatgtgaac tgaatacagg
     2821 tttaaaagtt aaccccagaa cctaaaaatg caagatgttt ttgatacagc atagtcagaa
     2881 tagatgttcc ccatggcata aagggtagct aggagtgttg tggaaagcca gtcatgtttc
     2941 ccttacagca ccttttgctc atccctctga tgagtctcca gcatgagacg cattccttct
     3001 gaaggccaga ggggctgttc tgctgaggga tgtggtgctt acaagcacag tgctgtttga
     3061 gaagagttaa ggtatgagga aaagcagctt ccttgggtgc cagttacctt attttctaaa
     3121 aaggcaaggg gaggggttat tttgatttgt ctgagacaaa gtctcactat gtagcctaag
     3181 ctgtcgtgga gctcccagta cctaggctgg cctcaaactc aagctaaacc tgtctctgtc
     3241 tcctagtctg gtaacatagt acataccaat acactctaca ggaagagtct cattttggtt
     3301 ttaagattta taatatgtag aataaatctc atgaaggttt ttcctgagac actgaatttt
     3361 cttggatttt tttttttctg ggtttgactt gtaaaaaaaa aaacagcatt catcaaactc
     3421 atagttaaat aaatgagaat ttggctttca tggaagtaat tcactagtta tcacctctct
     3481 gtgttgcttc ccatgtactc caaggcattt aaaatttact aaaaatgttt ctactttaag
     3541 gtatataaaa tgcaaacact caaagtagaa gattggcata tggtcttttg cagatggtgg
     3601 gagaagaggg gagggaggca gcactgagga ccctgggaga gagcagtgtg gagggacgct
     3661 ctcccctgtc ttttctggtg cctcaacatc ccaaagagct cgtttggctt ccacaagaac
     3721 aagctgagtg ctggactcaa gaaccgcctg ttagtgagtg ggctgtacag tagtcctgtc
     3781 ctatggatta ggaagagggg gagcttgcat ctctaatctg gcctctcgtg acatgtttga
     3841 aaggaataga agatgcatat taagccgaac cagttttttt tttcctccca gaattgaagg
     3901 agggaggcgt aaggaacttg tgtagaaaac taccaagtac acgacagaag atagctgtcc
     3961 agttcgacag aagatagctg cccagttcgg catgagatgt ttgaaaaaca aaagaggcaa
     4021 aatggccgaa tagggcttaa ctgcctcagt tagggcagag tcacctaggt ttacacgcag
     4081 gattagcagc agcagcgcga cacaggcagg agccctggca ctcttctctc ctcagttagt
     4141 cctcagcata aagtcaggtc agcatttctt gtgcttcagg tcattaacaa ctgaggtaga
     4201 ggcattttat gttgctacaa gttactgttt ctgtagtact gggactgaac gcagggccca
     4261 ctcacatgtt agacaagctc taccactgag ccaccacctt agccctctgt acaattttgt
     4321 attttgagac atggtcttag gacgttgcct aggctggcct tgagtttgtt cagtggctga
     4381 gcctggtctt cagtttatat tcttgtcacc caggtaacca ggaataaggc cagccctacc
     4441 agcccaggct gcttgaaggt cttttaggga aggggtttgg ggagcagggt cttatgtgac
     4501 agagtagctt cacacttgcc atgtagctga aggtgacctc aaattcctag tgctctcctg
     4561 ggtgctagga ttttaggtct ctgtcatcat gaccagctaa ggacagaatt agaccagcat
     4621 gaacttcttc aaaattcatg tgcaagacat tactatggga ttttgttggt gtgcctgtac
     4681 tgaaaaagcc agtagtaaga tggccgactc agatgtctta agggagtatc tcacttcccc
     4741 agtgagagac ttcatgcaga agttacagtt gggttccttt ggaatcttgt tgaagtggtt
     4801 tagtccaggc tggcctcata cttgcagtcc tgcctcagcc tacctaatgt ttagattcca
     4861 tggtgcacca gtggtcacct cagctgtgag gcatgcagga ataacagact cgagccatca
     4921 gactctctcc cttctgccct gacaggacac cctcaggtgc acattcagcc tgctctagcc
     4981 tacatgctgg gtgttttccg tatgtcccaa acctgtgtct gtcatgagtg agacttggtc
     5041 tcagcacacc gttgttcttt ctcttcttgt aattacatgt aaactctgtt tagccttcaa
     5101 atcctagatt gcagaatctt ttgtctcggt gtttgcagta atgctttgct gttgctggct
     5161 tggcactgaa ctttgatgcc cataaaatcc tggcagactt acgtcactgg ggatgaatgt
     5221 aagccttgca caaacttaga gctattcaca tacgatgagc cttcagcaag ctgcccagtc
     5281 ctcatggcag acttacttac ctggctgtag ctgcttcttt ccttttgtta aacctctagc
     5341 aatcaatgta gatttaactc atcttttagt tttcttagga atcacgcaga cttaactttc
     5401 agttggcctc tcaaggaaga gaaaagaagt tgctgccaat aatttcacag cacatttttg
     5461 gctttgcact gtgttctctg ttcaccattg aatgtgaata gcatggtcat cgggagttta
     5521 tgattggaga acaacagtac tagagataca gcctgtactc tgtctaatgt gacttgtccc
     5581 tttcctctgc agttggggct cactgcttct tccctgcctt aggagccatt gggggtctga
     5641 gtgggtcaga gacagtgtat ttagttgaca ctgttaactc actgattatg tgctgtgctt
     5701 cattatgtta agagaccaag ttaatcaacg gttatacagt acatagtctt gctatgtgtt
     5761 aagctctgcc tcttggctag tagatgtcta aaatctgggg aatagcatcc aagaagtact
     5821 attgtatttg ggggttacaa aagcagacct agacaagtgt tcacttgaat gatacctgtt
     5881 ggtcagaaag attttattaa aagattatga tcatgtaaaa attacagtca gtactcaacc
     5941 cttctagcaa aatatttttt tgaaaaataa actaaatgcc t
//
