LOCUS       NM_023989               1808 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus SUMO specific peptidase 2 (Senp2), mRNA.
ACCESSION   NM_023989
VERSION     NM_023989.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1808)
  AUTHORS   Gupta,S., Wang,M., Azuma,Y. and Muma,N.A.
  TITLE     Regulation of Serotonin 1A Receptor SUMOylation by SENP2 and
            PIASxalpha
  JOURNAL   Int J Mol Sci 22 (24), 13176 (2021)
   PUBMED   34947973
  REMARK    GeneRIF: Regulation of Serotonin 1A Receptor SUMOylation by SENP2
            and PIASxalpha.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1808)
  AUTHORS   Bu,F.T., Chen,Y., Yu,H.X., Chen,X., Yang,Y., Pan,X.Y., Wang,Q.,
            Wu,Y.T., Huang,C., Meng,X.M. and Li,J.
  TITLE     SENP2 alleviates CCl4-induced liver fibrosis by promoting activated
            hepatic stellate cell apoptosis and reversion
  JOURNAL   Toxicol Lett 289, 86-98 (2018)
   PUBMED   29535048
  REMARK    GeneRIF: Data suggest that SENP2 in hepatic stellate cells is
            involved in regulation of apoptosis in these cells and in
            development/reversion of liver fibrosis (here, carbon
            tetrachloride-induced liver fibrosis).
REFERENCE   3  (bases 1 to 1808)
  AUTHORS   Bernstock,J.D., Ye,D., Smith,J.A., Lee,Y.J., Gessler,F.A.,
            Yasgar,A., Kouznetsova,J., Jadhav,A., Wang,Z., Pluchino,S.,
            Zheng,W., Simeonov,A., Hallenbeck,J.M. and Yang,W.
  TITLE     Quantitative high-throughput screening identifies cytoprotective
            molecules that enhance SUMO conjugation via the inhibition of
            SUMO-specific protease (SENP)2
  JOURNAL   FASEB J 32 (3), 1677-1691 (2018)
   PUBMED   29146736
  REMARK    GeneRIF: Quantitative high-throughput screening identifies
            cytoprotective molecules that enhance SUMO conjugation via the
            inhibition of SUMO-specific protease (SENP)2.
REFERENCE   4  (bases 1 to 1808)
  AUTHORS   Cong,L., Pakala,S.B., Ohshiro,K., Li,D.Q. and Kumar,R.
  TITLE     SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor
            antigen 1 (MTA1) synergistically regulate its transcriptional
            repressor function
  JOURNAL   J Biol Chem 286 (51), 43793-43808 (2011)
   PUBMED   21965678
REFERENCE   5  (bases 1 to 1808)
  AUTHORS   Ran,Y., Liu,T.T., Zhou,Q., Li,S., Mao,A.P., Li,Y., Liu,L.J.,
            Cheng,J.K. and Shu,H.B.
  TITLE     SENP2 negatively regulates cellular antiviral response by
            deSUMOylating IRF3 and conditioning it for ubiquitination and
            degradation
  JOURNAL   J Mol Cell Biol 3 (5), 283-292 (2011)
   PUBMED   22028379
REFERENCE   6  (bases 1 to 1808)
  AUTHORS   Best,J.L., Ganiatsas,S., Agarwal,S., Changou,A., Salomoni,P.,
            Shirihai,O., Meluh,P.B., Pandolfi,P.P. and Zon,L.I.
  TITLE     SUMO-1 protease-1 regulates gene transcription through PML
  JOURNAL   Mol Cell 10 (4), 843-855 (2002)
   PUBMED   12419228
REFERENCE   7  (bases 1 to 1808)
  AUTHORS   Zhang,H., Saitoh,H. and Matunis,M.J.
  TITLE     Enzymes of the SUMO modification pathway localize to filaments of
            the nuclear pore complex
  JOURNAL   Mol Cell Biol 22 (18), 6498-6508 (2002)
   PUBMED   12192048
REFERENCE   8  (bases 1 to 1808)
  AUTHORS   Kadoya,T., Yamamoto,H., Suzuki,T., Yukita,A., Fukui,A., Michiue,T.,
            Asahara,T., Tanaka,K., Asashima,M. and Kikuchi,A.
  TITLE     Desumoylation activity of Axam, a novel Axin-binding protein, is
            involved in downregulation of beta-catenin
  JOURNAL   Mol Cell Biol 22 (11), 3803-3819 (2002)
   PUBMED   11997515
REFERENCE   9  (bases 1 to 1808)
  AUTHORS   Hang,J. and Dasso,M.
  TITLE     Association of the human SUMO-1 protease SENP2 with the nuclear
            pore
  JOURNAL   J Biol Chem 277 (22), 19961-19966 (2002)
   PUBMED   11896061
REFERENCE   10 (bases 1 to 1808)
  AUTHORS   Kadoya,T., Kishida,S., Fukui,A., Hinoi,T., Michiue,T., Asashima,M.
            and Kikuchi,A.
  TITLE     Inhibition of Wnt signaling pathway by a novel axin-binding protein
  JOURNAL   J Biol Chem 275 (47), 37030-37037 (2000)
   PUBMED   10944533
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF260129.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF260129.1, FQ210639.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMD00132261,
                                           SAMD00132262 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1808
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q23"
     gene            1..1808
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /note="SUMO specific peptidase 2"
                     /db_xref="GeneID:78973"
                     /db_xref="RGD:708378"
     exon            1..121
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1787
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /EC_number="3.4.22.68"
                     /note="sentrin/SUMO-specific protease SENP2;
                     Axin-associating molecule; SUMO/sentrin specific peptidase
                     2; SUMO/sentrin specific protease 2; Sumo1/sentrin/SMT3
                     specific peptidase 2"
                     /codon_start=1
                     /product="sentrin-specific protease 2"
                     /protein_id="NP_076479.1"
                     /db_xref="GeneID:78973"
                     /db_xref="RGD:708378"
                     /translation="MYRWLTKVLGTILRLCERPAPGARALLKRRRSSSSLFSTAVDTD
                     EIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVSSACNGTRNVAPSGEVFSN
                     SPSCELTTSGSCSSMLKLGNKSPNGISDYPKIRVTVARDQPRRVLPSFGFTLKSEGYN
                     RRPSGRRHSKSNPESSLPWKPQEQGVTEMISEEGGKGARRPHCTVEEGVQKDEREKYL
                     KLLERLKEGAHGSTFPPAVSHHSSQRTQMDTLKTKGWMEEQNHGVRTTHLVPKQYRVV
                     ETRGPLCSVRSEKRYSKGKADTEKVVGLRFEKDGTRGHQLEPDLSEEVSARLRLGSGS
                     NGLLRRKISVLEAKEKNFPSKEKDRRTEDLFELTEDMEKEISNALGHGPPDEILSSAF
                     KLRITRGDIQTLKNYHWLNDEVINFYMNLLVERSKKQGYPALHALSTFFYPKLKSGGY
                     QAVKRWTKGVNLFDQELVLVPIHRKVHWSLVVMDLRKKCLKYLDSMGQKGHRICEILL
                     QYLQDESKTKRNTDLNLLEWTHYSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITF
                     TQHQMPLFRKKMVWEILHQQLL"
     exon            122..180
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            181..314
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            315..381
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            382..472
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            473..641
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            642..742
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            743..837
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            838..889
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            890..950
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1127
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1259
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1463
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            1464..1543
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1628
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            1629..1724
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
     exon            1725..1808
                     /gene="Senp2"
                     /gene_synonym="Axam"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgctgctgct caggcctgga atgtacagat ggctgactaa ggttctcggc accattcttc
       61 gcttgtgtga gcggcccgcg cccggggccc gcgccctgct caagaggcgg cgctccagca
      121 gctctctgtt ttctactgca gtggacactg atgaaatccc agctaaaaga ccaagactag
      181 attgcttcat tcaccaagtg aagaacagtc tctacaatgc ggccagctta tttggattcc
      241 cattccagct gaccaccaaa cccatggtgt cttctgcttg taatggaaca cggaatgtgg
      301 ccccttcagg agaggtgttc tcgaactctc cctcctgtga actgacgact tctggatcct
      361 gcagcagcat gctgaagctg ggtaataaat ctcctaatgg aataagtgac tatccaaaga
      421 tcagagtgac agtggcccga gatcagccac ggagagtcct gccttccttt ggttttacat
      481 tgaaatcaga aggctataat agaagaccaa gtggccgtcg ccatagcaaa agcaatccag
      541 agagttcctt accgtggaaa cctcaggagc aaggtgtaac agagatgatt tctgaagagg
      601 gtggcaaggg tgcaaggcgt ccccattgca ccgtggagga gggtgtccaa aaggacgaaa
      661 gagaaaaata cctaaagtta ttggagcgtc ttaaagaggg tgctcacgga agcacttttc
      721 ctcctgcagt ttcacatcat agttctcaga gaacgcagat ggacacatta aagaccaaag
      781 gctggatgga agaacagaat catggagtca gaacaaccca tttggttccc aaacagtata
      841 gagttgttga aacaagagga cctctctgtt cagtgagaag tgaaaagagg tattcaaaag
      901 gaaaagctga cacagagaag gtggtgggac tccgatttga aaaggacggt acaagaggac
      961 accagttgga gcctgatctg tcagaagaag tgtctgcccg gcttcgcctg ggaagtggaa
     1021 gcaatggcct actcagaagg aaaatatcag tgcttgaggc aaaggaaaag aacttcccaa
     1081 gcaaagagaa ggacagaaga acagaagatc tctttgaact tacagaggac atggaaaagg
     1141 aaatcagtaa tgccctgggc catggtcctc cagatgagat tttgagcagc gctttcaagt
     1201 tacgaatcac ccgtggagat atccagacct taaagaacta tcactggctc aatgatgagg
     1261 tcattaattt ttatatgaat cttttagtgg agaggagtaa aaagcaaggc tacccagcac
     1321 ttcatgcact cagtacattc ttctatccta aattaaagtc tggaggttac caagcagtga
     1381 aaagatggac caaaggggtg aatctcttcg atcaagaact tgttctggtt cctattcatc
     1441 ggaaggtaca ttggagcctg gtggtgatgg acctaagaaa aaagtgtctt aaatatctgg
     1501 attctatggg acaaaaaggc cacaggatct gtgagattct tcttcagtat ttacaggacg
     1561 aaagcaagac caaaagaaat acagatctca atctcttaga gtggacccac tacagcatga
     1621 agccacatga gattcctcaa cagttgaatg ggagtgattg tggaatgttt acttgtaaat
     1681 acgcagatta tatttctagg gacaaaccta tcacattcac tcagcaccag atgcctctct
     1741 tccggaagaa gatggtgtgg gaaatccttc accagcagtt gctgtgacaa tgccccgcct
     1801 ggtcttct
//
