LOCUS       NM_012710               1545 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus semenogelin 1 (Semg1), mRNA.
ACCESSION   NM_012710
VERSION     NM_012710.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1545)
  AUTHORS   O'Rand,M.G. and Widgren,E.E.
  TITLE     Loss of calcium in human spermatozoa via EPPIN, the semenogelin
            receptor
  JOURNAL   Biol Reprod 86 (2), 55 (2012)
   PUBMED   22075473
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1545)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   3  (bases 1 to 1545)
  AUTHORS   Mitra,A., Richardson,R.T. and O'Rand,M.G.
  TITLE     Analysis of recombinant human semenogelin as an inhibitor of human
            sperm motility
  JOURNAL   Biol Reprod 82 (3), 489-496 (2010)
   PUBMED   19889947
REFERENCE   4  (bases 1 to 1545)
  AUTHORS   Edstrom,A.M., Malm,J., Frohm,B., Martellini,J.A., Giwercman,A.,
            Morgelin,M., Cole,A.M. and Sorensen,O.E.
  TITLE     The major bactericidal activity of human seminal plasma is
            zinc-dependent and derived from fragmentation of the semenogelins
  JOURNAL   J Immunol 181 (5), 3413-3421 (2008)
   PUBMED   18714013
REFERENCE   5  (bases 1 to 1545)
  AUTHORS   Zhao,H., Lee,W.H., Shen,J.H., Li,H. and Zhang,Y.
  TITLE     Identification of novel semenogelin I-derived antimicrobial peptide
            from liquefied human seminal plasma
  JOURNAL   Peptides 29 (4), 505-511 (2008)
   PUBMED   18314226
REFERENCE   6  (bases 1 to 1545)
  AUTHORS   Kise,H., Nishioka,J., Kawamura,J. and Suzuki,K.
  TITLE     Characterization of semenogelin II and its molecular interaction
            with prostate-specific antigen and protein C inhibitor
  JOURNAL   Eur J Biochem 238 (1), 88-96 (1996)
   PUBMED   8665956
REFERENCE   7  (bases 1 to 1545)
  AUTHORS   Malm,J., Hellman,J., Magnusson,H., Laurell,C.B. and Lilja,H.
  TITLE     Isolation and characterization of the major gel proteins in human
            semen, semenogelin I and semenogelin II
  JOURNAL   Eur J Biochem 238 (1), 48-53 (1996)
   PUBMED   8665951
REFERENCE   8  (bases 1 to 1545)
  AUTHORS   Harris,S.E., Harris,M.A., Johnson,C.M., Bean,M.F., Dodd,J.G.,
            Matusik,R.J., Carr,S.A. and Crabb,J.W.
  TITLE     Structural characterization of the rat seminal vesicle secretion II
            protein and gene
  JOURNAL   J Biol Chem 265 (17), 9896-9903 (1990)
   PUBMED   2351680
REFERENCE   9  (bases 1 to 1545)
  AUTHORS   Lilja,H., Abrahamsson,P.A. and Lundwall,A.
  TITLE     Semenogelin, the predominant protein in human semen. Primary
            structure and identification of closely related proteins in the
            male accessory sex glands and on the spermatozoa
  JOURNAL   J Biol Chem 264 (3), 1894-1900 (1989)
   PUBMED   2912989
REFERENCE   10 (bases 1 to 1545)
  AUTHORS   Maffei,A., Paonessa,G., Abrescia,P., Metafora,S. and Guardiola,J.
  TITLE     Polymorphism of rat seminal vesicle secretory proteins:
            characterization of svp-1 and svp-2 and their identification with
            the major secretory proteins IV and V
  JOURNAL   Biochem Genet 22 (5-6), 567-576 (1984)
   PUBMED   6466291
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC061977.1.
            
            On Jan 1, 2004 this sequence version replaced NM_012710.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061977.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676811 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1545
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q42"
     gene            1..1545
                     /gene="Semg1"
                     /gene_synonym="RATSVPIIA; Svp1; SVPIIA; Svs2; SVS2P;
                     Svs2p2"
                     /note="semenogelin 1"
                     /db_xref="GeneID:25013"
                     /db_xref="RGD:3790"
     exon            1..82
                     /gene="Semg1"
                     /gene_synonym="RATSVPIIA; Svp1; SVPIIA; Svs2; SVS2P;
                     Svs2p2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1254
                     /gene="Semg1"
                     /gene_synonym="RATSVPIIA; Svp1; SVPIIA; Svs2; SVS2P;
                     Svs2p2"
                     /note="seminal vesicle protein, secretion 1; seminal
                     vesicle protein, secretion 2; SVS II; seminal vesicle
                     secretory protein II; seminal vesicle secretory protein 2;
                     semenogelin I"
                     /codon_start=1
                     /product="seminal vesicle secretory protein 2 precursor"
                     /protein_id="NP_036842.2"
                     /db_xref="GeneID:25013"
                     /db_xref="RGD:3790"
                     /translation="MKSSIFILSLFLLLERQAAVVGQYGGTKGHFQSSSSGFMLGQKG
                     HLNFGLKGGSEEAAEESIFMQSQHQMFGQDGGDMAQTSVSQEHTGVKGAAICRKGQVS
                     QLKSQESQIKSFRQVKSSGQLKSGGSQLKSFGQVKSSESQLKSFGQVKASGSQLKSFG
                     QVKASGSQLKSYGQMKSSGSQVKSFGQMKSSGSQVKSFGQMKASESQIKSFGQRKSQG
                     GQLQSYGQMKSYGQTKSLESQAKSFGQVKSQSGQMKSSYGQRKSYGEETQLKSFDQDA
                     QLKSYGQQKSQKQSSFSQVKSQSAQLKSFGQQKSLKGFSQQTQQKGFAMDEDLSQVRK
                     QFDDDDLSVQQKSTQQMKTEEDLSQFGQQRQFGQERSQSYKGYLAQYRKKLQEQQQQK
                     NFNQDNFFTKGGAGLYQAQLKG"
     exon            83..1294
                     /gene="Semg1"
                     /gene_synonym="RATSVPIIA; Svp1; SVPIIA; Svs2; SVS2P;
                     Svs2p2"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1469
                     /gene="Semg1"
                     /gene_synonym="RATSVPIIA; Svp1; SVPIIA; Svs2; SVS2P;
                     Svs2p2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cttgacaaga tgaagtcctc tatcttcatt ctatctctgt tcctccttct ggaaagacag
       61 gcagctgtgg ttggacagta tggtgggaca aaaggtcact tccagagcag ctcatcaggg
      121 tttatgcttg gtcagaaagg ccacctcaat ttcgggctca aaggaggaag tgaggaagca
      181 gctgaagaaa gcattttcat gcaatcacaa caccagatgt tcggccagga tggtggtgac
      241 atggcgcaga caagtgtttc acaagagcat acaggtgtaa agggggccgc gatttgtcgt
      301 aaaggacaag tatcccaatt gaaatcccaa gaatcccaaa taaaatcctt tagacaagta
      361 aaatccagtg gacagctgaa atctggagga tcccaattaa aatcctttgg acaagtgaaa
      421 tccagtgagt cccaattaaa atcctttggc caagtgaaag ccagtgggtc ccaattaaaa
      481 tccttcggac aagtgaaagc cagtgggtcc caattaaaat cctatggaca aatgaaatcc
      541 agtgggtccc aagtgaaatc ctttggacaa atgaaatcca gtgggtccca agtaaaatcc
      601 tttggacaaa tgaaagccag tgagtcccaa ataaaatcct ttggacaaag aaaatcccaa
      661 ggtggtcaac tacaatccta tggccaaatg aaatcctatg ggcagacgaa atccctagaa
      721 tcccaggcca aatccttcgg acaagtaaag tcccaaagtg gccaaatgaa atcctcctat
      781 ggtcagagaa aatcctatgg tgaagagact caactgaagt ctttcgacca agatgcccaa
      841 ctaaaatcct atggtcaaca aaaatcccaa aaacaatcct cctttagcca agtaaaatct
      901 caaagtgccc aactaaagtc ctttggccaa caaaaatccc tcaaagggtt ttctcaacaa
      961 actcaacaga aaggatttgc catggatgaa gatttgtcac aagtgcggaa acaatttgac
     1021 gatgatgacc tctctgtaca acagaagtct acccaacaga tgaaaacaga ggaagactta
     1081 tcccaatttg gacaacaacg acaatttgga caagaacgct cccaatccta taaaggatat
     1141 cttgcacaat acagaaagaa attacaggaa caacaacaac agaaaaattt taatcaggat
     1201 aactttttta caaagggagg ggcaggccta tatcaggctc aacttaaggg ataacatatt
     1261 cactgagcaa ctgaagacca agatcaatgt caaggactca cctcaccaga gtcaagtcta
     1321 tgataccttc aagatgcagg ctgcaacatc attccagttc gttggttcat ggacaatcct
     1381 ctactcactt tcgcttttct gtaggacttc tgcccctgga gcttccccca gacactagct
     1441 ttccaataaa aaaataactt tctgcatcaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaa
//
