LOCUS       NM_001108153            2622 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus semaphorin 7A (John Milton Hagen blood group)
            (Sema7a), mRNA.
ACCESSION   NM_001108153 XM_001072477 XM_243863
VERSION     NM_001108153.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2622)
  AUTHORS   Deng,J., Xu,T., Yang,J., Zhang,K.M., Li,Q., Yu,X.Y., Li,R., Fu,J.,
            Jiang,Q., Ma,J.X. and Chen,Y.M.
  TITLE     Sema7A, a brain immune regulator, regulates seizure activity in
            PTZ-kindled epileptic rats
  JOURNAL   CNS Neurosci Ther 26 (1), 101-116 (2020)
   PUBMED   31179640
  REMARK    GeneRIF: Sema7A, a brain immune regulator, regulates seizure
            activity in PTZ-kindled epileptic rats.
REFERENCE   2  (bases 1 to 2622)
  AUTHORS   Zhang,M., Yan,X., Liu,W., Sun,R., Xie,Y. and Jin,F.
  TITLE     Endothelial semaphorin 7A promotes seawater aspiration-induced
            acute lung injury through plexin C1 and beta1 integrin
  JOURNAL   Mol Med Rep 16 (4), 4215-4221 (2017)
   PUBMED   28765893
  REMARK    GeneRIF: SEMA7A promotes seawater induced lung edema via plexin C1
            and stimulates seawater induced lung inflammation via beta1
            integrin.
REFERENCE   3  (bases 1 to 2622)
  AUTHORS   Kalaani,J., Roche,J., Hamade,E., Badran,B., Jaber,M., Gaillard,A.
            and Prestoz,L.
  TITLE     Axon guidance molecule expression after cell therapy in a mouse
            model of Parkinson's disease
  JOURNAL   Restor Neurol Neurosci 34 (6), 877-895 (2016)
   PUBMED   27858721
  REMARK    GeneRIF: This study shown that mrna of expression of semaphorin 7A
            after cell therapy in a mouse model of Parkinson's disease.
REFERENCE   4  (bases 1 to 2622)
  AUTHORS   Parkash,J., Messina,A., Langlet,F., Cimino,I., Loyens,A., Mazur,D.,
            Gallet,S., Balland,E., Malone,S.A., Pralong,F., Cagnoni,G.,
            Schellino,R., De Marchis,S., Mazzone,M., Pasterkamp,R.J.,
            Tamagnone,L., Prevot,V. and Giacobini,P.
  TITLE     Semaphorin7A regulates neuroglial plasticity in the adult
            hypothalamic median eminence
  JOURNAL   Nat Commun 6, 6385 (2015)
   PUBMED   25721933
  REMARK    GeneRIF: Semaphorin7A regulates neuroglial plasticity in the adult
            hypothalamic median eminence.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2622)
  AUTHORS   Zhang,M., Wang,L., Dong,M., Li,Z. and Jin,F.
  TITLE     Endothelial Semaphorin 7A promotes inflammation in seawater
            aspiration-induced acute lung injury
  JOURNAL   Int J Mol Sci 15 (11), 19650-19661 (2014)
   PUBMED   25353180
  REMARK    GeneRIF: SEMA7A is critical in the development of lung inflammation
            and pulmonary edema in seawater aspiration-induced ALI, and may be
            a therapeutic target for this disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2622)
  AUTHORS   Kopp,M.A., Brommer,B., Gatzemeier,N., Schwab,J.M. and Pruss,H.
  TITLE     Spinal cord injury induces differential expression of the
            profibrotic semaphorin 7A in the developing and mature glial scar
  JOURNAL   Glia 58 (14), 1748-1756 (2010)
   PUBMED   20645410
  REMARK    GeneRIF: After spinal cord injury, Sema7A-positive cells accumulate
            specifically in lesion areas resulting in significantly enhanced
            Sema7A expression at the injury site.
REFERENCE   7  (bases 1 to 2622)
  AUTHORS   Pasterkamp,R.J., Kolk,S.M., Hellemons,A.J. and Kolodkin,A.L.
  TITLE     Expression patterns of semaphorin7A and plexinC1 during rat neural
            development suggest roles in axon guidance and neuronal migration
  JOURNAL   BMC Dev Biol 7, 98 (2007)
   PUBMED   17727705
  REMARK    GeneRIF: Sema7A and plexinC1 expression patterns are consistent
            with these proteins serving both cooperative and separate functions
            during neural development
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2622)
  AUTHORS   Suzuki,K., Okuno,T., Yamamoto,M., Pasterkamp,R.J., Takegahara,N.,
            Takamatsu,H., Kitao,T., Takagi,J., Rennert,P.D., Kolodkin,A.L.,
            Kumanogoh,A. and Kikutani,H.
  TITLE     Semaphorin 7A initiates T-cell-mediated inflammatory responses
            through alpha1beta1 integrin
  JOURNAL   Nature 446 (7136), 680-684 (2007)
   PUBMED   17377534
REFERENCE   9  (bases 1 to 2622)
  AUTHORS   Foster,L.J., Zeemann,P.A., Li,C., Mann,M., Jensen,O.N. and
            Kassem,M.
  TITLE     Differential expression profiling of membrane proteins by
            quantitative proteomics in a human mesenchymal stem cell line
            undergoing osteoblast differentiation
  JOURNAL   Stem Cells 23 (9), 1367-1377 (2005)
   PUBMED   16210410
REFERENCE   10 (bases 1 to 2622)
  AUTHORS   Pasterkamp,R.J., Peschon,J.J., Spriggs,M.K. and Kolodkin,A.L.
  TITLE     Semaphorin 7A promotes axon outgrowth through integrins and MAPKs
  JOURNAL   Nature 424 (6947), 398-405 (2003)
   PUBMED   12879062
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473975.1.
            
            On or before Oct 22, 2008 this sequence version replaced
            XM_001072477.1, XM_243863.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2622
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q24"
     gene            1..2622
                     /gene="Sema7a"
                     /note="semaphorin 7A (John Milton Hagen blood group)"
                     /db_xref="GeneID:315711"
                     /db_xref="RGD:1305192"
     exon            1..183
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     CDS             6..2006
                     /gene="Sema7a"
                     /note="semaphorin-7A; sema domain, immunoglobulin domain
                     (Ig), and GPI membrane anchor, (semaphorin) 7A; semaphorin
                     7A, GPI membrane anchor"
                     /codon_start=1
                     /product="semaphorin-7A precursor"
                     /protein_id="NP_001101623.1"
                     /db_xref="GeneID:315711"
                     /db_xref="RGD:1305192"
                     /translation="MTPPPPGRAAPSAPRARVLSLPARFGLPLRLRLLLVFWVTAASA
                     QGHSRSGPRISAVWKGQDHVDFGQPEPHNVLFHEPGSFSVWVGGRGKVYLFNFPEGKN
                     ASVRTVNIGSTKGSCQDKQDCENYITLLERRGNGLLVCGTNARKPSCWNLVNDSVVMS
                     LGEMKGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQ
                     NPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSV
                     SKWNTFLKAMLVCSDAATNRNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCV
                     YSLGDIDRVFRTSSLKGYHMGLPNPRPGMCLPKKQPIPTETFQVADSHPEVAQRVEPM
                     GPLKTPLFHSKYHYQKVVVHRMQASNGETFHVLYLTTDRGTIHKVVESGDQEHSFVFN
                     IMEIQPFHRAAAIQAISLDADRRKLYVTSPWEVSQVPLDMCGVYSGGCHGCLMSRDPY
                     CGWDQDQDRCVSIYSSQRSVLQSINPAEPHRECPNPNPDEAPLQKVSLARNSRYYLTC
                     PMESRHATYLWRHEENVEQSCEPGHQSPSCILFIENLTARQYGHYRCEAQEGSYLHEA
                     QHWELLPEDRALAEQLLGHARALAASFWLGVLPTLVLGLLVH"
     exon            184..326
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            327..368
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            369..461
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            462..549
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            550..660
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            661..800
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            801..985
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1094
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1293
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1421
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1582
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1583..1644
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..2622
                     /gene="Sema7a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcgggatgac gcctcctcct cccggacgtg ccgcccccag cgcaccgcgc gcccgcgtcc
       61 tcagcctgcc ggctcggttc gggctcccgc tgcggctgcg gctgctgctg gtgttctggg
      121 tgaccgccgc ctccgcccaa ggccactcga ggagcggacc ccgtatctcc gccgtctgga
      181 aagggcagga ccatgtggac tttggccagc ctgagccaca caatgtgctt ttccatgagc
      241 cgggcagctt ctctgtctgg gtaggtggac gaggcaaggt ctacctcttc aacttccccg
      301 agggcaagaa tgcctctgtg cgcacggtga acattggctc cacaaaaggg tcctgtcagg
      361 acaaacagga ctgcgagaat tacatcactc ttcttgagag gcggggtaat ggactgctgg
      421 tctgtggcac caatgcccgg aaacccagct gctggaactt ggtgaatgac agtgtggtga
      481 tgtcacttgg tgagatgaaa ggctatgccc ccttcagccc ggatgagaac tccctggttc
      541 tgtttgaagg ggatgaagtg tactctacaa tccggaagca ggaatacaat ggcaagatcc
      601 ctcgctttcg ccgcattcgg ggagagagtg aactgtacac aagtgatact gtcatgcaga
      661 atccacagtt catcaaggcc accattgtgc accaggacca agcctatgat gataagatct
      721 actacttctt ccgagaagac aaccctgaca agaaccccga ggctccgctc aatgtatccc
      781 gagtggccca gttatgcagg ggggaccagg gtggtgagag ttcattgtct gtctccaagt
      841 ggaacacctt cctgaaagcc atgctggttt gcagcgacgc agccaccaac aggaacttca
      901 atcgactgca agatgtcttc ctactccctg accccagtgg ccagtggagg gataccaggg
      961 tctatggcgt tttctccaac ccctggaact actcagctgt ctgcgtgtat tcgcttggtg
     1021 acattgacag agtcttccgt acctcctcac tcaaaggcta ccacatgggc cttcccaacc
     1081 ctcgacctgg catgtgcctc ccaaaaaagc aacccatacc cacggaaacc ttccaggtag
     1141 ccgacagtca cccggaggtg gcccagagag tggaacccat ggggccactg aagacaccat
     1201 tgttccactc taagtaccat taccagaaag tggttgtcca ccgcatgcaa gccagcaatg
     1261 gggagacctt ccatgtactt tacctaacca cagacagggg caccattcac aaggtggtgg
     1321 aatcagggga ccaggaacac agctttgtct tcaacatcat ggagatccag ccctttcacc
     1381 gtgcagctgc catccaggcc atatcgttgg atgctgaccg gcggaagctc tatgtgacct
     1441 ccccgtggga agtgagccag gtacccctgg acatgtgtgg ggtctacagt gggggctgcc
     1501 atggctgcct catgtcccga gacccctact gtggctggga ccaggaccag gaccgctgtg
     1561 tgtctatcta cagctcccaa cggtcagtgc tgcagtccat caatccagct gagccacaca
     1621 gagagtgtcc caaccccaac ccagatgagg ctccattgca gaaggtttcc ctggcccgga
     1681 actctcgata ctacctgacc tgccccatgg agtcccgcca cgccacctac ttatggcgcc
     1741 acgaggagaa tgtggaacag agctgtgagc caggccacca aagccccagc tgcattctat
     1801 tcatagagaa cctcactgcc cgtcagtacg gccactaccg ctgcgaggcc caagagggtt
     1861 cctacctcca tgaggctcaa cactgggagc tgctgccgga ggacagagcg ctggccgaac
     1921 agctcttggg ccatgcccgg gccctggccg cctccttctg gctgggggtc ctgcccacac
     1981 tcgtactagg tctgctggtt cactagggct tctaggagct gggtgtaccc caggcttctg
     2041 tagcccagga gtactagaaa aatgtcacac tcagccggcc ggcccgggag ctccctgccc
     2101 acagatcttc caggggtact gagtaatcca gtgggggaca aagggcctgg agatgtccag
     2161 ccgcaggcgg ctgctggggc ccaggtgggg tagggacagt gagggactgt aaaacgaagg
     2221 cgccgactgt gaagctgggc catcagcaac tcaagacttt atcttctcga gaatattttt
     2281 cgaaatctcc tcacgcttga cttcatgcag tgatacactt agcccatcag cctggcagtg
     2341 ggctttggga aggggagctg ggaccccatc tctggacctt ggggctgagt tctttgggat
     2401 cctctgtacc cggctacttc cttccctgcc ccactgctgg gtggccagtg tccctgcaga
     2461 cccaggctgc tcctccgtac ctccctccca gcctgggtcc caccggacag cgccttgcat
     2521 gtttattgga ggatgtttgc tttccggaca gaaggatggg aaaagctcta tttttatgtt
     2581 aggtttattt catgtatagc tattctgact gcatctgtat ga
//
