LOCUS       NP_445923                887 aa            linear   ROD 15-JUN-2024
DEFINITION  semaphorin-6B precursor [Rattus norvegicus].
ACCESSION   NP_445923
VERSION     NP_445923.1
DBSOURCE    REFSEQ: accession NM_053471.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 887)
  AUTHORS   Suto,F., Ito,K., Uemura,M., Shimizu,M., Shinkawa,Y., Sanbo,M.,
            Shinoda,T., Tsuboi,M., Takashima,S., Yagi,T. and Fujisawa,H.
  TITLE     Plexin-a4 mediates axon-repulsive activities of both secreted and
            transmembrane semaphorins and plays roles in nerve fiber guidance
  JOURNAL   J Neurosci 25 (14), 3628-3637 (2005)
   PUBMED   15814794
REFERENCE   2  (residues 1 to 887)
  AUTHORS   Kikuchi,K., Ishida,H. and Kimura,T.
  TITLE     Molecular cloning of a novel member of semaphorin family genes,
            semaphorin Z
  JOURNAL   Brain Res Mol Brain Res 51 (1-2), 229-237 (1997)
   PUBMED   9427525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB000776.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..887
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     Protein         1..887
                     /product="semaphorin-6B precursor"
                     /note="sema Z; semaphorin-Z; sema domain, transmembrane
                     domain (TM), and cytoplasmic domain, (semaphorin) 6B"
                     /calculated_mol_wt=92791
     sig_peptide     1..26
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2980
     mat_peptide     27..887
                     /product="Semaphorin-6B. /id=PRO_0000032343"
                     /note="propagated from UniProtKB/Swiss-Prot (O70141.1)"
                     /calculated_mol_wt=92791
     Region          58..526
                     /region_name="Sema_6B"
                     /note="The Sema domain, a protein interacting module, of
                     semaphorin 6B (Sema6B); cd11267"
                     /db_xref="CDD:200528"
     Site            75
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70141.1)"
     Site            order(118..121,172..173,198,200..201,208,222..224,229,
                     276..277,280,401)
                     /site_type="other"
                     /note="plexin binding site [polypeptide binding]"
                     /db_xref="CDD:200528"
     Site            156
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70141.1)"
     Site            168
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70141.1)"
     Site            order(253,295,297,299..301,303,327,329..333,362,422..423,
                     425)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:200528"
     Site            292
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70141.1)"
     Site            387
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70141.1)"
     Site            442
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70141.1)"
     Site            463
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O70141.1)"
     Region          527..>556
                     /region_name="PSI"
                     /note="Plexin repeat; pfam01437"
                     /db_xref="CDD:396154"
     Site            606..626
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (O70141.1)"
     Region          656..675
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70141.1)"
     Site            667
                     /site_type="methylation"
                     /note="Omega-N-methylarginine.
                     /evidence=ECO:0000250|UniProtKB:O54951; propagated from
                     UniProtKB/Swiss-Prot (O70141.1)"
     Region          697..717
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70141.1)"
     Region          <698..885
                     /region_name="PHA03247"
                     /note="large tegument protein UL36; Provisional"
                     /db_xref="CDD:223021"
     Region          759..887
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (O70141.1)"
     CDS             1..887
                     /gene="Sema6b"
                     /coded_by="NM_053471.4:213..2876"
                     /db_xref="GeneID:84609"
                     /db_xref="RGD:69278"
ORIGIN      
        1 mwtprapppr pallflllll lrvthglfpd eppplsvapr dylshypvfv gsgpgrltpa
       61 egaedlniqr vlrvnrtlfi gdrdnlyqve lepststelr yqrkltwrsn psdidvcrmk
      121 gkqegecrnf vkvlllrdes tlfvcgsnaf npicanysmd tlqllgdnis gmarcpydpk
      181 hanvalfsdg mlftatvtdf laidaviyrs lgdrptlrtv khdskwfkep yfvhavewgs
      241 hvyfffreia mefnylekvv vsrvarvckn dvggsprvle kqwtsflkar lncsvpgdsh
      301 fyfnvlqavt gvvslggrpv ilavfstpsn sipgsavcaf dmnqvaavfe grfreqkspe
      361 siwtpvpedq vprprpgcca apgmqynasn alpdeilnfv kthplmdeav pslghspwiv
      421 rtlirhqltr vavdvgagpw gnqtivflgs evgtvlkflv kpnasvsgtt gpsifleefe
      481 tyrpdrcgrs ssagewgqrl lsleldaasg gllaafprcv vrvpvarcql ysgcmkncig
      541 sqdpycgwap dgsciflrpg tsatfeqdvs gastsglgdc tgllraslsd draglvsvnl
      601 lvtssvaafv vgavvsgfsv gwfvglrerr elarrkdkea ilahggseav lsvsrlgerr
      661 gtgtggrgga gggpggppea llaplmqngw tkaallhggp hdldsgllpt peqtplpqkr
      721 lptthphaha lgprawdhsh allsasasts llllahtrap eqppvptesg pesrlcaprs
      781 crashpgdfp ltphaspdrr rvvsaptgpl dsssvgddlp gpwsppatss lrrpgphgpp
      841 taalrrthtf nsgearpggh rprrhapads thllpcgtge rtappvp
//
