LOCUS       NM_001107659           10501 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus semaphorin 5A (Sema5a), mRNA.
ACCESSION   NM_001107659 XM_001066339 XM_241275
VERSION     NM_001107659.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 10501)
  AUTHORS   Matsuoka,R.L., Chivatakarn,O., Badea,T.C., Samuels,I.S., Cahill,H.,
            Katayama,K., Kumar,S.R., Suto,F., Chedotal,A., Peachey,N.S.,
            Nathans,J., Yoshida,Y., Giger,R.J. and Kolodkin,A.L.
  TITLE     Class 5 transmembrane semaphorins control selective Mammalian
            retinal lamination and function
  JOURNAL   Neuron 71 (3), 460-473 (2011)
   PUBMED   21835343
REFERENCE   2  (bases 1 to 10501)
  AUTHORS   Sadanandam,A., Rosenbaugh,E.G., Singh,S., Varney,M. and Singh,R.K.
  TITLE     Semaphorin 5A promotes angiogenesis by increasing endothelial cell
            proliferation, migration, and decreasing apoptosis
  JOURNAL   Microvasc Res 79 (1), 1-9 (2010)
   PUBMED   19850054
REFERENCE   3  (bases 1 to 10501)
  AUTHORS   Pineda,D., Garcia,B., Olmos,J.L., Davila,J.C., Real,M.A. and
            Guirado,S.
  TITLE     Semaphorin5A expression in the developing chick telencephalon
  JOURNAL   Brain Res Bull 66 (4-6), 436-440 (2005)
   PUBMED   16144627
  REMARK    GeneRIF: Semaphorin5A expression in the developing chick
            telencephalon.
REFERENCE   4  (bases 1 to 10501)
  AUTHORS   Fiore,R., Rahim,B., Christoffels,V.M., Moorman,A.F. and
            Puschel,A.W.
  TITLE     Inactivation of the Sema5a gene results in embryonic lethality and
            defective remodeling of the cranial vascular system
  JOURNAL   Mol Cell Biol 25 (6), 2310-2319 (2005)
   PUBMED   15743826
  REMARK    Erratum:[Mol Cell Biol. 2020 Sep 28;40(20):e00409-20. doi:
            10.1128/MCB.00409-20.. PMID: 32989048]
REFERENCE   5  (bases 1 to 10501)
  AUTHORS   Kantor,D.B., Chivatakarn,O., Peer,K.L., Oster,S.F., Inatani,M.,
            Hansen,M.J., Flanagan,J.G., Yamaguchi,Y., Sretavan,D.W., Giger,R.J.
            and Kolodkin,A.L.
  TITLE     Semaphorin 5A is a bifunctional axon guidance cue regulated by
            heparan and chondroitin sulfate proteoglycans
  JOURNAL   Neuron 44 (6), 961-975 (2004)
   PUBMED   15603739
REFERENCE   6  (bases 1 to 10501)
  AUTHORS   Artigiani,S., Conrotto,P., Fazzari,P., Gilestro,G.F., Barberis,D.,
            Giordano,S., Comoglio,P.M. and Tamagnone,L.
  TITLE     Plexin-B3 is a functional receptor for semaphorin 5A
  JOURNAL   EMBO Rep 5 (7), 710-714 (2004)
   PUBMED   15218527
REFERENCE   7  (bases 1 to 10501)
  AUTHORS   Oster,S.F., Bodeker,M.O., He,F. and Sretavan,D.W.
  TITLE     Invariant Sema5A inhibition serves an ensheathing function during
            optic nerve development
  JOURNAL   Development 130 (4), 775-784 (2003)
   PUBMED   12506007
REFERENCE   8  (bases 1 to 10501)
  AUTHORS   Simmons,A.D., Puschel,A.W., McPherson,J.D., Overhauser,J. and
            Lovett,M.
  TITLE     Molecular cloning and mapping of human semaphorin F from the
            Cri-du-chat candidate interval
  JOURNAL   Biochem Biophys Res Commun 242 (3), 685-691 (1998)
   PUBMED   9464278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jan 9, 2008 this sequence version replaced NM_001107659.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643429.7448.1,
                                           SRR26360190.1357902.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-489               JAXUCZ010000002.1  85020724-85021212
            490-592             JAXUCZ010000002.1  85123207-85123309
            593-790             JAXUCZ010000002.1  85184171-85184368
            791-890             JAXUCZ010000002.1  85222790-85222889
            891-936             JAXUCZ010000002.1  85238002-85238047
            937-999             JAXUCZ010000002.1  85296121-85296183
            1000-1098           JAXUCZ010000002.1  85305962-85306060
            1099-1312           JAXUCZ010000002.1  85307529-85307742
            1313-1598           JAXUCZ010000002.1  85319669-85319954
            1599-1734           JAXUCZ010000002.1  85325414-85325549
            1735-1939           JAXUCZ010000002.1  85329503-85329707
            1940-2147           JAXUCZ010000002.1  85364064-85364271
            2148-2265           JAXUCZ010000002.1  85373591-85373708
            2266-2447           JAXUCZ010000002.1  85383955-85384136
            2448-2591           JAXUCZ010000002.1  85386973-85387116
            2592-2739           JAXUCZ010000002.1  85396673-85396820
            2740-2965           JAXUCZ010000002.1  85424985-85425210
            2966-3184           JAXUCZ010000002.1  85428802-85429020
            3185-3355           JAXUCZ010000002.1  85435221-85435391
            3356-3511           JAXUCZ010000002.1  85437528-85437683
            3512-3559           JAXUCZ010000002.1  85438467-85438514
            3560-3771           JAXUCZ010000002.1  85442520-85442731
            3772-10501          JAXUCZ010000002.1  85445209-85451938
FEATURES             Location/Qualifiers
     source          1..10501
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q23"
     gene            1..10501
                     /gene="Sema5a"
                     /note="semaphorin 5A"
                     /db_xref="GeneID:310207"
                     /db_xref="RGD:1308650"
     exon            1..489
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            490..592
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            593..790
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     CDS             667..3891
                     /gene="Sema5a"
                     /note="sema F; semaphorin-F; sema domain, seven
                     thrombospondin repeats (type 1 and type 1-like),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     (semaphorin) 5A"
                     /codon_start=1
                     /product="semaphorin-5A precursor"
                     /protein_id="NP_001101129.1"
                     /db_xref="GeneID:310207"
                     /db_xref="RGD:1308650"
                     /translation="MKGACILAWLFSSLGVWRLARPETQDPAKCQRAEHPVVSYKEIG
                     PWLREFRAENAVDFSRLTFDPGQKELVVGARNYLFRLQLEDLSLIQAVQWECDEATKK
                     ACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTIRSLSNLTEIHDQISGMAR
                     CPYSPQHNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPN
                     FVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARL
                     NCSRPGEVPFYYNELQSTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGP
                     FKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTTV
                     PSFMEDNSRFSHVAVDVVQGRDTLVHIIYLATDYGTIKKVRAPLSQSSGSCLLEEIEL
                     FPERKSEPIRSLKILHSQSVLFVGLQEHVVKIPLKRCHFHQTRGACIGAQDPYCGWDA
                     VMKKCTSLEESLSMTQWDQSVPTCPTRNLTVDGSFGPWSPWTPCTHTDGTAVGSCLCR
                     SRSCDSPAPQCGGWQCEGPRMEITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSN
                     PTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCEN
                     GPDCAGCNVEYQPCNTNACPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDP
                     NLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSR
                     DCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEFQECNILPCPVDGVWSCWSSWSKCSAT
                     CGGGHYMRTRSCTNPAPAYGGDICLGLHTEEALCNTQTCPENWSEWSEWSVCDASGTQ
                     VRTRQCILLFPVGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMM
                     AVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAALNSSITNHINKLDKYDS
                     VEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY"
     exon            791..890
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            891..936
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            937..999
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1098
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1312
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1598
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1734
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..1939
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2147
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2148..2265
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2447
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2591
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2592..2739
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2740..2965
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            2966..3184
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            3185..3355
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            3356..3511
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            3512..3559
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3771
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
     exon            3772..10501
                     /gene="Sema5a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccagctct ggtctactcg ctaggaaggc ggcgtcggca gcggctgctc acgttgtgcc
       61 caatcccgcg cgcgctgcgc tcccgccgcg ggtgggctcc tcagcctttg gctggaggtg
      121 gccccagcct tgcggcggca tctgtatccc accttcccac tgcggggagg tcccggcacg
      181 tgcaatcctt ctttggggtg ttctggttcg cacgcgcgga cctaaacaga gggtacccaa
      241 ctttgccatc tcaccggttg ccctctctcg gcgcgagcct gttcactcag ctgcacaact
      301 ggagactcca gcaggcgagc tggtccccag cctggcgcgc tgcgagtgga ggatagctct
      361 ggagaagtgg ccgggtgtag tggttgttgc tgcctcgact ttcctcctgg cgcactgaag
      421 aggaccctgg gagcagctcc gggccccggg gcgctggatg actagtagga ggaacgcgcc
      481 ccgcatctgg gctggtgtgt gacaactggg cttgggtacc catgtggctg tgcagttcat
      541 tgtgattcat gacggaggcc acacgtctgt ctctgccctc tctctctcct gggtactttt
      601 cacacatgag gagaaggtga gcttcgtaga agacacgttc ccagagtcgg agaccccttg
      661 cccaccatga agggagcctg catccttgca tggctgttct caagcctggg agtgtggaga
      721 cttgctcggc ctgagaccca ggaccctgcc aagtgccaga gagctgagca ccccgtcgtc
      781 tcctacaaag aaattggccc ctggttacgg gaattcagag ccgagaatgc tgtggatttc
      841 tcgaggttaa catttgaccc aggacagaaa gaacttgtcg taggagcaag aaactatctc
      901 ttcagactac agctcgagga tctgtctctc atccaggctg tgcagtggga gtgtgatgaa
      961 gccacgaaga aggcctgtta cagcaagggc aaatcgaagg aggaatgtca gaactacata
     1021 cgagtgctct tagtgggcgg ggaccggctc ttcacctgtg ggaccaatgc cttcacaccc
     1081 gtctgtacca tccgctcctt aagtaacctg actgagatcc atgatcagat cagtggcatg
     1141 gctcgatgtc cctatagtcc ccagcacaat tctacagctc tactcactgc cagtggcgag
     1201 ctctatgctg caacagccat ggatttccca gggcgcgatc cagccattta tcgaagtctg
     1261 ggcactttac ctcctcttcg aactgcacag tacaactcca aatggctcaa tgaaccaaac
     1321 tttgtgtctt cctacgacat cgggaacttc acctacttct tcttccgaga aaatgccgtg
     1381 gaacacgact gtgggaagac tgtgttctcc agggcagcca gggtctgcaa gaatgacatt
     1441 ggaggacgat ttcttctgga ggatacctgg actaccttca tgaaggctcg cctcaactgc
     1501 tctcggcctg gtgaggtgcc gttctactac aacgagcttc aaagcacctt cttcctgccg
     1561 gagctggatc tgatctacgg catcttcacc accaatgtaa acagcattgc tgcctctgct
     1621 gtctgtgtct tcaacctgag cgccatctca caggccttca atggaccctt caagtaccaa
     1681 gagaactctc gctcagcctg gctgccttat cccaacccca accccaattt tcagtgcggc
     1741 accatggacc agggcctgta tgtaaacctg acggaaagaa acctacagga tgctcagaag
     1801 ttcatcctga tgcatgaagt ggtgcagcca gtgaccacag tgccttcctt catggaagac
     1861 aacagccgtt tctcccatgt ggctgtcgat gttgtgcaag gcagggacac ccttgtccat
     1921 atcatctatc tggccacaga ttatggcacc attaaaaaag tgcgggctcc gctgagtcag
     1981 agctcgggca gctgtttgct agaagagatt gagctttttc cagagaggaa gagtgagccc
     2041 atcaggagcc taaagatcct ccacagccag agtgtcctat ttgtggggct acaggagcat
     2101 gtggtcaaga tccccctgaa gagatgccat tttcatcaaa cacgtggtgc ctgcattggt
     2161 gctcaggacc cttactgtgg ctgggatgcg gtgatgaaga agtgcaccag cctggaggag
     2221 agcctgagca tgacccagtg ggatcagagc gtccccacct gtccgaccag aaatctcacc
     2281 gtagatggga gctttggccc gtggtctcca tggacaccct gtactcacac tgatggcact
     2341 gctgtgggat cctgcctctg ccggtcccga tcctgtgaca gcccagctcc acagtgtggc
     2401 ggctggcagt gtgagggccc tagaatggag atcaccaact gttccaggaa tggaggctgg
     2461 actccctgga cctcctggtc tccctgcagc accacttgtg gcattggctt ccaggtgcgg
     2521 cagcgctcct gcagcaaccc tacgcccagg catggagggc gtgtgtgcgt gggccagaac
     2581 agggaggaaa gatactgcaa tgaacattta ctctgcccac cacacgtgtt ctggacaggc
     2641 tggggacctt gggaacgctg cacagcccag tgcgggggtg gcattcaagc tcgccgtagg
     2701 acctgtgaaa atgggcctga ctgtgcagga tgcaatgtgg aataccagcc ttgtaacacc
     2761 aatgcatgcc cagagttgaa gaagaccaca ccatggaccc cctggacacc tgtcaacatc
     2821 tctgacaatg ggggccacta tgagcagcgg ttccgctaca cctgtaaagc tcgcctgcca
     2881 gatccaaact tattggaagt aggaagacaa aggatagaaa tgcggtactg ttctagtgat
     2941 gggaccagtg gctgctccac agatggactt tctggagact ttctaagagc tgggagatac
     3001 tctgcccata cagtcaatgg ggcatggtca gcctggactt cctggtcaca gtgcagcaga
     3061 gactgcagca ggggcattcg aaacaggaag cgtgtttgca acaacccaga gcccaagtat
     3121 ggaggtatgc catgccttgg tccatcactg gagttccagg aatgcaacat tttaccctgt
     3181 ccagtggatg gtgtgtggtc ttgctggtca tcctggtcta aatgctcagc aacttgtggg
     3241 ggtggacact acatgagaac ccgttcgtgt acgaatccag ccccagcata cggaggggac
     3301 atctgcctgg gactgcacac ggaagaggcc ctctgtaaca cacagacctg cccagagaac
     3361 tggtcagagt ggtcagagtg gtctgtgtgt gatgcatctg gtacccaggt ccgtactcgg
     3421 cagtgcatcc ttctgtttcc tgtgggcagc cagtgttctg gaaatactac agagagccgg
     3481 ccttgtgtat ttgactctaa tttcatccca gaagtgtctg tggcaagatc cagcagcgta
     3541 gaagagaaaa ggtgtggaga gttcaacatg ttccacatga tggctgtggg acttagcagt
     3601 tccatcctcg gctgcctcct tacactgctt gtctacacct actgccagcg gtaccagcag
     3661 cagtcccatg atgcaactgt catccatcct gtttctcccg ccgccctcaa cagcagcata
     3721 actaaccaca tcaacaaact ggataaatac gattccgtgg aggccatcaa ggcatttaac
     3781 aaaaacaact tgatcctaga ggagagaaac aaatacttca acccacatct cactgggaag
     3841 acctactcca acgcctactt tacagatctc aacaattatg atgaatacta gcagctctta
     3901 cacttctggc tccttgtaaa ctctctgttc ctcaaagctg tactccatga ctgcccatat
     3961 ttctgagact tcagagatga tgtgtggatc catttcaagt gcatttcaaa ccaggacttt
     4021 cccatcacta ccaaaaaaag cgcacaccct tatacctaaa tgtggtgttg tgaaaatctg
     4081 gtctgtagaa aacatttggt gttgcgaagt gagccatgat atgacatttt gtgttatgct
     4141 catcccaaac tctaactggt ctactgtttt catgagtgtc atttcataaa tgtgccaacc
     4201 atgttagaaa gtgtgttcag aagcatagcg ttgtcatgct tttaagtgca gagggtcagg
     4261 atgttttaac ttggaaacaa acaaacaaac aattataacc aggcacttta atctgagaga
     4321 tgtcttcccc acacacacag ggtccagagt aattcacaga atgaaggtgt ggctactgcc
     4381 aactccctca acctgggtga ctctataggt tcttggaaac agctttgttg cacttggagt
     4441 gattcctgcc cagggattcc atctgccctg gacctgccaa gtcatggtct actgaaaccc
     4501 tctgctttgg tctggagcag tgattgtcat ccctgtttgg tgaacacatg aaacagagaa
     4561 cagccaatga gacacacagc agtattctgc agcttgcagt gaaactaatc ttactctaac
     4621 ttttggattc tgtgtcatcc aaggaagttc cttgtcatga tgggggcctg aaggccacct
     4681 tcctgggtgc tgaagagcca gtctgagcat ttgcatagac tccacacccc ttcctccctc
     4741 cctccatgag gagaaaattc ttgatttatg atggaaaata ttgaaatacc aaactgtaat
     4801 tgaaagctac tttttaattt ttttgtatta tgcagtgttg aattaactga tgtaattgaa
     4861 agctactttt ttatttttta tttttttgtg ttatgctgtg ttgaatgaac tgatgttaat
     4921 ggcttttttg ttttttgttt tttgttttgt attcagcatc tttgatgtga ctaatgtgta
     4981 gcaatggccc ctatcaaaag cattaaaggt gtgtaaagct gtccctctgg agctcagtgc
     5041 aatcccactg aagcaacact ccagtaccat ggtctcctca tttgtcccct gctgccccaa
     5101 caccagagga gggaatggct ctggtgtctg ttactaagtt gctgcctccc tgtcctccag
     5161 cttactgagt cccacttctg ctccaagaca gtagcagtca agatgtacca taagcagtaa
     5221 cggatgagaa ggtcaggatt ttagtggcct ctctctctca tcccaatggt tgactgttct
     5281 aaggctactc ttaagatcct cagacaagta aagaagagtg gttagcatct gaaacatggt
     5341 gtagaggtac cgatctaatg cattttaaag gtgaagacaa atggtttgtc tgggccactg
     5401 gtcactatga taaaggcctg agtaggcagt catatatgtt aagggcatat aaactttcag
     5461 gttctatgca aatgtatagc atgaggagtg aagattacag ggtttttatg agtatatgtt
     5521 ttcccccatg gaatataaag aagcaacctc agaagacatt ccaaaaaatc ttatgattaa
     5581 tcacaaatta ttctcatata aacacatttt tcagacataa ctctgtgtta aaattgaaat
     5641 taaaacagca gatgggctct gggagatgtg tcagattgtg aggaaatggc atatgggaat
     5701 attgcgatgg gacattgtgt ggcatttcac acacttcttc tacagtgtat gtggcctcca
     5761 ttacacacac atttttaaaa tccacactca gcagacagaa cgtgtcagat gatttattca
     5821 ttgtctctag ggtggaattt tagtggatgc ttcaactcat ctcattgctt tcttttaaga
     5881 aaagaataaa tcctcctggt atagcactat tctagtgttt taaaaagaat ctccccttct
     5941 tgaatatttc tagtttaaaa ggtcactttc tttcccctgg gaagaagagt acaaatattt
     6001 caagaattta tggctaaact tgataggaaa tgctttctaa atgacctcta atctggcctt
     6061 catcagtttg atatagtaac cccaccccag agttctcatt ttcaaagaca gttttctgat
     6121 attagtattg ctttttaaaa gtctcctcct tgtctgcttt gttctccctt caaatcccca
     6181 cctccagcca ccagtccttt gctcttattt agccaaacaa ttggagcaat ttcttaggag
     6241 tgccttgagc tgcattctgg ttttcactac ctgctgcatg acttattttc tgcaggtgta
     6301 cagctgcagc tcctggtgca gtctatacca cactccagac ttctcattaa cacatcacac
     6361 acacgtgcat aacacacaca cacacacaca cacacacaca cacacacaca cacacatgtt
     6421 tgagttaggt tgcactctac gggtcctgtt ttaaattctg ccctgacatt ttcatttttc
     6481 ccctactttc tccccacaac ccttcttcct ttcctttatt gcttctttat ttcatctctt
     6541 tcttcttttg ccttttgatg aaagaaaaac agagtagaat taatacttta agttgtatct
     6601 ggctgaacct gttgttaaat gacattaatc aacttatctt ctggagttag ggttcaagtc
     6661 tggttttcat taggaaactg gcttcagtca cactaacatt cattggaatt tggtcccgat
     6721 gttgtttggg gtcctctcac tgataagact gtcatcgatc ctgctaagtg atgacattct
     6781 gcagaaataa agagtaaaat attttcacac ttcatagcca gaggtatttc caaatactcc
     6841 ggggactttc ttggaactgt gggctctgtc atactgactg aagctatctt ggtgatccta
     6901 aggaattctt ggacactggg agatgctctg cttcacagaa aattctctgt catcatagtc
     6961 ctagactttt ccttcaaaac tttccaatgc aagctaaaca cctttatgcc tctgcccctt
     7021 aagacttact catgacactt aagcatcttg gtcctgttgg atgaatgaaa atgcatatta
     7081 aagtaaattc tacctaaaaa catgtatgtt gatggaagaa aagagggttt cttgagtgca
     7141 tgatcaagtg atagagacac tgaaggaact gaagagaagt cataaactga atgtttgtaa
     7201 gggcatctgc tatggagatg tctctatcat taggaaggac aggtcttgcc ttcaatactg
     7261 taggcaattt ctcatcaaga ggaatccatc tatgtactat gctattatgt ggttgaatag
     7321 ctcaagagat gtcatcctaa agatatctga cttgaactat cagtttgcct aaacacagcc
     7381 tactgtgcat gtaaccacat gtttcttttc tgaattcttt tttccttttc gaataaacca
     7441 caaatatttc cccaacagat caagccaaat tcctcatcaa ttattcccca gggtcatcaa
     7501 cttttttaac ttttaagttt cctagacttt ttggtgggct gttcatattt taactcgcac
     7561 tttggagtac actagtgcta ctgtatcaaa agacaatttg ggagccccaa ctagaaatag
     7621 cagatgccat gtaccaatgg gtgataccgt attagatcaa ctgttggcag gttattttca
     7681 agtctacagg ctcaaaaata tcattttcca tggagatgtc aaaacagtaa acttagactc
     7741 ctttgaaatt ctctggtgtt tttctagagt ctaaagatgg aactggtcat acccagtttg
     7801 tccaatcatt cttacacctt tactacttca tggggcatct agagacttat gttaatacac
     7861 cattgccaat attccaaagc ctattattac ccatgggttt gtgataatat ctactatcca
     7921 ttactaaaga gcattatgaa aaaatgcttc tttttatcta agagatgtac cacagggaat
     7981 gctatgtaag aagttactgt ccagagccca gagattgttt atctctgcag cttaccttcc
     8041 cagttgttat cattaattaa aatgatgtaa agagattttc caagctctat aaatactaat
     8101 ctatggcctt gaggtagtct ctctggatta tctcatggta caaagaaaat gtgttgtttt
     8161 ccagtttgct actgtaccct tcagggaaca aaaaccctgt ggataatata caacattgaa
     8221 ctattgacag aagttgtgaa cgttactctt ctctgtgggt ttcatatcat aatgttgcat
     8281 tatcagagat ttgatacaaa ttgcagaagc aacttggaaa cctgtctctt aaaatagttc
     8341 aggctgcaaa gactgtgcag tctcctggat accaaattca gagcctccta caaatagtat
     8401 agttcataat gaagtcccag ccctagtaca tgatctcttt gaaagatgat gtcctgccct
     8461 ttacgcctgt tgtccatgac cagagcctat accaactctg ttcccaggta gaagtgcttt
     8521 cctgggaaga cactgtacct ggaactaaac tgatcaagaa aaagcagtga tggggaatca
     8581 ctaaaatgca aatcaggcag gaaaatctcc accccttcat aatccagcaa ggacctaaaa
     8641 ccagtcaatt agccataatc gtcatctttc tctgcttctt gggaattgaa taccgactgg
     8701 ttccaatgtt agacaaatgc aagcaaaacg aaaagcctag gctctgataa acacaactgc
     8761 tcttccatcc agacaataaa ggacgcctgt tatctgtgga agatgtagta ctgacttccc
     8821 tgtacaaagt tgctagtgcc ttgtataagc tatgtgctgt cacttttcct ggttattgat
     8881 tgtcccaatt agaagccact cggtggttgt atacactttg aggaaatcta ctccgtgtgt
     8941 ctctttgaac tcaggaacag aaaatgagag aaatgtgtca tgttcgagtg tggttttgct
     9001 ctcagaacag gataaagagt gcgttgtgtc cagatgaagt gaccctgttt cagcctgcaa
     9061 gaaactgatg ttgctttaac ttttacatct tcatgggaat ggagtagagc ctttcctggg
     9121 gtaggagagt cagctctgtt tctgtagaag tcagtgggtg tttctgttgc tcttcatgca
     9181 catacataga tataccgaaa acagatacag gctacttaca gccacacagg ttgtgaaatg
     9241 agaaccaact ggaacatcat ttggattgtt ttatcatatt ctgcaaatcc aatatcagaa
     9301 ctgctcaaaa gttcacaaaa ttactatttt tcgcttgggt ttaaaacatt agcagtgtct
     9361 tctatgctga agttgaccac tgatctctta cactgtgact gtggactcga atcagcttat
     9421 agatctgctt ccaaagcatg cacagtggga gcttccaacc actgaatcac catgatattc
     9481 acctcatctg ccaataagat gcaccagctt cttccagtgt aagattctgc agaacctgtg
     9541 accacttgac tttacacctg ctatgcctcc ttgcctgttt tgtgatacaa aataaaattg
     9601 tttgggattg ctcattcatt gaaatttctt ctaggccaac ttcagccctt ggtaaacttg
     9661 cggactgttc ctgatgttaa gattaaaact tcaaaggcgc tatttattag tcacacagag
     9721 ccatttcaag agaaaggagc tctgcctttc cccatcagtt tccttagaga agagacactt
     9781 ggctctgtgt ggagttgctg ctggctgctg agtgttctct tcctggtaca atgggcaacc
     9841 cacactatta ggcccttatg tttggctgaa atcttactag ccatgtgcac tggtcttttc
     9901 tacagctttc atttttctgt ttcactcatt aacccactgc attgatattc ttcctgggag
     9961 ctggtcaggc ccttgcctca aattgtgctt aatgacacct ggcagatagc ttgttttcag
    10021 aaatcatttt aagaccctaa ttatgtcaac ccaggcaggg ataattctgt ctttcatgga
    10081 accaattatg gaacttccaa aaaggggaga gcagggacac ttcccaacca atcaaccaaa
    10141 ccaaactcac acccatctaa ccaaacatta ataagatgaa tcattattat ggtaaatgtc
    10201 accttgtatc tgccctaggc acattccaat atcagcatct ccaccttctt cattgcttct
    10261 aacattgaag ttataaaatg gtcctgcctt ttgccaagag cacagcacta ctcccttctg
    10321 agacctccct ccccaccccg agcatcacct ctctgccaac attttgtgga aactaaaaga
    10381 atcttactat gtacagataa attgtattat attttttgta cttaatgttt tgtgtaaata
    10441 gtttgccttg ttcagttgta tgtgagtatt caaataaacc ctgccattta ggagacaatt
    10501 a
//
