LOCUS       NM_001012078            3179 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus semaphorin 4A (Sema4a), mRNA.
ACCESSION   NM_001012078 XM_227402
VERSION     NM_001012078.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3179)
  AUTHORS   McDermott,J.E., Goldblatt,D. and Paradis,S.
  TITLE     Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and
            glutamatergic synapse development in the mammalian hippocampus
  JOURNAL   Mol Cell Neurosci 92, 50-66 (2018)
   PUBMED   29981480
REFERENCE   2  (bases 1 to 3179)
  AUTHORS   Yukawa,K., Tanaka,T., Yoshida,K., Takeuchi,N., Ito,T.,
            Takamatsu,H., Kikutani,H. and Kumanogoh,A.
  TITLE     Sema4A induces cell morphological changes through B-type
            plexin-mediated signaling
  JOURNAL   Int J Mol Med 25 (2), 225-230 (2010)
   PUBMED   20043131
REFERENCE   3  (bases 1 to 3179)
  AUTHORS   Toyofuku,T., Yabuki,M., Kamei,J., Kamei,M., Makino,N., Kumanogoh,A.
            and Hori,M.
  TITLE     Semaphorin-4A, an activator for T-cell-mediated immunity,
            suppresses angiogenesis via Plexin-D1
  JOURNAL   EMBO J 26 (5), 1373-1384 (2007)
   PUBMED   17318185
REFERENCE   4  (bases 1 to 3179)
  AUTHORS   Kumanogoh,A., Shikina,T., Suzuki,K., Uematsu,S., Yukawa,K.,
            Kashiwamura,S., Tsutsui,H., Yamamoto,M., Takamatsu,H.,
            Ko-Mitamura,E.P., Takegahara,N., Marukawa,S., Ishida,I.,
            Morishita,H., Prasad,D.V., Tamura,M., Mizui,M., Toyofuku,T.,
            Akira,S., Takeda,K., Okabe,M. and Kikutani,H.
  TITLE     Nonredundant roles of Sema4A in the immune system: defective T cell
            priming and Th1/Th2 regulation in Sema4A-deficient mice
  JOURNAL   Immunity 22 (3), 305-316 (2005)
   PUBMED   15780988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1 and BC081943.1.
            
            On Sep 6, 2012 this sequence version replaced NM_001012078.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081943.1, SRR26360172.861029.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-56                JAXUCZ010000002.1  176212203-176212258 c
            57-3179             BC081943.1         1-3123
FEATURES             Location/Qualifiers
     source          1..3179
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3179
                     /gene="Sema4a"
                     /note="semaphorin 4A"
                     /db_xref="GeneID:310630"
                     /db_xref="RGD:1304636"
     exon            1..198
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            199..366
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2510
                     /gene="Sema4a"
                     /note="sema domain, immunoglobulin domain (Ig),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     (semaphorin) 4A"
                     /codon_start=1
                     /product="semaphorin-4A precursor"
                     /protein_id="NP_001012078.2"
                     /db_xref="GeneID:310630"
                     /db_xref="RGD:1304636"
                     /translation="MTMALPSLGQDPWSLLSVFFFQLFLLLSLPPASGTGGQGPVPRV
                     KYHAGDGHRALSFFQQKGLRDFDTLLLSGDGNTLYVGAREAILALNIENPGIPRLRNM
                     IPWPASEKKKNECAFKKKSNETQCFNFIRVLVSYNATHLYACGTFAFSPACTFIELQD
                     SFLLPILKDKVTDGKGQSPFDPAHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQP
                     VLKTDIFLRWLHPDASFVAAIPSTQVVYFFFEETASEFDFFEELYTSRVAQVCKNDVG
                     GEKLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLPADSPSVPRIYAVFTSQWQVGG
                     TRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEVNPRPGSCSMGPSSDKALT
                     FMKDHFLMDEHVVGAPLLVKSGVEYTQLAVETAQGLDGSSHVVLYLGTSTGSLHKAVV
                     PQNSSAYLVEEIQLSPNSEPVQNLQLAPTQGAVFAGFSEGIWRVPRANCSVYKSCVDC
                     VLARDPHCAWDPESRLCSLLSGSPLTWKQDMERGNPEWACARGPMARSPRRQSSPQLI
                     KEVLTVPNSILELPCPQLSALASYHWSHGKAKIPEASSTVYNGSLLLLPQDGVGGLYQ
                     CVATENGYSYPVVSYWVDSQDQPLALDPELAGVPRERVQVPLTRVGGGASMAAQRSYW
                     PHFLIVTVLLAIVLLGVLTLLLASPLGVLRARGKVQGCGMLPPREKAPLSREQHLQPS
                     KDHRTSASDVDADNNHLGAEVA"
     exon            367..527
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            528..590
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            591..689
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            690..795
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            796..912
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1037
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1210
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1361
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1542
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1661
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1662..1819
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1917
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
     exon            1918..3154
                     /gene="Sema4a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcacaactc gaggtagaaa ttctggtttc cctggcctga aacccacact ggctctggca
       61 ggatgagtgc ctggagggcc gcgctcccat tccagccagg ctgagcctgc tttccatgcc
      121 cggaccccct tccttgcctt ggatggcacc ctgattcagg gtttgaacac aggacttctc
      181 cgtgtggctg gctcaaggaa ccatctggtg actgtctccg gatgaccatg gccctaccat
      241 ccctgggcca agacccctgg agtctcctga gtgttttttt cttccaactg ttcctgctgc
      301 tgtcactgcc accagcttcc gggactggtg ggcagggacc cgtgcccaga gtcaagtacc
      361 atgcgggaga tgggcacagg gccctcagct tctttcaaca aaaaggcctc cgggactttg
      421 acaccctgct cctgagtgga gatggcaaca ctctgtatgt gggggctcgg gaggccatct
      481 tggccctgaa tatcgagaat ccaggaatcc caaggctgag gaacatgata ccctggccag
      541 ccagtgagaa aaaaaagaac gaatgtgcct ttaagaagaa aagcaatgag acacagtgtt
      601 tcaacttcat tcgtgtgctg gtctcttaca atgccactca cctctatgcc tgcgggactt
      661 ttgccttcag ccccgcctgc accttcattg aactccaaga ttccttcctg ttgcccatct
      721 tgaaggacaa ggtcacagat gggaagggtc aaagcccctt tgaccctgct cacaagcaca
      781 cagctgtctt ggtcgatggg atgctttatt ctggcaccat gaacaacttc ctgggcagcg
      841 aacccatcct gatgcggaca ctgggatccc agcctgttct caagactgac atcttcctac
      901 gctggctgca cccggacgcc tccttcgtgg cagccatccc atctacccag gtcgtctatt
      961 tcttctttga ggagacagcc agcgagtttg acttctttga ggagctgtac acatccaggg
     1021 tggctcaagt ctgcaagaac gacgtaggcg gtgaaaagct gctgcagaag aagtggacca
     1081 ccttcctgaa agcccagctg ctctgcgctc agccagggca gctgccattc aacatcatcc
     1141 gccacgcggt cctgctgccc gccgattctc cctctgttcc ccgcatctac gcagtcttta
     1201 cctcccagtg gcaggttggt gggaccagga gctcagcagt ctgtgccttc tctctcacgg
     1261 acattgagcg agtctttaaa ggaaagtaca aggagctgaa caaagaaacc tcccgctgga
     1321 ccacttacag gggctcagag gtcaacccga ggccaggcag ctgctccatg ggcccctcct
     1381 ctgacaaagc cttgaccttc atgaaggacc attttctgat ggatgagcat gtggtaggag
     1441 ctcccctgct ggtgaagtct ggcgtggagt acacacagct tgccgtggaa acagctcagg
     1501 gccttgacgg gagcagccat gtggtccttt acctgggtac ctctacgggg tccctgcaca
     1561 aagctgtggt gcctcagaat agcagtgctt atcttgtgga ggagattcag ctgagcccta
     1621 actctgagcc tgttcagaac ctgcagctgg cccccaccca gggtgcagtg ttcgcaggct
     1681 tctctgaagg catctggagg gttcccaggg ccaactgcag tgtctataag agctgtgtgg
     1741 actgtgtcct tgccagggac cctcactgtg cctgggaccc tgaatcaaga ctgtgcagcc
     1801 ttctgtctgg ctctcccctg acttggaagc aggacatgga acgcggcaac ccggagtggg
     1861 catgcgcccg tggccccatg gccaggagcc cccggcgtca gagctcccct caactcatta
     1921 aagaagtcct gacagtcccc aactccatcc tggagctgcc ctgcccccag ctgtcagcac
     1981 tggcctctta ccactggagt cacggcaaag ccaaaatccc agaagcctct tctactgtct
     2041 ataatggctc cctcttgttg ctgccacagg atggcgttgg gggcctctac cagtgcgtgg
     2101 ccactgaaaa cggctattcg taccctgtag tctcctactg ggtagacagc caggaccagc
     2161 ccctggcact ggatcctgag ctggcgggcg ttccccggga gcgagtgcag gtcccactga
     2221 ccagggtcgg aggcggggct tctatggctg cccagcggtc ctactggccc cattttctca
     2281 tcgttactgt cctcctggcc attgtgctct tgggagtgct cactctcctc cttgcttccc
     2341 cactgggagt gcttcgggct cggggtaagg ttcagggctg tgggatgctg ccccccaggg
     2401 aaaaggcccc actgagcagg gaacagcacc tccagccttc caaggaccac aggacctctg
     2461 ccagcgacgt agatgctgac aacaaccatc tgggcgctga agtggcttaa actgagacac
     2521 ggatggctga ccatgttggc taggccaggc atgcacggtg ccactctgac cagggtagga
     2581 ggctctcctg ctagtgtgtg ccacctacag cacccagtaa ggcctccctt gtgggactct
     2641 cttatgcaag cacatgggct gtctccacac catggcagag agacagacag gattctttga
     2701 ttttgatcga ccccaagagc tctcctgcaa caaacattct ccaggaccct gaaaggtgtg
     2761 gctttctgtg gtgacagacc caaacatcca agtgagctgg ggccattcct gcaaactcca
     2821 tcctgaaagc tgctgctttg aacaccagcc ctccctcctc ccagggtctc caagattctt
     2881 tatggagttg gccccttgtg tttcccttac caatcatgcc atgtgtttgg gaaagtcatt
     2941 tctgaagtct aaccaccttc cttcttgctt cagtttggac agattgttat tgtctctgcc
     3001 ctggctagaa tggtgggcat aatctgagcc ttgttgttca cttgtctagt gtggctgacc
     3061 cttgacctct tcctcctccc tttgttttgg gattcacaac tgcttgtcac agacaattta
     3121 ttttttatta aaaaagatat aagctttaaa caaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
