LOCUS       NM_001106579            4476 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus semaphorin 3E (Sema3e), mRNA.
ACCESSION   NM_001106579 XM_001064828 XM_231354
VERSION     NM_001106579.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4476)
  AUTHORS   Zhou YF, Chen AQ, Wu JH, Mao L, Xia YP, Jin HJ, He QW, Miao QR, Yue
            ZY, Liu XL, Huang M, Li YN and Hu B.
  TITLE     Sema3E/PlexinD1 signaling inhibits postischemic angiogenesis by
            regulating endothelial DLL4 and filopodia formation in a rat model
            of ischemic stroke
  JOURNAL   FASEB J 33 (4), 4947-4961 (2019)
   PUBMED   30653356
REFERENCE   2  (bases 1 to 4476)
  AUTHORS   Zhou YF, Li PC, Wu JH, Haslam JA, Mao L, Xia YP, He QW, Wang XX,
            Lei H, Lan XL, Miao QR, Yue ZY, Li YN and Hu B.
  TITLE     Sema3E/PlexinD1 inhibition is a therapeutic strategy for improving
            cerebral perfusion and restoring functional loss after stroke in
            aged rats
  JOURNAL   Neurobiol Aging 70, 102-116 (2018)
   PUBMED   30007159
  REMARK    GeneRIF: Study found that depletion of Sema3E/PlexinD1 signaling
            with lentivirus-mediated PlexinD1-specific-shRNA improves tissue
            survival and functional outcome following stroke. Sema3E/PlexinD1
            inhibition not only increases cortical perfusion but also
            ameliorates blood-brain barrier damage.
REFERENCE   3  (bases 1 to 4476)
  AUTHORS   Tata A, Stoppel DC, Hong S, Ben-Zvi A, Xie T and Gu C.
  TITLE     An image-based RNAi screen identifies SH3BP1 as a key effector of
            Semaphorin 3E-PlexinD1 signaling
  JOURNAL   J Cell Biol 205 (4), 573-590 (2014)
   PUBMED   24841563
REFERENCE   4  (bases 1 to 4476)
  AUTHORS   Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X,
            Cuello F, Sur S, Drozdov I, Langley SR, Lu R, Stathopoulou K,
            Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A and Mayr
            M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   5  (bases 1 to 4476)
  AUTHORS   Ding JB, Oh WJ, Sabatini BL and Gu C.
  TITLE     Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse
            formation in the striatum
  JOURNAL   Nat Neurosci 15 (2), 215-223 (2011)
   PUBMED   22179111
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4476)
  AUTHORS   Sakurai A, Gavard J, Annas-Linhares Y, Basile JR, Amornphimoltham
            P, Palmby TR, Yagi H, Zhang F, Randazzo PA, Li X, Weigert R and
            Gutkind JS.
  TITLE     Semaphorin 3E initiates antiangiogenic signaling through plexin D1
            by regulating Arf6 and R-Ras
  JOURNAL   Mol Cell Biol 30 (12), 3086-3098 (2010)
   PUBMED   20385769
REFERENCE   7  (bases 1 to 4476)
  AUTHORS   Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson
            CE, Jessell TM, Kolodkin AL and Ginty DD.
  TITLE     Semaphorin 3E and plexin-D1 control vascular pattern independently
            of neuropilins
  JOURNAL   Science 307 (5707), 265-268 (2005)
   PUBMED   15550623
REFERENCE   8  (bases 1 to 4476)
  AUTHORS   Lalani,S.R., Safiullah,A.M., Molinari,L.M., Fernbach,S.D.,
            Martin,D.M. and Belmont,J.W.
  TITLE     SEMA3E mutation in a patient with CHARGE syndrome
  JOURNAL   J Med Genet 41 (7), e94 (2004)
   PUBMED   15235037
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474020.1.
            
            On or before Oct 22, 2008 this sequence version replaced
            XM_231354.4, XM_001064828.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5756307, SAMEA5760383
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..4476
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..4476
                     /gene="Sema3e"
                     /note="semaphorin 3E"
                     /db_xref="GeneID:296789"
                     /db_xref="RGD:1310973"
     exon            1..713
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     CDS             599..2926
                     /gene="Sema3e"
                     /note="sema domain, immunoglobulin domain (Ig), short
                     basic domain, secreted, (semaphorin) 3E"
                     /codon_start=1
                     /product="semaphorin-3E precursor"
                     /protein_id="NP_001100049.1"
                     /db_xref="GeneID:296789"
                     /db_xref="RGD:1310973"
                     /translation="MAPTGHILTLLLWGHLLELWTPGYTANPSYPRLRLSHKELLELN
                     RTSIFQSPFGFLDLHTMLLDEYQERLFVGGRDLVYSLNLERVSDGYREIYWPSTAVKV
                     EECIMKGKDANECANYVRVLHHYNRTHLLTCATGAFDPHCAFIRVGHHSEDPLFHLES
                     HRSERGRGRCPFDPNSSFVSTLVGNELFAGLYSDYWGRDSAIFRSLGKLGHIRTEHDD
                     ERLLKEPKFVGSYMIPDNEDPEDNKMYFFFTEKALEAENNAHTIYTRVGRLCVNDMGG
                     QRILVNKWSTFLKARLVCSVPGMNGIDTHFDELEDVFLLPTRDPKNPVIFGLFNTTSN
                     IFRGHAVCVYHMSSIREAFNGPYAHKEGPEYHWSLYEGKVPYPRPGSCASKVNGGKYG
                     STKDYPDDAIRFARMHPLMYQPIKPVHKKPILVKTDGKYNLRQLAVDRVEAEDGQYDV
                     LFIGTDTGIVLKVITIYNQETEWMEEVILEELQIFKDPAPIISMEISSKRQQLYIGSA
                     SAVAQVRFHHCDMYGSACADCCLARDPYCAWDGISCSRYYPTGAHSKRRFRRQDVRHG
                     NAAQQCFGQQFVGDALDRTEERLAYGIESNSTLLECTPRSLQAKVVWFVQKGRDVRKE
                     EVKTDDRVVKMDLGLLFLRVRKSDAGTYFCQTVEHSFVHTVRKITLEVVEEHKVEGMF
                     HKDREEEKHHKMPCPPLTGMSQGTKPWYKEFLQLIGYSNFQRVEEYCEKVWCTDKKRK
                     KLKMSPSKWKYANPQEKRLRSKAEHFRLPRHTLVS"
     exon            714..874
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            875..934
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1054
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1148
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1268
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1411
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            1412..1526
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1596
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1741
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..1964
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            1965..2056
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2098
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2265
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2333
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            2334..2473
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..4476
                     /gene="Sema3e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acacttccta gaaacgcgca cgggctcaac cctgcctgaa ctttcctgta aacagagcgc
       61 tgacaggcgg catccccact gggtggatcc cgcgctcctg gcgcaagtgg cacttcttgc
      121 ttttaattat cgagaggaga ggcgaatacg aactagctgc acggcaagtc agtgcaggag
      181 gctgacttct gcgaggcttg cggggaggct gggggaagag ctgggggagg ctgctgctct
      241 gctccggctg ttttctcaat gaatagctgg cggggagact gaagctagcc acagcctcct
      301 cctcactccg cggctgggtg acggcgacag ctccagccgg gacctggctc tcaagacgcg
      361 ctccttggaa tgtcctcttg ctctgcgctt ctaacccacg ggtccccagg acagaaaggc
      421 tttccggatc caaatattgg tcggcaaatg gtacttggga atggtatttt ctgatgacaa
      481 ccccttctgt ttgtgacaaa gcctgtcgcc cgcagttgcc cctgaagaga agtacgaagt
      541 aaaactcagt cctgccttaa agtgtggctg agggaccaga ggagagtcag cacgcaccat
      601 ggcaccgacc ggacacatcc tcaccttgct gctctggggt cacctgctgg agctctggac
      661 cccaggttac actgcgaacc cctcctatcc caggctacga ctgtctcata aagaactctt
      721 ggaactgaac aggacgtcaa tatttcaaag cccctttggt tttcttgatc tccacacaat
      781 gctgctggat gagtatcaag aacggctctt tgtgggaggc agagaccttg tctattccct
      841 gaacttggaa cgcgtcagtg atggctacag agagatatac tggcctagca cagcagtaaa
      901 agtagaagaa tgcataatga aaggaaaaga cgcaaatgag tgtgccaatt atgtccgggt
      961 tttgcatcac tacaacagga cacaccttct gacctgtgct acgggagcct ttgatccaca
     1021 ctgtgccttt atccgagtcg ggcaccattc agaggacccc ctgtttcacc tggagtcaca
     1081 cagatctgag agaggaaggg gcagatgtcc ttttgacccc aactcctcct ttgtgtccac
     1141 actagttggt aatgaactgt ttgctgggct ctacagtgac tactggggcc gagactcagc
     1201 gatcttccgc agcctgggga agctcggcca tatccgcacc gagcatgacg atgagcggct
     1261 gctgaaagaa ccaaaatttg taggttcata tatgattcct gataacgaag acccagagga
     1321 caacaaaatg tacttcttct tcactgagaa ggcattggag gcagagaaca atgcccacac
     1381 gatctacacc cgagtggggc ggctgtgcgt gaatgacatg ggaggacaga gaatcctggt
     1441 gaataagtgg agcacattcc tcaaagcacg gctggtttgc tcagtaccag ggatgaatgg
     1501 aattgacaca cactttgacg aattagagga tgtgttttta ctgcctaccc gagatcccaa
     1561 gaatccagtg atatttggac tatttaatac taccagcaat atttttagag gccatgctgt
     1621 atgtgtgtat cacatgtcaa gtatccggga agcctttaat ggcccatatg cacataaaga
     1681 aggccctgaa tatcactggt cactgtatga aggaaaggtc ccctacccaa ggcctggttc
     1741 ttgtgccagc aaagtgaatg gaggaaagta cggatccacc aaagactacc ctgacgacgc
     1801 catccgattc gcaaggatgc atccactaat gtatcagccc ataaaacctg tccataaaaa
     1861 accaatactg gtaaaaacgg atggaaaata taacctgagg caactagcag tggaccgagt
     1921 ggaagcggag gatggccagt atgacgtttt atttattgga acagacacag gaatcgtgct
     1981 gaaagtaatc acaatttaca accaagaaac agagtggatg gaggaagtca ttctggagga
     2041 acttcaaata ttcaaggatc cagcccctat catttctatg gagatttctt caaagaggca
     2101 acagctctat attgggtcag cctctgctgt ggcacaagtc agattccatc actgtgacat
     2161 gtacggcagc gcctgtgctg actgctgcct ggctcgagac ccttactgtg cctgggatgg
     2221 tatctcctgc tccaggtact acccgacagg tgcacactca aagaggagat tccgcaggca
     2281 ggatgttcgg cacggcaacg ccgcccagca gtgctttggg cagcaatttg tgggagacgc
     2341 tttggatagg actgaagaga ggctggctta tggcatagag agcaacagta ctttgctgga
     2401 atgcacccca cgatcactac aagcaaaagt tgtctggttt gtacagaagg gacgcgacgt
     2461 aagaaaggaa gaggtaaaga cggatgacag agttgttaag atggacttgg gcttgctctt
     2521 cctcagagtc cgcaagtcgg atgcagggac ctacttttgc caaacggtag aacatagctt
     2581 cgtccacact gtgcgcaaaa tcaccttgga ggtggtcgaa gagcataaag tggaggggat
     2641 gtttcataag gaccgcgaag aggaaaaaca tcacaagatg ccctgccctc ccttaactgg
     2701 tatgtctcag gggacaaaac cctggtacaa ggaattcttg cagctgattg gctacagcaa
     2761 cttccagaga gtggaagaat actgcgaaaa ggtgtggtgt acagataaga agaggaaaaa
     2821 gctgaaaatg tctccctcca agtggaagta tgccaacccc caggaaaaga ggcttcgctc
     2881 caaagctgag catttccgcc tgcccaggca cacgctggtc tcttgagggc gccctctgct
     2941 ggctgccgag gaacctagaa tggaaacatt tttgtaaagg gggggggggg gagactgaaa
     3001 gcatgcaaag tgtttctatt acttcaaaga gcattctgtc gtactgagag gcgagaaagg
     3061 tgttttaagt tattctgcat actcatctga ctgtgcaaac ctctcacagt actagtactt
     3121 aaaccagtgt cttgcttaaa aggcttcaca ttgtatttat caacatgatc cgggctgtaa
     3181 ctttgagctt gcttttcagg gaaattattt tgccactggg atatgtatta taactataat
     3241 gttaagcaaa ggttataggt tttcataatc gagaaaaatg taaaactaaa tcagctctga
     3301 tctttctgga gtcttttgtt attgttagat tttttttttg ttttgttttt gtttttttca
     3361 ctttgcaagc atgaggtaaa atgtacagaa tatcagatac tgtaggatta ccatgtgaac
     3421 tttttggtcg gttgctgttt tgttttcttt ttttttaagc cataaatttt aagtagctgt
     3481 gttgtggttg ctataaaccg taaaagaaac ctcggtccat ccgttcttag gcttgttctc
     3541 ttcatggaac actcactaaa ctatattaaa aatatttctg ttttataaac aagacatatc
     3601 ctttaaattt caccttggtg tggaaggaag gaagataatc tctcagaaag atatttttaa
     3661 atgttttcaa accatgaaag aattctgttt aaacggtctg tgctgccctc ttgtggtcga
     3721 agagggcatc gtctctgtcg gtactgtttt cctgcaaaga tttgaaaaac aaaatttatg
     3781 agtagatgaa tctagttcct ttttctgaag acaagattaa aaatttaatt gtaaatcata
     3841 atttaatatg gaaacagcgt gcttgtggat aattgataac ttcacaacac aatggagata
     3901 ttaactgcat ttgagctctg aaatagtaaa aagtaaactt tcagtccttc cctgagacaa
     3961 gaagatattc tggaagtatg ttttacctgt aaagaaactt tcaaagcatt ctctctcaca
     4021 cgtgaaacct ttctatttta tatttgcttt gagggttcat gttactgctg atgtcttcag
     4081 agaaccatta tcttggtctt ctaaatattt ccaaaattta tatttttcag aatgttcatt
     4141 tcttgagatc tttcctcttt gtactttgaa gagttatcag ttatcctttc taaaaaagta
     4201 tgagctttat gaaacttttt agtttggtaa gagtgaagca cgtggtgtgt gcatgacaaa
     4261 gttgaagact tagacgtgaa tgtaacaact ctttatggca gctttctcta ctggtggata
     4321 cctgctgcat aatcaagaat ataaagtgtt gggaacctca gtggatttct ttatcactct
     4381 aggatgaaag accacataag tatcccatag aagtttttaa gttcagaatt tctaaaacat
     4441 ctaacaaata taaatacaga gaaatttaac acgctc
//
