LOCUS       NM_001106578            4792 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus semaphorin 3C (Sema3c), mRNA.
ACCESSION   NM_001106578 XM_001064163 XM_231381
VERSION     NM_001106578.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4792)
  AUTHORS   Plein,A., Calmont,A., Fantin,A., Denti,L., Anderson,N.A.,
            Scambler,P.J. and Ruhrberg,C.
  TITLE     Neural crest-derived SEMA3C activates endothelial NRP1 for cardiac
            outflow tract septation
  JOURNAL   J Clin Invest 125 (7), 2661-2676 (2015)
   PUBMED   26053665
REFERENCE   2  (bases 1 to 4792)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   3  (bases 1 to 4792)
  AUTHORS   Vadivel,A., Alphonse,R.S., Collins,J.J., van Haaften,T.,
            O'Reilly,M., Eaton,F. and Thebaud,B.
  TITLE     The axonal guidance cue semaphorin 3C contributes to alveolar
            growth and repair
  JOURNAL   PLoS One 8 (6), e67225 (2013)
   PUBMED   23840631
  REMARK    GeneRIF: Sema3C promotes normal alveolar growth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4792)
  AUTHORS   Kodo,K., Nishizawa,T., Furutani,M., Arai,S., Yamamura,E., Joo,K.,
            Takahashi,T., Matsuoka,R. and Yamagishi,H.
  TITLE     GATA6 mutations cause human cardiac outflow tract defects by
            disrupting semaphorin-plexin signaling
  JOURNAL   Proc Natl Acad Sci U S A 106 (33), 13933-13938 (2009)
   PUBMED   19666519
REFERENCE   5  (bases 1 to 4792)
  AUTHORS   Oschipok,L.W., Teh,J., McPhail,L.T. and Tetzlaff,W.
  TITLE     Expression of Semaphorin3C in axotomized rodent facial and
            rubrospinal neurons
  JOURNAL   Neurosci Lett 434 (1), 113-118 (2008)
   PUBMED   18308469
  REMARK    GeneRIF: This demonstrates that increased Sema3C mRNA levels in
            axotomized rubrospinal neurons is common to both mouse and rat
            injury models.
REFERENCE   6  (bases 1 to 4792)
  AUTHORS   Gonthier,B., Nasarre,C., Roth,L., Perraut,M., Thomasset,N.,
            Roussel,G., Aunis,D. and Bagnard,D.
  TITLE     Functional interaction between matrix metalloproteinase-3 and
            semaphorin-3C during cortical axonal growth and guidance
  JOURNAL   Cereb Cortex 17 (7), 1712-1721 (2007)
   PUBMED   17021275
REFERENCE   7  (bases 1 to 4792)
  AUTHORS   Gitler,A.D., Lu,M.M. and Epstein,J.A.
  TITLE     PlexinD1 and semaphorin signaling are required in endothelial cells
            for cardiovascular development
  JOURNAL   Dev Cell 7 (1), 107-116 (2004)
   PUBMED   15239958
REFERENCE   8  (bases 1 to 4792)
  AUTHORS   Miller,L.E., Weidler,C., Falk,W., Angele,P., Schaumburger,J.,
            Scholmerich,J. and Straub,R.H.
  TITLE     Increased prevalence of semaphorin 3C, a repellent of sympathetic
            nerve fibers, in the synovial tissue of patients with rheumatoid
            arthritis
  JOURNAL   Arthritis Rheum 50 (4), 1156-1163 (2004)
   PUBMED   15077297
REFERENCE   9  (bases 1 to 4792)
  AUTHORS   Feiner,L., Webber,A.L., Brown,C.B., Lu,M.M., Jia,L., Feinstein,P.,
            Mombaerts,P., Epstein,J.A. and Raper,J.A.
  TITLE     Targeted disruption of semaphorin 3C leads to persistent truncus
            arteriosus and aortic arch interruption
  JOURNAL   Development 128 (16), 3061-3070 (2001)
   PUBMED   11688556
REFERENCE   10 (bases 1 to 4792)
  AUTHORS   Mangasser-Stephan,K., Dooley,S., Welter,C., Mutschler,W. and
            Hanselmann,R.G.
  TITLE     Identification of human semaphorin E gene expression in rheumatoid
            synovial cells by mRNA differential display
  JOURNAL   Biochem Biophys Res Commun 234 (1), 153-156 (1997)
   PUBMED   9168980
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169108.1.
            
            On or before Sep 14, 2008 this sequence version replaced
            XM_231381.4, XM_001064163.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169108.1, SRR8487231.123795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676787, SAMN16676788
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..4792
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q11"
     gene            1..4792
                     /gene="Sema3c"
                     /note="semaphorin 3C"
                     /db_xref="GeneID:296787"
                     /db_xref="RGD:1309343"
     exon            1..117
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..2270
                     /gene="Sema3c"
                     /note="sema domain, immunoglobulin domain (Ig), short
                     basic domain, secreted, (semaphorin) 3C"
                     /codon_start=1
                     /product="semaphorin-3C precursor"
                     /protein_id="NP_001100048.1"
                     /db_xref="GeneID:296787"
                     /db_xref="RGD:1309343"
                     /translation="MALREICVLVGVFICSICVQGSSQPQARVYLTFDELRETKTSEY
                     FSLSHQQLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEPLSVFWPASTIKVEECK
                     MAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCE
                     SGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWL
                     SEPMFVDAHVIPDGTDPNDAKVYFFFKERLTDNNRSTKQIHSMVARICPNDTGGQRSL
                     VNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKG
                     SAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKD
                     FPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLG
                     TDRGTVQKVVVLPTNSSASGELILEELEVFKNHVPITTMKISSKKQQLYVSSNEGVSQ
                     VSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRG
                     FNLKAYRNAAEIVQYGVRNNSTFLECAPKSPQASIKWLLQKDKDRRKEVKLNERIIAT
                     SQGLLIRSVQDSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKWSPWTWAGS
                     VRALPFHPKDILGAFSHSEMQLINQYCKDTRQQQQLGEEPQKMRGDYGKLKALINSRK
                     SRNRRNQLPES"
     exon            118..278
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            279..341
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            342..461
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            462..552
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            553..672
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            673..815
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            816..930
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1000
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1145
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1368
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1457
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            1458..1499
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1657
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1725
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1856
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
     exon            1857..4768
                     /gene="Sema3c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaaatcaga agaaatggca ttacgggaga tttgtgtgtt ggttggagta tttatttgtt
       61 ccatttgcgt ccaaggatca tcccagcccc aagcaagagt gtatttaaca ttcgatgagc
      121 ttcgagaaac caaaacctct gaatacttta gtctgtccca ccagcagtta gactacagaa
      181 tattactgat ggatgaagat caagaccgga tatacgtggg gagcaaagac cacatcctgt
      241 ccttgaatat caacaatatc agtcaagaac ctttgagtgt tttctggcca gcatcaacaa
      301 tcaaagttga agagtgcaaa atggctggca aagatcctac acacggctgt gggaatttcg
      361 tccgcgttat tcagaccttc aaccgtactc acttgtatgt ctgtgggagt ggagcgttca
      421 gcccagtgtg cacctacctg aacaggggaa ggaggtcaga ggaccaagtt ttcatgatcg
      481 actctaaatg tgaatcagga aaaggacgat gctctttcaa ccccaatgtg aacaccgtgt
      541 ctgttatgat caatgaggaa ctcttctcag gaatgtatat agatttcatg ggtacagatg
      601 ctgctatttt tcgaagttta actaagagga atgcagtccg gactgatcaa cacaattcaa
      661 aatggctgag tgaacctatg tttgttgacg cacatgtgat cccagatggc actgatccga
      721 atgatgctaa ggtctatttc ttcttcaaag aaagattgac tgacaacaac aggagcacaa
      781 aacagataca ttccatggtc gcaagaatat gccctaatga cactggtgga caacgtagtc
      841 ttgtcaacaa gtggaccaca ttcttaaagg caaggcttgt gtgctcagtc acagatgaag
      901 atggcccaga gacacatttt gatgaactag aggatgtttt cctgctggaa acggacaacc
      961 caagaacaac acttgtgtat ggcatcttca caacatcaag ctctgttttt aaaggatcag
     1021 ctgtgtgtgt gtatcattta tctgatatac agactgtatt caatgggcct tttgcccaca
     1081 aggaagggcc caatcaccaa ctgatatcct atcaaggtag aattccatat cctcgtcctg
     1141 gaacttgccc aggaggggct tttacaccca atatgagaac caccaaggac ttcccagatg
     1201 atgttgtcac tttcattcgg aaccaccctc tcatgtacaa ttccatctac cccatccaca
     1261 gaaggcctct gatcgtccgc ataggcactg actacaagta cacaaagatt gctgtggacc
     1321 gtgtgaatgc tgctgatggg cgataccacg ttctgttcct cgggacagat cggggcaccg
     1381 tgcagaaggt cgtagtcctt cctaccaaca gctctgctag tggggagctc attctggagg
     1441 agctggaagt ctttaagaat catgttccta taacaacaat gaaaatctca tccaaaaagc
     1501 aacagttgta cgtgagctcc aatgaggggg tttcccaagt ctctctgcat cgttgccata
     1561 tctacggcac agcctgtgca gactgctgcc tggcaaggga cccatactgc gcctgggatg
     1621 gccactcctg ctctaggttc taccccactg ggaaacgaag gagccgaaga caagacgtga
     1681 gacacgggaa tccattgaca cagtgccgag ggttcaatct gaaagcatac agaaatgcgg
     1741 ctgaaattgt tcagtacgga gtaagaaata acagcacttt ccttgaatgt gctcccaagt
     1801 ctccgcaggc atctatcaag tggttgctgc agaaagacaa agacaggagg aaggaggtta
     1861 aactgaatga acgcattata gccacttccc aaggactact gatccgctct gttcaagatt
     1921 ctgaccaagg actctaccac tgcattgcca cagagaacag cttcaaacag accatagcca
     1981 agattaactt caaagtttta gattcagaaa tggtggccgt tgtgacagac aagtggtccc
     2041 catggacatg ggctggatct gtgagggctc tacccttcca tccaaaggac atcctggggg
     2101 cattcagcca ctcggaaatg cagctcatca accagtactg caaagacacc cggcagcaac
     2161 agcagctggg ggaggagcca cagaagatga gaggggacta tggcaaacta aaggcgctca
     2221 tcaacagcag gaaaagcaga aacaggagga atcagcttcc agagtcataa aacattcatc
     2281 cttggagttt ggccaccagg aacaaatgct ctgtcttcac tagtcaacta ctaagcaaaa
     2341 tcttgtgctt tacccatgag aaatccctga caaaagctgg agactcacta taaaaagtgt
     2401 gttctttgtg gactgaaatg agcatgcatc ttcttgtatg atacagacta gcgctagaca
     2461 tgtcatggtc ctcatggtgc atagaaatat ttaacttatc ccatatttta tttatatctt
     2521 tatgtgtctt ttcttcaaca ccaatgcagc atcagaagca gaactgttac acccggtaaa
     2581 ttaccctgcg ctgttccttc tgtgctctag gggtttacct ttctaattgt cactggtttt
     2641 tatacatgaa aacgaattcc agttcacaat tttcacatag taaatgtcct ataaatgtgt
     2701 gtgacatcca atgtcttgga ggttacacaa atgacaggga agagagcatc cagatgttac
     2761 ataaagtcaa gagtgactca taaagagaaa gtgatgagtt catatgcttc ccgtgattta
     2821 tattcttgct tgtccctttg cttaagattg taagatgtgt cagttgctga tgtctgccat
     2881 caatggttgt tctcttgttt tggaaagaca aaatgaatag cctgtaccat cccatctttg
     2941 atgggagatc tatcagtgag acattgacat ttctactgtt atgttatcat cttccaaaca
     3001 aaagcacttt gtcttttgga agttatttaa gttattatag acttagataa actcttgcat
     3061 tatttaattg atttactgtt ttggttttaa tgccctagtc tacctggaaa attaaaggaa
     3121 acagggatga aatattaaag catgtaattt ttccatgcag agtagagcta accaaaatta
     3181 aaaaggaaga tcaaagcata cgatttgcca tgtaaaggaa tgtgtaacat gtagtttgtt
     3241 ttccacatta gcattaggaa tcaaactgta gaagtaattt gtacatccaa gaaccagttt
     3301 cacaaaccat actgagtttt cagacaaagt atcatgattt tataaacata tctaccattc
     3361 taaggttatt attaaatcaa gaaagaaaat ctcaacacac tataaacaaa atagaatatc
     3421 tattttcact cagacatttt tttccacttg ataatacttc tttaggaata ttgatacact
     3481 tgttcaggga cctgtgtaac cattgaaaaa ttttagtact atcttctaat tacacatttg
     3541 gattgttaaa tgagaaatgt ataatcctaa aatcagtttc tgcaatttaa atggataaaa
     3601 tataggagat tttcttatat gtcttttaat tatacatctt tcatttaatt tcatttcatt
     3661 tgaatatgtt tatatcttca gataaaaaga gaaattttac aaaacactat tgaaacacac
     3721 tttgtattaa caattcattt agaaggtaat taaaacggat ctacatcctt ttacagtgct
     3781 gtgggaaaga actccaggaa gtaaaattat gagttggtag taggaccatg tgtttagcat
     3841 gcactgggtt caaacagaca gaaaggaaga aatatgagga ggaagagagg caggcataaa
     3901 aaaaagaata gagaggaaag aaggagagca ggaaggagga aaagaaggca aagaaagaca
     3961 gagagaatac attcattatc agaagattaa aaaaatgtta gttacatgat ggtcagtttg
     4021 ggggttctaa gagtgcacct cagtgttaga gaagacaaca gttaaaacag agggcataaa
     4081 tgtacccaaa tgtgtacagt accacaataa cctatacagt catcatatgc aaatgattag
     4141 cttgtttaaa atgttcacac tttggttttc cttatgcata tacaaatagc agtgtgttca
     4201 caagcaatgc taacaccgcc ctctatgttt ataacaaatc tattgtatga agagagttaa
     4261 aataaaatga catccaaggc accattcccc ttgctcctct tagcttcaaa ctgctagtca
     4321 gtgatgttta gttctatgat attatttgtt ctatttaata cctcctgttt tttttaccat
     4381 aattatattt taaatcctca tttcctttcc tcaaaagata tagaaattac tgttcagcaa
     4441 aacctggcca aaagtaaaac atatgtattt ctcaaagaca taattaatac atattggtta
     4501 tgggtgattc cttggcttta tgttgtttac ttgggaaatt taatggttta acatgttttt
     4561 ttttgtattg tacataaaat tacctagaaa tgcactttta ccccacaatg taggttcgtg
     4621 aatagattta gcatgatgaa gctgtcttta cagtgaatgt tcccccatgt agagaaagca
     4681 aactagatat agttaccaca tgagaattta attagatgtt gaaaaaaaat catttgtctg
     4741 gaaaaaataa aacattgaat tcccccaaaa aaaaaaaaaa aaaaaaaaaa aa
//
