LOCUS       NM_017310               3268 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus semaphorin 3A (Sema3a), mRNA.
ACCESSION   NM_017310
VERSION     NM_017310.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3268)
  AUTHORS   Guo,Z., Qin,Y., Li,Y. and Tang,P.
  TITLE     Sema3A ameliorates the pathological progression of osteoarthritis
            by modulating mitochondrial damage in chondrocytes
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (2), 244-249 (2024)
   PUBMED   38430015
  REMARK    GeneRIF: Sema3A ameliorates the pathological progression of
            osteoarthritis by modulating mitochondrial damage in chondrocytes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3268)
  AUTHORS   Qiu,Q., Yu,X., Chen,Q. and He,X.
  TITLE     Sema3A inactivates the ERK/JNK signalling pathways to alleviate
            inflammation and oxidative stress in lipopolysaccharide-stimulated
            rat endothelial cells and lung tissues
  JOURNAL   Autoimmunity 56 (1), 2200908 (2023)
   PUBMED   37128697
  REMARK    GeneRIF: Sema3A inactivates the ERK/JNK signalling pathways to
            alleviate inflammation and oxidative stress in
            lipopolysaccharide-stimulated rat endothelial cells and lung
            tissues.
REFERENCE   3  (bases 1 to 3268)
  AUTHORS   Huang,J., Lian,S.L., Han,J.H., Lu,Z.C. and Ding,Y.
  TITLE     Pure platelet-rich plasma promotes semaphorin-3A expression: a
            novel insight to ameliorate intervertebral disk degeneration in
            vitro
  JOURNAL   J Orthop Surg Res 18 (1), 789 (2023)
   PUBMED   37864189
  REMARK    GeneRIF: Pure platelet-rich plasma promotes semaphorin-3A
            expression: a novel insight to ameliorate intervertebral disk
            degeneration in vitro.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3268)
  AUTHORS   Sun,Z., Yan,K., Liu,S., Yu,X., Xu,J., Liu,J. and Li,S.
  TITLE     Semaphorin 3A promotes the osteogenic differentiation of rat bone
            marrow-derived mesenchymal stem cells in inflammatory environments
            by suppressing the Wnt/beta-catenin signaling pathway
  JOURNAL   J Mol Histol 52 (6), 1245-1255 (2021)
   PUBMED   33566267
  REMARK    GeneRIF: Semaphorin 3A promotes the osteogenic differentiation of
            rat bone marrow-derived mesenchymal stem cells in inflammatory
            environments by suppressing the Wnt/beta-catenin signaling pathway.
REFERENCE   5  (bases 1 to 3268)
  AUTHORS   Richeri,A., Vierci,G., Martinez,G.F., Latorre,M.P., Chalar,C. and
            Brauer,M.M.
  TITLE     Neuropilin-1 receptor in the rapid and selective estrogen-induced
            neurovascular remodeling of rat uterus
  JOURNAL   Cell Tissue Res 381 (2), 299-308 (2020)
   PUBMED   32242249
  REMARK    GeneRIF: Neuropilin-1 receptor in the rapid and selective
            estrogen-induced neurovascular remodeling of rat uterus.
            Erratum:[Cell Tissue Res. 2020 Aug;381(2):379. doi:
            10.1007/s00441-020-03230-9.. PMID: 32542406]
REFERENCE   6  (bases 1 to 3268)
  AUTHORS   Mikule,K., Gatlin,J.C., de la Houssaye,B.A. and Pfenninger,K.H.
  TITLE     Growth cone collapse induced by semaphorin 3A requires
            12/15-lipoxygenase
  JOURNAL   J Neurosci 22 (12), 4932-4941 (2002)
   PUBMED   12077190
REFERENCE   7  (bases 1 to 3268)
  AUTHORS   Cheng,H.J., Bagri,A., Yaron,A., Stein,E., Pleasure,S.J. and
            Tessier-Lavigne,M.
  TITLE     Plexin-A3 mediates semaphorin signaling and regulates the
            development of hippocampal axonal projections
  JOURNAL   Neuron 32 (2), 249-263 (2001)
   PUBMED   11683995
REFERENCE   8  (bases 1 to 3268)
  AUTHORS   Chedotal,A., Del Rio,J.A., Ruiz,M., He,Z., Borrell,V., de
            Castro,F., Ezan,F., Goodman,C.S., Tessier-Lavigne,M., Sotelo,C. and
            Soriano,E.
  TITLE     Semaphorins III and IV repel hippocampal axons via two distinct
            receptors
  JOURNAL   Development 125 (21), 4313-4323 (1998)
   PUBMED   9753685
REFERENCE   9  (bases 1 to 3268)
  AUTHORS   Giger,R.J., Wolfer,D.P., De Wit,G.M. and Verhaagen,J.
  TITLE     Anatomy of rat semaphorin III/collapsin-1 mRNA expression and
            relationship to developing nerve tracts during neuroembryogenesis
  JOURNAL   J Comp Neurol 375 (3), 378-392 (1996)
   PUBMED   8915837
REFERENCE   10 (bases 1 to 3268)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Oct 5, 2022 this sequence version replaced NM_017310.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X95286.1, SRR26643299.18094.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840107,
                                           SAMN12840109 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-398               JAXUCZ010000004.1  22448260-22448657   c
            399-556             JAXUCZ010000004.1  22382172-22382329   c
            557-619             JAXUCZ010000004.1  22377183-22377245   c
            620-739             JAXUCZ010000004.1  22362488-22362607   c
            740-833             JAXUCZ010000004.1  22322512-22322605   c
            834-953             JAXUCZ010000004.1  22313901-22314020   c
            954-1096            JAXUCZ010000004.1  22285812-22285954   c
            1097-1211           JAXUCZ010000004.1  22285316-22285430   c
            1212-1281           JAXUCZ010000004.1  22285162-22285231   c
            1282-1426           JAXUCZ010000004.1  22282879-22283023   c
            1427-1646           JAXUCZ010000004.1  22279103-22279322   c
            1647-1738           JAXUCZ010000004.1  22274820-22274911   c
            1739-1780           JAXUCZ010000004.1  22266262-22266303   c
            1781-1938           JAXUCZ010000004.1  22262825-22262982   c
            1939-2006           JAXUCZ010000004.1  22260200-22260267   c
            2007-2149           JAXUCZ010000004.1  22247818-22247960   c
            2150-3268           JAXUCZ010000004.1  22245322-22246440   c
FEATURES             Location/Qualifiers
     source          1..3268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q12"
     gene            1..3268
                     /gene="Sema3a"
                     /note="semaphorin 3A"
                     /db_xref="GeneID:29751"
                     /db_xref="RGD:3657"
     exon            1..398
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..2605
                     /gene="Sema3a"
                     /note="sema domain, immunoglobulin domain (Ig), short
                     basic domain, sec; sema III; semaphorin III; sema domain,
                     immunoglobulin domain (Ig), short basic domain, secreted,
                     (semaphorin) 3A"
                     /codon_start=1
                     /product="semaphorin-3A precursor"
                     /protein_id="NP_059006.1"
                     /db_xref="GeneID:29751"
                     /db_xref="RGD:3657"
                     /translation="MGWFTGIACLFWGILLTARANYANGKNNVPRLKLSYKEMLESNN
                     VITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDE
                     CKWAGKDILKECANFIKVLKAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDS
                     HFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDS
                     RWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGH
                     RSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNI
                     FKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDST
                     KDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMF
                     IGTDVGTVLKVVSVPKETWHDLEEVLLEEMTVFREPTTISAMELSTKQQQLYIGSTAG
                     VAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTH
                     CSDLQHHDNHHGHSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRV
                     GDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDD
                     DGDGSKTKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGH
                     SQGSSNKWKHMQESKKGRNRRTHEFERAPRSV"
     exon            399..556
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            557..619
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            620..739
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            740..833
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            834..953
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1096
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1097..1211
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1212..1281
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1282..1426
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1646
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1738
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1739..1780
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1938
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2006
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2149
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
     exon            2150..3268
                     /gene="Sema3a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tttttttctt ctttccacac aacagttgtg cctcattatc cggtgcctgg ctcgattttt
       61 ttttttcttt ctttttcttt tttgagggtt tgaagtttct gtgattccgt gactgttaca
      121 gaagaagaga cgttagtgtt gccatgaggt cttgattgtc tgcatttatg aatgaaactg
      181 acctaaatca cctgttacct ccagtttcca gattgtttga acttctctgg ccgcacaata
      241 caggaaggaa ggctgctgca gctcagggac ctccagcgtc tgcagcatgg gctggttcac
      301 tgggattgcc tgtcttttct ggggtatatt acttacagca agagcaaact atgcaaacgg
      361 aaagaacaat gtgccaagac tgaaattatc gtacaaagaa atgttggaat ccaacaatgt
      421 gatcactttc aatggcttgg ccaacagctc cagttatcac acttttcttc tggatgagga
      481 acggagtaga ctgtatgttg gagcaaagga tcatatattt tcattcaact tggtgaatat
      541 taaagatttt caaaagattg tgtggccagt atcttatacc aggagagatg aatgcaagtg
      601 ggctggaaaa gatatcctga aagaatgtgc aaatttcatc aaggtcctca aggcttataa
      661 tcagactcac ttgtacgcct gtggaacggg ggctttccat ccaatttgca cctatattga
      721 agttggacat catcctgagg acaacatttt taaactgcag gactcacatt ttgaaaacgg
      781 tcgtgggaag agtccttatg accccaaact tctgactgcc tctcttctaa tagatggtga
      841 gttgtactct ggaactgctg cggatttcat gggacgagac tttgctatct tcagaacatt
      901 ggggcaccat catcccatca ggaccgagca gcacgactcc cggtggctca atgatcctag
      961 attcatcagt gcccatctca tcccagagag tgataaccct gaagatgaca aagtatattt
     1021 tttcttccga gaaaatgcaa tagatggaga acattctgga aaagccactc atgctagaat
     1081 aggtcagata tgcaagaatg actttggagg acacagaagt cttgtgaata aatggacaac
     1141 tttcctgaaa gcacgcctga tttgctctgt gccaggtccc aatggcattg acacacattt
     1201 tgatgaatta caggatgtat tcttaatgaa ctctaaagat cctaaaaatc caattgtcta
     1261 tggagtgttc acaacatcaa gcaacatctt taagggctct gctgtgtgta tgtacagtat
     1321 gagtgatgta agaagggtgt tccttggtcc atatgctcac agagatggtc ccaactatca
     1381 gtgggtacct taccaaggaa gagtccctta tccacgacca ggaacttgtc ccagtaaaac
     1441 atttggtgga tttgactcca caaaggacct tcctgatgat gtcataacct ttgcaagaag
     1501 ccatccagcc atgtacaacc cagtgtttcc tattaataat cgcccaataa tgatcaaaac
     1561 agatgtaaat tatcagttca cacaaattgt tgtagaccgg gtggatgcag aagatggcca
     1621 gtatgatgtt atgttcatcg gaacagatgt tggaactgtc cttaaagtgg tttcagtccc
     1681 caaggagact tggcatgacc tagaagaagt tcttctggaa gaaatgacag tcttccggga
     1741 accaacaact atttcagcaa tggagctttc tactaaacag caacaactgt acattggctc
     1801 aactgctgga gtagcacagc ttcctctaca ccgttgtgac atttatggca aagcctgtgc
     1861 agagtgctgc cttgctcggg acccttattg tgcctgggat gggtcatcat gctcacgcta
     1921 ttttcctact gcaaagaggc gcacaagacg acaggatata aggaatggag acccactgac
     1981 tcactgctcc gacttgcagc atcatgataa tcatcatggg cacagtcttg aagagagaat
     2041 catctatgga gtagaaaata gtagcacatt cttggaatgc agtccgaagt cacagagagc
     2101 cttggtatat tggcaatttc agaggcgaaa tgaagatcga aaggaggaga tcagagtggg
     2161 tgatcatatc atcaggacag aacaggggct cctgcttcgt agtctgcaga agaaggattc
     2221 aggcaattac ctgtgtcacg ccgtggagca cggtttcatg caaactcttc ttaaggtgac
     2281 cctggaagtc atcgatacag aacatttgga ggaacttctt cataaagatg acgatggaga
     2341 tggctctaag accaaagaaa tgtccagtag catgacaccc agccagaagg tctggtacag
     2401 agacttcatg cagctcatca accaccccaa cctgaacaca atggatgagt tctgtgaaca
     2461 agtgtggaaa agggaccgaa aacaacgccg acaaaggccg gggcactctc aagggagcag
     2521 caacaagtgg aagcacatgc aggagagcaa gaaaggtaga aacaggagga cccacgagtt
     2581 tgagagggca cccagaagtg tctgagctgc gccacctccc aaaacctcaa acaagtacaa
     2641 acttgcttag ataataactg gaaaaaatgc aatacacatg accatttcat ggcattatgt
     2701 ggatgtttac aatggtggga agttcaacca tgttccacca atttaagtcc gcgaggaacc
     2761 tttccagcag gctttcttca gactaccaac gcctgacaga gatcacaggt gagcgtaggt
     2821 gtccatgtcc gctgacttag tgtttcctct gagcgttcat tttgctttct tctttgcctg
     2881 agaaataaaa atgtcatttg ccatgctgcc gttgaaagga gaaaaactgc atcagcagag
     2941 ccattttatc gaagcgagag ttgaaaataa actgcatgga ttcagtaagc agatgactat
     3001 tccaaaacgt gattggagtc aaggatgttt tgtctaccag cactcgtgtt tatatgtact
     3061 ggagtagtaa aaaaaaagga gaatggaact gagtgaaata gtctgaggag atataaaaac
     3121 ataaaccatc catcatccgg aagagaaatg gagtacactg atctactact gatgtcttct
     3181 ttcagctttg atctaaagat gtattttatt aaagctataa tttaaatgta ccatggcaaa
     3241 catgcagtaa agattagctg ttttctaa
//
