LOCUS       NM_001126090             753 bp    mRNA    linear   ROD 20-MAR-2023
DEFINITION  Rattus norvegicus SEM1 26S proteasome subunit (Sem1), mRNA.
ACCESSION   NM_001126090 XM_001054221 XM_001057613
VERSION     NM_001126090.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 753)
  AUTHORS   Ge P, Luo Y, Liu CL and Hu B.
  TITLE     Protein aggregation and proteasome dysfunction after brain ischemia
  JOURNAL   Stroke 38 (12), 3230-3236 (2007)
   PUBMED   17975104
  REMARK    GeneRIF: analysis of proteasome 19 and 26 dysfunction after brain
            ischemia
REFERENCE   2  (bases 1 to 753)
  AUTHORS   Wang X, Chen CF, Baker PR, Chen PL, Kaiser P and Huang L.
  TITLE     Mass spectrometric characterization of the affinity-purified human
            26S proteasome complex
  JOURNAL   Biochemistry 46 (11), 3553-3565 (2007)
   PUBMED   17323924
REFERENCE   3  (bases 1 to 753)
  AUTHORS   Baillat D, Hakimi MA, Naar AM, Shilatifard A, Cooch N and
            Shiekhattar R.
  TITLE     Integrator, a multiprotein mediator of small nuclear RNA
            processing, associates with the C-terminal repeat of RNA polymerase
            II
  JOURNAL   Cell 123 (2), 265-276 (2005)
   PUBMED   16239144
REFERENCE   4  (bases 1 to 753)
  AUTHORS   Gudmundsdottir K, Lord CJ, Witt E, Tutt AN and Ashworth A.
  TITLE     DSS1 is required for RAD51 focus formation and genomic stability in
            mammalian cells
  JOURNAL   EMBO Rep 5 (10), 989-993 (2004)
   PUBMED   15359272
REFERENCE   5  (bases 1 to 753)
  AUTHORS   Sone T, Saeki Y, Toh-e A and Yokosawa H.
  TITLE     Sem1p is a novel subunit of the 26 S proteasome from Saccharomyces
            cerevisiae
  JOURNAL   J Biol Chem 279 (27), 28807-28816 (2004)
   PUBMED   15117943
REFERENCE   6  (bases 1 to 753)
  AUTHORS   Yang H, Jeffrey PD, Miller J, Kinnucan E, Sun Y, Thoma NH, Zheng N,
            Chen PL, Lee WH and Pavletich NP.
  TITLE     BRCA2 function in DNA binding and recombination from a
            BRCA2-DSS1-ssDNA structure
  JOURNAL   Science 297 (5588), 1837-1848 (2002)
   PUBMED   12228710
  REMARK    GeneRIF: 3.1 angstrom crystal structure of approximately
            90-kilodalton BRCA2 domain bound to DSS1, which reveals three
            oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH)
            motif.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473959.1.
            
            On or before Apr 30, 2008 this sequence version replaced
            XM_001054221.1, XM_001057613.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FM099107.1, DV214647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..753
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q21"
     gene            1..753
                     /gene="Sem1"
                     /gene_synonym="Dss1; Shfm1"
                     /note="SEM1 26S proteasome subunit"
                     /db_xref="GeneID:680532"
                     /db_xref="RGD:1590628"
     exon            1..203
                     /gene="Sem1"
                     /gene_synonym="Dss1; Shfm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..340
                     /gene="Sem1"
                     /gene_synonym="Dss1; Shfm1"
                     /note="26S proteasome complex subunit DSS1; split
                     hand/foot malformation (ectrodactyly) type 1; SEM1, 26S
                     proteasome complex subunit"
                     /codon_start=1
                     /product="26S proteasome complex subunit SEM1"
                     /protein_id="NP_001119562.1"
                     /db_xref="GeneID:680532"
                     /db_xref="RGD:1590628"
                     /translation="MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWD
                     DDNVEDDFSNQLRAELEKHGYKMETS"
     exon            204..297
                     /gene="Sem1"
                     /gene_synonym="Dss1; Shfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..753
                     /gene="Sem1"
                     /gene_synonym="Dss1; Shfm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccctgtagc tcttcccctc tagtctctat ggttgcgccg gcgttggtag tatcggcgcc
       61 tcactagtac tgaggcttcc aactttgtgg tcgatctctg agcgttgttg gggcttggcg
      121 ctgcgctatg tccgagaaga agcagcctgt cgacttgggt ctcctggaag aggacgacga
      181 gttcgaggag tttcccgcgg aagactgggc cggcttagat gaagatgaag atgcacatgt
      241 ctgggaggat aattgggatg atgacaatgt agaagacgac ttctccaatc agttacgcgc
      301 tgagctggag aagcatggtt acaagatgga gacttcatag catccaggaa tgttccagga
      361 acttaaacat ggactctacc acattctcgg acagagaaac cagcatggga tactttagag
      421 aatatgttta tttcattatc tctgggattt atttttgttt gtataagaaa aacataagta
      481 aataaatgtt ttgatctaat ctttttggtt cagatgtctt gatcttttgc ctctatccct
      541 aaattttata ctcatgagtt ttaagaaact tattaatatt atcccagtaa agttcacatt
      601 ataaaatttt ttaatactaa tcaaacagtc agatgttggg ctttatcaga ttatccaatt
      661 ttacaagatg tttctattgt atgacattaa attttaatac cttctgtctt ttactataag
      721 caacattttc tgaagtttga aggagaccct tta
//
